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Found 442 hits of Enz. Inhib. data with enzyme = 'Coagulation factor X and plasma kallikrein' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306676
PNG
((+-)-N-[(6-amino-2,4-dimethyl- pyridin-3-yl)methyl...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc2c(O)nnc(O)c2cc31
Show InChI InChI=1S/C25H21N5O4/c1-10-5-20(26)28-11(2)19(10)9-27-23(31)12-3-4-13-14(6-12)22-16-8-18-17(7-15(16)21(13)34-22)24(32)29-30-25(18)33/h3-8,21-22H,9H2,1-2H3,(H2,26,28)(H,27,31)(H,29,32)(H,30,33)
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n/an/a 0n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306556
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-dimethyl-phenyl)m...)
Show SMILES Cc1cc(cc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F)C(N)=N
Show InChI InChI=1S/C31H25F2N3O2/c1-15-9-19(30(34)35)10-16(2)26(15)14-36-31(37)18-4-7-23-25(12-18)29-24-11-17(3-6-22(24)28(23)38-29)21-8-5-20(32)13-27(21)33/h3-13,28-29H,14H2,1-2H3,(H3,34,35)(H,36,37)/t28-,29+/m0/s1
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n/an/a 0.741n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306637
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)c(F)c1
Show InChI InChI=1S/C26H21F2N3O2/c27-21-9-15(25(29)30)10-22(28)20(21)11-31-26(32)14-4-6-17-19(8-14)24-18-7-13(12-1-2-12)3-5-16(18)23(17)33-24/h3-10,12,23-24H,1-2,11H2,(H3,29,30)(H,31,32)/t23-,24+/m0/s1
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n/an/a 0.759n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306613
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)c(F)c1
Show InChI InChI=1S/C29H19F4N3O2/c30-16-3-6-17(25(33)11-16)13-1-4-18-20(7-13)27-21-8-14(2-5-19(21)26(18)38-27)29(37)36-12-22-23(31)9-15(28(34)35)10-24(22)32/h1-11,26-27H,12H2,(H3,34,35)(H,36,37)/t26-,27+/m0/s1
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n/an/a 0.759n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306663
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-(3,...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)N4CC(F)(F)C4)c3c2)cc1
Show InChI InChI=1S/C26H22F2N4O2/c27-26(28)12-32(13-26)17-6-8-19-21(10-17)23-20-9-16(5-7-18(20)22(19)34-23)25(33)31-11-14-1-3-15(4-2-14)24(29)30/h1-10,22-23H,11-13H2,(H3,29,30)(H,31,33)/t22-,23+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306528
PNG
((+-)-N-[(4-carbamimidoylphenyl) methyl]-12-(2,4- d...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3C4OC(c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C29H21F2N3O2/c30-19-7-10-20(25(31)13-19)17-5-8-21-23(11-17)27-24-12-18(6-9-22(24)26(21)36-27)29(35)34-14-15-1-3-16(4-2-15)28(32)33/h1-13,26-27H,14H2,(H3,32,33)(H,34,35)
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306668
PNG
((1S,8R)-N-[(4-carbamimidoyl-2- methylphenyl)-methy...)
Show SMILES Cc1cc(ccc1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-n1cccn1)C(N)=N
Show InChI InChI=1S/C27H23N5O2/c1-15-11-16(26(28)29)3-4-18(15)14-30-27(33)17-5-7-20-22(12-17)25-23-13-19(32-10-2-9-31-32)6-8-21(23)24(20)34-25/h2-13,24-25H,14H2,1H3,(H3,28,29)(H,30,33)/t24-,25+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306662
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-methylpheny])-methy...)
Show SMILES Cc1cc(ccc1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F)C(N)=N
Show InChI InChI=1S/C30H23F2N3O2/c1-15-10-17(29(33)34)2-3-19(15)14-35-30(36)18-5-8-23-25(12-18)28-24-11-16(4-7-22(24)27(23)37-28)21-9-6-20(31)13-26(21)32/h2-13,27-28H,14H2,1H3,(H3,33,34)(H,35,36)/t27-,28+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306685
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2)c(F)c1
Show InChI InChI=1S/C29H21F2N3O2/c30-20-7-3-15(4-8-20)16-5-9-21-23(11-16)27-24-12-18(6-10-22(24)26(21)36-27)29(35)34-14-19-2-1-17(28(32)33)13-25(19)31/h1-13,26-27H,14H2,(H3,32,33)(H,34,35)/t26-,27+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306686
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-dimethyl-phenyl)m...)
Show SMILES Cc1cc(cc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(ccc34)C3CC3)c2c1)C(N)=N
Show InChI InChI=1S/C28H27N3O2/c1-14-9-19(27(29)30)10-15(2)24(14)13-31-28(32)18-6-8-21-23(12-18)26-22-11-17(16-3-4-16)5-7-20(22)25(21)33-26/h5-12,16,25-26H,3-4,13H2,1-2H3,(H3,29,30)(H,31,32)/t25-,26+/m0/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306703
PNG
((1S,8R)-N-[(4- carbamimidoylphenyl) methyl]-11,12-...)
Show SMILES CCc1cc2[C@@H]3O[C@H](c2cc1CC)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H27N3O2/c1-3-16-11-22-23(12-17(16)4-2)25-21-13-19(9-10-20(21)24(22)32-25)27(31)30-14-15-5-7-18(8-6-15)26(28)29/h5-13,24-25H,3-4,14H2,1-2H3,(H3,28,29)(H,30,31)/t24-,25+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306708
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-11,12-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(C3CC3)c(cc42)C2CC2)cc1
Show InChI InChI=1S/C29H27N3O2/c30-28(31)18-3-1-15(2-4-18)14-32-29(33)19-9-10-20-23(11-19)27-25-13-22(17-7-8-17)21(16-5-6-16)12-24(25)26(20)34-27/h1-4,9-13,16-17,26-27H,5-8,14H2,(H3,30,31)(H,32,33)/t26-,27+/m1/s1
PDB

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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306535
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meth...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5cc(F)cn5)ccc34)c2c1
Show InChI InChI=1S/C27H24FN5O2/c1-14-7-24(29)32-15(2)23(14)11-30-27(34)17-4-6-20-22(9-17)26-21-8-16(3-5-19(21)25(20)35-26)12-33-13-18(28)10-31-33/h3-10,13,25-26H,11-12H2,1-2H3,(H2,29,32)(H,30,34)/t25-,26+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306536
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meth...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5cc(Cl)cn5)ccc34)c2c1
Show InChI InChI=1S/C27H24ClN5O2/c1-14-7-24(29)32-15(2)23(14)11-30-27(34)17-4-6-20-22(9-17)26-21-8-16(3-5-19(21)25(20)35-26)12-33-13-18(28)10-31-33/h3-10,13,25-26H,11-12H2,1-2H3,(H2,29,32)(H,30,34)/t25-,26+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306538
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meht...)
Show SMILES Cc1cnn(Cc2ccc3[C@@H]4O[C@H](c3c2)c2cc(ccc42)C(=O)NCc2c(C)cc(N)nc2C)c1
Show InChI InChI=1S/C28H27N5O2/c1-15-11-31-33(13-15)14-18-4-6-20-22(9-18)27-23-10-19(5-7-21(23)26(20)35-27)28(34)30-12-24-16(2)8-25(29)32-17(24)3/h4-11,13,26-27H,12,14H2,1-3H3,(H2,29,32)(H,30,34)/t26-,27+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306558
PNG
((1R,8S)-N-[(4- carbamimidoylphenyl) methyl]-12-(4-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C29H22FN3O2/c30-21-9-5-17(6-10-21)19-7-11-22-24(13-19)27-25-14-20(8-12-23(25)26(22)35-27)29(34)33-15-16-1-3-18(4-2-16)28(31)32/h1-14,26-27H,15H2,(H3,31,32)(H,33,34)/t26-,27+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306559
PNG
((1R,8S)-N-[(4- carbamimidoylphenyl) methyl]-12-(2,...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)cc1
Show InChI InChI=1S/C29H21F2N3O2/c30-19-7-10-20(25(31)13-19)17-5-8-21-23(11-17)27-24-12-18(6-9-22(24)26(21)36-27)29(35)34-14-15-1-3-16(4-2-15)28(32)33/h1-13,26-27H,14H2,(H3,32,33)(H,34,35)/t26-,27+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306565
PNG
((1R,8S)-N-{[6-amino-2-methyl- 4-(propan-2-yl)-pyri...)
Show SMILES CC(C)c1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(F)cc1F
Show InChI InChI=1S/C31H27F2N3O2/c1-15(2)23-13-28(34)36-16(3)26(23)14-35-31(37)18-5-8-22-25(11-18)30-24-10-17(4-7-21(24)29(22)38-30)20-9-6-19(32)12-27(20)33/h4-13,15,29-30H,14H2,1-3H3,(H2,34,36)(H,35,37)/t29-,30+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306581
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)meth...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@H](c4cc(Cn5ccccc5=O)ccc34)c2c1
Show InChI InChI=1S/C29H26N4O3/c1-16-11-25(30)32-17(2)24(16)14-31-29(35)19-7-9-21-23(13-19)28-22-12-18(6-8-20(22)27(21)36-28)15-33-10-4-3-5-26(33)34/h3-13,27-28H,14-15H2,1-2H3,(H2,30,32)(H,31,35)/t27-,28+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306620
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-[(3...)
Show SMILES CN(c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N)c1cccc(Cl)c1
Show InChI InChI=1S/C30H25ClN4O2/c1-35(21-4-2-3-20(31)14-21)22-10-12-24-26(15-22)28-25-13-19(9-11-23(25)27(24)37-28)30(36)34-16-17-5-7-18(8-6-17)29(32)33/h2-15,27-28H,16H2,1H3,(H3,32,33)(H,34,36)/t27-,28+/m1/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306642
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES CC(=C)c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1c(F)cc(cc1F)C(N)=N
Show InChI InChI=1S/C26H21F2N3O2/c1-12(2)13-3-5-16-18(7-13)24-19-8-14(4-6-17(19)23(16)33-24)26(32)31-11-20-21(27)9-15(25(29)30)10-22(20)28/h3-10,23-24H,1,11H2,2H3,(H3,29,30)(H,31,32)/t23-,24+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306647
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccccc2F)c(F)c1
Show InChI InChI=1S/C29H21F2N3O2/c30-24-4-2-1-3-19(24)15-7-9-20-22(11-15)27-23-12-17(8-10-21(23)26(20)36-27)29(35)34-14-18-6-5-16(28(32)33)13-25(18)31/h1-13,26-27H,14H2,(H3,32,33)(H,34,35)/t26-,27+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306648
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2-fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(F)cc2F)c(F)c1
Show InChI InChI=1S/C29H20F3N3O2/c30-18-5-8-19(25(32)12-18)14-3-6-20-22(9-14)27-23-10-16(4-7-21(23)26(20)37-27)29(36)35-13-17-2-1-15(28(33)34)11-24(17)31/h1-12,26-27H,13H2,(H3,33,34)(H,35,36)/t26-,27+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306652
PNG
((1R,8S)-N-((4-carbamimidoyl- 2,6-difluorophenyl)me...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(CCC(F)(F)F)ccc45)c3c2)c(F)c1
Show InChI InChI=1S/C26H20F5N3O2/c27-20-9-14(24(32)33)10-21(28)19(20)11-34-25(35)13-2-4-16-18(8-13)23-17-7-12(5-6-26(29,30)31)1-3-15(17)22(16)36-23/h1-4,7-10,22-23H,5-6,11H2,(H3,32,33)(H,34,35)/t22-,23+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306658
PNG
((1R,8S)-N-[(4-carbamimidoyl-2- fluorophenyl)-methy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)c(F)c1
Show InChI InChI=1S/C26H22FN3O2/c27-22-11-15(25(28)29)3-4-17(22)12-30-26(31)16-6-8-19-21(10-16)24-20-9-14(13-1-2-13)5-7-18(20)23(19)32-24/h3-11,13,23-24H,1-2,12H2,(H3,28,29)(H,30,31)/t23-,24+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306544
PNG
((1R,8S)-N-[(4- carbamimidoylphenyl) methyl]-12-(2-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccccc2F)cc1
Show InChI InChI=1S/C29H22FN3O2/c30-25-4-2-1-3-20(25)18-9-11-21-23(13-18)27-24-14-19(10-12-22(24)26(21)35-27)29(34)33-15-16-5-7-17(8-6-16)28(31)32/h1-14,26-27H,15H2,(H3,31,32)(H,33,34)/t26-,27+/m0/s1
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n/an/a 1.74n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306671
PNG
((+-)-N-[(4-carbamimidoylphenyl) methyl]-11,12-diet...)
Show SMILES CCc1cc2C3OC(c2cc1CC)c1cc(ccc31)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H27N3O2/c1-3-16-11-22-23(12-17(16)4-2)25-21-13-19(9-10-20(21)24(22)32-25)27(31)30-14-15-5-7-18(8-6-15)26(28)29/h5-13,24-25H,3-4,14H2,1-2H3,(H3,28,29)(H,30,31)
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n/an/a 1.82n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306616
PNG
((1R,8S)-N-[(4- carbamimidoylphenyl) methyl]-12- cy...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)C4CC4)c3c2)cc1
Show InChI InChI=1S/C26H23N3O2/c27-25(28)16-3-1-14(2-4-16)13-29-26(30)18-8-10-20-22(12-18)24-21-11-17(15-5-6-15)7-9-19(21)23(20)31-24/h1-4,7-12,15,23-24H,5-6,13H2,(H3,27,28)(H,29,30)/t23-,24+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306654
PNG
((1R,8S)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES CC(C)c1ccc2[C@@H]3O[C@H](c2c1)c1cc(ccc31)C(=O)NCc1c(F)cc(cc1F)C(N)=N
Show InChI InChI=1S/C26H23F2N3O2/c1-12(2)13-3-5-16-18(7-13)24-19-8-14(4-6-17(19)23(16)33-24)26(32)31-11-20-21(27)9-15(25(29)30)10-22(20)28/h3-10,12,23-24H,11H2,1-2H3,(H3,29,30)(H,31,32)/t23-,24+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306632
PNG
((1S,8R)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2nccs2)c(F)c1
Show InChI InChI=1S/C26H18F2N4O2S/c27-20-9-14(24(29)30)10-21(28)19(20)11-32-25(33)12-1-3-15-17(7-12)23-18-8-13(26-31-5-6-35-26)2-4-16(18)22(15)34-23/h1-10,22-23H,11H2,(H3,29,30)(H,32,33)/t22-,23+/m1/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306593
PNG
((1S,8R)-N-[(4-carbamimidoyl- phenyl)methyl]-12-(py...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)N4CCCC4)c3c2)cc1
Show InChI InChI=1S/C27H26N4O2/c28-26(29)17-5-3-16(4-6-17)15-30-27(32)18-7-9-20-22(13-18)25-23-14-19(31-11-1-2-12-31)8-10-21(23)24(20)33-25/h3-10,13-14,24-25H,1-2,11-12,15H2,(H3,28,29)(H,30,32)/t24-,25+/m1/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306574
PNG
((1S,8R)-N-[(4- carbamimidoylphenyl)methyl]- 12-(5-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-c2ccc(Cl)s2)cc1
Show InChI InChI=1S/C27H20ClN3O2S/c28-23-10-9-22(34-23)16-5-7-18-20(11-16)25-21-12-17(6-8-19(21)24(18)33-25)27(32)31-13-14-1-3-15(4-2-14)26(29)30/h1-12,24-25H,13H2,(H3,29,30)(H,31,32)/t24-,25+/m0/s1
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306490
PNG
((+-)-N-[(6-amino-4-methoxy-2- methylpyridin-3-yl)m...)
Show SMILES COc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(Cn5cc(C)cn5)ccc34)c2c1
Show InChI InChI=1S/C28H27N5O3/c1-15-11-31-33(13-15)14-17-4-6-19-21(8-17)27-22-9-18(5-7-20(22)26(19)36-27)28(34)30-12-23-16(2)32-25(29)10-24(23)35-3/h4-11,13,26-27H,12,14H2,1-3H3,(H2,29,32)(H,30,34)
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306492
PNG
((+-)-N-[(6-amino-4-ethoxy-2- methylpyridin-3-yl)me...)
Show SMILES CCOc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(Cn5cc(C)cn5)ccc34)c2c1
Show InChI InChI=1S/C29H29N5O3/c1-4-36-25-11-26(30)33-17(3)24(25)13-31-29(35)19-6-8-21-23(10-19)28-22-9-18(5-7-20(22)27(21)37-28)15-34-14-16(2)12-32-34/h5-12,14,27-28H,4,13,15H2,1-3H3,(H2,30,33)(H,31,35)
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Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304228
PNG
(2-(1-((4-carboxy-3- fluorophenyl)amino)-3- cyclobu...)
Show SMILES OC(=O)c1ccc(NC(=O)C(CC2CCC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1F
Show InChI InChI=1S/C26H21ClF4N2O4/c27-19-8-7-17(24(30)31)22(23(19)29)14-4-9-21(33(37)12-14)18(10-13-2-1-3-13)25(34)32-15-5-6-16(26(35)36)20(28)11-15/h4-9,11-13,18,24H,1-3,10H2,(H,32,34)(H,35,36)
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n/an/a 2.10n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306643
PNG
((1S,8R)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)m...)
Show SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@@H](c3c2)c2cc(ccc42)-n2cccn2)c(F)c1
Show InChI InChI=1S/C26H19F2N5O2/c27-21-9-14(25(29)30)10-22(28)20(21)12-31-26(34)13-2-4-16-18(8-13)24-19-11-15(33-7-1-6-32-33)3-5-17(19)23(16)35-24/h1-11,23-24H,12H2,(H3,29,30)(H,31,34)/t23-,24+/m1/s1
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n/an/a 2.45n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306678
PNG
((+-)-N-[(6-amino-2,4-dimethyl- pyridin-3-yl)methyl...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(c(C=C)cc31)-c1ccc(F)cc1F
Show InChI InChI=1S/C31H25F2N3O2/c1-4-17-10-24-25(13-22(17)20-8-6-19(32)12-27(20)33)30-23-11-18(5-7-21(23)29(24)38-30)31(37)35-14-26-15(2)9-28(34)36-16(26)3/h4-13,29-30H,1,14H2,2-3H3,(H2,34,36)(H,35,37)
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n/an/a 2.69n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304195
PNG
(2-(1-((4- carboxyphenyl)amino)-1- oxo-3-(2- (trifl...)
Show SMILES OC(=O)c1ccc(NC(=O)C(CC2CC2C(F)(F)F)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1
Show InChI InChI=1S/C26H19ClF6N2O4/c27-19-7-6-16(23(29)30)21(22(19)28)13-3-8-20(35(39)11-13)17(9-14-10-18(14)26(31,32)33)24(36)34-15-4-1-12(2-5-15)25(37)38/h1-8,11,14,17-18,23H,9-10H2,(H,34,36)(H,37,38)
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n/an/a 2.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304171
PNG
(2-((2R)-1-((4- carboxyphenyl)amino)-3-(2- methylcy...)
Show SMILES CC1CC1C[C@@H](C(=O)Nc1ccc(cc1)C(O)=O)c1ccc(c[n+]1[O-])-c1c(F)c(Cl)ccc1C(F)F
Show InChI InChI=1S/C26H22ClF3N2O4/c1-13-10-16(13)11-19(25(33)31-17-5-2-14(3-6-17)26(34)35)21-9-4-15(12-32(21)36)22-18(24(29)30)7-8-20(27)23(22)28/h2-9,12-13,16,19,24H,10-11H2,1H3,(H,31,33)(H,34,35)/t13?,16?,19-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306497
PNG
((1R,8S)-N-[(6-amino-2,4- dimethylpyridin-3-yl)-met...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2[C@H]3O[C@@H](c2c1)c1cc(ccc31)-c1ccc(Cl)cc1C#N
Show InChI InChI=1S/C30H23ClN4O2/c1-15-9-27(33)35-16(2)26(15)14-34-30(36)18-4-7-23-25(12-18)29-24-11-17(3-6-22(24)28(23)37-29)21-8-5-20(31)10-19(21)13-32/h3-12,28-29H,14H2,1-2H3,(H2,33,35)(H,34,36)/t28-,29+/m0/s1
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n/an/a 3.02n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306530
PNG
((+-)-N-{[6-amino-2-methyl-4- (propan-2-yl)pyridin-...)
Show SMILES CC(C)c1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(ccc31)-c1ccc(F)cc1F
Show InChI InChI=1S/C31H27F2N3O2/c1-15(2)23-13-28(34)36-16(3)26(23)14-35-31(37)18-5-8-22-25(11-18)30-24-10-17(4-7-21(24)29(22)38-30)20-9-6-19(32)12-27(20)33/h4-13,15,29-30H,14H2,1-3H3,(H2,34,36)(H,35,37)
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n/an/a 3.02n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304179
PNG
(2-(1-((4-carboxyphenyl)amino)- 3-cyclopropyl-1-oxo...)
Show SMILES COc1cc(C(CC2CC2)C(=O)Nc2ccc(cc2)C(O)=O)[n+]([O-])cc1-c1c(F)c(Cl)ccc1OC(F)F
Show InChI InChI=1S/C26H22ClF3N2O6/c1-37-21-11-19(32(36)12-17(21)22-20(38-26(29)30)9-8-18(27)23(22)28)16(10-13-2-3-13)24(33)31-15-6-4-14(5-7-15)25(34)35/h4-9,11-13,16,26H,2-3,10H2,1H3,(H,31,33)(H,34,35)
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n/an/a 3.30n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304195
PNG
(2-(1-((4- carboxyphenyl)amino)-1- oxo-3-(2- (trifl...)
Show SMILES OC(=O)c1ccc(NC(=O)C(CC2CC2C(F)(F)F)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1
Show InChI InChI=1S/C26H19ClF6N2O4/c27-19-7-6-16(23(29)30)21(22(19)28)13-3-8-20(35(39)11-13)17(9-14-10-18(14)26(31,32)33)24(36)34-15-4-1-12(2-5-15)25(37)38/h1-8,11,14,17-18,23H,9-10H2,(H,34,36)(H,37,38)
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n/an/a 3.60n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306494
PNG
((+-)-N-[(6-amino-4-ethyl-2- methylpyridin-3-yl)met...)
Show SMILES CCc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c2c1)c1cc(ccc31)-c1ccc(C)cc1C#N
Show InChI InChI=1S/C32H28N4O2/c1-4-19-14-29(34)36-18(3)28(19)16-35-32(37)21-7-10-25-27(13-21)31-26-12-20(6-9-24(26)30(25)38-31)23-8-5-17(2)11-22(23)15-33/h5-14,30-31H,4,16H2,1-3H3,(H2,34,36)(H,35,37)
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n/an/a 3.98n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306475
PNG
((+-)-N-[(6-amino-4-methoxy- 2-methylpyridin-3-yl)m...)
Show SMILES COc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(Cn5cccn5)ccc34)c2c1
Show InChI InChI=1S/C27H25N5O3/c1-15-22(23(34-2)12-24(28)31-15)13-29-27(33)17-5-7-19-21(11-17)26-20-10-16(14-32-9-3-8-30-32)4-6-18(20)25(19)35-26/h3-12,25-26H,13-14H2,1-2H3,(H2,28,31)(H,29,33)
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n/an/a 3.98n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306546
PNG
((+-)-N-[(4-carbamimidoylphenyl) methyl]-12-phenyl-...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3C4OC(c3c2)c2cc(ccc42)-c2ccccc2)cc1
Show InChI InChI=1S/C29H23N3O2/c30-28(31)19-8-6-17(7-9-19)16-32-29(33)21-11-13-23-25(15-21)27-24-14-20(18-4-2-1-3-5-18)10-12-22(24)26(23)34-27/h1-15,26-27H,16H2,(H3,30,31)(H,32,33)
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n/an/a 4.57n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304232
PNG
(2-(3-(bicyclo[1.1.1]pentan- 1-yl)-1-((4-carboxy-3-...)
Show SMILES OC(=O)c1ccc(NC(=O)C(CC23CC(C2)C3)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1F
Show InChI InChI=1S/C27H21ClF4N2O4/c28-19-5-4-17(24(31)32)22(23(19)30)14-1-6-21(34(38)12-14)18(11-27-8-13(9-27)10-27)25(35)33-15-2-3-16(26(36)37)20(29)7-15/h1-7,12-13,18,24H,8-11H2,(H,33,35)(H,36,37)
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n/an/a 4.70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM304095
PNG
((R)-2-(1-((4-Carboxyphenyl)amino)-3-cyclobutyl-1-o...)
Show SMILES OC(=O)c1ccc(NC(=O)[C@H](CC2CCC2)c2ccc(c[n+]2[O-])-c2c(F)c(Cl)ccc2C(F)F)cc1
Show InChI InChI=1S/C26H22ClF3N2O4/c27-20-10-9-18(24(29)30)22(23(20)28)16-6-11-21(32(36)13-16)19(12-14-2-1-3-14)25(33)31-17-7-4-15(5-8-17)26(34)35/h4-11,13-14,19,24H,1-3,12H2,(H,31,33)(H,34,35)/t19-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...


US Patent US10143681 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306371
PNG
((+-)-N-[(6-amino-2,4- dimethylpyridin-3-yl)- methy...)
Show SMILES Cc1cc(N)nc(C)c1CNC(=O)c1ccc2C3OC(c4cc(CN5CCC=N5)ccc34)c2c1
Show InChI InChI=1S/C27H27N5O2/c1-15-10-24(28)31-16(2)23(15)13-29-27(33)18-5-7-20-22(12-18)26-21-11-17(14-32-9-3-8-30-32)4-6-19(21)25(20)34-26/h4-8,10-12,25-26H,3,9,13-14H2,1-2H3,(H2,28,31)(H,29,33)
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n/an/a 4.79n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X and plasma kallikrein


(Homo sapiens (Human))
BDBM306672
PNG
((+-)-N-[(4-carbamimidoyl- phenyl)methyl]-11,12- di...)
Show SMILES NC(=N)c1ccc(CNC(=O)c2ccc3C4OC(c3c2)c2cc(C3CC3)c(cc42)C2CC2)cc1
Show InChI InChI=1S/C29H27N3O2/c30-28(31)18-3-1-15(2-4-18)14-32-29(33)19-9-10-20-23(11-19)27-25-13-22(17-7-8-17)21(16-5-6-16)12-24(25)26(20)34-27/h1-4,9-13,16-17,26-27H,5-8,14H2,(H3,30,31)(H,32,33)
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n/an/a 4.90n/an/an/an/an/an/a



Global Blood Therapeutics, Inc.

US Patent


Assay Description
The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...


US Patent US10144746 (2018)

More data for this
Ligand-Target Pair
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