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Compile Data Set for Download or QSAR

Found 152 hits of Enz. Inhib. data with enzyme = 'Diacylglycerol O-acyltransferase 2' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323669
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CC(C1)Oc1ccccc1
Show InChI InChI=1S/C27H30N4O4/c1-2-33-24-12-6-7-13-25(24)35-22-11-8-14-30(17-22)27-28-15-20(16-29-27)26(32)31-18-23(19-31)34-21-9-4-3-5-10-21/h3-7,9-10,12-13,15-16,22-23H,2,8,11,14,17-19H2,1H3/t22-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323644
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1Cc2ccccc2C1
Show InChI InChI=1S/C26H28N4O3/c1-2-32-23-11-5-6-12-24(23)33-22-10-7-13-29(18-22)26-27-14-21(15-28-26)25(31)30-16-19-8-3-4-9-20(19)17-30/h3-6,8-9,11-12,14-15,22H,2,7,10,13,16-18H2,1H3/t22-/m1/s1
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n/an/a 1.40n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323668
PNG
(N-((S)-2,3-dihydro-1H- inden-1-yl)-2-((R)-3-(2- et...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N[C@H]1CCc2ccccc12
Show InChI InChI=1S/C27H30N4O3/c1-2-33-24-11-5-6-12-25(24)34-21-9-7-15-31(18-21)27-28-16-20(17-29-27)26(32)30-23-14-13-19-8-3-4-10-22(19)23/h3-6,8,10-12,16-17,21,23H,2,7,9,13-15,18H2,1H3,(H,30,32)/t21-,23+/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274961
PNG
(US9877957, Example 1)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CCN(CC2)c2ccc(cc2)C(F)(F)F)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C36H41F3N4O4/c1-35(2,3)41-34(46)43-19-16-30-29(24-6-5-7-25(20-24)33(45)47-4)13-8-26(31(30)22-43)21-40-32(44)23-14-17-42(18-15-23)28-11-9-27(10-12-28)36(37,38)39/h5-13,20,23H,14-19,21-22H2,1-4H3,(H,40,44)(H,41,46)
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n/an/a 1.75n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323626
PNG
(US10188653, Example 15)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C28H32N4O5/c1-3-36-24-8-4-5-9-25(24)37-23-7-6-14-32(18-23)28-30-16-22(17-31-28)26(33)29-15-20-10-12-21(13-11-20)19(2)27(34)35/h4-5,8-13,16-17,19,23H,3,6-7,14-15,18H2,1-2H3,(H,29,33)(H,34,35)/t19?,23-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276763
PNG
(US10071992, Example 8)
Show SMILES CCOc1cc(F)cnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1
Show InChI InChI=1S/C21H20FN5O4/c1-2-30-18-6-15(22)10-26-21(18)31-17-5-13(7-23-11-17)19-24-8-14(9-25-19)20(28)27-16-3-4-29-12-16/h5-11,16H,2-4,12H2,1H3,(H,27,28)/t16-/m0/s1
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n/an/a 3.70n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323638
PNG
((R)-N-benzyl-2-(3-(2- ethoxyphenoxy)piperidin- 1-y...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C25H28N4O3/c1-2-31-22-12-6-7-13-23(22)32-21-11-8-14-29(18-21)25-27-16-20(17-28-25)24(30)26-15-19-9-4-3-5-10-19/h3-7,9-10,12-13,16-17,21H,2,8,11,14-15,18H2,1H3,(H,26,30)/t21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276759
PNG
(US10071992, Example 4)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC(C)(C)C#N
Show InChI InChI=1S/C21H20N6O3/c1-4-29-17-6-5-7-24-20(17)30-16-8-14(9-23-12-16)18-25-10-15(11-26-18)19(28)27-21(2,3)13-22/h5-12H,4H2,1-3H3,(H,27,28)
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276749
PNG
(US10188653, Example 19.21 | WO2015140658, Example ...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NC(C)(C)CO
Show InChI InChI=1S/C22H30N4O4/c1-4-29-18-9-5-6-10-19(18)30-17-8-7-11-26(14-17)21-23-12-16(13-24-21)20(28)25-22(2,3)15-27/h5-6,9-10,12-13,17,27H,4,7-8,11,14-15H2,1-3H3,(H,25,28)/t17-/m1/s1
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n/an/a 7.90n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323662
PNG
((R)-(3,3-difluoroazetidin- 1-yl)(2-(3-(2- ethoxyph...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C21H24F2N4O3/c1-2-29-17-7-3-4-8-18(17)30-16-6-5-9-26(12-16)20-24-10-15(11-25-20)19(28)27-13-21(22,23)14-27/h3-4,7-8,10-11,16H,2,5-6,9,12-14H2,1H3/t16-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276749
PNG
(US10188653, Example 19.21 | WO2015140658, Example ...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NC(C)(C)CO
Show InChI InChI=1S/C22H30N4O4/c1-4-29-18-9-5-6-10-19(18)30-17-8-7-11-26(14-17)21-23-12-16(13-24-21)20(28)25-22(2,3)15-27/h5-6,9-10,12-13,17,27H,4,7-8,11,14-15H2,1-3H3,(H,25,28)/t17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323602
PNG
(US10188653, Example 8)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cc1F)C(=O)NCc1ccnc(c1)C(O)=O
Show InChI InChI=1S/C26H27FN4O5/c1-2-35-22-7-3-4-8-23(22)36-19-6-5-11-31(16-19)24-20(27)13-18(15-29-24)25(32)30-14-17-9-10-28-21(12-17)26(33)34/h3-4,7-10,12-13,15,19H,2,5-6,11,14,16H2,1H3,(H,30,32)(H,33,34)/t19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323655
PNG
((R)-N-cyclobutyl-2-(3-(2- ethoxyphenoxy)piperidin-...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NC1CCC1
Show InChI InChI=1S/C22H28N4O3/c1-2-28-19-10-3-4-11-20(19)29-18-9-6-12-26(15-18)22-23-13-16(14-24-22)21(27)25-17-7-5-8-17/h3-4,10-11,13-14,17-18H,2,5-9,12,15H2,1H3,(H,25,27)/t18-/m1/s1
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n/an/a 10.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323634
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(iso...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccon1
Show InChI InChI=1S/C22H25N5O4/c1-2-29-19-7-3-4-8-20(19)31-18-6-5-10-27(15-18)22-24-12-16(13-25-22)21(28)23-14-17-9-11-30-26-17/h3-4,7-9,11-13,18H,2,5-6,10,14-15H2,1H3,(H,23,28)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323652
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(iso...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)Nc1ccon1
Show InChI InChI=1S/C21H23N5O4/c1-2-28-17-7-3-4-8-18(17)30-16-6-5-10-26(14-16)21-22-12-15(13-23-21)20(27)24-19-9-11-29-25-19/h3-4,7-9,11-13,16H,2,5-6,10,14H2,1H3,(H,24,25,27)/t16-/m1/s1
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n/an/a 11.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323647
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(oxa...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1cocn1
Show InChI InChI=1S/C22H25N5O4/c1-2-30-19-7-3-4-8-20(19)31-18-6-5-9-27(13-18)22-24-10-16(11-25-22)21(28)23-12-17-14-29-15-26-17/h3-4,7-8,10-11,14-15,18H,2,5-6,9,12-13H2,1H3,(H,23,28)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274966
PNG
(N2-(tert-butyl)-N8-(2-(5-chloro-1H-benzo[d]imidazo...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C31H31ClF3N5O2/c1-30(2,3)39-29(42)40-14-12-22-21(18-5-4-6-19(15-18)31(33,34)35)8-9-23(24(22)17-40)28(41)36-13-11-27-37-25-10-7-20(32)16-26(25)38-27/h4-10,15-16H,11-14,17H2,1-3H3,(H,36,41)(H,37,38)(H,39,42)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323649
PNG
((R)-N-(4-amino-2-methyl- 4-oxobutan-2-yl)-2-(3-(2-...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NC(C)(C)CC(N)=O
Show InChI InChI=1S/C23H31N5O4/c1-4-31-18-9-5-6-10-19(18)32-17-8-7-11-28(15-17)22-25-13-16(14-26-22)21(30)27-23(2,3)12-20(24)29/h5-6,9-10,13-14,17H,4,7-8,11-12,15H2,1-3H3,(H2,24,29)(H,27,30)/t17-/m1/s1
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n/an/a 12.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276752
PNG
(2-(5-((3-ethoxypyridin- 2-yl)oxy)pyridin-3-yl)-N-(...)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1(C)CCS(=O)(=O)C1
Show InChI InChI=1S/C22H23N5O5S/c1-3-31-18-5-4-7-24-21(18)32-17-9-15(10-23-13-17)19-25-11-16(12-26-19)20(28)27-22(2)6-8-33(29,30)14-22/h4-5,7,9-13H,3,6,8,14H2,1-2H3,(H,27,28)
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276748
PNG
(US10071992, Example 3.5 | US10071992, Example 5)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC(C)(C)CO
Show InChI InChI=1S/C21H23N5O4/c1-4-29-17-6-5-7-23-20(17)30-16-8-14(9-22-12-16)18-24-10-15(11-25-18)19(28)26-21(2,3)13-27/h5-12,27H,4,13H2,1-3H3,(H,26,28)
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n/an/a 14n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323640
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CC(C1)OC
Show InChI InChI=1S/C22H28N4O4/c1-3-29-19-8-4-5-9-20(19)30-17-7-6-10-25(13-17)22-23-11-16(12-24-22)21(27)26-14-18(15-26)28-2/h4-5,8-9,11-12,17-18H,3,6-7,10,13-15H2,1-2H3/t17-/m1/s1
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n/an/a 14.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323667
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CCCCC1
Show InChI InChI=1S/C23H30N4O3/c1-2-29-20-10-4-5-11-21(20)30-19-9-8-14-27(17-19)23-24-15-18(16-25-23)22(28)26-12-6-3-7-13-26/h4-5,10-11,15-16,19H,2-3,6-9,12-14,17H2,1H3/t19-/m1/s1
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n/an/a 15.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274967
PNG
(N2-(tert-butyl)-N8-(2-(5,6-dichloro-1H- benzo[d]im...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C31H30Cl2F3N5O2/c1-30(2,3)40-29(43)41-12-10-20-19(17-5-4-6-18(13-17)31(34,35)36)7-8-21(22(20)16-41)28(42)37-11-9-27-38-25-14-23(32)24(33)15-26(25)39-27/h4-8,13-15H,9-12,16H2,1-3H3,(H,37,42)(H,38,39)(H,40,43)
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n/an/a 15.9n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM275020
PNG
(N2-(tert-butyl)-N8-(2-(6-chloro-1H- benzo[d]imidaz...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C31H31ClF3N5O2/c1-30(2,3)39-29(42)40-14-12-22-21(18-5-4-6-19(15-18)31(33,34)35)8-9-23(24(22)17-40)28(41)36-13-11-27-37-25-10-7-20(32)16-26(25)38-27/h4-10,15-16H,11-14,17H2,1-3H3,(H,36,41)(H,37,38)(H,39,42)
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n/an/a 16.7n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274963
PNG
(US9877957, Example 3 | methyl 3-(8-((3-(tert-butyl...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)c2cc(nn2C)C(C)(C)C)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C32H41N5O4/c1-31(2,3)27-17-26(36(7)35-27)28(38)33-18-22-12-13-23(20-10-9-11-21(16-20)29(39)41-8)24-14-15-37(19-25(22)24)30(40)34-32(4,5)6/h9-13,16-17H,14-15,18-19H2,1-8H3,(H,33,38)(H,34,40)
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n/an/a 17n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276750
PNG
((S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-...)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1
Show InChI InChI=1S/C21H21N5O4/c1-2-29-18-4-3-6-23-21(18)30-17-8-14(9-22-12-17)19-24-10-15(11-25-19)20(27)26-16-5-7-28-13-16/h3-4,6,8-12,16H,2,5,7,13H2,1H3,(H,26,27)/t16-/m0/s1
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n/an/a 17.2n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323635
PNG
((R)-N-(cyclopropylmethyl)- 2-(3-(2- ethoxyphenoxy)...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCC1CC1
Show InChI InChI=1S/C22H28N4O3/c1-2-28-19-7-3-4-8-20(19)29-18-6-5-11-26(15-18)22-24-13-17(14-25-22)21(27)23-12-16-9-10-16/h3-4,7-8,13-14,16,18H,2,5-6,9-12,15H2,1H3,(H,23,27)/t18-/m1/s1
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n/an/a 18.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276760
PNG
(US10071992, Example 6a)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1(CO)CCOC1
Show InChI InChI=1S/C22H23N5O5/c1-2-31-18-4-3-6-24-21(18)32-17-8-15(9-23-12-17)19-25-10-16(11-26-19)20(29)27-22(13-28)5-7-30-14-22/h3-4,6,8-12,28H,2,5,7,13-14H2,1H3,(H,27,29)
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n/an/a 20.9n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323646
PNG
(((1R,4R)-2-oxa-5- azabicyclo[2.2.1]heptan-5- yl)(2...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1C[C@H]2C[C@@H]1CO2
Show InChI InChI=1S/C23H28N4O4/c1-2-29-20-7-3-4-8-21(20)31-18-6-5-9-26(13-18)23-24-11-16(12-25-23)22(28)27-14-19-10-17(27)15-30-19/h3-4,7-8,11-12,17-19H,2,5-6,9-10,13-15H2,1H3/t17-,18-,19-/m1/s1
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n/an/a 21.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323650
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(pyr...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1cnccn1
Show InChI InChI=1S/C23H26N6O3/c1-2-31-20-7-3-4-8-21(20)32-19-6-5-11-29(16-19)23-27-12-17(13-28-23)22(30)26-15-18-14-24-9-10-25-18/h3-4,7-10,12-14,19H,2,5-6,11,15-16H2,1H3,(H,26,30)/t19-/m1/s1
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n/an/a 22.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323632
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H28N4O4/c1-2-29-19-7-3-4-8-20(19)30-18-6-5-9-26(16-18)22-23-14-17(15-24-22)21(27)25-10-12-28-13-11-25/h3-4,7-8,14-15,18H,2,5-6,9-13,16H2,1H3/t18-/m1/s1
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n/an/a 22.6n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276761
PNG
((S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-...)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@]1(CO)CCOC1
Show InChI InChI=1S/C22H23N5O5/c1-2-31-18-4-3-6-24-21(18)32-17-8-15(9-23-12-17)19-25-10-16(11-26-19)20(29)27-22(13-28)5-7-30-14-22/h3-4,6,8-12,28H,2,5,7,13-14H2,1H3,(H,27,29)/t22-/m0/s1
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n/an/a 23.2n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323664
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CCCC1
Show InChI InChI=1S/C22H28N4O3/c1-2-28-19-9-3-4-10-20(19)29-18-8-7-13-26(16-18)22-23-14-17(15-24-22)21(27)25-11-5-6-12-25/h3-4,9-10,14-15,18H,2,5-8,11-13,16H2,1H3/t18-/m1/s1
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n/an/a 24.5n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323643
PNG
((R)-azetidin-1-yl(2-(3-(2- ethoxyphenoxy)piperidin...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1CCC1
Show InChI InChI=1S/C21H26N4O3/c1-2-27-18-8-3-4-9-19(18)28-17-7-5-10-25(15-17)21-22-13-16(14-23-21)20(26)24-11-6-12-24/h3-4,8-9,13-14,17H,2,5-7,10-12,15H2,1H3/t17-/m1/s1
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n/an/a 26.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323663
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(2-(...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCCc1cn[nH]c1O
Show InChI InChI=1S/C23H28N6O4/c1-2-32-19-7-3-4-8-20(19)33-18-6-5-11-29(15-18)23-25-12-17(13-26-23)21(30)24-10-9-16-14-27-28-22(16)31/h3-4,7-8,12-14,18H,2,5-6,9-11,15H2,1H3,(H,24,30)(H2,27,28,31)/t18-/m1/s1
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n/an/a 29.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323641
PNG
((R)-N-(2-(1H-1,2,4-triazol- 1-yl)ethyl)-2-(3-(2- e...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCCn1cncn1
Show InChI InChI=1S/C22H27N7O3/c1-2-31-19-7-3-4-8-20(19)32-18-6-5-10-28(14-18)22-25-12-17(13-26-22)21(30)24-9-11-29-16-23-15-27-29/h3-4,7-8,12-13,15-16,18H,2,5-6,9-11,14H2,1H3,(H,24,30)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274968
PNG
(N2-(tert-butyl)-N8-(2-(5-fluoro-1H- benzo[d]imidaz...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C31H31F4N5O2/c1-30(2,3)39-29(42)40-14-12-22-21(18-5-4-6-19(15-18)31(33,34)35)8-9-23(24(22)17-40)28(41)36-13-11-27-37-25-10-7-20(32)16-26(25)38-27/h4-10,15-16H,11-14,17H2,1-3H3,(H,36,41)(H,37,38)(H,39,42)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323653
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(pyr...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)Nc1cncnc1
Show InChI InChI=1S/C22H24N6O3/c1-2-30-19-7-3-4-8-20(19)31-18-6-5-9-28(14-18)22-25-10-16(11-26-22)21(29)27-17-12-23-15-24-13-17/h3-4,7-8,10-13,15,18H,2,5-6,9,14H2,1H3,(H,27,29)/t18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323637
PNG
((R)-(2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)pyrimi...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N1Cc2cnn(C)c2C1
Show InChI InChI=1S/C24H28N6O3/c1-3-32-21-8-4-5-9-22(21)33-19-7-6-10-29(15-19)24-25-11-17(12-26-24)23(31)30-14-18-13-27-28(2)20(18)16-30/h4-5,8-9,11-13,19H,3,6-7,10,14-16H2,1-2H3/t19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323595
PNG
(US10188653, Example 4)
Show SMILES CCNC(=O)c1cnc(nc1)N1CCC[C@H](C1)Oc1ccccc1OCC
Show InChI InChI=1S/C20H26N4O3/c1-3-21-19(25)15-12-22-20(23-13-15)24-11-7-8-16(14-24)27-18-10-6-5-9-17(18)26-4-2/h5-6,9-10,12-13,16H,3-4,7-8,11,14H2,1-2H3,(H,21,25)/t16-/m1/s1
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US Patent
n/an/a 35n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM276757
PNG
(2-(5-((3-ethoxypyridin- 2-yl)oxy)pyridin-3-yl)- N-...)
Show SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C21H23N5O5S/c1-5-30-17-7-6-8-23-20(17)31-16-9-14(10-22-13-16)18-24-11-15(12-25-18)19(27)26-21(2,3)32(4,28)29/h6-13H,5H2,1-4H3,(H,26,27)
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n/an/a 35.4n/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...


US Patent US10071992 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323612
PNG
(US10188653, Example 9)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1cc(ccc1C)C(O)=O
Show InChI InChI=1S/C27H30N4O5/c1-3-35-23-8-4-5-9-24(23)36-22-7-6-12-31(17-22)27-29-15-21(16-30-27)25(32)28-14-20-13-19(26(33)34)11-10-18(20)2/h4-5,8-11,13,15-16,22H,3,6-7,12,14,17H2,1-2H3,(H,28,32)(H,33,34)/t22-/m1/s1
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n/an/a 38.1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274964
PNG
(N-(tert-butyl)-5-(3-methoxyphenyl)-8- ((3-(trifluo...)
Show SMILES COc1cccc(c1)-c1ccc(CNC(=O)c2cc(n[nH]2)C(F)(F)F)c2CN(CCc12)C(=O)NC(C)(C)C
Show InChI InChI=1S/C27H30F3N5O3/c1-26(2,3)32-25(37)35-11-10-20-19(16-6-5-7-18(12-16)38-4)9-8-17(21(20)15-35)14-31-24(36)22-13-23(34-33-22)27(28,29)30/h5-9,12-13H,10-11,14-15H2,1-4H3,(H,31,36)(H,32,37)(H,33,34)
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n/an/a 41.4n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323624
PNG
(US10188653, Example 13)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1ccc(cc1C)C(O)=O
Show InChI InChI=1S/C27H30N4O5/c1-3-35-23-8-4-5-9-24(23)36-22-7-6-12-31(17-22)27-29-15-21(16-30-27)25(32)28-14-20-11-10-19(26(33)34)13-18(20)2/h4-5,8-11,13,15-16,22H,3,6-7,12,14,17H2,1-2H3,(H,28,32)(H,33,34)/t22-/m1/s1
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n/an/a 45.2n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323645
PNG
(2-((R)-3-(2-ethoxy- phenoxy)piperidin-1-yl)- N-((R...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)N[C@H]1CNC(=O)C1
Show InChI InChI=1S/C22H27N5O4/c1-2-30-18-7-3-4-8-19(18)31-17-6-5-9-27(14-17)22-24-11-15(12-25-22)21(29)26-16-10-20(28)23-13-16/h3-4,7-8,11-12,16-17H,2,5-6,9-10,13-14H2,1H3,(H,23,28)(H,26,29)/t16-,17-/m1/s1
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n/an/a 46.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323627
PNG
(US10188653, Example 16)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1cc(C)cc(c1)C(O)=O
Show InChI InChI=1S/C27H30N4O5/c1-3-35-23-8-4-5-9-24(23)36-22-7-6-10-31(17-22)27-29-15-21(16-30-27)25(32)28-14-19-11-18(2)12-20(13-19)26(33)34/h4-5,8-9,11-13,15-16,22H,3,6-7,10,14,17H2,1-2H3,(H,28,32)(H,33,34)/t22-/m1/s1
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n/an/a 47.7n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM274969
PNG
(N8-(2-(1H-benzo[d]imidazol-2-yl)ethyl)-N2- (tert-b...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCCc1nc2ccccc2[nH]1
Show InChI InChI=1S/C31H32F3N5O2/c1-30(2,3)38-29(41)39-16-14-22-21(19-7-6-8-20(17-19)31(32,33)34)11-12-23(24(22)18-39)28(40)35-15-13-27-36-25-9-4-5-10-26(25)37-27/h4-12,17H,13-16,18H2,1-3H3,(H,35,40)(H,36,37)(H,38,41)
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n/an/a 51.1n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323659
PNG
((R)-2-(3-(2- ethoxyphenoxy)piperidin- 1-yl)-N-(3-(...)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCCC(=O)NC
Show InChI InChI=1S/C22H29N5O4/c1-3-30-18-8-4-5-9-19(18)31-17-7-6-12-27(15-17)22-25-13-16(14-26-22)21(29)24-11-10-20(28)23-2/h4-5,8-9,13-14,17H,3,6-7,10-12,15H2,1-2H3,(H,23,28)(H,24,29)/t17-/m1/s1
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n/an/a 53.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM275028
PNG
(N2-(tert-butyl)-N8-(imidazo[1,2-a]pyridin-3- ylmet...)
Show SMILES CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)NCc1cnc2ccccn12
Show InChI InChI=1S/C30H30F3N5O2/c1-29(2,3)36-28(40)37-14-12-23-22(19-7-6-8-20(15-19)30(31,32)33)10-11-24(25(23)18-37)27(39)35-17-21-16-34-26-9-4-5-13-38(21)26/h4-11,13,15-16H,12,14,17-18H2,1-3H3,(H,35,39)(H,36,40)
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n/an/a 53.4n/an/an/an/a7.025



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...


US Patent US9877957 (2018)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 2


(Homo sapiens (human))
BDBM323623
PNG
(US10188653, Example 12)
Show SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NCc1cc(cnc1C)C(O)=O
Show InChI InChI=1S/C26H29N5O5/c1-3-35-22-8-4-5-9-23(22)36-21-7-6-10-31(16-21)26-29-14-20(15-30-26)24(32)28-12-18-11-19(25(33)34)13-27-17(18)2/h4-5,8-9,11,13-15,21H,3,6-7,10,12,16H2,1-2H3,(H,28,32)(H,33,34)/t21-/m1/s1
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n/an/a 62.3n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...


US Patent US10188653 (2019)

More data for this
Ligand-Target Pair
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