BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 12 hits of Enz. Inhib. data with enzyme = 'Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor' and Substrate = 'BDBM21397'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29558
PNG
(1-(m-trifluorophenyl)piperazine, 5)
Show SMILES CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2cccc(c2)C(F)(F)F)C(=O)C1
Show InChI InChI=1S/C22H30F3N3O2/c1-21(2)15-19(29)28(20(30)16-21)9-4-3-8-26-10-12-27(13-11-26)18-7-5-6-17(14-18)22(23,24)25/h5-7,14H,3-4,8-13,15-16H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.34E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29563
PNG
(1-(m-trifluorophenyl)piperazine, 10)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2=C(CCCC2)C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h3-5,16,18-19H,1-2,6-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.64E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29564
PNG
(1-(m-trifluorophenyl)piperazine, 11)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3CC=CCC3C2=O)CC1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)17-6-5-7-18(16-17)28-14-12-27(13-15-28)10-3-4-11-29-21(30)19-8-1-2-9-20(19)22(29)31/h1-2,5-7,16,19-20H,3-4,8-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.72E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29567
PNG
(1-(m-trifluorophenyl)piperazine, 14)
Show SMILES CC1=C(C)C(=O)N(C2CCC(CC2)N2CCN(CC2)c2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C23H28F3N3O2/c1-15-16(2)22(31)29(21(15)30)19-8-6-18(7-9-19)27-10-12-28(13-11-27)20-5-3-4-17(14-20)23(24,25)26/h3-5,14,18-19H,6-13H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.60E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29566
PNG
(1-(m-trifluorophenyl)piperazine, 13)
Show SMILES CC1=C(C)C(=O)N(CCCCN2CCN(CC2)c2cccc(c2)C(F)(F)F)C1=O
Show InChI InChI=1S/C21H26F3N3O2/c1-15-16(2)20(29)27(19(15)28)9-4-3-8-25-10-12-26(13-11-25)18-7-5-6-17(14-18)21(22,23)24/h5-7,14H,3-4,8-13H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.37E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29565
PNG
(1-(m-trifluorophenyl)piperazine, 12)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)C2CC=CCC2C1=O
Show InChI InChI=1S/C25H30F3N3O2/c26-25(27,28)17-4-3-5-20(16-17)30-14-12-29(13-15-30)18-8-10-19(11-9-18)31-23(32)21-6-1-2-7-22(21)24(31)33/h1-5,16,18-19,21-22H,6-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.68E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29562
PNG
(1-(m-trifluorophenyl)piperazine, 9)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)C3=C(CCCC3)C2=O)CC1
Show InChI InChI=1S/C23H28F3N3O2/c24-23(25,26)17-6-5-7-18(16-17)28-14-12-27(13-15-28)10-3-4-11-29-21(30)19-8-1-2-9-20(19)22(29)31/h5-7,16H,1-4,8-15H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29560
PNG
(1-(m-trifluorophenyl)piperazine, 7)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)CCCC2=O)CC1
Show InChI InChI=1S/C20H26F3N3O2/c21-20(22,23)16-5-3-6-17(15-16)25-13-11-24(12-14-25)9-1-2-10-26-18(27)7-4-8-19(26)28/h3,5-6,15H,1-2,4,7-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29561
PNG
(1-(m-trifluorophenyl)piperazine, 8)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)CCCC1=O
Show InChI InChI=1S/C22H28F3N3O2/c23-22(24,25)16-3-1-4-19(15-16)27-13-11-26(12-14-27)17-7-9-18(10-8-17)28-20(29)5-2-6-21(28)30/h1,3-4,15,17-18H,2,5-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29559
PNG
(1-(m-trifluorophenyl)piperazine, 6)
Show SMILES CC1(C)CC(=O)N(C2CCC(CC2)N2CCN(CC2)c2cccc(c2)C(F)(F)F)C(=O)C1
Show InChI InChI=1S/C24H32F3N3O2/c1-23(2)15-21(31)30(22(32)16-23)19-8-6-18(7-9-19)28-10-12-29(13-11-28)20-5-3-4-17(14-20)24(25,26)27/h3-5,14,18-19H,6-13,15-16H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29557
PNG
(1-(m-trifluorophenyl)piperazine, 4)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)CCC1=O
Show InChI InChI=1S/C21H26F3N3O2/c22-21(23,24)15-2-1-3-18(14-15)26-12-10-25(11-13-26)16-4-6-17(7-5-16)27-19(28)8-9-20(27)29/h1-3,14,16-17H,4-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>2.50E+4n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM29556
PNG
(1-(m-trifluorophenyl)piperazine, 3)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCN2C(=O)CCC2=O)CC1
Show InChI InChI=1S/C19H24F3N3O2/c20-19(21,22)15-4-3-5-16(14-15)24-12-10-23(11-13-24)8-1-2-9-25-17(26)6-7-18(25)27/h3-5,14H,1-2,6-13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>3.00E+4n/an/an/an/an/an/an/an/a



Polish Academy of Science



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...


Bioorg Med Chem 15: 7116-25 (2007)


Article DOI: 10.1016/j.bmc.2007.07.029
BindingDB Entry DOI: 10.7270/Q2G15Z6G
More data for this
Ligand-Target Pair