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Found 385 hits of Enz. Inhib. data with enzyme = 'Dipeptidyl peptidase I' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201017
PNG
(US9540373, 6 | US9879026, Example 6)
Show SMILES CN1CCC2(CC1)C(=O)Nc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C29H32FN5O2/c1-35-10-8-29(9-11-35)23-14-17(5-7-25(23)34-28(29)37)18-2-3-19(24(30)15-18)12-22(16-31)33-27(36)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,36)(H,34,37)/t20-,21+,22-,26-/m0/s1
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n/an/a 0.200n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201014
PNG
(US9540373, 3 | US9879026, Example 3)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNCC3)c2c1
Show InChI InChI=1S/C28H30FN5O2/c29-23-14-17(16-4-6-24-22(13-16)28(27(36)34-24)7-9-31-10-8-28)1-2-18(23)11-21(15-30)33-26(35)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,35)(H,34,36)/t19-,20+,21-,25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201015
PNG
(US9540373, 4 | US9879026, Example 4)
Show SMILES CN1C(=O)C2(CCNCC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C29H32FN5O2/c1-35-25-7-5-17(14-23(25)29(28(35)37)8-10-32-11-9-29)18-2-3-19(24(30)15-18)12-22(16-31)34-27(36)26-20-4-6-21(13-20)33-26/h2-3,5,7,14-15,20-22,26,32-33H,4,6,8-13H2,1H3,(H,34,36)/t20-,21+,22-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201026
PNG
(US9540373, 15 | US9879026, Example 15)
Show SMILES CN1CCC2(CCc3ccc(cc23)-c2ccc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)c2)CC1
Show InChI InChI=1S/C30H35FN4O/c1-35-12-10-30(11-13-35)9-8-19-2-3-20(16-26(19)30)21-4-5-22(27(31)17-21)14-25(18-32)34-29(36)28-23-6-7-24(15-23)33-28/h2-5,16-17,23-25,28,33H,6-15H2,1H3,(H,34,36)/t23-,24+,25-,28-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201027
PNG
(US9540373, 16 | US9879026, Example 16)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2NC(=O)C3(CCNC3)c2c1
Show InChI InChI=1S/C27H28FN5O2/c28-22-12-16(15-4-6-23-21(11-15)27(26(35)33-23)7-8-30-14-27)1-2-17(22)9-20(13-29)32-25(34)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,34)(H,33,35)/t18-,19+,20-,24-,27?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201023
PNG
(US9540373, 12 | US9879026, Example 12)
Show SMILES CN1CC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H27FN4O3/c1-32-13-27(14-32)22-10-15(5-7-21(22)26(34)35-27)16-2-3-17(23(28)11-16)8-20(12-29)31-25(33)24-18-4-6-19(9-18)30-24/h2-3,5,7,10-11,18-20,24,30H,4,6,8-9,13-14H2,1H3,(H,31,33)/t18-,19+,20-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201020
PNG
(US9540373, 9 | US9879026, Example 9)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNC3)c2c1
Show InChI InChI=1S/C27H27FN4O3/c28-23-12-16(15-4-6-21-22(11-15)27(35-26(21)34)7-8-30-14-27)1-2-17(23)9-20(13-29)32-25(33)24-18-3-5-19(10-18)31-24/h1-2,4,6,11-12,18-20,24,30-31H,3,5,7-10,14H2,(H,32,33)/t18-,19+,20-,24-,27?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201018
PNG
(US9540373, 7 | US9879026, Example 7)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CCNCC3)c2c1
Show InChI InChI=1S/C28H29FN4O3/c29-24-14-17(16-4-6-22-23(13-16)28(36-27(22)35)7-9-31-10-8-28)1-2-18(24)11-21(15-30)33-26(34)25-19-3-5-20(12-19)32-25/h1-2,4,6,13-14,19-21,25,31-32H,3,5,7-12H2,(H,33,34)/t19-,20+,21-,25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201013
PNG
(US9540373, 2 | US9879026, Example 2)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CCC3(CCNCC3)c2c1
Show InChI InChI=1S/C29H33FN4O/c30-26-16-20(19-2-1-18-7-8-29(25(18)15-19)9-11-32-12-10-29)3-4-21(26)13-24(17-31)34-28(35)27-22-5-6-23(14-22)33-27/h1-4,15-16,22-24,27,32-33H,5-14H2,(H,34,35)/t22-,23+,24-,27-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201021
PNG
(US9540373, 10 | US9879026, Example 10)
Show SMILES CN1CCC2(C1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H29FN4O3/c1-33-9-8-28(15-33)23-12-16(5-7-22(23)27(35)36-28)17-2-3-18(24(29)13-17)10-21(14-30)32-26(34)25-19-4-6-20(11-19)31-25/h2-3,5,7,12-13,19-21,25,31H,4,6,8-11,15H2,1H3,(H,32,34)/t19-,20+,21-,25-,28?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150482
PNG
(US8987249, 156 | US9713606, 156)
Show SMILES CC1(C)OC(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H26FN3O3/c1-26(2)21-11-14(6-8-20(21)25(32)33-26)15-3-4-16(22(27)12-15)9-19(13-28)30-24(31)23-17-5-7-18(10-17)29-23/h3-4,6,8,11-12,17-19,23,29H,5,7,9-10H2,1-2H3,(H,30,31)/t17-,18+,19-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201024
PNG
(US9540373, 13 | US9879026, Example 13)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCNCC3)c2c1
Show InChI InChI=1S/C28H31FN4O2/c29-25-14-18(17-2-4-21-16-35-28(24(21)13-17)7-9-31-10-8-28)1-3-19(25)11-23(15-30)33-27(34)26-20-5-6-22(12-20)32-26/h1-4,13-14,20,22-23,26,31-32H,5-12,16H2,(H,33,34)/t20-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201016
PNG
(US9540373, 5 | US9879026, Example 5)
Show SMILES CN1C(=O)C2(CCN(C)CC2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C30H34FN5O2/c1-35-11-9-30(10-12-35)24-15-18(6-8-26(24)36(2)29(30)38)19-3-4-20(25(31)16-19)13-23(17-32)34-28(37)27-21-5-7-22(14-21)33-27/h3-4,6,8,15-16,21-23,27,33H,5,7,9-14H2,1-2H3,(H,34,37)/t21-,22+,23-,27-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201022
PNG
(US9540373, 11 | US9879026, Example 11)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OC3(CNC3)c2c1
Show InChI InChI=1S/C26H25FN4O3/c27-22-10-15(14-4-6-20-21(9-14)26(12-29-13-26)34-25(20)33)1-2-16(22)7-19(11-28)31-24(32)23-17-3-5-18(8-17)30-23/h1-2,4,6,9-10,17-19,23,29-30H,3,5,7-8,12-13H2,(H,31,32)/t17-,18+,19-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150329
PNG
(US8987249, 3 | US9713606, 3)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1
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n/an/a 0.700n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201019
PNG
(US9540373, 8 | US9879026, Example 8)
Show SMILES CN1CCC2(CC1)OC(=O)c1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C29H31FN4O3/c1-34-10-8-29(9-11-34)24-14-17(5-7-23(24)28(36)37-29)18-2-3-19(25(30)15-18)12-22(16-31)33-27(35)26-20-4-6-21(13-20)32-26/h2-3,5,7,14-15,20-22,26,32H,4,6,8-13H2,1H3,(H,33,35)/t20-,21+,22-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150481
PNG
(US8987249, 155 | US9713606, 155)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H32FN5O3S/c1-32-10-12-33(13-11-32)37(35,36)24-8-5-18(6-9-24)19-2-3-20(25(28)16-19)14-23(17-29)31-27(34)26-21-4-7-22(15-21)30-26/h2-3,5-6,8-9,16,21-23,26,30H,4,7,10-15H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1
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n/an/a 0.800n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150649
PNG
(US8987249, 323 | US9713606, 323)
Show SMILES Fc1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-16-17-9-19(25)12(7-18(17)22(30)29-20(16)8-13)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150648
PNG
(US8987249, 322 | US9713606, 322)
Show SMILES Fc1cc2c3ccccc3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N
Show InChI InChI=1S/C23H21FN4O2/c24-19-10-17-16-3-1-2-4-20(16)28-22(29)18(17)9-13(19)8-15(11-25)27-23(30)21-12-5-6-14(7-12)26-21/h1-4,9-10,12,14-15,21,26H,5-8H2,(H,27,30)(H,28,29)/t12-,14+,15-,21-/m0/s1
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n/an/a 0.800n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150551
PNG
(US8987249, 225 | US9713606, 225)
Show SMILES CN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H30FN5O2S/c1-31-6-8-32(9-7-31)26(34)23-13-19(15-35-23)16-2-3-17(22(27)12-16)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1
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n/an/a 0.800n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150618
PNG
(US8987249, 292 | US9713606, 292)
Show SMILES Fc1cc2c3ccc(cc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N
Show InChI InChI=1S/C24H20FN5O2/c25-20-9-18-17-4-1-12(10-26)5-21(17)30-23(31)19(18)8-14(20)7-16(11-27)29-24(32)22-13-2-3-15(6-13)28-22/h1,4-5,8-9,13,15-16,22,28H,2-3,6-7H2,(H,29,32)(H,30,31)/t13-,15+,16?,22-/m0/s1
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n/an/a 0.900n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150552
PNG
(US8987249, 226 | US9713606, 226)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCn2nccc2C1
Show InChI InChI=1S/C27H27FN6O2S/c28-23-11-16(19-12-24(37-15-19)27(36)33-7-8-34-22(14-33)5-6-30-34)1-2-17(23)9-21(13-29)32-26(35)25-18-3-4-20(10-18)31-25/h1-2,5-6,11-12,15,18,20-21,25,31H,3-4,7-10,14H2,(H,32,35)/t18-,20+,21-,25-/m0/s1
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n/an/a 0.900n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150483
PNG
(US8987249, 157 | US9713606, 157)
Show SMILES NC(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H21FN4O2S/c22-17-7-11(14-8-18(20(24)27)29-10-14)1-2-12(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1
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n/an/a 0.900n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150604
PNG
(US8987249, 278 | US9713606, 278)
Show SMILES CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-14-18(4-6-20(25)15-26(34)35)17-3-5-19(24(29)13-17)11-23(16-30)32-28(36)27-21-7-8-22(12-21)31-27/h3-6,13-14,21-23,27,31H,7-12,15H2,1-2H3,(H,32,36)/t21-,22+,23-,27-/m0/s1
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n/an/a 1n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150672
PNG
(US8987249, 346 | US9713606, 346)
Show SMILES CN1CCC(CC1)N1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C30H34FN5O2/c1-35-10-8-25(9-11-35)36-27-15-19(3-5-21(27)16-28(36)37)18-2-4-20(26(31)14-18)12-24(17-32)34-30(38)29-22-6-7-23(13-22)33-29/h2-5,14-15,22-25,29,33H,6-13,16H2,1H3,(H,34,38)/t22-,23+,24-,29-/m0/s1
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n/an/a 1n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201025
PNG
(US9540373, 14 | US9879026, Example 14)
Show SMILES CN1CCC2(CC1)OCc1ccc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C29H33FN4O2/c1-34-10-8-29(9-11-34)25-14-18(3-5-22(25)17-36-29)19-2-4-20(26(30)15-19)12-24(16-31)33-28(35)27-21-6-7-23(13-21)32-27/h2-5,14-15,21,23-24,27,32H,6-13,17H2,1H3,(H,33,35)/t21-,23+,24-,27-/m0/s1
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n/an/a 1n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150553
PNG
(US8987249, 227 | US9713606, 227)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H34FN5O2S/c1-17(2)33-7-9-34(10-8-33)28(36)25-14-21(16-37-25)18-3-4-19(24(29)13-18)11-23(15-30)32-27(35)26-20-5-6-22(12-20)31-26/h3-4,13-14,16-17,20,22-23,26,31H,5-12H2,1-2H3,(H,32,35)/t20-,22+,23-,26-/m0/s1
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n/an/a 1n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150650
PNG
(US8987249, 324 | US9713606, 324)
Show SMILES Fc1ccc2c3cc(F)c(C[C@H](NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F
Show InChI InChI=1S/C23H19F3N4O2/c24-17-4-3-14-15-8-18(25)11(7-16(15)22(31)30-21(14)19(17)26)6-13(9-27)29-23(32)20-10-1-2-12(5-10)28-20/h3-4,7-8,10,12-13,20,28H,1-2,5-6H2,(H,29,32)(H,30,31)/t10-,12+,13-,20-/m0/s1
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n/an/a 1n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201030
PNG
(US9540373, 19 | US9879026, Example 19)
Show SMILES CN1CCC2(CC1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-13-24(31-15-21(22)27(36)37-28)17-3-2-16(23(29)12-17)10-20(14-30)33-26(35)25-18-4-5-19(11-18)32-25/h2-3,12-13,15,18-20,25,32H,4-11H2,1H3,(H,33,35)/t18-,19+,20-,25-/m0/s1
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n/an/a 1n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201012
PNG
(US9540373, 1 | US9879026, Example 1)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2c1
Show InChI InChI=1S/C31H35FN4O3/c32-28-14-20(1-3-21(28)11-25(15-33)35-30(37)29-22-5-6-24(12-22)34-29)19-2-4-23-16-39-31(27(23)13-19)7-9-36(10-8-31)26-17-38-18-26/h1-4,13-14,22,24-26,29,34H,5-12,16-18H2,(H,35,37)/t22-,24+,25-,29-/m0/s1
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n/an/a 1.10n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150550
PNG
(US8987249, 224 | US9713606, 224)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H32FN5O3S/c1-32-9-11-33(12-10-32)37(35,36)24-4-2-3-18(15-24)19-5-6-20(25(28)16-19)13-23(17-29)31-27(34)26-21-7-8-22(14-21)30-26/h2-6,15-16,21-23,26,30H,7-14H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1
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n/an/a 1.20n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150651
PNG
(US8987249, 325 | US9713606, 325)
Show SMILES Fc1cc2c3cc(cc(F)c3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N
Show InChI InChI=1S/C24H19F2N5O2/c25-19-8-16-17-3-11(9-27)4-20(26)22(17)31-23(32)18(16)7-13(19)6-15(10-28)30-24(33)21-12-1-2-14(5-12)29-21/h3-4,7-8,12,14-15,21,29H,1-2,5-6H2,(H,30,33)(H,31,32)/t12-,14+,15-,21-/m0/s1
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n/an/a 1.30n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150665
PNG
(US8987249, 339 | US9713606, 339)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cc(ccc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H31F2N5O3S/c1-33-8-10-34(11-9-33)38(36,37)25-15-18(5-7-23(25)28)17-2-3-19(24(29)14-17)12-22(16-30)32-27(35)26-20-4-6-21(13-20)31-26/h2-3,5,7,14-15,20-22,26,31H,4,6,8-13H2,1H3,(H,32,35)/t20-,21+,22-,26-/m0/s1
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n/an/a 1.30n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150668
PNG
(US8987249, 342 | US9713606, 342)
Show SMILES CN(C)CCn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H30FN5O2/c1-30(2)9-10-31-15-19(6-8-23(31)32)16-3-4-17(22(26)13-16)11-21(14-27)29-25(33)24-18-5-7-20(12-18)28-24/h3-4,6,8,13,15,18,20-21,24,28H,5,7,9-12H2,1-2H3,(H,29,33)/t18-,20+,21-,24-/m0/s1
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n/an/a 1.30n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150619
PNG
(US8987249, 293 | US9713606, 293)
Show SMILES Fc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-16-17-9-19(25)12(7-18(17)22(30)29-20(16)8-13)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15?,21-/m0/s1
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n/an/a 1.30n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150330
PNG
(US8987249, 4 | US9713606, 4)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1
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n/an/a 1.40n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201032
PNG
(US9540373, 21 | US9879026, Example 21)
Show SMILES CN1CCC2(CC1)OC(=O)c1ncc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H30FN5O3/c1-34-8-6-28(7-9-34)22-12-19(15-31-25(22)27(36)37-28)16-2-3-17(23(29)13-16)10-21(14-30)33-26(35)24-18-4-5-20(11-18)32-24/h2-3,12-13,15,18,20-21,24,32H,4-11H2,1H3,(H,33,35)/t18-,20+,21-,24-/m0/s1
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n/an/a 1.40n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150336
PNG
(US8987249, 10 | US9713606, 10)
Show SMILES CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H23FN4O3/c1-30-21-11-14(5-7-19(21)23(31)25(30)33)13-2-3-15(20(26)10-13)8-18(12-27)29-24(32)22-16-4-6-17(9-16)28-22/h2-3,5,7,10-11,16-18,22,28H,4,6,8-9H2,1H3,(H,29,32)/t16-,17+,18-,22-/m0/s1
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n/an/a 1.5n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150484
PNG
(US8987249, 158 | US9713606, 158)
Show SMILES COCCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H29FN4O3/c1-35-9-8-32-24-13-17(3-5-19(24)14-25(32)33)16-2-4-18(23(28)12-16)10-22(15-29)31-27(34)26-20-6-7-21(11-20)30-26/h2-5,12-13,20-22,26,30H,6-11,14H2,1H3,(H,31,34)/t20-,21+,22-,26-/m0/s1
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n/an/a 1.5n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150485
PNG
(US8987249, 159 | US9713606, 159)
Show SMILES CS(=O)(=O)c1ccc(cc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H23FN4O3S/c1-33(31,32)22-7-5-14(8-18(22)12-26)15-2-3-16(21(25)11-15)9-20(13-27)29-24(30)23-17-4-6-19(10-17)28-23/h2-3,5,7-8,11,17,19-20,23,28H,4,6,9-10H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1
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n/an/a 1.60n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201031
PNG
(US9540373, 20 | US9879026, Example 20)
Show SMILES CN1CCC2(C1)OC(=O)c1cnc(cc21)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H28FN5O3/c1-33-7-6-27(14-33)21-11-23(30-13-20(21)26(35)36-27)16-3-2-15(22(28)10-16)8-19(12-29)32-25(34)24-17-4-5-18(9-17)31-24/h2-3,10-11,13,17-19,24,31H,4-9,14H2,1H3,(H,32,34)/t17-,18+,19-,24-,27?/m0/s1
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n/an/a 1.60n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201029
PNG
(US9540373, 18 | US9879026, Example 18)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cc2c(cn1)C(=O)OC21CCNCC1
Show InChI InChI=1S/C27H28FN5O3/c28-22-11-16(23-12-21-20(14-31-23)26(35)36-27(21)5-7-30-8-6-27)2-1-15(22)9-19(13-29)33-25(34)24-17-3-4-18(10-17)32-24/h1-2,11-12,14,17-19,24,30,32H,3-10H2,(H,33,34)/t17-,18+,19-,24-/m0/s1
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n/an/a 1.60n/an/an/an/an/a25



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201028
PNG
(US9540373, 17 | US9879026, Example 17)
Show SMILES CN1C(=O)C2(CCCN(C)C2)c2cc(ccc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C30H34FN5O2/c1-35-11-3-10-30(17-35)24-14-18(7-9-26(24)36(2)29(30)38)19-4-5-20(25(31)15-19)12-23(16-32)34-28(37)27-21-6-8-22(13-21)33-27/h4-5,7,9,14-15,21-23,27,33H,3,6,8,10-13,17H2,1-2H3,(H,34,37)/t21-,22+,23-,27-,30?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150620
PNG
(US8987249, 294 | US9713606, 294)
Show SMILES Fc1cc2c3ccccc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N
Show InChI InChI=1S/C23H21FN4O2/c24-19-10-17-16-3-1-2-4-20(16)28-22(29)18(17)9-13(19)8-15(11-25)27-23(30)21-12-5-6-14(7-12)26-21/h1-4,9-10,12,14-15,21,26H,5-8H2,(H,27,30)(H,28,29)/t12-,14+,15?,21-/m0/s1
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n/an/a 1.60n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150562
PNG
(US8987249, 236 | US9713606, 236)
Show SMILES NC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H21FN4O2S/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1
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n/an/a 1.60n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150554
PNG
(US8987249, 228 | US9713606, 228)
Show SMILES COCCN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H34FN5O3S/c1-37-11-10-33-6-8-34(9-7-33)28(36)25-15-21(17-38-25)18-2-3-19(24(29)14-18)12-23(16-30)32-27(35)26-20-4-5-22(13-20)31-26/h2-3,14-15,17,20,22-23,26,31H,4-13H2,1H3,(H,32,35)/t20-,22+,23-,26-/m0/s1
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n/an/a 1.60n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150555
PNG
(US8987249, 229 | US9713606, 229)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C28H32FN5O2S/c29-24-13-17(20-14-25(37-16-20)28(36)34-9-7-33(8-10-34)23-5-6-23)1-2-18(24)11-22(15-30)32-27(35)26-19-3-4-21(12-19)31-26/h1-2,13-14,16,19,21-23,26,31H,3-12H2,(H,32,35)/t19-,21+,22-,26-/m0/s1
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n/an/a 1.70n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150486
PNG
(US8987249, 160 | US9713606, 160)
Show SMILES Cc1nn(C)cc1-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H24FN5O/c1-12-18(11-27(2)26-12)13-3-4-14(19(22)9-13)7-17(10-23)25-21(28)20-15-5-6-16(8-15)24-20/h3-4,9,11,15-17,20,24H,5-8H2,1-2H3,(H,25,28)/t15-,16+,17-,20-/m0/s1
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n/an/a 1.70n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM150337
PNG
(US8987249, 11 | US9713606, 11)
Show SMILES Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19?,22-/m0/s1
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n/an/a 1.70n/an/an/an/a6.025



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F) were purchased from PerkinElmer (Prod. No. 6007270). The substrate Gly-Arg-AMC was from Biotrend (Prod....


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Dipeptidyl peptidase I


(Homo sapiens (Human))
BDBM201037
PNG
(US9540373, 25 | US9879026, Example 25)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC3(CCN(CC3)C3COC3)c2n1
Show InChI InChI=1S/C30H34FN5O3/c31-25-13-19(2-1-18(25)11-23(14-32)34-29(37)27-20-3-5-22(12-20)33-27)26-6-4-21-15-39-30(28(21)35-26)7-9-36(10-8-30)24-16-38-17-24/h1-2,4,6,13,20,22-24,27,33H,3,5,7-12,15-17H2,(H,34,37)/t20-,22+,23-,27-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Assay conditions: The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 μg/ml, respectively), and then activated by mixing in...


US Patent US9879026 (2018)

More data for this
Ligand-Target Pair
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