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Compile Data Set for Download or QSAR

Found 275 hits of Enz. Inhib. data with enzyme = 'Dipeptidyl peptidase IX' and Substrate = 'BDBM11057'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11644
PNG
((2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidi...)
Show SMILES N[C@@H](C1CCCC1)C(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C12H19N3O/c13-8-10-6-3-7-15(10)12(16)11(14)9-4-1-2-5-9/h9-11H,1-7,14H2/t10-,11-/m0/s1
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3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12643
PNG
(6-{[4-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl...)
Show SMILES O=C(CNC1CC[C@@H](CC1)Oc1ccc(cn1)C#N)N1CCC[C@H]1C#N
Show InChI InChI=1S/C19H23N5O2/c20-10-14-3-8-18(23-12-14)26-17-6-4-15(5-7-17)22-13-19(25)24-9-1-2-16(24)11-21/h3,8,12,15-17,22H,1-2,4-7,9,13H2/t15?,16-,17-/m0/s1
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10n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11695
PNG
((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12?,13?,14-,16?,17?/m0/s1
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68n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12652
PNG
((1S,6R)-3-(1,2,3,4-tetrahydroisoquinolin-2-ylmethy...)
Show SMILES [NH3+][C@H]1CC(CN2CCc3ccccc3C2)=CC[C@@H]1c1cc(F)c(F)cc1F
Show InChI InChI=1S/C22H23F3N2/c23-19-11-21(25)20(24)10-18(19)17-6-5-14(9-22(17)26)12-27-8-7-15-3-1-2-4-16(15)13-27/h1-5,10-11,17,22H,6-9,12-13,26H2/p+1/t17-,22+/m1/s1
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73 -9.63n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6439-42 (2006)


Article DOI: 10.1021/jm060955d
BindingDB Entry DOI: 10.7270/Q2G73BXR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12645
PNG
((2S)-1-[2-(cyclopentylamino)acetyl]pyrrolidine-2-c...)
Show SMILES O=C(CNC1CCCC1)N1CCC[C@H]1C#N
Show InChI InChI=1S/C12H19N3O/c13-8-11-6-3-7-15(11)12(16)9-14-10-4-1-2-5-10/h10-11,14H,1-7,9H2/t11-/m0/s1
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293n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12654
PNG
((1S,6R)-3-(3-carbamoylphenoxymethyl)-6-(2,4,5-trif...)
Show SMILES NC(=O)c1cccc(OCC2=CC[C@@H]([C@@H]([NH3+])C2)c2cc(F)c(F)cc2F)c1
Show InChI InChI=1S/C20H19F3N2O2/c21-16-9-18(23)17(22)8-15(16)14-5-4-11(6-19(14)24)10-27-13-3-1-2-12(7-13)20(25)26/h1-4,7-9,14,19H,5-6,10,24H2,(H2,25,26)/p+1/t14-,19+/m1/s1
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430 -8.59n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6439-42 (2006)


Article DOI: 10.1021/jm060955d
BindingDB Entry DOI: 10.7270/Q2G73BXR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12653
PNG
((1S,6R)-3-{[(3-carbamoylphenyl)amino]methyl}-6-(2,...)
Show SMILES NC(=O)c1cccc(NCC2=CC[C@@H]([C@@H]([NH3+])C2)c2cc(F)c(F)cc2F)c1
Show InChI InChI=1S/C20H20F3N3O/c21-16-9-18(23)17(22)8-15(16)14-5-4-11(6-19(14)24)10-26-13-3-1-2-12(7-13)20(25)27/h1-4,7-9,14,19,26H,5-6,10,24H2,(H2,25,27)/p+1/t14-,19+/m1/s1
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500 -8.50n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6439-42 (2006)


Article DOI: 10.1021/jm060955d
BindingDB Entry DOI: 10.7270/Q2G73BXR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM13792
PNG
(2-{[2-(3-aminopiperidin-1-yl)-5-methyl-4,6-dioxo-1...)
Show SMILES CN1C(=O)c2nc(N3CCCC(N)C3)n(Cc3ccccc3C#N)c2C1=O
Show InChI InChI=1S/C19H20N6O2/c1-23-17(26)15-16(18(23)27)25(10-13-6-3-2-5-12(13)9-20)19(22-15)24-8-4-7-14(21)11-24/h2-3,5-6,14H,4,7-8,10-11,21H2,1H3
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>3.00E+3>-7.45n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


Bioorg Med Chem Lett 16: 6226-30 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.024
BindingDB Entry DOI: 10.7270/Q2MP51H4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM13800
PNG
(2-(3-aminopiperidin-1-yl)-1-{[2-(trifluoromethyl)p...)
Show SMILES NC1CCCN(C1)c1nc2c(C(=O)c3ccccc3C2=O)n1Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O2/c25-24(26,27)18-10-4-1-6-14(18)12-31-20-19(29-23(31)30-11-5-7-15(28)13-30)21(32)16-8-2-3-9-17(16)22(20)33/h1-4,6,8-10,15H,5,7,11-13,28H2
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>3.00E+3>-7.45n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


Bioorg Med Chem Lett 16: 6226-30 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.024
BindingDB Entry DOI: 10.7270/Q2MP51H4
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15510
PNG
((4R,5R)-5-amino-1-(2-(benzo[d][1,3]dioxol-5-yl)eth...)
Show SMILES N[C@H]1CN(CCc2ccc3OCOc3c2)C(=O)C[C@@H]1c1cc(F)c(F)cc1F
Show InChI InChI=1S/C20H19F3N2O3/c21-14-8-16(23)15(22)6-12(14)13-7-20(26)25(9-17(13)24)4-3-11-1-2-18-19(5-11)28-10-27-18/h1-2,5-6,8,13,17H,3-4,7,9-10,24H2/t13-,17+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 50: 1983-7 (2007)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2VQ30XV
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15514
PNG
((4R,5R)-5-amino-1-(3-(methylsulfonyl)phenethyl)-4-...)
Show SMILES CS(=O)(=O)c1cccc(CCN2C[C@H](N)[C@H](CC2=O)c2cc(F)c(F)cc2F)c1
Show InChI InChI=1S/C20H21F3N2O3S/c1-29(27,28)13-4-2-3-12(7-13)5-6-25-11-19(24)15(9-20(25)26)14-8-17(22)18(23)10-16(14)21/h2-4,7-8,10,15,19H,5-6,9,11,24H2,1H3/t15-,19+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 50: 1983-7 (2007)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2VQ30XV
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15515
PNG
(3-(2-((4R,5R)-5-amino-2-oxo-4-(2,4,5-trifluorophen...)
Show SMILES N[C@H]1CN(CCc2cccc(c2)C(O)=O)C(=O)C[C@@H]1c1cc(F)c(F)cc1F
Show InChI InChI=1S/C20H19F3N2O3/c21-15-9-17(23)16(22)7-13(15)14-8-19(26)25(10-18(14)24)5-4-11-2-1-3-12(6-11)20(27)28/h1-3,6-7,9,14,18H,4-5,8,10,24H2,(H,27,28)/t14-,18+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 50: 1983-7 (2007)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2VQ30XV
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15494
PNG
(3-{6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyr...)
Show SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C21H17F3N4O2/c22-15-6-17(24)16(23)5-13(15)14-8-28(9-18(14)25)20-7-19(26-10-27-20)11-2-1-3-12(4-11)21(29)30/h1-7,10,14,18H,8-9,25H2,(H,29,30)/t14-,18+/m1/s1
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>3.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


Bioorg Med Chem Lett 17: 2005-12 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.026
BindingDB Entry DOI: 10.7270/Q20G3HCQ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12644
PNG
((2S)-1-[2-(tert-butylamino)acetyl]pyrrolidine-2-ca...)
Show SMILES CC(C)(C)NCC(=O)N1CCC[C@H]1C#N
Show InChI InChI=1S/C11H19N3O/c1-11(2,3)13-8-10(15)14-6-4-5-9(14)7-12/h9,13H,4-6,8H2,1-3H3/t9-/m0/s1
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3.30E+3n/an/an/an/an/an/an/an/a



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Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12656
PNG
(((4R,5S)-5-Amino-4-(2,4,5-trifluorophenyl)cyclohex...)
Show SMILES [NH3+][C@H]1CC(=CC[C@@H]1c1cc(F)c(F)cc1F)C(=O)N1CCn2c(C1)nnc2C(F)(F)F
Show InChI InChI=1S/C19H17F6N5O/c20-12-7-14(22)13(21)6-11(12)10-2-1-9(5-15(10)26)17(31)29-3-4-30-16(8-29)27-28-18(30)19(23,24)25/h1,6-7,10,15H,2-5,8,26H2/p+1/t10-,15+/m1/s1
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4.00E+3 -7.28n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6439-42 (2006)


Article DOI: 10.1021/jm060955d
BindingDB Entry DOI: 10.7270/Q2G73BXR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15498
PNG
((3R,4S)-1-[6-(3-methanesulfonylphenyl)pyrimidin-4-...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc(ncn1)N1C[C@H](N)[C@H](C1)c1cc(F)c(F)cc1F
Show InChI InChI=1S/C21H19F3N4O2S/c1-31(29,30)13-4-2-3-12(5-13)20-8-21(27-11-26-20)28-9-15(19(25)10-28)14-6-17(23)18(24)7-16(14)22/h2-8,11,15,19H,9-10,25H2,1H3/t15-,19+/m1/s1
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1.09E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


Bioorg Med Chem Lett 17: 2005-12 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.026
BindingDB Entry DOI: 10.7270/Q20G3HCQ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15500
PNG
((3R,4S)-1-[4-(3-methanesulfonylphenyl)-1,3,5-triaz...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1ncnc(n1)N1C[C@H](N)[C@H](C1)c1cc(F)c(F)cc1F
Show InChI InChI=1S/C20H18F3N5O2S/c1-31(29,30)12-4-2-3-11(5-12)19-25-10-26-20(27-19)28-8-14(18(24)9-28)13-6-16(22)17(23)7-15(13)21/h2-7,10,14,18H,8-9,24H2,1H3/t14-,18+/m1/s1
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1.11E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


Bioorg Med Chem Lett 17: 2005-12 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.026
BindingDB Entry DOI: 10.7270/Q20G3HCQ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12655
PNG
((1S,6R)-3-[(3-carbamoylphenyl)carbamoyl]-6-(2,4,5-...)
Show SMILES NC(=O)c1cccc(NC(=O)C2=CC[C@@H]([C@@H]([NH3+])C2)c2cc(F)c(F)cc2F)c1
Show InChI InChI=1S/C20H18F3N3O2/c21-15-9-17(23)16(22)8-14(15)13-5-4-11(7-18(13)24)20(28)26-12-3-1-2-10(6-12)19(25)27/h1-4,6,8-9,13,18H,5,7,24H2,(H2,25,27)(H,26,28)/p+1/t13-,18+/m1/s1
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1.40E+4 -6.55n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6439-42 (2006)


Article DOI: 10.1021/jm060955d
BindingDB Entry DOI: 10.7270/Q2G73BXR
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15497
PNG
((3R,4S)-1-{6-[3-(morpholine-4-sulfonyl)phenyl]pyri...)
Show SMILES N[C@H]1CN(C[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)-c1cccc(c1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C24H24F3N5O3S/c25-19-10-21(27)20(26)9-17(19)18-12-31(13-22(18)28)24-11-23(29-14-30-24)15-2-1-3-16(8-15)36(33,34)32-4-6-35-7-5-32/h1-3,8-11,14,18,22H,4-7,12-13,28H2/t18-,22+/m1/s1
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1.75E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


Bioorg Med Chem Lett 17: 2005-12 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.026
BindingDB Entry DOI: 10.7270/Q20G3HCQ
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15523
PNG
((3R, 4R)-1-(6-(3, 3-Difluoropyrrolidin-1-yl)pyrimi...)
Show SMILES N[C@H]1CN(CC[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)N1CCC(F)(F)C1
Show InChI InChI=1S/C19H20F5N5/c20-13-6-15(22)14(21)5-12(13)11-1-3-28(8-16(11)25)17-7-18(27-10-26-17)29-4-2-19(23,24)9-29/h5-7,10-11,16H,1-4,8-9,25H2/t11-,16+/m1/s1
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1.83E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 50: 1983-7 (2007)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2VQ30XV
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15524
PNG
((3R)-1-{6-[(3R,4R)-3-amino-4-(2,4,5-trifluoropheny...)
Show SMILES N[C@H]1CN(CC[C@@H]1c1cc(F)c(F)cc1F)c1cc(ncn1)N1CC[C@@H](O)C1
Show InChI InChI=1S/C19H22F3N5O/c20-14-6-16(22)15(21)5-13(14)12-2-4-27(9-17(12)23)19-7-18(24-10-25-19)26-3-1-11(28)8-26/h5-7,10-12,17,28H,1-4,8-9,23H2/t11-,12-,17+/m1/s1
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1.97E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 50: 1983-7 (2007)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2VQ30XV
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12638
PNG
((2S,5R)-5-ethynyl-1-{N-(4-trans(5-cyano-pyridin-2-...)
Show SMILES O=C(CN[C@H]1CC[C@@H](CC1)Oc1ccc(cn1)C#N)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C21H23N5O2/c1-2-17-6-7-18(12-23)26(17)21(27)14-24-16-4-8-19(9-5-16)28-20-10-3-15(11-22)13-25-20/h1,3,10,13,16-19,24H,4-9,14H2/t16-,17-,18-,19-/m0/s1
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2.30E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12648
PNG
((2S,5R)-5-Ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyri...)
Show SMILES CC1(CCN(CC1)c1cc(ccn1)C(O)=O)NCC(=O)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C21H25N5O3/c1-3-16-4-5-17(13-22)26(16)19(27)14-24-21(2)7-10-25(11-8-21)18-12-15(20(28)29)6-9-23-18/h1,6,9,12,16-17,24H,4-5,7-8,10-11,14H2,2H3,(H,28,29)/t16-,17-/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM15518
PNG
((3R,4R)-1-(6-(3-(methylsulfonyl)phenyl)pyrimidin-4...)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1cc(ncn1)N1CC[C@@H]([C@@H](N)C1)c1cc(F)c(F)cc1F
Show InChI InChI=1S/C22H21F3N4O2S/c1-32(30,31)14-4-2-3-13(7-14)21-10-22(28-12-27-21)29-6-5-15(20(26)11-29)16-8-18(24)19(25)9-17(16)23/h2-4,7-10,12,15,20H,5-6,11,26H2,1H3/t15-,20+/m1/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 50: 1983-7 (2007)


Article DOI: 10.1021/jm061436d
BindingDB Entry DOI: 10.7270/Q2VQ30XV
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12639
PNG
((2S,5R)-1-(N-(tert-butyl)glycyl)-5-ethynylpyrrolid...)
Show SMILES CC(C)(C)NCC(=O)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C13H19N3O/c1-5-10-6-7-11(8-14)16(10)12(17)9-15-13(2,3)4/h1,10-11,15H,6-7,9H2,2-4H3/t10-,11-/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12635
PNG
((2S,5R)-1-(N-cyclopentylglycyl)-5-ethynylpyrrolidi...)
Show SMILES O=C(CNC1CCCC1)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C14H19N3O/c1-2-12-7-8-13(9-15)17(12)14(18)10-16-11-5-3-4-6-11/h1,11-13,16H,3-8,10H2/t12-,13-/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11642
PNG
((2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-eth...)
Show SMILES N[C@@H](C1CCCC1)C(=O)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C14H19N3O/c1-2-11-7-8-12(9-15)17(11)14(18)13(16)10-5-3-4-6-10/h1,10-13H,3-8,16H2/t11-,12-,13-/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12646
PNG
((2S,5R)-5-ethynyl-1-(N-(4-methyl-1-(5-cyano-pyridi...)
Show SMILES CC1(CCN(CC1)c1ccc(cn1)C#N)NCC(=O)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C21H24N6O/c1-3-17-5-6-18(13-23)27(17)20(28)15-25-21(2)8-10-26(11-9-21)19-7-4-16(12-22)14-24-19/h1,4,7,14,17-18,25H,5-6,8-11,15H2,2H3/t17-,18-/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12647
PNG
((2S,5R)-5-ethynyl-1-(N-(4-methyl-1-(5-carboxy-pyri...)
Show SMILES CC1(CCN(CC1)c1ccc(cn1)C(O)=O)NCC(=O)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C21H25N5O3/c1-3-16-5-6-17(12-22)26(16)19(27)14-24-21(2)8-10-25(11-9-21)18-7-4-15(13-23-18)20(28)29/h1,4,7,13,16-17,24H,5-6,8-11,14H2,2H3,(H,28,29)/t16-,17-/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM12642
PNG
((2S,5R)-5-ethynyl-1-[N-(3-hydroxy-1-adamantyl)glyc...)
Show SMILES OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N1[C@H](CC[C@H]1C#N)C#C
Show InChI InChI=1S/C19H25N3O2/c1-2-15-3-4-16(10-20)22(15)17(23)11-21-18-6-13-5-14(7-18)9-19(24,8-13)12-18/h1,13-16,21,24H,3-9,11-12H2/t13?,14?,15-,16-,18?,19?/m0/s1
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>3.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...


J Med Chem 49: 6416-20 (2006)


Article DOI: 10.1021/jm060777o
BindingDB Entry DOI: 10.7270/Q2M043M1
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11465
PNG
((2S,3R)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/t7-,8+/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM17300
PNG
((2S,3R)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pen...)
Show SMILES CC[C@@H](C)[C@H]([NH3+])C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/p+1/t7-,8+/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11464
PNG
((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/t7-,8-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM17299
PNG
((2S,3S)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pen...)
Show SMILES CC[C@H](C)[C@H]([NH3+])C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/p+1/t7-,8-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11218
PNG
((2S,3S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC[C@H]1C#N)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-13-3-4-19(28)14-25)17-7-5-15(6-8-17)16-9-11-18(24)12-10-16/h5-12,19-21H,3-4,13,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM17313
PNG
((1S)-1-{4-[(2,4-difluorobenzene)sulfonamido]cycloh...)
Show SMILES [NH3+][C@@H](C1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1F)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C18H24F3N3O3S/c19-12-3-6-16(15(21)9-12)28(26,27)23-14-4-1-11(2-5-14)17(22)18(25)24-8-7-13(20)10-24/h3,6,9,11,13-14,17,23H,1-2,4-5,7-8,10,22H2/p+1/t11?,13-,14?,17-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11463
PNG
(CHEMBL22310 | N-{4-[(1S)-1-amino-2-[(3S)-3-fluorop...)
Show SMILES N[C@@H]([C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(F)cc1F)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C18H24F3N3O3S/c19-12-3-6-16(15(21)9-12)28(26,27)23-14-4-1-11(2-5-14)17(22)18(25)24-8-7-13(20)10-24/h3,6,9,11,13-14,17,23H,1-2,4-5,7-8,10,22H2/t11-,13-,14-,17-/m0/s1
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n/an/a 2.72E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11969
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11966
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-7-8-28(12-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11967
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-19-20(12-31)33-22(30-19)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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n/an/a 9.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11958
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)[nH]nc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-12-14(8-26)24-25-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11152
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-oxo-3-(pyrrolidin-...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCCC1)c1ccc(cc1)-c1ccc2ncnn2c1
Show InChI InChI=1S/C22H26N6O2/c1-26(2)21(29)19(20(23)22(30)27-11-3-4-12-27)16-7-5-15(6-8-16)17-9-10-18-24-14-25-28(18)13-17/h5-10,13-14,19-20H,3-4,11-12,23H2,1-2H3/p+1/t19-,20-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


J Med Chem 49: 3614-27 (2006)


Article DOI: 10.1021/jm060015t
BindingDB Entry DOI: 10.7270/Q2N87807
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11964
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H...)
Show SMILES Cc1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H19F2N3OS/c1-10-21-15-4-5-22(9-16(15)24-10)17(23)8-13(20)7-11-6-12(18)2-3-14(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3/t13-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11949
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluoro...)
Show SMILES Cc1nn(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)30(28-14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11974
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CN(CCc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-13-28(9-8-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM17317
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)C1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H29F4N3O4S/c1-13(19(26)20(29)28-11-10-15(22)12-28)14-2-4-16(5-3-14)27-33(30,31)18-8-6-17(7-9-18)32-21(23,24)25/h6-9,13-16,19,27H,2-5,10-12,26H2,1H3/p+1/t13-,14?,15-,16?,19-/m0/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11216
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O2S/c1-24(2)20(26)18(19(23)21(27)25-11-12-28-13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11959
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-...)
Show SMILES Cn1nc(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H19F5N4O/c1-26-15-9-27(5-4-13(15)17(25-26)18(21,22)23)16(28)8-12(24)7-10-6-11(19)2-3-14(10)20/h2-3,6,12H,4-5,7-9,24H2,1H3/t12-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase IX


(Homo sapiens (human))
BDBM11950
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES Cc1c2CN(CCc2nn1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)28-30(14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
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