BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 267 hits of Enz. Inhib. data with enzyme = 'Dipeptidyl peptidase 2 (DPP II)' and Substrate = 'BDBM11156'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11522
PNG
((2S,3S)-3-{4-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-y...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1noc(n1)C1CC1
Show InChI InChI=1S/C25H27FN4O2/c1-15(22(27)25(31)30-12-11-21(26)14-30)16-5-7-17(8-6-16)19-3-2-4-20(13-19)23-28-24(32-29-23)18-9-10-18/h2-8,13,15,18,21-22H,9-12,14,27H2,1H3/p+1/t15-,21-,22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 96n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11510
PNG
((2S,3S)-3-{4-[4-(ethoxycarbonyl)phenyl]phenyl}-1-[...)
Show SMILES CCOC(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](C)[C@H]([NH3+])C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C23H27FN2O3/c1-3-29-23(28)19-10-8-18(9-11-19)17-6-4-16(5-7-17)15(2)21(25)22(27)26-13-12-20(24)14-26/h4-11,15,20-21H,3,12-14,25H2,1-2H3/p+1/t15-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11674
PNG
((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...)
Show SMILES C[C@@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1nc(no1)-c1ccc(NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C17H20ClF2N5O4S/c1-9(13(21)16(26)25-6-5-17(19,20)8-25)15-22-14(23-29-15)11-4-3-10(7-12(11)18)24-30(2,27)28/h3-4,7,9,13,24H,5-6,8,21H2,1-2H3/p+1/t9-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11499
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(3-m...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C21H26FN3O3S/c1-14(20(23)21(26)25-11-10-18(22)13-25)15-6-8-16(9-7-15)17-4-3-5-19(12-17)24-29(2,27)28/h3-9,12,14,18,20,24H,10-11,13,23H2,1-2H3/p+1/t14-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11507
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-m...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)[C@H](C)[C@H]([NH3+])C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C21H25FN2O2/c1-14(20(23)21(25)24-12-11-18(22)13-24)15-3-5-16(6-4-15)17-7-9-19(26-2)10-8-17/h3-10,14,18,20H,11-13,23H2,1-2H3/p+1/t14-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11521
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nnc[nH]1
Show InChI InChI=1S/C22H24FN5O/c1-14(20(24)22(29)28-10-9-19(23)12-28)15-5-7-16(8-6-15)17-3-2-4-18(11-17)21-25-13-26-27-21/h2-8,11,13-14,19-20H,9-10,12,24H2,1H3,(H,25,26,27)/p+1/t14-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11494
PNG
((2S,3S)-3-[4-(2-chlorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C20H22ClFN2O/c1-13(19(23)20(25)24-11-10-16(22)12-24)14-6-8-15(9-7-14)17-4-2-3-5-18(17)21/h2-9,13,16,19H,10-12,23H2,1H3/p+1/t13-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 380n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11498
PNG
((2S,3S)-3-{4-[3-(ethoxycarbonyl)phenyl]phenyl}-1-[...)
Show SMILES CCOC(=O)c1cccc(c1)-c1ccc(cc1)[C@H](C)[C@H]([NH3+])C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C23H27FN2O3/c1-3-29-23(28)19-6-4-5-18(13-19)17-9-7-16(8-10-17)15(2)21(25)22(27)26-12-11-20(24)14-26/h4-10,13,15,20-21H,3,11-12,14,25H2,1-2H3/p+1/t15-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11183
PNG
((2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-3-[4-(1-me...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1ccc(cc1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C20H23F2N3O2/c1-13(18(23)19(27)25-10-9-20(21,22)12-25)14-3-5-15(6-4-14)16-7-8-17(26)24(2)11-16/h3-8,11,13,18H,9-10,12,23H2,1-2H3/p+1/t13-,18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 550n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 1346-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.052
BindingDB Entry DOI: 10.7270/Q2CR5RK7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11506
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H22F4N2O/c1-13(19(26)20(28)27-11-10-18(22)12-27)14-2-4-15(5-3-14)16-6-8-17(9-7-16)21(23,24)25/h2-9,13,18-19H,10-12,26H2,1H3/p+1/t13-,18-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 670n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11192
PNG
((2S,3R)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](CN1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C24H29F2N3O/c25-20-9-7-18(8-10-20)17-3-5-19(6-4-17)22(16-28-12-1-2-13-28)23(27)24(30)29-14-11-21(26)15-29/h3-10,21-23H,1-2,11-16,27H2/p+1/t21-,22-,23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11488
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1nccs1
Show InChI InChI=1S/C17H20FN3OS/c1-11(15(19)17(22)21-8-6-14(18)10-21)12-2-4-13(5-3-12)16-20-7-9-23-16/h2-5,7,9,11,14-15H,6,8,10,19H2,1H3/p+1/t11-,14-,15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 720n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11185
PNG
((2S,3S)-3-[4-(1-methyl-6-oxo-1,6-dihydropyridin-3-...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C19H23N3O2S/c1-13(18(20)19(24)22-9-10-25-12-22)14-3-5-15(6-4-14)16-7-8-17(23)21(2)11-16/h3-8,11,13,18H,9-10,12,20H2,1-2H3/p+1/t13-,18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 810n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 1346-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.052
BindingDB Entry DOI: 10.7270/Q2CR5RK7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11504
PNG
((2S,3S)-3-[4-(3-carbamoylphenyl)phenyl]-1-[(3S)-3-...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C21H24FN3O2/c1-13(19(23)21(27)25-10-9-18(22)12-25)14-5-7-15(8-6-14)16-3-2-4-17(11-16)20(24)26/h2-8,11,13,18-19H,9-10,12,23H2,1H3,(H2,24,26)/p+1/t13-,18-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 820n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11520
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1c[nH]c(=O)[nH]1
Show InChI InChI=1S/C23H25FN4O2/c1-14(21(25)22(29)28-10-9-19(24)13-28)15-5-7-16(8-6-15)17-3-2-4-18(11-17)20-12-26-23(30)27-20/h2-8,11-12,14,19,21H,9-10,13,25H2,1H3,(H2,26,27,30)/p+1/t14-,19-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 830n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11668
PNG
((2S,3S)-3-[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-...)
Show SMILES C[C@@H]([C@H]([NH3+])C(=O)N1CCCC1)c1nnc(o1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H18Cl2N4O2/c1-9(13(19)16(23)22-6-2-3-7-22)14-20-21-15(24-14)11-5-4-10(17)8-12(11)18/h4-5,8-9,13H,2-3,6-7,19H2,1H3/p+1/t9-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11517
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-n1cnnn1
Show InChI InChI=1S/C21H23FN6O/c1-14(20(23)21(29)27-10-9-18(22)12-27)15-5-7-16(8-6-15)17-3-2-4-19(11-17)28-13-24-25-26-28/h2-8,11,13-14,18,20H,9-10,12,23H2,1H3/p+1/t14-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 870n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11518
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-{4-[3-(...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nnco1
Show InChI InChI=1S/C22H23FN4O2/c1-14(20(24)22(28)27-10-9-19(23)12-27)15-5-7-16(8-6-15)17-3-2-4-18(11-17)21-26-25-13-29-21/h2-8,11,13-14,19-20H,9-10,12,24H2,1H3/p+1/t14-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 960n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11647
PNG
((2S,3S)-2-amino-3-{3-[2-(difluoromethyl)phenyl]-1,...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccccc1C(F)F
Show InChI InChI=1S/C17H20F2N4O2/c1-10(13(20)17(24)23-8-4-5-9-23)16-21-15(22-25-16)12-7-3-2-6-11(12)14(18)19/h2-3,6-7,10,13-14H,4-5,8-9,20H2,1H3/t10-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11670
PNG
((2S,3S)-3-[4-(2,4-dichlorophenyl)-1,3-oxazol-2-yl]...)
Show SMILES C[C@@H]([C@H]([NH3+])C(=O)N1CCCC1)c1nc(co1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H19Cl2N3O2/c1-10(15(20)17(23)22-6-2-3-7-22)16-21-14(9-24-16)12-5-4-11(18)8-13(12)19/h4-5,8-10,15H,2-3,6-7,20H2,1H3/p+1/t10-,15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.05E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11493
PNG
((2S,3S)-3-[4-(2-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C20H22F2N2O/c1-13(19(23)20(25)24-11-10-16(21)12-24)14-6-8-15(9-7-14)17-4-2-3-5-18(17)22/h2-9,13,16,19H,10-12,23H2,1H3/p+1/t13-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11187
PNG
((2S,3S)-1-(4-fluoropiperidin-1-yl)-3-[4-(1-methyl-...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CCC(F)CC1)c1ccc(cc1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C21H26FN3O2/c1-14(20(23)21(27)25-11-9-18(22)10-12-25)15-3-5-16(6-4-15)17-7-8-19(26)24(2)13-17/h3-8,13-14,18,20H,9-12,23H2,1-2H3/p+1/t14-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 1346-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.052
BindingDB Entry DOI: 10.7270/Q2CR5RK7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11524
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1nc(=O)o[nH]1
Show InChI InChI=1S/C22H23FN4O3/c1-13(19(24)21(28)27-10-9-18(23)12-27)14-5-7-15(8-6-14)16-3-2-4-17(11-16)20-25-22(29)30-26-20/h2-8,11,13,18-19H,9-10,12,24H2,1H3,(H,25,26,29)/p+1/t13-,18-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11519
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1n[nH]c(=O)[nH]1
Show InChI InChI=1S/C22H24FN5O2/c1-13(19(24)21(29)28-10-9-18(23)12-28)14-5-7-15(8-6-14)16-3-2-4-17(11-16)20-25-22(30)27-26-20/h2-8,11,13,18-19H,9-10,12,24H2,1H3,(H2,25,26,27,30)/p+1/t13-,18-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11508
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-m...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(C)cc1
Show InChI InChI=1S/C21H25FN2O/c1-14-3-5-17(6-4-14)18-9-7-16(8-10-18)15(2)20(23)21(25)24-12-11-19(22)13-24/h3-10,15,19-20H,11-13,23H2,1-2H3/p+1/t15-,19-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11512
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-m...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H25FN2O3S/c1-14(20(23)21(25)24-12-11-18(22)13-24)15-3-5-16(6-4-15)17-7-9-19(10-8-17)28(2,26)27/h3-10,14,18,20H,11-13,23H2,1-2H3/p+1/t14-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11514
PNG
((2S,3S)-3-[4-(2,5-difluorophenyl)phenyl]-1-[(3S)-3...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F3N2O/c1-12(19(24)20(26)25-9-8-16(22)11-25)13-2-4-14(5-3-13)17-10-15(21)6-7-18(17)23/h2-7,10,12,16,19H,8-9,11,24H2,1H3/p+1/t12-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11663
PNG
((2S,3S)-2-amino-3-[3-(4-bromo-2-chlorophenyl)-1,2,...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccc(Br)cc1Cl
Show InChI InChI=1S/C16H18BrClN4O2/c1-9(13(19)16(23)22-6-2-3-7-22)15-20-14(21-24-15)11-5-4-10(17)8-12(11)18/h4-5,8-9,13H,2-3,6-7,19H2,1H3/t9-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11503
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(NS(=O)(=O)C(F)(F)F)c1
Show InChI InChI=1S/C21H23F4N3O3S/c1-13(19(26)20(29)28-10-9-17(22)12-28)14-5-7-15(8-6-14)16-3-2-4-18(11-16)27-32(30,31)21(23,24)25/h2-8,11,13,17,19,27H,9-10,12,26H2,1H3/p+1/t13-,17-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11662
PNG
((2S,3S)-2-amino-3-[3-(2,4-dichlorophenyl)-1,2,4-ox...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H18Cl2N4O2/c1-9(13(19)16(23)22-6-2-3-7-22)15-20-14(21-24-15)11-5-4-10(17)8-12(11)18/h4-5,8-9,13H,2-3,6-7,19H2,1H3/t9-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11665
PNG
(N-(4-{5-[(2S,3S)-3-amino-4-oxo-4-(pyrrolidin-1-yl)...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccc(NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C17H22ClN5O4S/c1-10(14(19)17(24)23-7-3-4-8-23)16-20-15(21-27-16)12-6-5-11(9-13(12)18)22-28(2,25)26/h5-6,9-10,14,22H,3-4,7-8,19H2,1-2H3/t10-,14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11487
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C17H21FN4O/c1-12(16(19)17(23)21-10-7-14(18)11-21)13-3-5-15(6-4-13)22-9-2-8-20-22/h2-6,8-9,12,14,16H,7,10-11,19H2,1H3/p+1/t12-,14-,16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11676
PNG
((2S,3S)-3-[3-(2-chloro-4-methanesulfonylphenyl)-1,...)
Show SMILES CS(=O)(=O)c1ccc(-c2noc(n2)[C@@H](CC2CC2)[C@H]([NH3+])C(=O)N2CC[C@H](F)C2)c(Cl)c1
Show InChI InChI=1S/C20H24ClFN4O4S/c1-31(28,29)13-4-5-14(16(21)9-13)18-24-19(30-25-18)15(8-11-2-3-11)17(23)20(27)26-7-6-12(22)10-26/h4-5,9,11-12,15,17H,2-3,6-8,10,23H2,1H3/p+1/t12-,15-,17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11673
PNG
((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...)
Show SMILES C[C@@H]([C@H]([NH3+])C(=O)N1CC[C@@H](F)C1)c1nc(no1)-c1ccc(NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C17H21ClFN5O4S/c1-9(14(20)17(25)24-6-5-10(19)8-24)16-21-15(22-28-16)12-4-3-11(7-13(12)18)23-29(2,26)27/h3-4,7,9-10,14,23H,5-6,8,20H2,1-2H3/p+1/t9-,10+,14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11509
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-m...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C21H26FN3O3S/c1-14(20(23)21(26)25-12-11-18(22)13-25)15-3-5-16(6-4-15)17-7-9-19(10-8-17)24-29(2,27)28/h3-10,14,18,20,24H,11-13,23H2,1-2H3/p+1/t14-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11650
PNG
((2S,3S)-2-amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifl...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N4O2/c1-10(13(21)16(25)24-8-4-5-9-24)15-22-14(23-26-15)11-6-2-3-7-12(11)17(18,19)20/h2-3,6-7,10,13H,4-5,8-9,21H2,1H3/t10-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.80E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11515
PNG
((2S,3S)-3-[4-(3,4-difluorophenyl)phenyl]-1-[(3S)-3...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H21F3N2O/c1-12(19(24)20(26)25-9-8-16(21)11-25)13-2-4-14(5-3-13)15-6-7-17(22)18(23)10-15/h2-7,10,12,16,19H,8-9,11,24H2,1H3/p+1/t12-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11513
PNG
((2S,3S)-3-[4-(3,5-difluorophenyl)phenyl]-1-[(3S)-3...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H21F3N2O/c1-12(19(24)20(26)25-7-6-16(21)11-25)13-2-4-14(5-3-13)15-8-17(22)10-18(23)9-15/h2-5,8-10,12,16,19H,6-7,11,24H2,1H3/p+1/t12-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11171
PNG
((2S,3S)-3-{4-[1-(4-fluorophenyl)-6-oxo-1,6-dihydro...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(=O)n(c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H25F2N3O2/c1-16(24(28)25(32)29-13-12-21(27)15-29)17-2-4-18(5-3-17)19-6-11-23(31)30(14-19)22-9-7-20(26)8-10-22/h2-11,14,16,21,24H,12-13,15,28H2,1H3/p+1/t16-,21-,24-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 1346-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.052
BindingDB Entry DOI: 10.7270/Q2CR5RK7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11651
PNG
((2S,3S)-2-amino-3-[3-(2-chlorophenyl)-1,2,4-oxadia...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccccc1Cl
Show InChI InChI=1S/C16H19ClN4O2/c1-10(13(18)16(22)21-8-4-5-9-21)15-19-14(20-23-15)11-6-2-3-7-12(11)17/h2-3,6-7,10,13H,4-5,8-9,18H2,1H3/t10-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11660
PNG
((2S,3S)-2-amino-3-[3-(3,5-dichlorophenyl)-1,2,4-ox...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C16H18Cl2N4O2/c1-9(13(19)16(23)22-4-2-3-5-22)15-20-14(21-24-15)10-6-11(17)8-12(18)7-10/h6-9,13H,2-5,19H2,1H3/t9-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11170
PNG
((2S,3S)-3-{4-[1-(2-ethoxy-1,1-difluoro-2-oxoethyl)...)
Show SMILES CCOC(=O)C(F)(F)n1cc(ccc1=O)-c1ccc(cc1)[C@H](C)[C@H]([NH3+])C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C23H26F3N3O4/c1-3-33-22(32)23(25,26)29-12-17(8-9-19(29)30)16-6-4-15(5-7-16)14(2)20(27)21(31)28-11-10-18(24)13-28/h4-9,12,14,18,20H,3,10-11,13,27H2,1-2H3/p+1/t14-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 1346-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.052
BindingDB Entry DOI: 10.7270/Q2CR5RK7
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11191
PNG
((2S,3R)-4-(dimethylamino)-3-[4-(4-fluorophenyl)phe...)
Show SMILES CN(C)C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H27F2N3O/c1-26(2)14-20(21(25)22(28)27-12-11-19(24)13-27)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-21H,11-14,25H2,1-2H3/p+1/t19-,20-,21-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11648
PNG
((2S,3S)-2-amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifl...)
Show SMILES C[C@@H]([C@H](N)C(=O)N1CCCC1)c1nc(no1)-c1ccccc1OC(F)(F)F
Show InChI InChI=1S/C17H19F3N4O3/c1-10(13(21)16(25)24-8-4-5-9-24)15-22-14(23-27-15)11-6-2-3-7-12(11)26-17(18,19)20/h2-3,6-7,10,13H,4-5,8-9,21H2,1H3/t10-,13-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11496
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H22F4N2O/c1-13(19(26)20(28)27-11-10-16(22)12-27)14-6-8-15(9-7-14)17-4-2-3-5-18(17)21(23,24)25/h2-9,13,16,19H,10-12,26H2,1H3/p+1/t13-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11497
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-m...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccccc1C
Show InChI InChI=1S/C21H25FN2O/c1-14-5-3-4-6-19(14)17-9-7-16(8-10-17)15(2)20(23)21(25)24-12-11-18(22)13-24/h3-10,15,18,20H,11-13,23H2,1-2H3/p+1/t15-,18-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11516
PNG
((2S,3S)-3-[4-(2,4-difluorophenyl)phenyl]-1-[(3S)-3...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1F
Show InChI InChI=1S/C20H21F3N2O/c1-12(19(24)20(26)25-9-8-16(22)11-25)13-2-4-14(5-3-13)17-7-6-15(21)10-18(17)23/h2-7,10,12,16,19H,8-9,11,24H2,1H3/p+1/t12-,16-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11672
PNG
((2S,3S)-3-[3-(2-chloro-4-methanesulfonamidophenyl)...)
Show SMILES C[C@@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1nc(no1)-c1ccc(NS(C)(=O)=O)cc1Cl
Show InChI InChI=1S/C17H21ClFN5O4S/c1-9(14(20)17(25)24-6-5-10(19)8-24)16-21-15(22-28-16)12-4-3-11(7-13(12)18)23-29(2,26)27/h3-4,7,9-10,14,23H,5-6,8,20H2,1-2H3/p+1/t9-,10-,14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.57E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 16: 5373-7 (2006)


Article DOI: 10.1016/j.bmcl.2006.07.061
BindingDB Entry DOI: 10.7270/Q2JD4V0K
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM11189
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H22F2N2O/c1-13(19(23)20(25)24-11-10-18(22)12-24)14-2-4-15(5-3-14)16-6-8-17(21)9-7-16/h2-9,13,18-19H,10-12,23H2,1H3/p+1/t13-,18-,19-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 267 total )  |  Next  |  Last  >>
Jump to: