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Compile Data Set for Download or QSAR

Found 64 hits of Enz. Inhib. data with enzyme = 'Dopamine D1 receptor' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364218
PNG
(US9856263, 1 | US9856263, 2 | US9856263, 3)
Show SMILES Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12
Show InChI InChI=1S/C21H17N5O/c1-14-12-16(27-21-18-4-3-9-25(18)10-7-23-21)5-6-17(14)20-15(2)24-13-19-22-8-11-26(19)20/h3-13H,1-2H3
KEGG

UniProtKB/SwissProt

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US Patent
4.5n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364218
PNG
(US9856263, 1 | US9856263, 2 | US9856263, 3)
Show SMILES Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12
Show InChI InChI=1S/C21H17N5O/c1-14-12-16(27-21-18-4-3-9-25(18)10-7-23-21)5-6-17(14)20-15(2)24-13-19-22-8-11-26(19)20/h3-13H,1-2H3
KEGG

UniProtKB/SwissProt

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US Patent
5.5n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364363
PNG
(US9856263, 15)
Show SMILES Cc1c(-c2ccc(Oc3nccn4cccc34)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H16N4O3/c1-12-16(22(2)19(25)21-17(12)24)13-5-7-14(8-6-13)26-18-15-4-3-10-23(15)11-9-20-18/h3-11H,1-2H3,(H,21,24,25)
KEGG

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US Patent
7.30n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364317
PNG
(US9856263, 37)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2nccn3cccc23)cc1Cl
Show InChI InChI=1S/C19H15ClN4O/c1-12-18(13(2)23-11-22-12)15-6-5-14(10-16(15)20)25-19-17-4-3-8-24(17)9-7-21-19/h3-11H,1-2H3
KEGG

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US Patent
12.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364293
PNG
((+)-1-[4-(3,5-Dimethylpyridazin-4-yl)-3-methylphen...)
Show SMILES Cc1cnnc(C)c1-c1ccc(Oc2nccn3cccc23)cc1C
Show InChI InChI=1S/C20H18N4O/c1-13-11-16(25-20-18-5-4-9-24(18)10-8-21-20)6-7-17(13)19-14(2)12-22-23-15(19)3/h4-12H,1-3H3
KEGG

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13.1n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364362
PNG
(US9856263, 14)
Show SMILES Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccn3cccc23)cc1
Show InChI InChI=1S/C19H16N4O2/c1-12-17(13(2)21-22-18(12)24)14-5-7-15(8-6-14)25-19-16-4-3-10-23(16)11-9-20-19/h3-11H,1-2H3,(H,22,24)
KEGG

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18.8n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364218
PNG
(US9856263, 1 | US9856263, 2 | US9856263, 3)
Show SMILES Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12
Show InChI InChI=1S/C21H17N5O/c1-14-12-16(27-21-18-4-3-9-25(18)10-7-23-21)5-6-17(14)20-15(2)24-13-19-22-8-11-26(19)20/h3-13H,1-2H3
KEGG

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20.5n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364284
PNG
(1-[4-(4, 6-Dimethylpyrimidin-5-yl)-3-methylphenoxy...)
Show SMILES Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C20H18N4O/c1-13-11-16(25-20-18-5-4-9-24(18)10-8-21-20)6-7-17(13)19-14(2)22-12-23-15(19)3/h4-12H,1-3H3
KEGG

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US Patent
22.1n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364307
PNG
(US9856263, 27)
Show SMILES COc1cc(Oc2nccn3cccc23)ccc1-c1c(C)cnnc1C
Show InChI InChI=1S/C20H18N4O2/c1-13-12-22-23-14(2)19(13)16-7-6-15(11-18(16)25-3)26-20-17-5-4-9-24(17)10-8-21-20/h4-12H,1-3H3
KEGG

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28.1n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285640
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16N4O3/c1-10-8-13(26-19-15-6-7-25-18(15)20-9-21-19)4-5-14(10)16-11(2)17(24)23-22-12(16)3/h4-9H,1-3H3,(H,23,24)
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30.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364319
PNG
(US9856263, 39)
Show SMILES Cc1cc(Oc2ncnn3cccc23)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H17N5O2/c1-12-9-14(26-19-16-5-4-8-24(16)22-11-21-19)6-7-15(12)18-13(2)20-10-17(25)23(18)3/h4-11H,1-3H3
KEGG

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US Patent
31.2n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364315
PNG
(US9856263, 35)
Show SMILES Cc1cc(Oc2nccn3cccc23)c(F)cc1-c1c(C)ncnc1C
Show InChI InChI=1S/C20H17FN4O/c1-12-9-18(26-20-17-5-4-7-25(17)8-6-22-20)16(21)10-15(12)19-13(2)23-11-24-14(19)3/h4-11H,1-3H3
KEGG

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31.5n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285644
PNG
(4,6-Dimethyl-5-[2-methyl-4-([1,2]thiazolo[4,5-c]py...)
Show SMILES Cc1cc(Oc2nccc3sncc23)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16N4O2S/c1-10-8-13(25-19-15-9-21-26-16(15)6-7-20-19)4-5-14(10)17-11(2)18(24)23-22-12(17)3/h4-9H,1-3H3,(H,23,24)
KEGG

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US Patent
32.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364321
PNG
(US9856263, 41)
Show SMILES COc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C20H18N4O2/c1-13-19(14(2)23-12-22-13)16-7-6-15(11-18(16)25-3)26-20-17-5-4-9-24(17)10-8-21-20/h4-12H,1-3H3
KEGG

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34.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364289
PNG
(4-[4-(3,5-Dimethylpyridazin-4-yl)-3-methylphenoxy]...)
Show SMILES Cc1cnnc(C)c1-c1ccc(Oc2ncnn3cccc23)cc1C
Show InChI InChI=1S/C19H17N5O/c1-12-9-15(25-19-17-5-4-8-24(17)22-11-20-19)6-7-16(12)18-13(2)10-21-23-14(18)3/h4-11H,1-3H3
KEGG

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35.8n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285640
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16N4O3/c1-10-8-13(26-19-15-6-7-25-18(15)20-9-21-19)4-5-14(10)16-11(2)17(24)23-22-12(16)3/h4-9H,1-3H3,(H,23,24)
KEGG

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US Patent
40.2n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285640
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)n[nH]c(=O)c1C
Show InChI InChI=1S/C19H16N4O3/c1-10-8-13(26-19-15-6-7-25-18(15)20-9-21-19)4-5-14(10)16-11(2)17(24)23-22-12(16)3/h4-9H,1-3H3,(H,23,24)
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44.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364316
PNG
(US9856263, 36)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2ncnn3cccc23)cc1Cl
Show InChI InChI=1S/C18H14ClN5O/c1-11-17(12(2)21-9-20-11)14-6-5-13(8-15(14)19)25-18-16-4-3-7-24(16)23-10-22-18/h3-10H,1-2H3
KEGG

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US Patent
48.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364314
PNG
(US9856263, 34)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2nccn3cccc23)c(F)c1
Show InChI InChI=1S/C19H15FN4O/c1-12-18(13(2)23-11-22-12)14-5-6-17(15(20)10-14)25-19-16-4-3-8-24(16)9-7-21-19/h3-11H,1-2H3
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49.4n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364305
PNG
(US9856263, 25)
Show SMILES COc1cc(Oc2nccn3cccc23)ccc1-c1cccnc1C
Show InChI InChI=1S/C20H17N3O2/c1-14-16(5-3-9-21-14)17-8-7-15(13-19(17)24-2)25-20-18-6-4-11-23(18)12-10-22-20/h3-13H,1-2H3
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56.4n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364285
PNG
(4-[4-(4,6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]...)
Show SMILES Cc1cc(Oc2ncnn3cccc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C19H17N5O/c1-12-9-15(25-19-17-5-4-8-24(17)23-11-22-19)6-7-16(12)18-13(2)20-10-21-14(18)3/h4-11H,1-3H3
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56.4n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364296
PNG
(US9856263, 16)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2ncnn3cccc23)cc1F
Show InChI InChI=1S/C18H14FN5O/c1-11-17(12(2)21-9-20-11)14-6-5-13(8-15(14)19)25-18-16-4-3-7-24(16)23-10-22-18/h3-10H,1-2H3
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58.2n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364310
PNG
(US9856263, 30)
Show SMILES Cc1ncnc(C#N)c1-c1ccc(Oc2nccn3cccc23)cc1F
Show InChI InChI=1S/C19H12FN5O/c1-12-18(16(10-21)24-11-23-12)14-5-4-13(9-15(14)20)26-19-17-3-2-7-25(17)8-6-22-19/h2-9,11H,1H3
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59n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364300
PNG
(US9856263, 20)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2nccn3cccc23)cc1F
Show InChI InChI=1S/C19H15FN4O/c1-12-18(13(2)23-11-22-12)15-6-5-14(10-16(15)20)25-19-17-4-3-8-24(17)9-7-21-19/h3-11H,1-2H3
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59.3n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364286
PNG
(4-[4-(4, 6-Dimethylpyrimidin-5-yl)-3-methylphenoxy...)
Show SMILES Cc1cc(Oc2nccn3nccc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C19H17N5O/c1-12-10-15(25-19-17-6-7-23-24(17)9-8-20-19)4-5-16(12)18-13(2)21-11-22-14(18)3/h4-11H,1-3H3
KEGG

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61.3n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364290
PNG
(2-(4,6-Dimethylpyrimidin-5-yl)-5-(pyrrolo[1,2-a]py...)
Show SMILES Cc1cnnc(C)c1-c1ccc(Oc2nccn3cccc23)cc1C#N
Show InChI InChI=1S/C20H15N5O/c1-13-12-23-24-14(2)19(13)17-6-5-16(10-15(17)11-21)26-20-18-4-3-8-25(18)9-7-22-20/h3-10,12H,1-2H3
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63.9n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285647
PNG
(5-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]-4,6-dim...)
Show SMILES Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2ncnc3occc23)cc1
Show InChI InChI=1S/C18H14N4O3/c1-10-15(11(2)21-22-16(10)23)12-3-5-13(6-4-12)25-18-14-7-8-24-17(14)19-9-20-18/h3-9H,1-2H3,(H,22,23)
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70.3n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364304
PNG
(US9856263, 24)
Show SMILES COc1cc(Oc2ncnn3cccc23)ccc1-c1cccnc1C
Show InChI InChI=1S/C19H16N4O2/c1-13-15(5-3-9-20-13)16-8-7-14(11-18(16)24-2)25-19-17-6-4-10-23(17)22-12-21-19/h3-12H,1-2H3
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83.9n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364309
PNG
(US9856263, 29)
Show SMILES Cc1ncnc(C)c1-c1cc(F)c(Oc2ncnn3cccc23)cc1F
Show InChI InChI=1S/C18H13F2N5O/c1-10-17(11(2)22-8-21-10)12-6-14(20)16(7-13(12)19)26-18-15-4-3-5-25(15)24-9-23-18/h3-9H,1-2H3
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85.7n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364306
PNG
(US9856263, 26)
Show SMILES Cc1ncnc(C)c1-c1cc(F)c(Oc2nccn3cccc23)cc1F
Show InChI InChI=1S/C19H14F2N4O/c1-11-18(12(2)24-10-23-11)13-8-15(21)17(9-14(13)20)26-19-16-4-3-6-25(16)7-5-22-19/h3-10H,1-2H3
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86.1n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364292
PNG
((-)-1-[4-(3,5-Dimethylpyridazin-4-yl)-3-methylphen...)
Show SMILES Cc1cnnc(C)c1-c1ccc(Oc2nccn3cccc23)cc1C
Show InChI InChI=1S/C20H18N4O/c1-13-11-16(25-20-18-5-4-9-24(18)10-8-21-20)6-7-17(13)19-14(2)12-22-23-15(19)3/h4-12H,1-3H3
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96.3n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364301
PNG
(US9856263, 21)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2nccn3cccc23)cc1
Show InChI InChI=1S/C19H16N4O/c1-13-18(14(2)22-12-21-13)15-5-7-16(8-6-15)24-19-17-4-3-10-23(17)11-9-20-19/h3-12H,1-2H3
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102n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364302
PNG
(US9856263, 22)
Show SMILES Cc1cnnc(C)c1-c1ccc(Oc2ncnn3cccc23)cc1F
Show InChI InChI=1S/C18H14FN5O/c1-11-9-21-23-12(2)17(11)14-6-5-13(8-15(14)19)25-18-16-4-3-7-24(16)22-10-20-18/h3-10H,1-2H3
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105n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364288
PNG
(6-Methyl-5-[2-methyl-4-(pyrazolo[1,5-a]pyrazin-4-y...)
Show SMILES Cc1cc(Oc2nccn3nccc23)ccc1-c1c(C)ncc2nccn12
Show InChI InChI=1S/C20H16N6O/c1-13-11-15(27-20-17-5-6-24-26(17)10-8-22-20)3-4-16(13)19-14(2)23-12-18-21-7-9-25(18)19/h3-12H,1-2H3
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107n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364312
PNG
(US9856263, 32)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2ncnn3cccc23)c(F)c1C
Show InChI InChI=1S/C19H16FN5O/c1-11-14(17-12(2)21-9-22-13(17)3)6-7-16(18(11)20)26-19-15-5-4-8-25(15)24-10-23-19/h4-10H,1-3H3
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116n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285655
PNG
(1-cyclopropyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)p...)
Show SMILES Cc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H16N4O4/c1-11-16(24(13-4-5-13)20(26)23-17(11)25)12-2-6-14(7-3-12)28-19-15-8-9-27-18(15)21-10-22-19/h2-3,6-10,13H,4-5H2,1H3,(H,23,25,26)
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122n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285637
PNG
(6-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H16N4O3/c1-11-8-13(26-19-15-6-7-25-18(15)21-10-22-19)4-5-14(11)17-12(2)20-9-16(24)23(17)3/h4-10H,1-3H3
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127n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364318
PNG
(US9856263, 38)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2ncnn3cccc23)cc1C#N
Show InChI InChI=1S/C19H14N6O/c1-12-18(13(2)22-10-21-12)16-6-5-15(8-14(16)9-20)26-19-17-4-3-7-25(17)24-11-23-19/h3-8,10-11H,1-2H3
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141n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285656
PNG
(1-cyclopropyl-5-ethyl-6-[4-(furo[2,3-d]pyrimidin-4...)
Show SMILES CCc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C21H18N4O4/c1-2-15-17(25(13-5-6-13)21(27)24-18(15)26)12-3-7-14(8-4-12)29-20-16-9-10-28-19(16)22-11-23-20/h3-4,7-11,13H,2,5-6H2,1H3,(H,24,26,27)
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142n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM365624
PNG
(6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]-1,5-dim...)
Show SMILES Cc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C18H14N4O4/c1-10-14(22(2)18(24)21-15(10)23)11-3-5-12(6-4-11)26-17-13-7-8-25-16(13)19-9-20-17/h3-9H,1-2H3,(H,21,23,24)
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142n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285635
PNG
(4-[4-(4,6-Dimethylpyrimidin-5-yl)-3-methylphenoxy]...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncnc1C
Show InChI InChI=1S/C19H16N4O2/c1-11-8-14(25-19-16-6-7-24-18(16)22-10-23-19)4-5-15(11)17-12(2)20-9-21-13(17)3/h4-10H,1-3H3
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166n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364311
PNG
(US9856263, 31)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2nccn3cccc23)c(F)c1C
Show InChI InChI=1S/C20H17FN4O/c1-12-15(18-13(2)23-11-24-14(18)3)6-7-17(19(12)21)26-20-16-5-4-9-25(16)10-8-22-20/h4-11H,1-3H3
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179n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285654
PNG
(1-ethyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]...)
Show SMILES CCn1c(-c2ccc(Oc3ncnc4occc34)cc2)c(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H16N4O4/c1-3-23-15(11(2)16(24)22-19(23)25)12-4-6-13(7-5-12)27-18-14-8-9-26-17(14)20-10-21-18/h4-10H,3H2,1-2H3,(H,22,24,25)
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179n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364297
PNG
(US9856263, 17)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2nccn3nccc23)cc1F
Show InChI InChI=1S/C18H14FN5O/c1-11-17(12(2)22-10-21-11)14-4-3-13(9-15(14)19)25-18-16-5-6-23-24(16)8-7-20-18/h3-10H,1-2H3
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183n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285637
PNG
(6-[4-(furo[2,3-d]pyrimidin-4-yloxy)-2-methylphenyl...)
Show SMILES Cc1cc(Oc2ncnc3occc23)ccc1-c1c(C)ncc(=O)n1C
Show InChI InChI=1S/C19H16N4O3/c1-11-8-13(26-19-15-6-7-25-18(15)21-10-22-19)4-5-14(11)17-12(2)20-9-16(24)23(17)3/h4-10H,1-3H3
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196n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364308
PNG
(US9856263, 28)
Show SMILES Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)nnc2nccn12
Show InChI InChI=1S/C20H16N6O/c1-13-12-15(27-19-17-4-3-9-25(17)10-7-21-19)5-6-16(13)18-14(2)23-24-20-22-8-11-26(18)20/h3-12H,1-2H3
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198n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM364313
PNG
(US9856263, 33)
Show SMILES Cc1ncnc(C)c1-c1ccc(Oc2ncnn3cccc23)c(F)c1
Show InChI InChI=1S/C18H14FN5O/c1-11-17(12(2)21-9-20-11)13-5-6-16(14(19)8-13)25-18-15-4-3-7-24(15)23-10-22-18/h3-10H,1-2H3
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252n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
Frozen cells were quickly thawed, re-suspended in 50 mL warm media and allowed to sit for 5 min prior to centrifugation (1000 rpm) at room temperatur...


US Patent US9856263 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285652
PNG
(5-ethyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phenyl]...)
Show SMILES CCc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(C)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H16N4O4/c1-3-13-15(23(2)19(25)22-16(13)24)11-4-6-12(7-5-11)27-18-14-8-9-26-17(14)20-10-21-18/h4-10H,3H2,1-2H3,(H,22,24,25)
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274n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285649
PNG
(1,5-dimethyl-6-{4-[(3-methyl[1,2]oxazolo[4,5-c]pyr...)
Show SMILES Cc1noc2ccnc(Oc3ccc(cc3)-c3c(C)c(=O)[nH]c(=O)n3C)c12
Show InChI InChI=1S/C19H16N4O4/c1-10-16(23(3)19(25)21-17(10)24)12-4-6-13(7-5-12)26-18-15-11(2)22-27-14(15)8-9-20-18/h4-9H,1-3H3,(H,21,24,25)
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280n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Homo sapiens (Human))
BDBM285657
PNG
(1,5-diethyl-6-[4-(furo[2,3-d]pyrimidin-4-yloxy)phe...)
Show SMILES CCc1c(-c2ccc(Oc3ncnc4occc34)cc2)n(CC)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H18N4O4/c1-3-14-16(24(4-2)20(26)23-17(14)25)12-5-7-13(8-6-12)28-19-15-9-10-27-18(15)21-11-22-19/h5-11H,3-4H2,1-2H3,(H,23,25,26)
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309n/an/an/an/an/an/an/an/a



Pfizer Inc

US Patent


Assay Description
D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...


US Patent US9868744 (2018)

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Ligand-Target Pair
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