BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 7 hits of Enz. Inhib. data with enzyme = 'Cyclin-Dependent Kinase 7 (CDK7)' and Substrate = 'Biotinylated Peptide Substrate'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM8061
PNG
(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)
Show SMILES Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1
Show InChI InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
70 -9.92n/an/an/an/an/a7.230



Cyclacel Limited



Assay Description
In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...


Bioorg Med Chem Lett 14: 4237-40 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.012
BindingDB Entry DOI: 10.7270/Q2CJ8BPP
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM12028
PNG
(4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...)
Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1
Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.60E+4n/an/an/an/an/an/a



Palacky University



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...


J Med Chem 49: 6500-9 (2006)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2M61HHK
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM12025
PNG
(4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...)
Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.70E+4n/an/an/an/an/an/a



Palacky University



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...


J Med Chem 49: 6500-9 (2006)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2M61HHK
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM12027
PNG
(3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...)
Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1
Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8.20E+4n/an/an/an/an/an/a



Palacky University



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...


J Med Chem 49: 6500-9 (2006)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2M61HHK
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM12029
PNG
(4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...)
Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO
Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Palacky University



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...


J Med Chem 49: 6500-9 (2006)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2M61HHK
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM12024
PNG
(4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...)
Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1
Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Palacky University



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...


J Med Chem 49: 6500-9 (2006)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2M61HHK
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 7 (CDK7)


(Homo sapiens (human))
BDBM12026
PNG
(4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...)
Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Palacky University



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...


J Med Chem 49: 6500-9 (2006)


Article DOI: 10.1021/jm0605740
BindingDB Entry DOI: 10.7270/Q2M61HHK
More data for this
Ligand-Target Pair