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Found 8 hits of Enz. Inhib. data with enzyme = 'Dipeptidyl peptidase 4' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311858
PNG
(US10155775, Example 4)
Show SMILES CS(=O)(=O)c1ccc2CN(Cc2c1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F
Show InChI InChI=1S/C20H22F2N2O3S/c1-28(25,26)16-4-2-12-9-24(10-13(12)6-16)15-8-19(23)20(27-11-15)17-7-14(21)3-5-18(17)22/h2-7,15,19-20H,8-11,23H2,1H3/t15-,19+,20-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 2.60n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311861
PNG
(US10155775, Example 9)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C22H24F2N2O3S/c23-15-2-6-20(24)19(8-15)22-21(25)9-16(12-29-22)26-10-13-1-3-18(7-14(13)11-26)30(27,28)17-4-5-17/h1-3,6-8,16-17,21-22H,4-5,9-12,25H2/t16-,21+,22-/m1/s1
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PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311860
PNG
(US10155775, Example 8)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(cc2C1)S(N)(=O)=O
Show InChI InChI=1S/C19H21F2N3O3S/c20-13-2-4-17(21)16(6-13)19-18(22)7-14(10-27-19)24-8-11-1-3-15(28(23,25)26)5-12(11)9-24/h1-6,14,18-19H,7-10,22H2,(H2,23,25,26)/t14-,18+,19-/m1/s1
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US Patent
n/an/a 3.80n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM50003020
PNG
(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin)
Show SMILES CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F
Show InChI InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.20n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311855
PNG
(US10155775, Example 1)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2nn3c(CCCS3(=O)=O)c2C1
Show InChI InChI=1S/C19H22F2N4O3S/c20-11-3-4-15(21)13(6-11)19-16(22)7-12(10-28-19)24-8-14-17(9-24)23-25-18(14)2-1-5-29(25,26)27/h3-4,6,12,16,19H,1-2,5,7-10,22H2/t12-,16+,19-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311856
PNG
(US10155775, Example 2)
Show SMILES Cc1nn(c2CN(Cc12)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F)S(C)(=O)=O
Show InChI InChI=1S/C18H22F2N4O3S/c1-10-14-7-23(8-17(14)24(22-10)28(2,25)26)12-6-16(21)18(27-9-12)13-5-11(19)3-4-15(13)20/h3-5,12,16,18H,6-9,21H2,1-2H3/t12-,16+,18-/m1/s1
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PC sid
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n/an/a 5.10n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311859
PNG
(US10155775, Example 6)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2ccc(Br)cc2C1
Show InChI InChI=1S/C19H19BrF2N2O/c20-13-2-1-11-8-24(9-12(11)5-13)15-7-18(23)19(25-10-15)16-6-14(21)3-4-17(16)22/h1-6,15,18-19H,7-10,23H2/t15-,18+,19-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (human))
BDBM311857
PNG
(US10155775, Example 3)
Show SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)N1Cc2cc(sc2C1)C(O)=O
Show InChI InChI=1S/C18H18F2N2O3S/c19-10-1-2-13(20)12(4-10)17-14(21)5-11(8-25-17)22-6-9-3-15(18(23)24)26-16(9)7-22/h1-4,11,14,17H,5-8,21H2,(H,23,24)/t11-,14+,17-/m1/s1
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n/an/a 18.2n/an/an/an/an/an/a



Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.

US Patent


Assay Description
1. DPP-IV enzyme reaction buffer was prepared (50 mM HEPES (pH=7.8), 80 mM MgCl2, 150 mM NaCl, 1% BSA), and stored on ice for use; 2. The test compou...


US Patent US10155775 (2018)

More data for this
Ligand-Target Pair