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Compile Data Set for Download or QSAR

Found 297 hits of Enz. Inhib. data with enzyme = 'Dipeptidyl peptidase VIII' and Substrate = 'BDBM11561'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11465
PNG
((2S,3R)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Show SMILES CC[C@@H](C)[C@H](N)C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/t7-,8+/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17300
PNG
((2S,3R)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pen...)
Show SMILES CC[C@@H](C)[C@H]([NH3+])C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/p+1/t7-,8+/m1/s1
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n/an/a 220n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11224
PNG
((1S,2S)-1-[4-(3-cyanophenyl)phenyl]-1-(dimethylcar...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-11-10-19(24)14-28)17-8-6-16(7-9-17)18-5-3-4-15(12-18)13-25/h3-9,12,19-21H,10-11,14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17313
PNG
((1S)-1-{4-[(2,4-difluorobenzene)sulfonamido]cycloh...)
Show SMILES [NH3+][C@@H](C1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1F)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C18H24F3N3O3S/c19-12-3-6-16(15(21)9-12)28(26,27)23-14-4-1-11(2-5-14)17(22)18(25)24-8-7-13(20)10-24/h3,6,9,11,13-14,17,23H,1-2,4-5,7-8,10,22H2/p+1/t11?,13-,14?,17-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11463
PNG
(CHEMBL22310 | N-{4-[(1S)-1-amino-2-[(3S)-3-fluorop...)
Show SMILES N[C@@H]([C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(F)cc1F)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C18H24F3N3O3S/c19-12-3-6-16(15(21)9-12)28(26,27)23-14-4-1-11(2-5-14)17(22)18(25)24-8-7-13(20)10-24/h3,6,9,11,13-14,17,23H,1-2,4-5,7-8,10,22H2/t11-,13-,14-,17-/m0/s1
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n/an/a 993n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11218
PNG
((2S,3S)-1-[(2S)-2-cyanopyrrolidin-1-yl]-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC[C@H]1C#N)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H25FN4O2/c1-27(2)22(29)20(21(26)23(30)28-13-3-4-19(28)14-25)17-7-5-15(6-8-17)16-9-11-18(24)12-10-16/h5-12,19-21H,3-4,13,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11464
PNG
((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Show SMILES CC[C@H](C)[C@H](N)C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/t7-,8-/m0/s1
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n/an/a 2.17E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17299
PNG
((2S,3S)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pen...)
Show SMILES CC[C@H](C)[C@H]([NH3+])C(=O)N1CCSC1
Show InChI InChI=1S/C9H18N2OS/c1-3-7(2)8(10)9(12)11-4-5-13-6-11/h7-8H,3-6,10H2,1-2H3/p+1/t7-,8-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11967
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-19-20(12-31)33-22(30-19)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11969
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11968
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(methy...)
Show SMILES CSc1ccc(cc1)-c1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3OS2/c1-30-18-5-2-14(3-6-18)23-27-20-8-9-28(13-21(20)31-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11966
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2nc(sc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-7-8-28(12-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15554
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C23H25F4N3O2/c1-13-6-7-30(21(23(32)29-13)10-14-4-2-3-5-17(14)24)22(31)11-16(28)8-15-9-19(26)20(27)12-18(15)25/h2-5,9,12-13,16,21H,6-8,10-11,28H2,1H3,(H,29,32)/t13-,16-,21-/m1/s1
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n/an/a 5.30E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11962
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)noc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H16F5N3O2/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(26)25-4-3-12-14(8-25)24-27-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2/t11-/m1/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17319
PNG
((2S,3S)-3-{4-[(3-fluorobenzene)(methyl)amido]cyclo...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)C1CCC(CC1)N(C)C(=O)c1cccc(F)c1
Show InChI InChI=1S/C22H31F2N3O2/c1-14(20(25)22(29)27-11-10-18(24)13-27)15-6-8-19(9-7-15)26(2)21(28)16-4-3-5-17(23)12-16/h3-5,12,14-15,18-20H,6-11,13,25H2,1-2H3/p+1/t14-,15?,18-,19?,20-/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11223
PNG
((1S,2S)-1-[4-(2,5-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)ccc1F
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(24)12-28)14-5-3-13(4-6-14)17-11-15(23)7-8-18(17)25/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11964
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-methyl-4H...)
Show SMILES Cc1nc2CCN(Cc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H19F2N3OS/c1-10-21-15-4-5-22(9-16(15)24-10)17(23)8-13(20)7-11-6-12(18)2-3-14(11)19/h2-3,6,13H,4-5,7-9,20H2,1H3/t13-/m1/s1
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n/an/a 7.10E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11973
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-{2-[4-(trifl...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(cc1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H20F5N3OS/c24-16-5-6-18(25)14(9-16)10-17(29)11-21(32)31-8-7-20-19(12-31)30-22(33-20)13-1-3-15(4-2-13)23(26,27)28/h1-6,9,17H,7-8,10-12,29H2/t17-/m1/s1
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n/an/a 7.90E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11215
PNG
((2S,3S)-1-(3,3-difluoropyrrolidin-1-yl)-3-(dimethy...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCC(F)(F)C1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)20(29)18(19(26)21(30)28-12-11-22(24,25)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-19H,11-13,26H2,1-2H3/p+1/t18-,19-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11974
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-methan...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2CN(CCc2s1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N3O3S2/c1-33(30,31)18-5-2-14(3-6-18)23-27-20-13-28(9-8-21(20)32-23)22(29)12-17(26)11-15-10-16(24)4-7-19(15)25/h2-7,10,17H,8-9,11-13,26H2,1H3/t17-/m1/s1
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n/an/a 8.60E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11950
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES Cc1c2CN(CCc2nn1-c1ccc(F)cc1)C(=O)C[C@H](N)Cc1cc(F)ccc1F
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)28-30(14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 9.40E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11513
PNG
((2S,3S)-3-[4-(3,5-difluorophenyl)phenyl]-1-[(3S)-3...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C20H21F3N2O/c1-12(19(24)20(26)25-7-6-16(21)11-25)13-2-4-14(5-3-13)15-8-17(22)10-18(23)9-15/h2-5,8-10,12,16,19H,6-7,11,24H2,1H3/p+1/t12-,16-,19-/m0/s1
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n/an/a 9.80E+3n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11958
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)[nH]nc2C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-12-14(8-26)24-25-16(12)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17317
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)C1CCC(CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H29F4N3O4S/c1-13(19(26)20(29)28-11-10-15(22)12-28)14-2-4-16(5-3-14)27-33(30,31)18-8-6-17(7-9-18)32-21(23,24)25/h6-9,13-16,19,27H,2-5,10-12,26H2,1H3/p+1/t13-,14?,15-,16?,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11960
PNG
((3R)-3-amino-1-{3-cyclopropyl-1H,4H,5H,6H,7H-pyraz...)
Show SMILES N[C@@H](CC(=O)N1CCc2c(C1)n[nH]c2C1CC1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C19H22F2N4O/c20-13-3-4-16(21)12(7-13)8-14(22)9-18(26)25-6-5-15-17(10-25)23-24-19(15)11-1-2-11/h3-4,7,11,14H,1-2,5-6,8-10,22H2,(H,23,24)/t14-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15552
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](CC(F)(F)F)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C18H21F6N3O2/c1-9-2-3-27(15(17(29)26-9)8-18(22,23)24)16(28)6-11(25)4-10-5-13(20)14(21)7-12(10)19/h5,7,9,11,15H,2-4,6,8,25H2,1H3,(H,26,29)/t9-,11-,15-/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17324
PNG
((2S,3S)-3-{4-[cyclopropane(methyl)amido]cyclohexyl...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)C1CCC(CC1)N(C)C(=O)C1CC1
Show InChI InChI=1S/C19H32FN3O2/c1-12(17(21)19(25)23-10-9-15(20)11-23)13-5-7-16(8-6-13)22(2)18(24)14-3-4-14/h12-17H,3-11,21H2,1-2H3/p+1/t12-,13?,15-,16?,17-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11227
PNG
((1S,2S)-1-(dimethylcarbamoyl)-3-[(3S)-3-fluoropyrr...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C21H25FN4O2/c1-25(2)20(27)18(19(23)21(28)26-11-9-17(22)13-26)15-7-5-14(6-8-15)16-4-3-10-24-12-16/h3-8,10,12,17-19H,9,11,13,23H2,1-2H3/p+1/t17-,18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM13524
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES CC[C@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H22F3N3O2/c1-2-15-17(25)22-4-3-5-23(15)16(24)8-11(21)6-10-7-13(19)14(20)9-12(10)18/h7,9,11,15H,2-6,8,21H2,1H3,(H,22,25)/t11-,15-/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 49-52 (2007)


Article DOI: 10.1016/j.bmcl.2006.09.099
BindingDB Entry DOI: 10.7270/Q2F47MC2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11216
PNG
((1S,2S)-1-(dimethylcarbamoyl)-1-[4-(4-fluorophenyl...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CCSC1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O2S/c1-24(2)20(26)18(19(23)21(27)25-11-12-28-13-25)16-5-3-14(4-6-16)15-7-9-17(22)10-8-15/h3-10,18-19H,11-13,23H2,1-2H3/p+1/t18-,19-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11222
PNG
((1S,2S)-1-[4-(3,4-difluorophenyl)phenyl]-1-(dimeth...)
Show SMILES CN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H24F3N3O2/c1-27(2)21(29)19(20(26)22(30)28-10-9-16(23)12-28)14-5-3-13(4-6-14)15-7-8-17(24)18(25)11-15/h3-8,11,16,19-20H,9-10,12,26H2,1-2H3/p+1/t16-,19-,20-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15536
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(CCOCc2ccccc2)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C25H30F3N3O3/c1-17-25(33)30(10-11-34-16-18-6-3-2-4-7-18)8-5-9-31(17)24(32)14-20(29)12-19-13-22(27)23(28)15-21(19)26/h2-4,6-7,13,15,17,20H,5,8-12,14,16,29H2,1H3/t17-,20-/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11207
PNG
((2S,3S)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)N1CCCC1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C24H27F2N3O2/c25-19-9-7-17(8-10-19)16-3-5-18(6-4-16)21(23(30)28-12-1-2-13-28)22(27)24(31)29-14-11-20(26)15-29/h3-10,20-22H,1-2,11-15,27H2/p+1/t20-,21-,22-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11191
PNG
((2S,3R)-4-(dimethylamino)-3-[4-(4-fluorophenyl)phe...)
Show SMILES CN(C)C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H27F2N3O/c1-26(2)14-20(21(25)22(28)27-12-11-19(24)13-27)17-5-3-15(4-6-17)16-7-9-18(23)10-8-16/h3-10,19-21H,11-14,25H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15549
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](CC(F)(F)F)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C18H21F6N3O2/c1-9-7-26-17(29)15(6-18(22,23)24)27(8-9)16(28)4-11(25)2-10-3-13(20)14(21)5-12(10)19/h3,5,9,11,15H,2,4,6-8,25H2,1H3,(H,26,29)/t9-,11+,15+/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11972
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2sc(nc2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H20F3N3OS/c23-15-3-1-13(2-4-15)22-27-19-12-28(8-7-20(19)30-22)21(29)11-17(26)10-14-9-16(24)5-6-18(14)25/h1-6,9,17H,7-8,10-12,26H2/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11520
PNG
((2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-{...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1cccc(c1)-c1c[nH]c(=O)[nH]1
Show InChI InChI=1S/C23H25FN4O2/c1-14(21(25)22(29)28-10-9-19(24)13-28)15-5-7-16(8-6-15)17-3-2-4-18(11-17)20-12-26-23(30)27-20/h2-8,11-12,14,19,21H,9-10,13,25H2,1H3,(H2,26,27,30)/p+1/t14-,19-,21-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2533-6 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.055
BindingDB Entry DOI: 10.7270/Q2K935SH
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11949
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluoro...)
Show SMILES Cc1nn(c2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)ccc1F)-c1ccc(F)cc1
Show InChI InChI=1S/C23H23F3N4O/c1-14-20-13-29(9-8-22(20)30(28-14)19-5-2-16(24)3-6-19)23(31)12-18(27)11-15-10-17(25)4-7-21(15)26/h2-7,10,18H,8-9,11-13,27H2,1H3/t18-/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11204
PNG
((1S,2S)-1-[ethyl(methyl)carbamoyl]-1-[4-(4-fluorop...)
Show SMILES CCN(C)C(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C23H27F2N3O2/c1-3-27(2)22(29)20(21(26)23(30)28-13-12-19(25)14-28)17-6-4-15(5-7-17)16-8-10-18(24)11-9-16/h4-11,19-21H,3,12-14,26H2,1-2H3/p+1/t19-,20-,21-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15553
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@@H]1CCN([C@H](Cc2ccccc2C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C24H28F3N3O2/c1-14-5-3-4-6-16(14)11-22-24(32)29-15(2)7-8-30(22)23(31)12-18(28)9-17-10-20(26)21(27)13-19(17)25/h3-6,10,13,15,18,22H,7-9,11-12,28H2,1-2H3,(H,29,32)/t15-,18-,22-/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15558
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1N(CC[C@@H](Cc2ccccc2F)NC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C23H25F4N3O2/c1-13-23(32)29-17(9-14-4-2-3-5-18(14)24)6-7-30(13)22(31)11-16(28)8-15-10-20(26)21(27)12-19(15)25/h2-5,10,12-13,16-17H,6-9,11,28H2,1H3,(H,29,32)/t13-,16-,17+/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11203
PNG
((1S,2S)-1-[4-(4-fluorophenyl)phenyl]-3-[(3S)-3-flu...)
Show SMILES [NH3+][C@@H]([C@@H](C(=O)Nc1nnn[nH]1)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CC[C@H](F)C1
Show InChI InChI=1S/C21H21F2N7O2/c22-15-7-5-13(6-8-15)12-1-3-14(4-2-12)17(19(31)25-21-26-28-29-27-21)18(24)20(32)30-10-9-16(23)11-30/h1-8,16-18H,9-11,24H2,(H2,25,26,27,28,29,31)/p+1/t16-,17-,18-/m0/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15557
PNG
((3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES CC[C@@H]1CCN([C@H](C)C(=O)N1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C18H24F3N3O2/c1-3-13-4-5-24(10(2)18(26)23-13)17(25)8-12(22)6-11-7-15(20)16(21)9-14(11)19/h7,9-10,12-13H,3-6,8,22H2,1-2H3,(H,23,26)/t10-,12-,13-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM17315
PNG
((2S,3S)-3-{4-[(2,4-difluorobenzene)sulfonamido]cyc...)
Show SMILES C[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)C1CCC(CC1)NS(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C20H28F3N3O3S/c1-12(19(24)20(27)26-9-8-15(22)11-26)13-2-5-16(6-3-13)25-30(28,29)18-7-4-14(21)10-17(18)23/h4,7,10,12-13,15-16,19,25H,2-3,5-6,8-9,11,24H2,1H3/p+1/t12-,13?,15-,16?,19-/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product, which was monitored by excitation at 400 nm and measurement of fluorescent ...


Bioorg Med Chem Lett 17: 2879-85 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.066
BindingDB Entry DOI: 10.7270/Q2V986BG
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15534
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES C[C@H]1N(CCCN(C)C1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H22F3N3O2/c1-10-17(25)22(2)4-3-5-23(10)16(24)8-12(21)6-11-7-14(19)15(20)9-13(11)18/h7,9-10,12H,3-6,8,21H2,1-2H3/t10-,12-/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM13526
PNG
((3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...)
Show SMILES N[C@@H](CC(=O)N1CCCNC(=O)[C@H]1Cc1ccccc1)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C22H24F3N3O2/c23-17-13-19(25)18(24)11-15(17)10-16(26)12-21(29)28-8-4-7-27-22(30)20(28)9-14-5-2-1-3-6-14/h1-3,5-6,11,13,16,20H,4,7-10,12,26H2,(H,27,30)/t16-,20-/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 49-52 (2007)


Article DOI: 10.1016/j.bmcl.2006.09.099
BindingDB Entry DOI: 10.7270/Q2F47MC2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11944
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluor...)
Show SMILES N[C@@H](CC(=O)N1CCc2n[nH]c(c2C1)C(F)(F)F)Cc1cc(F)ccc1F
Show InChI InChI=1S/C17H17F5N4O/c18-10-1-2-13(19)9(5-10)6-11(23)7-15(27)26-4-3-14-12(8-26)16(25-24-14)17(20,21)22/h1-2,5,11H,3-4,6-8,23H2,(H,24,25)/t11-/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM15543
PNG
((3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)b...)
Show SMILES C[C@H]1CNC(=O)[C@@H](C)N(C1)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
Show InChI InChI=1S/C17H22F3N3O2/c1-9-7-22-17(25)10(2)23(8-9)16(24)5-12(21)3-11-4-14(19)15(20)6-13(11)18/h4,6,9-10,12H,3,5,7-8,21H2,1-2H3,(H,22,25)/t9-,10+,12+/m0/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 17: 1903-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.039
BindingDB Entry DOI: 10.7270/Q2QZ2870
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11209
PNG
((1S,2S)-1-(N',N'-dimethylhydrazinecarbonyl)-1-[4-(...)
Show SMILES CN(C)NC(=O)[C@H]([C@H]([NH3+])C(=O)N1CC[C@H](F)C1)c1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H26F2N4O2/c1-27(2)26-21(29)19(20(25)22(30)28-12-11-18(24)13-28)16-5-3-14(4-6-16)15-7-9-17(23)10-8-15/h3-10,18-20H,11-13,25H2,1-2H3,(H,26,29)/p+1/t18-,19-,20-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 3048-52 (2005)


Article DOI: 10.1016/j.bmcl.2005.04.028
BindingDB Entry DOI: 10.7270/Q2833Q73
More data for this
Ligand-Target Pair
Dipeptidyl peptidase VIII


(Homo sapiens (human))
BDBM11954
PNG
((3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluoro...)
Show SMILES N[C@@H](CC(=O)N1CCc2[nH]nc(c2C1)-c1ccc(F)cc1)Cc1cc(F)ccc1F
Show InChI InChI=1S/C22H21F3N4O/c23-15-3-1-13(2-4-15)22-18-12-29(8-7-20(18)27-28-22)21(30)11-17(26)10-14-9-16(24)5-6-19(14)25/h1-6,9,17H,7-8,10-12,26H2,(H,27,28)/t17-/m1/s1
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Assay Description
The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...


Bioorg Med Chem Lett 15: 2253-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.012
BindingDB Entry DOI: 10.7270/Q2445JQ5
More data for this
Ligand-Target Pair
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