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Found 60 hits of Enz. Inhib. data with enzyme = 'Dihydroorotate Dehydrogenase (DHODH)' and Substrate = 'BDBM14700'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate Dehydrogenase (DHODH)


(Rattus norvegicus (rat))
BDBM15339
PNG
(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Show SMILES Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
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Article
PubMed
n/an/a 127n/an/an/an/a8.030



University of Copenhagen



Assay Description
To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...


Protein Sci 13: 1031-42 (2004)


Article DOI: 10.1110/ps.03533004
BindingDB Entry DOI: 10.7270/Q2FB5163
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM24400
PNG
(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)
Show SMILES Cc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-8-15(21-16(19-11)17-10-18-21)20-14-7-6-12-4-2-3-5-13(12)9-14/h2-10,20H,1H3
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n/an/a 230n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28843
PNG
(N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1...)
Show SMILES Cc1cc(Nc2ccc(c(F)c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H9F4N5/c1-7-4-11(22-12(20-7)18-6-19-22)21-8-2-3-9(10(14)5-8)13(15,16)17/h2-6,21H,1H3
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PubMed
n/an/a 260n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Rattus norvegicus (rat))
BDBM15339
PNG
(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Show SMILES Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
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n/an/a 367n/an/an/an/a8.030



University of Copenhagen



Assay Description
To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...


Protein Sci 13: 1031-42 (2004)


Article DOI: 10.1110/ps.03533004
BindingDB Entry DOI: 10.7270/Q2FB5163
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28817
PNG
(5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]tria...)
Show SMILES Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H10F3N5/c1-8-6-11(21-12(19-8)17-7-18-21)20-10-4-2-9(3-5-10)13(14,15)16/h2-7,20H,1H3
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n/an/a 380n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Rattus norvegicus (rat))
BDBM16301
PNG
(3-[4-(4-chlorophenyl)cyclohexyl]naphthalene-1,2,4-...)
Show SMILES Clc1ccc(cc1)C1CCC(CC1)C1C(=O)C(=O)c2ccccc2C1=O
Show InChI InChI=1/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,19H,5-8H2
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PubMed
n/an/a 698n/an/an/an/a8.030



University of Copenhagen



Assay Description
To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...


Protein Sci 13: 1031-42 (2004)


Article DOI: 10.1110/ps.03533004
BindingDB Entry DOI: 10.7270/Q2FB5163
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Rattus norvegicus (rat))
BDBM16301
PNG
(3-[4-(4-chlorophenyl)cyclohexyl]naphthalene-1,2,4-...)
Show SMILES Clc1ccc(cc1)C1CCC(CC1)C1C(=O)C(=O)c2ccccc2C1=O
Show InChI InChI=1/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,19H,5-8H2
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PubMed
n/an/a 904n/an/an/an/a8.030



University of Copenhagen



Assay Description
To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...


Protein Sci 13: 1031-42 (2004)


Article DOI: 10.1110/ps.03533004
BindingDB Entry DOI: 10.7270/Q2FB5163
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28815
PNG
(N-(4-bromophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]p...)
Show SMILES Cc1cc(Nc2ccc(Br)cc2)n2ncnc2n1
Show InChI InChI=1S/C12H10BrN5/c1-8-6-11(18-12(16-8)14-7-15-18)17-10-4-2-9(13)3-5-10/h2-7,17H,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28838
PNG
(N-[4-bromo-3-(trifluoromethyl)phenyl]-5-methyl-[1,...)
Show SMILES Cc1cc(Nc2ccc(Br)c(c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H9BrF3N5/c1-7-4-11(22-12(20-7)18-6-19-22)21-8-2-3-10(14)9(5-8)13(15,16)17/h2-6,21H,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28837
PNG
(N-[4-chloro-3-(trifluoromethyl)phenyl]-5-methyl-[1...)
Show SMILES Cc1cc(Nc2ccc(Cl)c(c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H9ClF3N5/c1-7-4-11(22-12(20-7)18-6-19-22)21-8-2-3-10(14)9(5-8)13(15,16)17/h2-6,21H,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28842
PNG
(N-(3-fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazo...)
Show SMILES Cc1cc(Nc2ccc(C)c(F)c2)n2ncnc2n1
Show InChI InChI=1S/C13H12FN5/c1-8-3-4-10(6-11(8)14)18-12-5-9(2)17-13-15-7-16-19(12)13/h3-7,18H,1-2H3
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PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28821
PNG
(5-methyl-N-(4-nitrophenyl)-[1,2,4]triazolo[1,5-a]p...)
Show SMILES Cc1cc(Nc2ccc(cc2)[N+]([O-])=O)n2ncnc2n1
Show InChI InChI=1S/C12H10N6O2/c1-8-6-11(17-12(15-8)13-7-14-17)16-9-2-4-10(5-3-9)18(19)20/h2-7,16H,1H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM24413
PNG
(JMC521864 Compund DSM2 | N-(anthracen-2-yl)-5-meth...)
Show SMILES Cc1cc(Nc2ccc3cc4ccccc4cc3c2)n2ncnc2n1
Show InChI InChI=1S/C20H15N5/c1-13-8-19(25-20(23-13)21-12-22-25)24-18-7-6-16-9-14-4-2-3-5-15(14)10-17(16)11-18/h2-12,24H,1H3
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28819
PNG
(5-methyl-N-[4-(trifluoromethoxy)phenyl]-[1,2,4]tri...)
Show SMILES Cc1cc(Nc2ccc(OC(F)(F)F)cc2)n2ncnc2n1
Show InChI InChI=1S/C13H10F3N5O/c1-8-6-11(21-12(19-8)17-7-18-21)20-9-2-4-10(5-3-9)22-13(14,15)16/h2-7,20H,1H3
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PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28840
PNG
(N-(3,4-dimethylphenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2ccc(C)c(C)c2)n2ncnc2n1
Show InChI InChI=1S/C14H15N5/c1-9-4-5-12(6-10(9)2)18-13-7-11(3)17-14-15-8-16-19(13)14/h4-8,18H,1-3H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28814
PNG
(N-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2ccc(Cl)cc2)n2ncnc2n1
Show InChI InChI=1S/C12H10ClN5/c1-8-6-11(18-12(16-8)14-7-15-18)17-10-4-2-9(13)3-5-10/h2-7,17H,1H3
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n/an/a 5.70E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28839
PNG
(5-methyl-N-[4-methyl-3-(trifluoromethyl)phenyl]-[1...)
Show SMILES Cc1cc(Nc2ccc(C)c(c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C14H12F3N5/c1-8-3-4-10(6-11(8)14(15,16)17)21-12-5-9(2)20-13-18-7-19-22(12)13/h3-7,21H,1-2H3
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n/an/a 7.30E+3n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28833
PNG
(N-(3,4-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2ccc(F)c(F)c2)n2ncnc2n1
Show InChI InChI=1S/C12H9F2N5/c1-7-4-11(19-12(17-7)15-6-16-19)18-8-2-3-9(13)10(14)5-8/h2-6,18H,1H3
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PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM24412
PNG
(5-methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-...)
Show SMILES Cc1cc(Nc2ccccc2)n2ncnc2n1
Show InChI InChI=1S/C12H11N5/c1-9-7-11(16-10-5-3-2-4-6-10)17-12(15-9)13-8-14-17/h2-8,16H,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28841
PNG
(4-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}...)
Show SMILES Cc1cc(Nc2ccc(C#N)c(c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C14H9F3N6/c1-8-4-12(23-13(21-8)19-7-20-23)22-10-3-2-9(6-18)11(5-10)14(15,16)17/h2-5,7,22H,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28816
PNG
(5-methyl-N-(4-methylphenyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1ccc(Nc2cc(C)nc3ncnn23)cc1
Show InChI InChI=1S/C13H13N5/c1-9-3-5-11(6-4-9)17-12-7-10(2)16-13-14-8-15-18(12)13/h3-8,17H,1-2H3
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28836
PNG
(N-(4-fluoro-3-methylphenyl)-5-methyl-[1,2,4]triazo...)
Show SMILES Cc1cc(Nc2ccc(F)c(C)c2)n2ncnc2n1
Show InChI InChI=1S/C13H12FN5/c1-8-5-10(3-4-11(8)14)18-12-6-9(2)17-13-15-7-16-19(12)13/h3-7,18H,1-2H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28834
PNG
(N-(3,5-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2cc(F)cc(F)c2)n2ncnc2n1
Show InChI InChI=1S/C12H9F2N5/c1-7-2-11(19-12(17-7)15-6-16-19)18-10-4-8(13)3-9(14)5-10/h2-6,18H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28820
PNG
(N-[4-(difluoromethoxy)phenyl]-5-methyl-[1,2,4]tria...)
Show SMILES Cc1cc(Nc2ccc(OC(F)F)cc2)n2ncnc2n1
Show InChI InChI=1S/C13H11F2N5O/c1-8-6-11(20-13(18-8)16-7-17-20)19-9-2-4-10(5-3-9)21-12(14)15/h2-7,12,19H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28810
PNG
(N-(3-chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2cccc(Cl)c2)n2ncnc2n1
Show InChI InChI=1S/C12H10ClN5/c1-8-5-11(18-12(16-8)14-7-15-18)17-10-4-2-3-9(13)6-10/h2-7,17H,1H3
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28818
PNG
(N-(4-methoxyphenyl)-5-methyl-[1,2,4]triazolo[1,5-a...)
Show SMILES COc1ccc(Nc2cc(C)nc3ncnn23)cc1
Show InChI InChI=1S/C13H13N5O/c1-9-7-12(18-13(16-9)14-8-15-18)17-10-3-5-11(19-2)6-4-10/h3-8,17H,1-2H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28812
PNG
(5-methyl-N-[3-(trifluoromethyl)phenyl]-[1,2,4]tria...)
Show SMILES Cc1cc(Nc2cccc(c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H10F3N5/c1-8-5-11(21-12(19-8)17-7-18-21)20-10-4-2-3-9(6-10)13(14,15)16/h2-7,20H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28835
PNG
(N-[3,5-bis(trifluoromethyl)phenyl]-5-methyl-[1,2,4...)
Show SMILES Cc1cc(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C14H9F6N5/c1-7-2-11(25-12(23-7)21-6-22-25)24-10-4-8(13(15,16)17)3-9(5-10)14(18,19)20/h2-6,24H,1H3
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Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28832
PNG
(N-(2-fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazo...)
Show SMILES Cc1ccc(Nc2cc(C)nc3ncnn23)c(F)c1
Show InChI InChI=1S/C13H12FN5/c1-8-3-4-11(10(14)5-8)18-12-6-9(2)17-13-15-7-16-19(12)13/h3-7,18H,1-2H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28831
PNG
(5-methyl-N-(2,3,4,5,6-pentafluorophenyl)-[1,2,4]tr...)
Show SMILES Cc1cc(Nc2c(F)c(F)c(F)c(F)c2F)n2ncnc2n1
Show InChI InChI=1S/C12H6F5N5/c1-4-2-5(22-12(20-4)18-3-19-22)21-11-9(16)7(14)6(13)8(15)10(11)17/h2-3,21H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28830
PNG
(5-methyl-N-(2,3,5,6-tetrafluorophenyl)-[1,2,4]tria...)
Show SMILES Cc1cc(Nc2c(F)c(F)cc(F)c2F)n2ncnc2n1
Show InChI InChI=1S/C12H7F4N5/c1-5-2-8(21-12(19-5)17-4-18-21)20-11-9(15)6(13)3-7(14)10(11)16/h2-4,20H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28829
PNG
(5-methyl-N-(2,4,6-trifluorophenyl)-[1,2,4]triazolo...)
Show SMILES Cc1cc(Nc2c(F)cc(F)cc2F)n2ncnc2n1
Show InChI InChI=1S/C12H8F3N5/c1-6-2-10(20-12(18-6)16-5-17-20)19-11-8(14)3-7(13)4-9(11)15/h2-5,19H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28828
PNG
(5-methyl-N-(2,4,5-trifluorophenyl)-[1,2,4]triazolo...)
Show SMILES Cc1cc(Nc2cc(F)c(F)cc2F)n2ncnc2n1
Show InChI InChI=1S/C12H8F3N5/c1-6-2-11(20-12(18-6)16-5-17-20)19-10-4-8(14)7(13)3-9(10)15/h2-5,19H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (Human))
BDBM28843
PNG
(N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1...)
Show SMILES Cc1cc(Nc2ccc(c(F)c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H9F4N5/c1-7-4-11(22-12(20-7)18-6-19-22)21-8-2-3-9(10(14)5-8)13(15,16)17/h2-6,21H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28826
PNG
(N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2c(F)cccc2F)n2ncnc2n1
Show InChI InChI=1S/C12H9F2N5/c1-7-5-10(19-12(17-7)15-6-16-19)18-11-8(13)3-2-4-9(11)14/h2-6,18H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28825
PNG
(N-(2,5-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2cc(F)ccc2F)n2ncnc2n1
Show InChI InChI=1S/C12H9F2N5/c1-7-4-11(19-12(17-7)15-6-16-19)18-10-5-8(13)2-3-9(10)14/h2-6,18H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28824
PNG
(N-(2,3-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2cccc(F)c2F)n2ncnc2n1
Show InChI InChI=1S/C12H9F2N5/c1-7-5-10(19-12(17-7)15-6-16-19)18-9-4-2-3-8(13)11(9)14/h2-6,18H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28823
PNG
(N-(4-benzylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2ccc(Cc3ccccc3)cc2)n2ncnc2n1
Show InChI InChI=1S/C19H17N5/c1-14-11-18(24-19(22-14)20-13-21-24)23-17-9-7-16(8-10-17)12-15-5-3-2-4-6-15/h2-11,13,23H,12H2,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28813
PNG
(N-(4-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2ccc(F)cc2)n2ncnc2n1
Show InChI InChI=1S/C12H10FN5/c1-8-6-11(18-12(16-8)14-7-15-18)17-10-4-2-9(13)3-5-10/h2-7,17H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28811
PNG
(5-methyl-N-(3-methylphenyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cccc(Nc2cc(C)nc3ncnn23)c1
Show InChI InChI=1S/C13H13N5/c1-9-4-3-5-11(6-9)17-12-7-10(2)16-13-14-8-15-18(12)13/h3-8,17H,1-2H3
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Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28809
PNG
(N-(3-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2cccc(F)c2)n2ncnc2n1
Show InChI InChI=1S/C12H10FN5/c1-8-5-11(18-12(16-8)14-7-15-18)17-10-4-2-3-9(13)6-10/h2-7,17H,1H3
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Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28808
PNG
(2-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}...)
Show SMILES Cc1cc(Nc2ccccc2C#N)n2ncnc2n1
Show InChI InChI=1S/C13H10N6/c1-9-6-12(19-13(17-9)15-8-16-19)18-11-5-3-2-4-10(11)7-14/h2-6,8,18H,1H3
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Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28807
PNG
(5-methyl-N-[2-(trifluoromethyl)phenyl]-[1,2,4]tria...)
Show SMILES Cc1cc(Nc2ccccc2C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C13H10F3N5/c1-8-6-11(21-12(19-8)17-7-18-21)20-10-5-3-2-4-9(10)13(14,15)16/h2-7,20H,1H3
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Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28806
PNG
(5-methyl-N-(2-methylphenyl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2ccccc2C)n2ncnc2n1
Show InChI InChI=1S/C13H13N5/c1-9-5-3-4-6-11(9)17-12-7-10(2)16-13-14-8-15-18(12)13/h3-8,17H,1-2H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28805
PNG
(N-(2-chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2ccccc2Cl)n2ncnc2n1
Show InChI InChI=1S/C12H10ClN5/c1-8-6-11(18-12(16-8)14-7-15-18)17-10-5-3-2-4-9(10)13/h2-7,17H,1H3
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University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28804
PNG
(N-(2-fluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2ccccc2F)n2ncnc2n1
Show InChI InChI=1S/C12H10FN5/c1-8-6-11(18-12(16-8)14-7-15-18)17-10-5-3-2-4-9(10)13/h2-7,17H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium berghei)
BDBM28827
PNG
(5-methyl-N-(2,3,4-trifluorophenyl)-[1,2,4]triazolo...)
Show SMILES Cc1cc(Nc2ccc(F)c(F)c2F)n2ncnc2n1
Show InChI InChI=1S/C12H8F3N5/c1-6-4-9(20-12(18-6)16-5-17-20)19-8-3-2-7(13)10(14)11(8)15/h2-5,19H,1H3
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (Human))
BDBM28842
PNG
(N-(3-fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazo...)
Show SMILES Cc1cc(Nc2ccc(C)c(F)c2)n2ncnc2n1
Show InChI InChI=1S/C13H12FN5/c1-8-3-4-10(6-11(8)14)18-12-5-9(2)17-13-15-7-16-19(12)13/h3-7,18H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (Human))
BDBM28840
PNG
(N-(3,4-dimethylphenyl)-5-methyl-[1,2,4]triazolo[1,...)
Show SMILES Cc1cc(Nc2ccc(C)c(C)c2)n2ncnc2n1
Show InChI InChI=1S/C14H15N5/c1-9-4-5-12(6-10(9)2)18-13-7-11(3)17-14-15-8-16-19(13)14/h4-8,18H,1-3H3
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (Human))
BDBM28810
PNG
(N-(3-chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)
Show SMILES Cc1cc(Nc2cccc(Cl)c2)n2ncnc2n1
Show InChI InChI=1S/C12H10ClN5/c1-8-5-11(18-12(16-8)14-7-15-18)17-10-4-2-3-9(13)6-10/h2-7,17H,1H3
PDB
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UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



University of Washington at Seattle



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 52: 1864-72 (2009)


Article DOI: 10.1021/jm801343r
BindingDB Entry DOI: 10.7270/Q2QN653C
More data for this
Ligand-Target Pair
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