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Compile Data Set for Download or QSAR

Found 3 hits of Enz. Inhib. data with enzyme = 'Cyclin-Dependent Kinase 1 (CDK1)' and Substrate = 'Substrate Peptide SerThr 18'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM25681
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-2-4-8(5-3-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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Article
PubMed
n/an/a 4.27E+3n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM25658
PNG
(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (human))
BDBM25680
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-6(2-4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis



Assay Description
Enzyme activity was assayed using Z-LYTE Enzymatic Kinase Assay format (Invitrogen Corp., Carlsbad, CA) in the SelectScreen Kinase Profiling Service...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair