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Found 48 hits of Enz. Inhib. data with enzyme = 'Dipeptidyl peptidase 4' and Substrate = 'BDBM11561'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11113
PNG
(6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Show SMILES O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C15H18N6O/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20)/t13-/m0/s1
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Article
PubMed
11n/a 15n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11593
PNG
(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dime...)
Show SMILES COc1cc(OC)cc(c1)-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H18Cl2N4O2/c1-26-12-5-10(6-13(8-12)27-2)19-24-17(15(9-22)18(23)25-19)14-4-3-11(20)7-16(14)21/h3-8H,9,22H2,1-2H3,(H2,23,24,25)
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Article
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11588
PNG
(1c-meta-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1cccc(F)c1
Show InChI InChI=1S/C17H13Cl2FN4/c18-10-4-5-12(14(19)7-10)15-13(8-21)16(22)24-17(23-15)9-2-1-3-11(20)6-9/h1-7H,8,21H2,(H2,22,23,24)
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n/an/a 0.200n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11589
PNG
(1c-para-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl)...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccc(F)cc1
Show InChI InChI=1S/C17H13Cl2FN4/c18-10-3-6-12(14(19)7-10)15-13(8-21)16(22)24-17(23-15)9-1-4-11(20)5-2-9/h1-7H,8,21H2,(H2,22,23,24)
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n/an/a 0.200n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11580
PNG
(1c-meta-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Show SMILES Cc1cccc(c1)-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4/c1-10-3-2-4-11(7-10)18-23-16(14(9-21)17(22)24-18)13-6-5-12(19)8-15(13)20/h2-8H,9,21H2,1H3,(H2,22,23,24)
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n/an/a 0.900n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11592
PNG
(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,4-difl...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C17H12Cl2F2N4/c18-9-2-3-10(12(19)6-9)15-11(7-22)16(23)25-17(24-15)8-1-4-13(20)14(21)5-8/h1-6H,7,22H2,(H2,23,24,25)
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PubMed
n/an/a 3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16281
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-meth...)
Show SMILES COc1cc2c(cc1F)nc(N1CCC[C@@H](N)C1)n(Cc1ccccc1C#N)c2=O
Show InChI InChI=1S/C22H22FN5O2/c1-30-20-9-17-19(10-18(20)23)26-22(27-8-4-7-16(25)13-27)28(21(17)29)12-15-6-3-2-5-14(15)11-24/h2-3,5-6,9-10,16H,4,7-8,12-13,25H2,1H3/t16-/m1/s1
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PubMed
n/an/a 4n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16274
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxo-...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2ccc(F)cc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H20FN5O/c22-16-7-8-19-18(10-16)20(28)27(12-15-5-2-1-4-14(15)11-23)21(25-19)26-9-3-6-17(24)13-26/h1-2,4-5,7-8,10,17H,3,6,9,12-13,24H2/t17-/m1/s1
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PubMed
n/an/a 4n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16279
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxo-3...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2ccc(Br)cc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H20BrN5O/c22-16-7-8-19-18(10-16)20(28)27(12-15-5-2-1-4-14(15)11-23)21(25-19)26-9-3-6-17(24)13-26/h1-2,4-5,7-8,10,17H,3,6,9,12-13,24H2/t17-/m1/s1
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PubMed
n/an/a 5n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16273
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-4-oxo-...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2cccc(F)c2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H20FN5O/c22-17-8-3-9-18-19(17)20(28)27(12-15-6-2-1-5-14(15)11-23)21(25-18)26-10-4-7-16(24)13-26/h1-3,5-6,8-9,16H,4,7,10,12-13,24H2/t16-/m1/s1
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PubMed
n/an/a 5n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16275
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-chloro-4-oxo-...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2ccc(Cl)cc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H20ClN5O/c22-16-7-8-19-18(10-16)20(28)27(12-15-5-2-1-4-14(15)11-23)21(25-19)26-9-3-6-17(24)13-26/h1-2,4-5,7-8,10,17H,3,6,9,12-13,24H2/t17-/m1/s1
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n/an/a 5n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16280
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-methoxy-4-oxo...)
Show SMILES COc1ccc2nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3C#N)c(=O)c2c1
Show InChI InChI=1S/C22H23N5O2/c1-29-18-8-9-20-19(11-18)21(28)27(13-16-6-3-2-5-15(16)12-23)22(25-20)26-10-4-7-17(24)14-26/h2-3,5-6,8-9,11,17H,4,7,10,13-14,24H2,1H3/t17-/m1/s1
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PubMed
n/an/a 8n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16285
PNG
(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Show SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O
Show InChI InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1
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Article
PubMed
n/an/a<10n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11578
PNG
(5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyr...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C17H14Cl2N4/c18-11-6-7-12(14(19)8-11)15-13(9-20)16(21)23-17(22-15)10-4-2-1-3-5-10/h1-8H,9,20H2,(H2,21,22,23)
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n/an/a 10n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16272
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-4-oxo-3,4-dihyd...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2ccccc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H21N5O/c22-12-15-6-1-2-7-16(15)13-26-20(27)18-9-3-4-10-19(18)24-21(26)25-11-5-8-17(23)14-25/h1-4,6-7,9-10,17H,5,8,11,13-14,23H2/t17-/m1/s1
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PubMed
n/an/a 13n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16278
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6,8-dichloro-4-...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2c(Cl)cc(Cl)cc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H19Cl2N5O/c22-15-8-17-19(18(23)9-15)26-21(27-7-3-6-16(25)12-27)28(20(17)29)11-14-5-2-1-4-13(14)10-24/h1-2,4-5,8-9,16H,3,6-7,11-12,25H2/t16-/m1/s1
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PubMed
n/an/a 13n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16276
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-7-chloro-4-oxo-...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2cc(Cl)ccc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H20ClN5O/c22-16-7-8-18-19(10-16)25-21(26-9-3-6-17(24)13-26)27(20(18)28)12-15-5-2-1-4-14(15)11-23/h1-2,4-5,7-8,10,17H,3,6,9,12-13,24H2/t17-/m1/s1
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PubMed
n/an/a 15n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16284
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-7-(mor...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2cc(N3CCOCC3)c(F)cc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C25H27FN6O2/c26-21-12-20-22(13-23(21)30-8-10-34-11-9-30)29-25(31-7-3-6-19(28)16-31)32(24(20)33)15-18-5-2-1-4-17(18)14-27/h1-2,4-5,12-13,19H,3,6-11,15-16,28H2/t19-/m1/s1
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PubMed
n/an/a 18n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16282
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-6,7-dimethoxy-4...)
Show SMILES COc1cc2nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3C#N)c(=O)c2cc1OC
Show InChI InChI=1S/C23H25N5O3/c1-30-20-10-18-19(11-21(20)31-2)26-23(27-9-5-8-17(25)14-27)28(22(18)29)13-16-7-4-3-6-15(16)12-24/h3-4,6-7,10-11,17H,5,8-9,13-14,25H2,1-2H3/t17-/m1/s1
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n/an/a 19n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16277
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-8-chloro-4-oxo-...)
Show SMILES N[C@@H]1CCCN(C1)c1nc2c(Cl)cccc2c(=O)n1Cc1ccccc1C#N
Show InChI InChI=1S/C21H20ClN5O/c22-18-9-3-8-17-19(18)25-21(26-10-4-7-16(24)13-26)27(20(17)28)12-15-6-2-1-5-14(15)11-23/h1-3,5-6,8-9,16H,4,7,10,12-13,24H2/t16-/m1/s1
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n/an/a 29n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM16283
PNG
(2-({2-[(3R)-3-aminopiperidin-1-yl]-8-methoxy-4-oxo...)
Show SMILES COc1cccc2c1nc(N1CCC[C@@H](N)C1)n(Cc1ccccc1C#N)c2=O
Show InChI InChI=1S/C22H23N5O2/c1-29-19-10-4-9-18-20(19)25-22(26-11-5-8-17(24)14-26)27(21(18)28)13-16-7-3-2-6-15(16)12-23/h2-4,6-7,9-10,17H,5,8,11,13-14,24H2,1H3/t17-/m1/s1
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n/an/a 30n/an/an/an/a7.422



Takeda Pharmaceutical Company Ltd.



Assay Description
Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....


J Med Chem 50: 2297-300 (2007)


Article DOI: 10.1021/jm070104l
BindingDB Entry DOI: 10.7270/Q2TM78C5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11587
PNG
(1c-ortho-F | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccccc1F
Show InChI InChI=1S/C17H13Cl2FN4/c18-9-5-6-10(13(19)7-9)15-12(8-21)16(22)24-17(23-15)11-3-1-2-4-14(11)20/h1-7H,8,21H2,(H2,22,23,24)
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n/an/a 47n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11583
PNG
(1c-para-Cl | 5-(aminomethyl)-2-(4-chlorophenyl)-6-...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13Cl3N4/c18-10-3-1-9(2-4-10)17-23-15(13(8-21)16(22)24-17)12-6-5-11(19)7-14(12)20/h1-7H,8,21H2,(H2,22,23,24)
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n/an/a 53n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11581
PNG
(1c-para-Me | 5-(aminomethyl)-6-(2,4-dichlorophenyl...)
Show SMILES Cc1ccc(cc1)-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4/c1-10-2-4-11(5-3-10)18-23-16(14(9-21)17(22)24-18)13-7-6-12(19)8-15(13)20/h2-8H,9,21H2,1H3,(H2,22,23,24)
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n/an/a 90n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11586
PNG
(1c-para-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Show SMILES COc1ccc(cc1)-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4O/c1-25-12-5-2-10(3-6-12)18-23-16(14(9-21)17(22)24-18)13-7-4-11(19)8-15(13)20/h2-8H,9,21H2,1H3,(H2,22,23,24)
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n/an/a 100n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11590
PNG
(1c-meta-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H13Cl2F3N4/c19-11-4-5-12(14(20)7-11)15-13(8-24)16(25)27-17(26-15)9-2-1-3-10(6-9)18(21,22)23/h1-7H,8,24H2,(H2,25,26,27)
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n/an/a 130n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11591
PNG
(1c-para-CF3 | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H13Cl2F3N4/c19-11-5-6-12(14(20)7-11)15-13(8-24)16(25)27-17(26-15)9-1-3-10(4-2-9)18(21,22)23/h1-7H,8,24H2,(H2,25,26,27)
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n/an/a 180n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11582
PNG
(1c-meta-Cl | 5-(aminomethyl)-2-(3-chlorophenyl)-6-...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1Cl)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H13Cl3N4/c18-10-3-1-2-9(6-10)17-23-15(13(8-21)16(22)24-17)12-5-4-11(19)7-14(12)20/h1-7H,8,21H2,(H2,22,23,24)
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n/an/a 240n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11585
PNG
(1c-meta-OMe | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Show SMILES COc1cccc(c1)-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4O/c1-25-12-4-2-3-10(7-12)18-23-16(14(9-21)17(22)24-18)13-6-5-11(19)8-15(13)20/h2-8H,9,21H2,1H3,(H2,22,23,24)
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n/an/a 340n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11584
PNG
(1c-ortho-OMe | 5-(aminomethyl)-6-(2,4-dichlorophen...)
Show SMILES COc1ccccc1-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4O/c1-25-15-5-3-2-4-12(15)18-23-16(13(9-21)17(22)24-18)11-7-6-10(19)8-14(11)20/h2-8H,9,21H2,1H3,(H2,22,23,24)
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n/an/a 350n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11565
PNG
(1b-para-Me | 5-(aminomethyl)-6-(4-methylphenyl)-2-...)
Show SMILES Cc1ccc(cc1)-c1nc(nc(N)c1CN)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-12-7-9-13(10-8-12)16-15(11-19)17(20)22-18(21-16)14-5-3-2-4-6-14/h2-10H,11,19H2,1H3,(H2,20,21,22)
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n/an/a 1.00E+3n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11577
PNG
(1b-para-CF3 | 5-(aminomethyl)-2-phenyl-6-[4-(trifl...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(cc1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C18H15F3N4/c19-18(20,21)13-8-6-11(7-9-13)15-14(10-22)16(23)25-17(24-15)12-4-2-1-3-5-12/h1-9H,10,22H2,(H2,23,24,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11568
PNG
(1b-para-Cl | 5-(aminomethyl)-6-(4-chlorophenyl)-2-...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C17H15ClN4/c18-13-8-6-11(7-9-13)15-14(10-19)16(20)22-17(21-15)12-4-2-1-3-5-12/h1-9H,10,19H2,(H2,20,21,22)
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n/an/a 1.40E+3n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11563
PNG
(1b-ortho-Me | 5-(aminomethyl)-6-(2-methylphenyl)-2...)
Show SMILES Cc1ccccc1-c1nc(nc(N)c1CN)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-12-7-5-6-10-14(12)16-15(11-19)17(20)22-18(21-16)13-8-3-2-4-9-13/h2-10H,11,19H2,1H3,(H2,20,21,22)
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n/an/a 1.50E+3n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11569
PNG
(1b-ortho-OMe | 5-(aminomethyl)-6-(2-methoxyphenyl)...)
Show SMILES COc1ccccc1-c1nc(nc(N)c1CN)-c1ccccc1
Show InChI InChI=1S/C18H18N4O/c1-23-15-10-6-5-9-13(15)16-14(11-19)17(20)22-18(21-16)12-7-3-2-4-8-12/h2-10H,11,19H2,1H3,(H2,20,21,22)
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n/an/a 1.50E+3n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11579
PNG
(1c-ortho-Me | 5-(aminomethyl)-6-(2,4-dichloropheny...)
Show SMILES Cc1ccccc1-c1nc(N)c(CN)c(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H16Cl2N4/c1-10-4-2-3-5-12(10)18-23-16(14(9-21)17(22)24-18)13-7-6-11(19)8-15(13)20/h2-8H,9,21H2,1H3,(H2,22,23,24)
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n/an/a 1.75E+3n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11566
PNG
(1b-ortho-Cl | 5-(aminomethyl)-6-(2-chlorophenyl)-2...)
Show SMILES NCc1c(N)nc(nc1-c1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C17H15ClN4/c18-14-9-5-4-8-12(14)15-13(10-19)16(20)22-17(21-15)11-6-2-1-3-7-11/h1-9H,10,19H2,(H2,20,21,22)
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n/an/a 2.50E+3n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11560
PNG
(5-(aminomethyl)-6-(2H-1,3-benzodioxol-5-yl)-2-phen...)
Show SMILES NCc1c(N)nc(nc1-c1ccc2OCOc2c1)-c1ccccc1
Show InChI InChI=1S/C18H16N4O2/c19-9-13-16(12-6-7-14-15(8-12)24-10-23-14)21-18(22-17(13)20)11-4-2-1-3-5-11/h1-8H,9-10,19H2,(H2,20,21,22)
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n/an/a 1.00E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11575
PNG
(1b-ortho-CF3 | 5-(aminomethyl)-2-phenyl-6-[2-(trif...)
Show SMILES NCc1c(N)nc(nc1-c1ccccc1C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C18H15F3N4/c19-18(20,21)14-9-5-4-8-12(14)15-13(10-22)16(23)25-17(24-15)11-6-2-1-3-7-11/h1-9H,10,22H2,(H2,23,24,25)
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n/an/a 1.40E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11572
PNG
(1b-ortho-F | 5-(aminomethyl)-6-(2-fluorophenyl)-2-...)
Show SMILES NCc1c(N)nc(nc1-c1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C17H15FN4/c18-14-9-5-4-8-12(14)15-13(10-19)16(20)22-17(21-15)11-6-2-1-3-7-11/h1-9H,10,19H2,(H2,20,21,22)
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n/an/a 1.40E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11574
PNG
(1b-para-F | 5-(aminomethyl)-6-(4-fluorophenyl)-2-p...)
Show SMILES NCc1c(N)nc(nc1-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C17H15FN4/c18-13-8-6-11(7-9-13)15-14(10-19)16(20)22-17(21-15)12-4-2-1-3-5-12/h1-9H,10,19H2,(H2,20,21,22)
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n/an/a 1.80E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11564
PNG
(1b-meta-Me | 5-(aminomethyl)-6-(3-methylphenyl)-2-...)
Show SMILES Cc1cccc(c1)-c1nc(nc(N)c1CN)-c1ccccc1
Show InChI InChI=1S/C18H18N4/c1-12-6-5-9-14(10-12)16-15(11-19)17(20)22-18(21-16)13-7-3-2-4-8-13/h2-10H,11,19H2,1H3,(H2,20,21,22)
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n/an/a 2.00E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11567
PNG
(1b-meta-Cl | 5-(aminomethyl)-6-(3-chlorophenyl)-2-...)
Show SMILES NCc1c(N)nc(nc1-c1cccc(Cl)c1)-c1ccccc1
Show InChI InChI=1S/C17H15ClN4/c18-13-8-4-7-12(9-13)15-14(10-19)16(20)22-17(21-15)11-5-2-1-3-6-11/h1-9H,10,19H2,(H2,20,21,22)
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n/an/a 3.10E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11573
PNG
(1b-meta-F | 5-(aminomethyl)-6-(3-fluorophenyl)-2-p...)
Show SMILES NCc1c(N)nc(nc1-c1cccc(F)c1)-c1ccccc1
Show InChI InChI=1S/C17H15FN4/c18-13-8-4-7-12(9-13)15-14(10-19)16(20)22-17(21-15)11-5-2-1-3-6-11/h1-9H,10,19H2,(H2,20,21,22)
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n/an/a 4.00E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11562
PNG
(5-(aminomethyl)-2,6-diphenylpyrimidin-4-amine | Am...)
Show SMILES NCc1c(N)nc(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C17H16N4/c18-11-14-15(12-7-3-1-4-8-12)20-17(21-16(14)19)13-9-5-2-6-10-13/h1-10H,11,18H2,(H2,19,20,21)
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n/an/a 4.20E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11571
PNG
(1b-para-OMe | 5-(aminomethyl)-6-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)-c1nc(nc(N)c1CN)-c1ccccc1
Show InChI InChI=1S/C18H18N4O/c1-23-14-9-7-12(8-10-14)16-15(11-19)17(20)22-18(21-16)13-5-3-2-4-6-13/h2-10H,11,19H2,1H3,(H2,20,21,22)
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n/an/a 4.70E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11570
PNG
(1b-meta-OMe | 5-(aminomethyl)-6-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)-c1nc(nc(N)c1CN)-c1ccccc1
Show InChI InChI=1S/C18H18N4O/c1-23-14-9-5-8-13(10-14)16-15(11-19)17(20)22-18(21-16)12-6-3-2-4-7-12/h2-10H,11,19H2,1H3,(H2,20,21,22)
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n/an/a 8.00E+4n/an/an/an/a7.522



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM11576
PNG
(1b-meta-CF3 | 5-(aminomethyl)-2-phenyl-6-[3-(trifl...)
Show SMILES NCc1c(N)nc(nc1-c1cccc(c1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C18H15F3N4/c19-18(20,21)13-8-4-7-12(9-13)15-14(10-22)16(23)25-17(24-15)11-5-2-1-3-6-11/h1-9H,10,22H2,(H2,23,24,25)
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n/an/a 1.70E+5n/an/an/an/an/an/a



Hoffmann-La Roche Inc.



Assay Description
DPP-IV inhibitors were measured for their ability to inhibit DPP-IV mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic a...


Bioorg Med Chem Lett 14: 1491-3 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.019
BindingDB Entry DOI: 10.7270/Q22B8W7M
More data for this
Ligand-Target Pair