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Found 135 hits of Enz. Inhib. data with enzyme = 'Corticotropin releasing factor receptor' and Substrate = '125I-Tyr(0)-ovine-CRF'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20977
PNG
(8-[butyl(ethyl)amino]-4-(2,6-dimethoxypyridin-3-yl...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)nc1OC
Show InChI InChI=1S/C21H29N5O3/c1-6-8-11-25(7-2)16-12-14(3)22-20-19(16)23-17(27)13-26(20)15-9-10-18(28-4)24-21(15)29-5/h9-10,12H,6-8,11,13H2,1-5H3,(H,23,27)
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n/an/a 0.820n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20973
PNG
(8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C
Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)
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n/an/a 0.920n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29452
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-21)
Show SMILES COc1cc(C)c(-c2c(C)nn3c(nc(C)nc23)N(CC=C)CC=C)c(OC)c1
Show InChI InChI=1S/C22H27N5O2/c1-8-10-26(11-9-2)22-24-16(5)23-21-20(15(4)25-27(21)22)19-14(3)12-17(28-6)13-18(19)29-7/h8-9,12-13H,1-2,10-11H2,3-7H3
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n/an/a 1n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29466
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-35)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1cc(F)c(OC)cc1Cl
Show InChI InChI=1S/C19H23ClFN5O/c1-6-12(7-2)24-19-23-11(4)22-18-17(10(3)25-26(18)19)13-8-15(21)16(27-5)9-14(13)20/h8-9,12H,6-7H2,1-5H3,(H,22,23,24)
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n/an/a 1n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29468
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-37)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1cc(F)c(OC)cc1Cl
Show InChI InChI=1S/C20H25ClFN5O3/c1-12-18(14-10-16(22)17(30-5)11-15(14)21)19-23-13(2)24-20(27(19)25-12)26(6-8-28-3)7-9-29-4/h10-11H,6-9H2,1-5H3
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n/an/a 1.18n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29450
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-19)
Show SMILES CCN(CC)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C20H27N5O2/c1-8-24(9-2)20-22-14(5)21-19-18(13(4)23-25(19)20)17-12(3)10-15(26-6)11-16(17)27-7/h10-11H,8-9H2,1-7H3
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n/an/a 1.20n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29453
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-22)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C23H31N5O2/c1-7-10-27(13-17-8-9-17)23-25-16(4)24-22-21(15(3)26-28(22)23)20-14(2)11-18(29-5)12-19(20)30-6/h11-12,17H,7-10,13H2,1-6H3
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n/an/a 1.48n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29500
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-25)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C21H28N6O/c1-6-11-26(12-16-7-8-16)21-24-15(4)23-20-19(14(3)25-27(20)21)17-9-10-18(28-5)22-13(17)2/h9-10,16H,6-8,11-12H2,1-5H3
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n/an/a 1.60n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29467
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-36)
Show SMILES CCN(CC)c1nc(C)nc2c(c(C)nn12)-c1cc(F)c(OC)cc1Cl
Show InChI InChI=1S/C18H21ClFN5O/c1-6-24(7-2)18-22-11(4)21-17-16(10(3)23-25(17)18)12-8-14(20)15(26-5)9-13(12)19/h8-9H,6-7H2,1-5H3
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n/an/a 1.64n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29456
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-25)
Show SMILES CCCCN(CC)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C22H31N5O2/c1-8-10-11-26(9-2)22-24-16(5)23-21-20(15(4)25-27(21)22)19-14(3)12-17(28-6)13-18(19)29-7/h12-13H,8-11H2,1-7H3
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n/an/a 1.72n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29457
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-26)
Show SMILES CCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C21H29N5O3/c1-8-25(9-10-27-5)21-23-15(4)22-20-19(14(3)24-26(20)21)18-13(2)11-16(28-6)12-17(18)29-7/h11-12H,8-10H2,1-7H3
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n/an/a 1.78n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29458
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-27)
Show SMILES COCCN(CC1CC1)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C23H31N5O3/c1-14-11-18(30-5)12-19(31-6)20(14)21-15(2)26-28-22(21)24-16(3)25-23(28)27(9-10-29-4)13-17-7-8-17/h11-12,17H,7-10,13H2,1-6H3
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n/an/a 1.80n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29440
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-9)
Show SMILES COc1ccc(-c2c(C)nn3c(nc(C)nc23)N(CCC#N)C2CC2)c(C)c1
Show InChI InChI=1S/C21H24N6O/c1-13-12-17(28-4)8-9-18(13)19-14(2)25-27-20(19)23-15(3)24-21(27)26(11-5-10-22)16-6-7-16/h8-9,12,16H,5-7,11H2,1-4H3
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n/an/a 1.88n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29465
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-34)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1cc(F)c(OC)cc1C
Show InChI InChI=1S/C20H26FN5O/c1-7-14(8-2)24-20-23-13(5)22-19-18(12(4)25-26(19)20)15-10-16(21)17(27-6)9-11(15)3/h9-10,14H,7-8H2,1-6H3,(H,22,23,24)
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n/an/a 1.90n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29438
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-7)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H29N5O/c1-6-11-26(13-17-7-8-17)22-24-16(4)23-21-20(15(3)25-27(21)22)19-10-9-18(28-5)12-14(19)2/h9-10,12,17H,6-8,11,13H2,1-5H3
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n/an/a 1.96n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29464
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-33)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1cc(C)c(OC)cc1C
Show InChI InChI=1S/C22H31N5O3/c1-14-13-19(30-7)15(2)12-18(14)20-16(3)25-27-21(20)23-17(4)24-22(27)26(8-10-28-5)9-11-29-6/h12-13H,8-11H2,1-7H3
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n/an/a 1.98n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20954
PNG
(2-(4-methoxy-2,6-dimethylphenoxy)-3,6-dimethyl-4-(...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(OC)cc2C)c1C
Show InChI InChI=1S/C21H29NO3/c1-8-17(9-2)24-19-12-15(5)22-21(16(19)6)25-20-13(3)10-18(23-7)11-14(20)4/h10-12,17H,8-9H2,1-7H3
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n/an/a 2n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29448
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-17)
Show SMILES CCCC(C)Nc1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C21H29N5O2/c1-8-9-13(3)22-21-24-15(5)23-20-19(14(4)25-26(20)21)18-12(2)10-16(27-6)11-17(18)28-7/h10-11,13H,8-9H2,1-7H3,(H,22,23,24)
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n/an/a 2.14n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29439
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-8)
Show SMILES CCCN(CCC#N)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H26N6O/c1-6-11-26(12-7-10-22)21-24-16(4)23-20-19(15(3)25-27(20)21)18-9-8-17(28-5)13-14(18)2/h8-9,13H,6-7,11-12H2,1-5H3
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n/an/a 2.16n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20978
PNG
(N-butyl-4-(2,6-dimethoxypyridin-3-yl)-N-ethyl-6-me...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)nc1OC
Show InChI InChI=1S/C21H31N5O2/c1-6-8-12-25(7-2)17-14-15(3)23-20-19(17)22-11-13-26(20)16-9-10-18(27-4)24-21(16)28-5/h9-10,14,22H,6-8,11-13H2,1-5H3
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n/an/a 2.20n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29437
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-6)
Show SMILES CCCCN(CC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O/c1-7-9-12-25(8-2)21-23-16(5)22-20-19(15(4)24-26(20)21)18-11-10-17(27-6)13-14(18)3/h10-11,13H,7-9,12H2,1-6H3
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n/an/a 2.30n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29505
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-30)
Show SMILES CCCCN(CCC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C21H30N6O/c1-7-9-13-26(12-8-2)21-24-16(5)23-20-19(15(4)25-27(20)21)17-10-11-18(28-6)22-14(17)3/h10-11H,7-9,12-13H2,1-6H3
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n/an/a 2.40n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29460
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-29)
Show SMILES CCN(CCC#N)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C21H26N6O2/c1-7-26(10-8-9-22)21-24-15(4)23-20-19(14(3)25-27(20)21)18-13(2)11-16(28-5)12-17(18)29-6/h11-12H,7-8,10H2,1-6H3
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n/an/a 2.48n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29436
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-5)
Show SMILES CCCN(CCC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O/c1-7-11-25(12-8-2)21-23-16(5)22-20-19(15(4)24-26(20)21)18-10-9-17(27-6)13-14(18)3/h9-10,13H,7-8,11-12H2,1-6H3
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n/an/a 2.58n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20950
PNG
(2-(4-bromo-2,6-dimethylphenoxy)-3,6-dimethyl-4-(pe...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Br)cc2C)c1C
Show InChI InChI=1S/C20H26BrNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
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n/an/a 2.60n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29462
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-31)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C22H31N5O3/c1-14-12-18(30-7)13-15(2)19(14)20-16(3)25-27-21(20)23-17(4)24-22(27)26(8-10-28-5)9-11-29-6/h12-13H,8-11H2,1-7H3
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n/an/a 2.74n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29446
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-15)
Show SMILES CC[C@H](C)Nc1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C20H27N5O2/c1-8-12(3)21-20-23-14(5)22-19-18(13(4)24-25(19)20)17-11(2)9-15(26-6)10-16(17)27-7/h9-10,12H,8H2,1-7H3,(H,21,22,23)/t12-/m0/s1
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n/an/a 2.90n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29488
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-13)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1cnc(OC)cc1C
Show InChI InChI=1S/C19H26N6O/c1-7-14(8-2)23-19-22-13(5)21-18-17(12(4)24-25(18)19)15-10-20-16(26-6)9-11(15)3/h9-10,14H,7-8H2,1-6H3,(H,21,22,23)
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n/an/a 3n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29489
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-14)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C19H26N6O/c1-7-14(8-2)23-19-22-13(5)21-18-17(12(4)24-25(18)19)15-9-10-16(26-6)20-11(15)3/h9-10,14H,7-8H2,1-6H3,(H,21,22,23)
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n/an/a 3.10n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29499
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-24)
Show SMILES COCCN(CC1CC1)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C21H28N6O2/c1-13-17(8-9-18(22-13)29-5)19-14(2)25-27-20(19)23-15(3)24-21(27)26(10-11-28-4)12-16-6-7-16/h8-9,16H,6-7,10-12H2,1-5H3
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n/an/a 3.10n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20959
PNG
(2-Aryloxy-4-alkoxy-pyridine, 40 | 2-[4-(methoxymet...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(COC)cc2C)c1C
Show InChI InChI=1S/C22H31NO3/c1-8-19(9-2)25-20-12-16(5)23-22(17(20)6)26-21-14(3)10-18(13-24-7)11-15(21)4/h10-12,19H,8-9,13H2,1-7H3
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n/an/a 3.20n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29461
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-30)
Show SMILES CCC1CCCCN1c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C23H31N5O2/c1-7-17-10-8-9-11-27(17)23-25-16(4)24-22-21(15(3)26-28(22)23)20-14(2)12-18(29-5)13-19(20)30-6/h12-13,17H,7-11H2,1-6H3
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n/an/a 3.26n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20985
PNG
(4-{8-[butyl(ethyl)amino]-6-methyl-2-oxo-1H,2H,3H,4...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(cc1C)C#N
Show InChI InChI=1S/C22H27N5O/c1-5-7-10-26(6-2)19-12-16(4)24-22-21(19)25-20(28)14-27(22)18-9-8-17(13-23)11-15(18)3/h8-9,11-12H,5-7,10,14H2,1-4H3,(H,25,28)
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n/an/a 3.30n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20986
PNG
(4-{8-[butyl(ethyl)amino]-6-methyl-1H,2H,3H,4H-pyri...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(cc1C)C#N
Show InChI InChI=1S/C22H29N5/c1-5-7-11-26(6-2)20-14-17(4)25-22-21(20)24-10-12-27(22)19-9-8-18(15-23)13-16(19)3/h8-9,13-14,24H,5-7,10-12H2,1-4H3
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n/an/a 3.5n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29493
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-18)
Show SMILES CCCC(C)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C19H26N6O/c1-7-8-11(2)20-19-23-14(5)22-18-17(13(4)24-25(18)19)15-9-10-16(26-6)21-12(15)3/h9-11H,7-8H2,1-6H3,(H,20,22,23)
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n/an/a 3.5n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20971
PNG
(2-Arylamino-4-alkyloxypyridine, 13 | 3,6-dimethyl-...)
Show SMILES CCC(CC)Oc1cc(C)nc(Nc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)24-19-12-16(6)22-21(17(19)7)23-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
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n/an/a 3.70n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29451
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-20)
Show SMILES CCCN(CCC)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C22H31N5O2/c1-8-10-26(11-9-2)22-24-16(5)23-21-20(15(4)25-27(21)22)19-14(3)12-17(28-6)13-18(19)29-7/h12-13H,8-11H2,1-7H3
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n/an/a 3.72n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29433
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-2)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1
Show InChI InChI=1S/C19H25N5O/c1-6-15(7-2)22-19-21-13(4)20-18-17(12(3)23-24(18)19)14-8-10-16(25-5)11-9-14/h8-11,15H,6-7H2,1-5H3,(H,20,21,22)
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n/an/a 3.80n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29471
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-40)
Show SMILES CCN(CC)c1nc(C)nc2c(c(C)nn12)-c1cc(OC)c(OC)cc1Br
Show InChI InChI=1S/C19H24BrN5O2/c1-7-24(8-2)19-22-12(4)21-18-17(11(3)23-25(18)19)13-9-15(26-5)16(27-6)10-14(13)20/h9-10H,7-8H2,1-6H3
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n/an/a 4.06n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20974
PNG
(N-butyl-N-ethyl-4-(4-methoxy-2-methylphenyl)-6-met...)
Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)cc1C
Show InChI InChI=1S/C22H32N4O/c1-6-8-12-25(7-2)20-15-17(4)24-22-21(20)23-11-13-26(22)19-10-9-18(27-5)14-16(19)3/h9-10,14-15,23H,6-8,11-13H2,1-5H3
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n/an/a 4.20n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 50: 2269-72 (2007)


Article DOI: 10.1021/jm0611410
BindingDB Entry DOI: 10.7270/Q25Q4TCS
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29434
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-3)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O3/c1-14-13-17(29-6)7-8-18(14)19-15(2)24-26-20(19)22-16(3)23-21(26)25(9-11-27-4)10-12-28-5/h7-8,13H,9-12H2,1-6H3
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n/an/a 4.20n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29463
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-32)
Show SMILES CCCCN(C)c1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C21H29N5O/c1-8-9-10-25(6)21-23-16(5)22-20-19(15(4)24-26(20)21)18-13(2)11-17(27-7)12-14(18)3/h11-12H,8-10H2,1-7H3
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n/an/a 4.22n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29492
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-17)
Show SMILES CCC[C@H](C)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C19H26N6O/c1-7-8-11(2)20-19-23-14(5)22-18-17(13(4)24-25(18)19)15-9-10-16(26-6)21-12(15)3/h9-11H,7-8H2,1-6H3,(H,20,22,23)/t11-/m0/s1
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n/an/a 4.5n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29504
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-29)
Show SMILES CCCCN(CC)c1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C20H28N6O/c1-7-9-12-25(8-2)20-23-15(5)22-19-18(14(4)24-26(19)20)16-10-11-17(27-6)21-13(16)3/h10-11H,7-9,12H2,1-6H3
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n/an/a 4.90n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29455
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-24)
Show SMILES COc1cc(C)c(-c2c(C)nn3c(nc(C)nc23)N(C)CC=C)c(OC)c1
Show InChI InChI=1S/C20H25N5O2/c1-8-9-24(5)20-22-14(4)21-19-18(13(3)23-25(19)20)17-12(2)10-15(26-6)11-16(17)27-7/h8,10-11H,1,9H2,2-7H3
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n/an/a 4.92n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29472
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-41)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1cc(OC)c(OC)cc1Br
Show InChI InChI=1S/C21H28BrN5O4/c1-13-19(15-11-17(30-5)18(31-6)12-16(15)22)20-23-14(2)24-21(27(20)25-13)26(7-9-28-3)8-10-29-4/h11-12H,7-10H2,1-6H3
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n/an/a 4.99n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29445
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 12-14)
Show SMILES CCC(CC)Nc1nc(C)nc2c(c(C)nn12)-c1c(C)cc(OC)cc1OC
Show InChI InChI=1S/C21H29N5O2/c1-8-15(9-2)24-21-23-14(5)22-20-19(13(4)25-26(20)21)18-12(3)10-16(27-6)11-17(18)28-7/h10-11,15H,8-9H2,1-7H3,(H,22,23,24)
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n/an/a 5n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3073-83 (2009)


Article DOI: 10.1021/jm9000242
BindingDB Entry DOI: 10.7270/Q23R0R6X
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM29494
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-19)
Show SMILES CCCCC(C)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C20H28N6O/c1-7-8-9-12(2)21-20-24-15(5)23-19-18(14(4)25-26(19)20)16-10-11-17(27-6)22-13(16)3/h10-12H,7-9H2,1-6H3,(H,21,23,24)
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n/an/a 5.10n/an/an/an/a7.223



Bristol-Myers Squibb Company



Assay Description
Naive rats were sacrificed by decapitation, and the brain and pituitary were collected. Slide-mounted brain sections were preincubated in an assay so...


J Med Chem 52: 3084-92 (2009)


Article DOI: 10.1021/jm900025h
BindingDB Entry DOI: 10.7270/Q20000D0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20966
PNG
(2-Aryloxy-4-alkylaminopyridine, 3a | 3,6-dimethyl-...)
Show SMILES CCC(CC)Nc1cc(C)nc(Oc2c(C)cc(C)cc2C)c1C
Show InChI InChI=1S/C21H30N2O/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3,(H,22,23)
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n/an/a 5.10n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1385-92 (2008)


Article DOI: 10.1021/jm070579c
BindingDB Entry DOI: 10.7270/Q29C6VQ7
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM20949
PNG
(2-(4-chloro-2,6-dimethylphenoxy)-3,6-dimethyl-4-(p...)
Show SMILES CCC(CC)Oc1cc(C)nc(Oc2c(C)cc(Cl)cc2C)c1C
Show InChI InChI=1S/C20H26ClNO2/c1-7-17(8-2)23-18-11-14(5)22-20(15(18)6)24-19-12(3)9-16(21)10-13(19)4/h9-11,17H,7-8H2,1-6H3
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n/an/a 5.5n/an/an/an/a7.022



Pfizer



Assay Description
The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.


J Med Chem 51: 1377-84 (2008)


Article DOI: 10.1021/jm070578k
BindingDB Entry DOI: 10.7270/Q2F47MDH
More data for this
Ligand-Target Pair
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