BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 40 hits of Enz. Inhib. data with enzyme = 'Dihydroorotate Dehydrogenase (DHODH)' and Substrate = 'BDBM15346'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14711
PNG
(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-8-12(3-2-4-13(8)18(20)21)14(19)17-11-6-9(15)5-10(16)7-11/h2-7H,1H3,(H,17,19)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 16n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24400
PNG
(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)
Show SMILES Cc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-8-15(21-16(19-11)17-10-18-21)20-14-7-6-12-4-2-3-5-13(12)9-14/h2-10,20H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 47n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM14710
PNG
(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)
Show SMILES Cc1cc(Br)ccc1NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H14BrNO/c1-12-10-16(19)8-9-17(12)20-18(21)15-7-6-13-4-2-3-5-14(13)11-15/h2-11H,1H3,(H,20,21)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15345
PNG
(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Show SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2NO/c18-14-7-8-16(15(19)10-14)20-17(21)13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H,20,21)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 50n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24413
PNG
(JMC521864 Compund DSM2 | N-(anthracen-2-yl)-5-meth...)
Show SMILES Cc1cc(Nc2ccc3cc4ccccc4cc3c2)n2ncnc2n1
Show InChI InChI=1S/C20H15N5/c1-13-8-19(25-20(23-13)21-12-22-25)24-18-7-6-16-9-14-4-2-3-5-15(14)10-17(16)11-18/h2-12,24H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 56n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15349
PNG
(Asinex compound no. 4 | N-(3-bromophenyl)-2-methyl...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C14H11BrN2O3/c1-9-12(6-3-7-13(9)17(19)20)14(18)16-11-5-2-4-10(15)8-11/h2-8H,1H3,(H,16,18)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 60n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15353
PNG
(2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide | Ch...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H14N2O3/c1-12-14(9-5-11-17(12)20(22)23)18(21)19-16-10-4-7-13-6-2-3-8-15(13)16/h2-11H,1H3,(H,19,21)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15354
PNG
(Asinex compound no. 9 | N-(3,4-dichlorophenyl)-2-m...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-8-10(3-2-4-13(8)18(20)21)14(19)17-9-5-6-11(15)12(16)7-9/h2-7H,1H3,(H,17,19)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15355
PNG
(2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benz...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c1-9-12(6-3-7-13(9)20(22)23)14(21)19-11-5-2-4-10(8-11)15(16,17)18/h2-8H,1H3,(H,19,21)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 80n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15350
PNG
(ChemBridge compound no. 5 | N-(3-chloro-4-fluoroph...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C14H10ClFN2O3/c1-8-10(3-2-4-13(8)18(20)21)14(19)17-9-5-6-12(16)11(15)7-9/h2-7H,1H3,(H,17,19)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24403
PNG
(5,6-dimethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1...)
Show SMILES Cc1nc2ncnn2c(Nc2ccc3ccccc3c2)c1C
Show InChI InChI=1S/C17H15N5/c1-11-12(2)20-17-18-10-19-22(17)16(11)21-15-8-7-13-5-3-4-6-14(13)9-15/h3-10,21H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 160n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24402
PNG
(5-ethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a]...)
Show SMILES CCc1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
Show InChI InChI=1S/C17H15N5/c1-2-14-10-16(22-17(21-14)18-11-19-22)20-15-8-7-12-5-3-4-6-13(12)9-15/h3-11,20H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 190n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24401
PNG
(N-(naphthalen-2-yl)-5-(trifluoromethyl)-[1,2,4]tri...)
Show SMILES FC(F)(F)c1cc(Nc2ccc3ccccc3c2)n2ncnc2n1
Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)13-8-14(24-15(23-13)20-9-21-24)22-12-6-5-10-3-1-2-4-11(10)7-12/h1-9,22H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 210n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15357
PNG
(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Show SMILES COc1ccccc1NC(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H16N2O2/c1-22-17-12-5-4-10-16(17)20-18(21)19-15-11-6-8-13-7-2-3-9-14(13)15/h2-12H,1H3,(H2,19,20,21)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 230n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15352
PNG
(ChemBridge compound no. 7 | N-(3,4-difluorophenyl)...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C14H10F2N2O3/c1-8-10(3-2-4-13(8)18(20)21)14(19)17-9-5-6-11(15)12(16)7-9/h2-7H,1H3,(H,17,19)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 260n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24409
PNG
(3-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}...)
Show SMILES Cc1cc(Nc2cc3ccccc3cc2O)n2ncnc2n1
Show InChI InChI=1S/C16H13N5O/c1-10-6-15(21-16(19-10)17-9-18-21)20-13-7-11-4-2-3-5-12(11)8-14(13)22/h2-9,20,22H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 330n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15356
PNG
(1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H13F3N2O/c19-18(20,21)14-9-3-4-10-16(14)23-17(24)22-15-11-5-7-12-6-1-2-8-13(12)15/h1-11H,(H2,22,23,24)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15348
PNG
(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)
Show SMILES Fc1ccccc1NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12FNO/c18-15-7-3-4-8-16(15)19-17(20)14-10-9-12-5-1-2-6-13(12)11-14/h1-11H,(H,19,20)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 470n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM15358
PNG
(3-(4-chlorophenyl)-1-quinolin-8-ylurea | Asinex co...)
Show SMILES Clc1ccc(NC(=O)Nc2cccc3cccnc23)cc1
Show InChI InChI=1S/C16H12ClN3O/c17-12-6-8-13(9-7-12)19-16(21)20-14-5-1-3-11-4-2-10-18-15(11)14/h1-10H,(H2,19,20,21)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 780n/an/an/an/a8.022



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24408
PNG
(N-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}q...)
Show SMILES Cc1cc(Nc2ccc3ncccc3c2)n2ncnc2n1
Show InChI InChI=1S/C15H12N6/c1-10-7-14(21-15(19-10)17-9-18-21)20-12-4-5-13-11(8-12)3-2-6-16-13/h2-9,20H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24407
PNG
(N-{5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}q...)
Show SMILES Cc1cc(Nc2cnc3ccccc3c2)n2ncnc2n1
Show InChI InChI=1S/C15H12N6/c1-10-6-14(21-15(19-10)17-9-18-21)20-12-7-11-4-2-3-5-13(11)16-8-12/h2-9,20H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24410
PNG
(2-methyl-7-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimi...)
Show SMILES Cc1cc(Nc2ccc3c(c2)oc(C)cc3=O)n2ncnc2n1
Show InChI InChI=1S/C16H13N5O2/c1-9-5-15(21-16(19-9)17-8-18-21)20-11-3-4-12-13(22)6-10(2)23-14(12)7-11/h3-8,20H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24404
PNG
(N,5-dimethyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1...)
Show SMILES CN(c1ccc2ccccc2c1)c1cc(C)nc2ncnn12
Show InChI InChI=1S/C17H15N5/c1-12-9-16(22-17(20-12)18-11-19-22)21(2)15-8-7-13-5-3-4-6-14(13)10-15/h3-11H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15348
PNG
(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)
Show SMILES Fc1ccccc1NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12FNO/c18-15-7-3-4-8-16(15)19-17(20)14-10-9-12-5-1-2-6-13(12)11-14/h1-11H,(H,19,20)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24411
PNG
(5-methyl-N-(naphthalen-1-yl)-[1,2,4]triazolo[1,5-a...)
Show SMILES Cc1cc(Nc2cccc3ccccc23)n2ncnc2n1
Show InChI InChI=1S/C16H13N5/c1-11-9-15(21-16(19-11)17-10-18-21)20-14-8-4-6-12-5-2-3-7-13(12)14/h2-10,20H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.50E+4n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15345
PNG
(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)
Show SMILES Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C17H11Cl2NO/c18-14-7-8-16(15(19)10-14)20-17(21)13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15354
PNG
(Asinex compound no. 9 | N-(3,4-dichlorophenyl)-2-m...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-8-10(3-2-4-13(8)18(20)21)14(19)17-9-5-6-11(15)12(16)7-9/h2-7H,1H3,(H,17,19)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.20E+4n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24405
PNG
(N-benzyl-5-methyl-N-(naphthalen-2-yl)-[1,2,4]triaz...)
Show SMILES Cc1cc(N(Cc2ccccc2)c2ccc3ccccc3c2)n2ncnc2n1
Show InChI InChI=1S/C23H19N5/c1-17-13-22(28-23(26-17)24-16-25-28)27(15-18-7-3-2-4-8-18)21-12-11-19-9-5-6-10-20(19)14-21/h2-14,16H,15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.30E+4n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15353
PNG
(2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide | Ch...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H14N2O3/c1-12-14(9-5-11-17(12)20(22)23)18(21)19-16-10-4-7-13-6-2-3-8-15(13)16/h2-11H,1H3,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24412
PNG
(5-methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-...)
Show SMILES Cc1cc(Nc2ccccc2)n2ncnc2n1
Show InChI InChI=1S/C12H11N5/c1-9-7-11(16-10-5-3-2-4-6-10)17-12(15-9)13-8-14-17/h2-8,16H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15349
PNG
(Asinex compound no. 4 | N-(3-bromophenyl)-2-methyl...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C14H11BrN2O3/c1-9-12(6-3-7-13(9)17(19)20)14(18)16-11-5-2-4-10(15)8-11/h2-8H,1H3,(H,16,18)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.05E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15357
PNG
(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)
Show SMILES COc1ccccc1NC(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H16N2O2/c1-22-17-12-5-4-10-16(17)20-18(21)19-15-11-6-8-13-7-2-3-9-14(13)15/h2-12H,1H3,(H2,19,20,21)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.12E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15350
PNG
(ChemBridge compound no. 5 | N-(3-chloro-4-fluoroph...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(Cl)c1
Show InChI InChI=1S/C14H10ClFN2O3/c1-8-10(3-2-4-13(8)18(20)21)14(19)17-9-5-6-12(16)11(15)7-9/h2-7H,1H3,(H,17,19)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.16E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15358
PNG
(3-(4-chlorophenyl)-1-quinolin-8-ylurea | Asinex co...)
Show SMILES Clc1ccc(NC(=O)Nc2cccc3cccnc23)cc1
Show InChI InChI=1S/C16H12ClN3O/c17-12-6-8-13(9-7-12)19-16(21)20-14-5-1-3-11-4-2-10-18-15(11)14/h1-10H,(H2,19,20,21)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.16E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15355
PNG
(2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benz...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N2O3/c1-9-12(6-3-7-13(9)20(22)23)14(21)19-11-5-2-4-10(8-11)15(16,17)18/h2-8H,1H3,(H,19,21)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.50E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM14711
PNG
(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C14H10Cl2N2O3/c1-8-12(3-2-4-13(8)18(20)21)14(19)17-11-6-9(15)5-10(16)7-11/h2-7H,1H3,(H,17,19)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 2.00E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Plasmodium falciparum)
BDBM24406
PNG
(4-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}...)
Show SMILES Cc1cc(Nc2ccc(cc2)C(N)=O)n2ncnc2n1
Show InChI InChI=1S/C13H12N6O/c1-8-6-11(19-13(17-8)15-7-16-19)18-10-4-2-9(3-5-10)12(14)20/h2-7,18H,1H3,(H2,14,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+5n/an/an/an/a8.020



University of Texas Southwestern Medical Center at Dallas



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Med Chem 51: 3649-53 (2008)


Article DOI: 10.1021/jm8001026
BindingDB Entry DOI: 10.7270/Q2PV6HNF
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15352
PNG
(ChemBridge compound no. 7 | N-(3,4-difluorophenyl)...)
Show SMILES Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(F)c1
Show InChI InChI=1S/C14H10F2N2O3/c1-8-10(3-2-4-13(8)18(20)21)14(19)17-9-5-6-11(15)12(16)7-9/h2-7H,1H3,(H,17,19)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM14710
PNG
(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)
Show SMILES Cc1cc(Br)ccc1NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C18H14BrNO/c1-12-10-16(19)8-9-17(12)20-18(21)15-7-6-13-4-2-3-5-14(13)11-15/h2-11H,1H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+5n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH)


(Homo sapiens (human))
BDBM15356
PNG
(1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...)
Show SMILES FC(F)(F)c1ccccc1NC(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C18H13F3N2O/c19-18(20,21)14-9-3-4-10-16(14)23-17(24)22-15-11-5-7-12-6-1-2-8-13(12)15/h1-11H,(H2,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



University of Texas Southwestern Medical Center



Assay Description
The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...


J Biol Chem 280: 21847-53 (2005)


Article DOI: 10.1074/jbc.M501100200
BindingDB Entry DOI: 10.7270/Q21G0JH3
More data for this
Ligand-Target Pair