BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 32 hits of Enz. Inhib. data with enzyme = 'Collagenase' and Substrate = 'BDBM28488'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (human))
BDBM28481
PNG
((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)NCCc3cccs3)cc21)C(O)=O
Show InChI InChI=1S/C24H25N3O6S2/c1-14(2)22(23(28)29)27-35(31,32)17-6-7-18-19-12-15(5-8-20(19)33-21(18)13-17)26-24(30)25-10-9-16-4-3-11-34-16/h3-8,11-14,22,27H,9-10H2,1-2H3,(H,28,29)(H2,25,26,30)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28485
PNG
((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)c2cc3ccccc3o2)cc1)C(O)=O
Show InChI InChI=1S/C26H24N2O6S/c1-16(2)24(26(30)31)28-35(32,33)21-13-9-18(10-14-21)17-7-11-20(12-8-17)27-25(29)23-15-19-5-3-4-6-22(19)34-23/h3-16,24,28H,1-2H3,(H,27,29)(H,30,31)/t24-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

MMDB
PDB
Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Collagenase


(Homo sapiens (human))
BDBM28479
PNG
((2S)-2-({12-[(cyclopentylcarbamoyl)amino]-8-oxatri...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)NC3CCCC3)cc21)C(O)=O
Show InChI InChI=1S/C23H27N3O6S/c1-13(2)21(22(27)28)26-33(30,31)16-8-9-17-18-11-15(7-10-19(18)32-20(17)12-16)25-23(29)24-14-5-3-4-6-14/h7-14,21,26H,3-6H2,1-2H3,(H,27,28)(H2,24,25,29)/t21-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28480
PNG
((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Nc3ccsc3)cc21)C(O)=O
Show InChI InChI=1S/C22H21N3O6S2/c1-12(2)20(21(26)27)25-33(29,30)15-4-5-16-17-9-13(3-6-18(17)31-19(16)10-15)23-22(28)24-14-7-8-32-11-14/h3-12,20,25H,1-2H3,(H,26,27)(H2,23,24,28)/t20-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.30n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28472
PNG
((2S)-3-methyl-2-[(12-{[(2-methylpropoxy)carbonyl]a...)
Show SMILES CC(C)COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C22H26N2O7S/c1-12(2)11-30-22(27)23-14-5-8-18-17(9-14)16-7-6-15(10-19(16)31-18)32(28,29)24-20(13(3)4)21(25)26/h5-10,12-13,20,24H,11H2,1-4H3,(H,23,27)(H,25,26)/t20-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28471
PNG
((2S)-3-methyl-2-({12-[(propoxycarbonyl)amino]-8-ox...)
Show SMILES CCCOC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H24N2O7S/c1-4-9-29-21(26)22-13-5-8-17-16(10-13)15-7-6-14(11-18(15)30-17)31(27,28)23-19(12(2)3)20(24)25/h5-8,10-12,19,23H,4,9H2,1-3H3,(H,22,26)(H,24,25)/t19-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28473
PNG
((2S)-2-[(12-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)OCCF)cc21)C(O)=O
Show InChI InChI=1S/C20H21FN2O7S/c1-11(2)18(19(24)25)23-31(27,28)13-4-5-14-15-9-12(22-20(26)29-8-7-21)3-6-16(15)30-17(14)10-13/h3-6,9-11,18,23H,7-8H2,1-2H3,(H,22,26)(H,24,25)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28478
PNG
((2S)-2-{[12-(carbamoylamino)-8-oxatricyclo[7.4.0.0...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(N)=O)cc21)C(O)=O
Show InChI InChI=1S/C18H19N3O6S/c1-9(2)16(17(22)23)21-28(25,26)11-4-5-12-13-7-10(20-18(19)24)3-6-14(13)27-15(12)8-11/h3-9,16,21H,1-2H3,(H,22,23)(H3,19,20,24)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 59n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28461
PNG
((2S)-2-({12-methanesulfonamido-8-oxatricyclo[7.4.0...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NS(C)(=O)=O)cc21)C(O)=O
Show InChI InChI=1S/C18H20N2O7S2/c1-10(2)17(18(21)22)20-29(25,26)12-5-6-13-14-8-11(19-28(3,23)24)4-7-15(14)27-16(13)9-12/h4-10,17,19-20H,1-3H3,(H,21,22)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 93n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28483
PNG
((2S)-2-[(11-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1cc(NC(=O)OCCF)ccc21)C(O)=O
Show InChI InChI=1S/C20H21FN2O7S/c1-11(2)18(19(24)25)23-31(27,28)13-4-6-15-14-5-3-12(22-20(26)29-8-7-21)9-16(14)30-17(15)10-13/h3-6,9-11,18,23H,7-8H2,1-2H3,(H,22,26)(H,24,25)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28470
PNG
((2S)-2-({12-[(ethoxycarbonyl)amino]-8-oxatricyclo[...)
Show SMILES CCOC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C20H22N2O7S/c1-4-28-20(25)21-12-5-8-16-15(9-12)14-7-6-13(10-17(14)29-16)30(26,27)22-18(11(2)3)19(23)24/h5-11,18,22H,4H2,1-3H3,(H,21,25)(H,23,24)/t18-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28477
PNG
((2S)-3-methyl-2-({12-[(4-methylphenoxycarbonyl)ami...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Oc3ccc(C)cc3)cc21)C(O)=O
Show InChI InChI=1S/C25H24N2O7S/c1-14(2)23(24(28)29)27-35(31,32)18-9-10-19-20-12-16(6-11-21(20)34-22(19)13-18)26-25(30)33-17-7-4-15(3)5-8-17/h4-14,23,27H,1-3H3,(H,26,30)(H,28,29)/t23-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28464
PNG
((2R)-3-methyl-2-({11-[(propoxycarbonyl)amino]-8-ox...)
Show SMILES CCCOC(=O)Nc1ccc2c(c1)oc1ccc(cc21)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H24N2O7S/c1-4-9-29-21(26)22-13-5-7-15-16-11-14(6-8-17(16)30-18(15)10-13)31(27,28)23-19(12(2)3)20(24)25/h5-8,10-12,19,23H,4,9H2,1-3H3,(H,22,26)(H,24,25)/t19-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 109n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28458
PNG
((2R)-3-methyl-2-{[11-(propane-2-sulfonamido)-8-oxa...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3cc(NS(=O)(=O)C(C)C)ccc3c2c1)C(O)=O
Show InChI InChI=1S/C20H24N2O7S2/c1-11(2)19(20(23)24)22-31(27,28)14-6-8-17-16(10-14)15-7-5-13(9-18(15)29-17)21-30(25,26)12(3)4/h5-12,19,21-22H,1-4H3,(H,23,24)/t19-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28469
PNG
((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Show SMILES COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O7S/c1-10(2)17(18(22)23)21-29(25,26)12-5-6-13-14-8-11(20-19(24)27-3)4-7-15(14)28-16(13)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28475
PNG
((2S)-2-({12-[(2-chlorophenoxycarbonyl)amino]-8-oxa...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Oc3ccccc3Cl)cc21)C(O)=O
Show InChI InChI=1S/C24H21ClN2O7S/c1-13(2)22(23(28)29)27-35(31,32)15-8-9-16-17-11-14(7-10-19(17)33-21(16)12-15)26-24(30)34-20-6-4-3-5-18(20)25/h3-13,22,27H,1-2H3,(H,26,30)(H,28,29)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28476
PNG
((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Oc3ccc(F)cc3)cc21)C(O)=O
Show InChI InChI=1S/C24H21FN2O7S/c1-13(2)22(23(28)29)27-35(31,32)17-8-9-18-19-11-15(5-10-20(19)34-21(18)12-17)26-24(30)33-16-6-3-14(25)4-7-16/h3-13,22,27H,1-2H3,(H,26,30)(H,28,29)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28474
PNG
((2S)-3-methyl-2-({12-[(phenoxycarbonyl)amino]-8-ox...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NC(=O)Oc3ccccc3)cc21)C(O)=O
Show InChI InChI=1S/C24H22N2O7S/c1-14(2)22(23(27)28)26-34(30,31)17-9-10-18-19-12-15(8-11-20(19)33-21(18)13-17)25-24(29)32-16-6-4-3-5-7-16/h3-14,22,26H,1-2H3,(H,25,29)(H,27,28)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28484
PNG
((2S)-2-({11-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1cc(NC(=O)Oc3ccc(F)cc3)ccc21)C(O)=O
Show InChI InChI=1S/C24H21FN2O7S/c1-13(2)22(23(28)29)27-35(31,32)17-8-10-19-18-9-5-15(11-20(18)34-21(19)12-17)26-24(30)33-16-6-3-14(25)4-7-16/h3-13,22,27H,1-2H3,(H,26,30)(H,28,29)/t22-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 361n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28465
PNG
((2R)-3-methyl-2-[(11-{[(propan-2-yloxy)carbonyl]am...)
Show SMILES CC(C)OC(=O)Nc1ccc2c(c1)oc1ccc(cc21)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C21H24N2O7S/c1-11(2)19(20(24)25)23-31(27,28)14-6-8-17-16(10-14)15-7-5-13(9-18(15)30-17)22-21(26)29-12(3)4/h5-12,19,23H,1-4H3,(H,22,26)(H,24,25)/t19-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28463
PNG
((2R)-2-({11-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Show SMILES COC(=O)Nc1ccc2c(c1)oc1ccc(cc21)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O7S/c1-10(2)17(18(22)23)21-29(25,26)12-5-7-15-14(9-12)13-6-4-11(8-16(13)28-15)20-19(24)27-3/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28466
PNG
((2R)-3-methyl-2-({11-[(phenoxycarbonyl)amino]-8-ox...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3cc(NC(=O)Oc4ccccc4)ccc3c2c1)C(O)=O
Show InChI InChI=1S/C24H22N2O7S/c1-14(2)22(23(27)28)26-34(30,31)17-9-11-20-19(13-17)18-10-8-15(12-21(18)33-20)25-24(29)32-16-6-4-3-5-7-16/h3-14,22,26H,1-2H3,(H,25,29)(H,27,28)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28462
PNG
((2S)-3-methyl-2-{[12-(2,2,2-trifluoroethane-1-sulf...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2c(c1)oc1ccc(NS(=O)(=O)CC(F)(F)F)cc21)C(O)=O
Show InChI InChI=1S/C19H19F3N2O7S2/c1-10(2)17(18(25)26)24-33(29,30)12-4-5-13-14-7-11(3-6-15(14)31-16(13)8-12)23-32(27,28)9-19(20,21)22/h3-8,10,17,23-24H,9H2,1-2H3,(H,25,26)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 670n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28482
PNG
((2S)-2-({11-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Show SMILES COC(=O)Nc1ccc2c(c1)oc1cc(ccc21)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H20N2O7S/c1-10(2)17(18(22)23)21-29(25,26)12-5-7-14-13-6-4-11(20-19(24)27-3)8-15(13)28-16(14)9-12/h4-10,17,21H,1-3H3,(H,20,24)(H,22,23)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28456
PNG
((2R)-2-({11-methanesulfonamido-8-oxatricyclo[7.4.0...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3cc(NS(C)(=O)=O)ccc3c2c1)C(O)=O
Show InChI InChI=1S/C18H20N2O7S2/c1-10(2)17(18(21)22)20-29(25,26)12-5-7-15-14(9-12)13-6-4-11(8-16(13)27-15)19-28(3,23)24/h4-10,17,19-20H,1-3H3,(H,21,22)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28486
PNG
((2R)-3-methyl-2-{8-oxatricyclo[7.4.0.0^{2,7}]tride...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3ccccc3c2c1)C(O)=O
Show InChI InChI=1S/C17H17NO5S/c1-10(2)16(17(19)20)18-24(21,22)11-7-8-15-13(9-11)12-5-3-4-6-14(12)23-15/h3-10,16,18H,1-2H3,(H,19,20)/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28460
PNG
((2R)-2-({11-benzenesulfonamido-8-oxatricyclo[7.4.0...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3cc(NS(=O)(=O)c4ccccc4)ccc3c2c1)C(O)=O
Show InChI InChI=1S/C23H22N2O7S2/c1-14(2)22(23(26)27)25-34(30,31)17-9-11-20-19(13-17)18-10-8-15(12-21(18)32-20)24-33(28,29)16-6-4-3-5-7-16/h3-14,22,24-25H,1-2H3,(H,26,27)/t22-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28457
PNG
((2S)-2-({11-methanesulfonamido-8-oxatricyclo[7.4.0...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2oc3cc(NS(C)(=O)=O)ccc3c2c1)C(O)=O
Show InChI InChI=1S/C18H20N2O7S2/c1-10(2)17(18(21)22)20-29(25,26)12-5-7-15-14(9-12)13-6-4-11(8-16(13)27-15)19-28(3,23)24/h4-10,17,19-20H,1-3H3,(H,21,22)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28487
PNG
((2S)-3-methyl-2-{8-oxatricyclo[7.4.0.0^{2,7}]tride...)
Show SMILES CC(C)[C@H](NS(=O)(=O)c1ccc2oc3ccccc3c2c1)C(O)=O
Show InChI InChI=1S/C17H17NO5S/c1-10(2)16(17(19)20)18-24(21,22)11-7-8-15-13(9-11)12-5-3-4-6-14(12)23-15/h3-10,16,18H,1-2H3,(H,19,20)/t16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28468
PNG
((2S)-2-({12-bromo-11-[(methoxycarbonyl)amino]-8-ox...)
Show SMILES COC(=O)Nc1cc2oc3ccc(cc3c2cc1Br)S(=O)(=O)N[C@@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H19BrN2O7S/c1-9(2)17(18(23)24)22-30(26,27)10-4-5-15-11(6-10)12-7-13(20)14(8-16(12)29-15)21-19(25)28-3/h4-9,17,22H,1-3H3,(H,21,25)(H,23,24)/t17-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28467
PNG
((2R)-2-({12-bromo-11-[(methoxycarbonyl)amino]-8-ox...)
Show SMILES COC(=O)Nc1cc2oc3ccc(cc3c2cc1Br)S(=O)(=O)N[C@H](C(C)C)C(O)=O
Show InChI InChI=1S/C19H19BrN2O7S/c1-9(2)17(18(23)24)22-30(26,27)10-4-5-15-11(6-10)12-7-13(20)14(8-16(12)29-15)21-19(25)28-3/h4-9,17,22H,1-3H3,(H,21,25)(H,23,24)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.54E+4n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM28459
PNG
((2R)-2-({11-[(3,5-dimethyl-1,2-oxazole-4-)sulfonam...)
Show SMILES CC(C)[C@@H](NS(=O)(=O)c1ccc2oc3cc(NS(=O)(=O)c4c(C)noc4C)ccc3c2c1)C(O)=O
Show InChI InChI=1S/C22H23N3O8S2/c1-11(2)20(22(26)27)25-34(28,29)15-6-8-18-17(10-15)16-7-5-14(9-19(16)32-18)24-35(30,31)21-12(3)23-33-13(21)4/h5-11,20,24-25H,1-4H3,(H,26,27)/t20-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



Wyeth Research



Assay Description
The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...


J Med Chem 52: 1799-802 (2009)


Article DOI: 10.1021/jm900093d
BindingDB Entry DOI: 10.7270/Q2X928NP
More data for this
Ligand-Target Pair