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Compile Data Set for Download or QSAR

Found 402 hits of Enz. Inhib. data with enzyme = 'Dopamine receptor D2L/neurotensin receptor NTS1' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382178
PNG
(US10273244, Example 10)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2cccc(c2)C#N)n1C
Show InChI InChI=1S/C23H27N7OS/c1-16-21(31-15-25-16)22-26-27-23(28(22)2)32-10-4-8-29-13-18-7-9-30(20(18)14-29)19-6-3-5-17(11-19)12-24/h3,5-6,11,15,18,20H,4,7-10,13-14H2,1-2H3/t18-,20+/m0/s1
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2.19n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154891
PNG
(CHEMBL3775872 | US10273244, Example 25)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)n1C
Show InChI InChI=1/C23H27F3N6O2S/c1-15-20(33-14-27-15)21-28-29-22(30(21)2)35-11-5-9-31-12-16-8-10-32(18(16)13-31)17-6-3-4-7-19(17)34-23(24,25)26/h3-4,6-7,14,16,18H,5,8-13H2,1-2H3
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4.37n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM372039
PNG
(US10239870, Example 312)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CCC[C@]3(C[C@H]3c3ccc(cc3)C(F)(F)F)C2)n1C
Show InChI InChI=1/C24H28F3N5OS/c1-16-20(33-15-28-16)21-29-30-22(31(21)2)34-12-4-11-32-10-3-9-23(14-32)13-19(23)17-5-7-18(8-6-17)24(25,26)27/h5-8,15,19H,3-4,9-14H2,1-2H3/t19-,23-/s2
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5.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154895
PNG
(CHEMBL3775534 | US10273244, Example 7)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cccc(c2)C#N)n1C
Show InChI InChI=1/C23H27N7OS/c1-16-21(31-15-25-16)22-26-27-23(28(22)2)32-10-4-8-29-13-18-7-9-30(20(18)14-29)19-6-3-5-17(11-19)12-24/h3,5-6,11,15,18,20H,4,7-10,13-14H2,1-2H3
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5.75n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154894
PNG
(CHEMBL3775338 | US10273244, Example 28)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cc(Cl)cc(Cl)c2)n1C
Show InChI InChI=1/C22H26Cl2N6OS/c1-14-20(31-13-25-14)21-26-27-22(28(21)2)32-7-3-5-29-11-15-4-6-30(19(15)12-29)18-9-16(23)8-17(24)10-18/h8-10,13,15,19H,3-7,11-12H2,1-2H3
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10.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154877
PNG
(CHEMBL3774621 | US10273244, Example 96)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7OS/c1-31-21(17-13-27-8-9-28-17)29-30-22(31)35-12-4-10-32-14-16-7-11-33(19(16)15-32)18-5-2-3-6-20(18)34-23(24,25)26/h2-3,5-6,8-9,13,16,19H,4,7,10-12,14-15H2,1H3
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11.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM372038
PNG
(US10239870, Example 310)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CCC[C@@]3(C[C@@H]3c3ccc(cc3)C(F)(F)F)C2)n1C
Show InChI InChI=1/C24H28F3N5OS/c1-16-20(33-15-28-16)21-29-30-22(31(21)2)34-12-4-11-32-10-3-9-23(14-32)13-19(23)17-5-7-18(8-6-17)24(25,26)27/h5-8,15,19H,3-4,9-14H2,1-2H3/t19-,23-/s2
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19.1n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154891
PNG
(CHEMBL3775872 | US10273244, Example 25)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)n1C
Show InChI InChI=1/C23H27F3N6O2S/c1-15-20(33-14-27-15)21-28-29-22(30(21)2)35-11-5-9-31-12-16-8-10-32(18(16)13-31)17-6-3-4-7-19(17)34-23(24,25)26/h3-4,6-7,14,16,18H,5,8-13H2,1-2H3
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20.4n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM301790
PNG
( N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)N3CCN(CC3)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C25H33Cl2N5O/c26-22-9-6-10-23(24(22)27)31-15-13-29(14-16-31)12-5-4-11-28-25(33)32-19-17-30(18-20-32)21-7-2-1-3-8-21/h1-3,6-10H,4-5,11-20H2,(H,28,33)
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21n/an/an/an/an/an/an/an/a



Southern Research Institute

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50192248
PNG
(CHEMBL3927895 | US10239870, Example 30)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(cc3F)C(F)(F)F)C2)n1C
Show InChI InChI=1/C23H25F4N5OS/c1-14-19(33-13-28-14)20-29-30-21(31(20)2)34-9-3-7-32-8-6-22(12-32)11-17(22)16-5-4-15(10-18(16)24)23(25,26)27/h4-5,10,13,17H,3,6-9,11-12H2,1-2H3/t17-,22+/s2
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25.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382178
PNG
(US10273244, Example 10)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2cccc(c2)C#N)n1C
Show InChI InChI=1S/C23H27N7OS/c1-16-21(31-15-25-16)22-26-27-23(28(22)2)32-10-4-8-29-13-18-7-9-30(20(18)14-29)19-6-3-5-17(11-19)12-24/h3,5-6,11,15,18,20H,4,7-10,13-14H2,1-2H3/t18-,20+/m0/s1
PDB

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33.9n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154890
PNG
(CHEMBL3774425 | US10273244, Example 113)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(c2)C(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7S/c1-31-21(19-13-27-7-8-28-19)29-30-22(31)34-11-3-9-32-14-16-6-10-33(20(16)15-32)18-5-2-4-17(12-18)23(24,25)26/h2,4-5,7-8,12-13,16,20H,3,6,9-11,14-15H2,1H3
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34.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154877
PNG
(CHEMBL3774621 | US10273244, Example 96)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccccc2OC(F)(F)F)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7OS/c1-31-21(17-13-27-8-9-28-17)29-30-22(31)35-12-4-10-32-14-16-7-11-33(19(16)15-32)18-5-2-3-6-20(18)34-23(24,25)26/h2-3,5-6,8-9,13,16,19H,4,7,10-12,14-15H2,1H3
PDB

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34.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382301
PNG
(US10273244, Example 178)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(c2)C(F)(F)F)nnc1-c1ccc(=O)[nH]c1
Show InChI InChI=1/C24H27F3N6OS/c1-31-22(16-6-7-21(34)28-13-16)29-30-23(31)35-11-3-9-32-14-17-8-10-33(20(17)15-32)19-5-2-4-18(12-19)24(25,26)27/h2,4-7,12-13,17,20H,3,8-11,14-15H2,1H3,(H,28,34)
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37.2n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382270
PNG
(US10273244, Example 139)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1ccncn1
Show InChI InChI=1S/C22H26FN7S/c1-28-21(19-7-9-24-15-25-19)26-27-22(28)31-12-2-10-29-13-16-8-11-30(20(16)14-29)18-5-3-17(23)4-6-18/h3-7,9,15-16,20H,2,8,10-14H2,1H3
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38.9n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371894
PNG
(US10239870, Example 118)
Show SMILES Cn1c(SCCCN2CC[C@]3(C[C@@H]3c3ccc(cc3)C(F)(F)F)C2)nnc1N1CCOCC1
Show InChI InChI=1/C23H30F3N5OS/c1-29-20(31-10-12-32-13-11-31)27-28-21(29)33-14-2-8-30-9-7-22(16-30)15-19(22)17-3-5-18(6-4-17)23(24,25)26/h3-6,19H,2,7-16H2,1H3/t19-,22+/s2
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41.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382217
PNG
(US10273244, Example 64)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(F)cc2)nnc1C1CCCCC1
Show InChI InChI=1S/C24H34FN5S/c1-28-23(18-6-3-2-4-7-18)26-27-24(28)31-15-5-13-29-16-19-12-14-30(22(19)17-29)21-10-8-20(25)9-11-21/h8-11,18-19,22H,2-7,12-17H2,1H3/t19-,22+/m0/s1
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43.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382188
PNG
(US10273244, Example 23)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(F)cc2)n1C
Show InChI InChI=1S/C22H27FN6OS/c1-15-20(30-14-24-15)21-25-26-22(27(21)2)31-11-3-9-28-12-16-8-10-29(19(16)13-28)18-6-4-17(23)5-7-18/h4-7,14,16,19H,3,8-13H2,1-2H3/t16-,19+/m1/s1
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45.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154875
PNG
(CHEMBL3775667 | US10273244, Example 94)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(c2)C#N)nnc1-c1cnccn1
Show InChI InChI=1/C23H26N8S/c1-29-22(20-14-25-7-8-26-20)27-28-23(29)32-11-3-9-30-15-18-6-10-31(21(18)16-30)19-5-2-4-17(12-19)13-24/h2,4-5,7-8,12,14,18,21H,3,6,9-11,15-16H2,1H3
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47.9n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382186
PNG
(US10273244, Example 21)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2F)C(F)(F)F)n1C
Show InChI InChI=1S/C23H26F4N6OS/c1-14-20(34-13-28-14)21-29-30-22(31(21)2)35-9-3-7-32-11-15-6-8-33(19(15)12-32)18-5-4-16(10-17(18)24)23(25,26)27/h4-5,10,13,15,19H,3,6-9,11-12H2,1-2H3/t15-,19+/m1/s1
PDB

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53.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382175
PNG
(US10273244, Example 6)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)n1C
Show InChI InChI=1S/C23H27F3N6OS/c1-15-20(33-14-27-15)21-28-29-22(30(21)2)34-11-3-9-31-12-16-8-10-32(19(16)13-31)18-6-4-17(5-7-18)23(24,25)26/h4-7,14,16,19H,3,8-13H2,1-2H3/t16-,19+/m1/s1
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53.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382227
PNG
(US10273244, Example 80)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nc2ccccc12
Show InChI InChI=1S/C24H27F3N4S/c1-29-21-6-3-2-5-20(21)28-23(29)32-14-4-12-30-15-17-11-13-31(22(17)16-30)19-9-7-18(8-10-19)24(25,26)27/h2-3,5-10,17,22H,4,11-16H2,1H3
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57.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50192239
PNG
(CHEMBL3922143 | US10239870, Example 48)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(F)cc3)C2)n1C
Show InChI InChI=1/C22H26FN5OS/c1-15-19(29-14-24-15)20-25-26-21(27(20)2)30-11-3-9-28-10-8-22(13-28)12-18(22)16-4-6-17(23)7-5-16/h4-7,14,18H,3,8-13H2,1-2H3/t18-,22+/s2
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57.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154902
PNG
(CHEMBL3774540 | US10273244, Example 2)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)n1C
Show InChI InChI=1/C23H27F3N6OS/c1-15-20(33-14-27-15)21-28-29-22(30(21)2)34-11-3-9-31-12-16-8-10-32(19(16)13-31)18-6-4-17(5-7-18)23(24,25)26/h4-7,14,16,19H,3,8-13H2,1-2H3
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58.9n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM301890
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCC(CC2)N2CCCCC2)CC1
Show InChI InChI=1S/C28H46F3N7O/c1-27(2,3)25-33-23(28(29,30)31)21-24(34-25)37-19-17-35(18-20-37)12-8-5-11-32-26(39)38-15-9-22(10-16-38)36-13-6-4-7-14-36/h21-22H,4-20H2,1-3H3,(H,32,39)
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59.3n/an/an/an/an/an/an/an/a



Southern Research Institute

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382186
PNG
(US10273244, Example 21)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCN([C@H]3C2)c2ccc(cc2F)C(F)(F)F)n1C
Show InChI InChI=1S/C23H26F4N6OS/c1-14-20(34-13-28-14)21-29-30-22(31(21)2)35-9-3-7-32-11-15-6-8-33(19(15)12-32)18-5-4-16(10-17(18)24)23(25,26)27/h4-5,10,13,15,19H,3,6-9,11-12H2,1-2H3/t15-,19+/m1/s1
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61.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154900
PNG
(CHEMBL3775005 | US10273244, Example 30)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2cccc(F)c2)n1C
Show InChI InChI=1/C22H27FN6OS/c1-15-20(30-14-24-15)21-25-26-22(27(21)2)31-10-4-8-28-12-16-7-9-29(19(16)13-28)18-6-3-5-17(23)11-18/h3,5-6,11,14,16,19H,4,7-10,12-13H2,1-2H3
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63.1n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50192029
PNG
(CHEMBL3917887 | US10239870, Example 39)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(F)cc3F)C2)n1C
Show InChI InChI=1/C22H25F2N5OS/c1-14-19(30-13-25-14)20-26-27-21(28(20)2)31-9-3-7-29-8-6-22(12-29)11-17(22)16-5-4-15(23)10-18(16)24/h4-5,10,13,17H,3,6-9,11-12H2,1-2H3/t17-,22+/s2
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66.1n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371834
PNG
(US10239870, Example 21 | US10239870, Example 26)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(CC3c3ccc(cc3F)C(F)(F)F)C2)n1C
Show InChI InChI=1/C23H25F4N5OS/c1-14-19(33-13-28-14)20-29-30-21(31(20)2)34-9-3-7-32-8-6-22(12-32)11-17(22)16-5-4-15(10-18(16)24)23(25,26)27/h4-5,10,13,17H,3,6-9,11-12H2,1-2H3/t17?,22-/s2
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70.8n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50192454
PNG
(CHEMBL3911264 | US10239870, Example 12)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@@]3(C[C@H]3c3ccc(cc3)C(F)(F)F)C2)n1C
Show InChI InChI=1/C23H26F3N5OS/c1-15-19(32-14-27-15)20-28-29-21(30(20)2)33-11-3-9-31-10-8-22(13-31)12-18(22)16-4-6-17(7-5-16)23(24,25)26/h4-7,14,18H,3,8-13H2,1-2H3/t18-,22+/s2
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74.1n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371969
PNG
(US10239870, Example 213)
Show SMILES Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3F)C(F)(F)F)C2)nnc1-c1ccncn1
Show InChI InChI=1/C23H24F4N6S/c1-32-20(19-5-7-28-14-29-19)30-31-21(32)34-10-2-8-33-9-6-22(13-33)12-17(22)16-4-3-15(11-18(16)24)23(25,26)27/h3-5,7,11,14,17H,2,6,8-10,12-13H2,1H3/t17?,22-/s2
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81.3n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371975
PNG
(US10239870, Example 221)
Show SMILES Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3F)C(F)(F)F)C2)nnc1-c1cnccn1
Show InChI InChI=1/C23H24F4N6S/c1-32-20(19-13-28-6-7-29-19)30-31-21(32)34-10-2-8-33-9-5-22(14-33)12-17(22)16-4-3-15(11-18(16)24)23(25,26)27/h3-4,6-7,11,13,17H,2,5,8-10,12,14H2,1H3/t17?,22-/s2
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87.1n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382229
PNG
(US10273244, Example 84)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1N1CCOCC1
Show InChI InChI=1S/C23H31F3N6OS/c1-29-21(31-10-12-33-13-11-31)27-28-22(29)34-14-2-8-30-15-17-7-9-32(20(17)16-30)19-5-3-18(4-6-19)23(24,25)26/h3-6,17,20H,2,7-16H2,1H3/t17-,20+/m0/s1
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89.1n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154843
PNG
(CHEMBL3775226 | US10273244, Example 17)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccc(cc2F)C(F)(F)F)n1C
Show InChI InChI=1/C23H26F4N6OS/c1-14-20(34-13-28-14)21-29-30-22(31(21)2)35-9-3-7-32-11-15-6-8-33(19(15)12-32)18-5-4-16(10-17(18)24)23(25,26)27/h4-5,10,13,15,19H,3,6-9,11-12H2,1-2H3
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91.2n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154878
PNG
(CHEMBL3774895 | US10273244, Example 114)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2cccc(OC(F)(F)F)c2)nnc1-c1cnccn1
Show InChI InChI=1/C23H26F3N7OS/c1-31-21(19-13-27-7-8-28-19)29-30-22(31)35-11-3-9-32-14-16-6-10-33(20(16)15-32)17-4-2-5-18(12-17)34-23(24,25)26/h2,4-5,7-8,12-13,16,20H,3,6,9-11,14-15H2,1H3
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95.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50192310
PNG
(CHEMBL3954568 | US10239870, Example 2)
Show SMILES Cc1ncoc1-c1nnc(SCCN2CC[C@]3(C[C@H]3c3ccc(cc3)C(F)(F)F)C2)n1C
Show InChI InChI=1/C22H24F3N5OS/c1-14-18(31-13-26-14)19-27-28-20(29(19)2)32-10-9-30-8-7-21(12-30)11-17(21)15-3-5-16(6-4-15)22(23,24)25/h3-6,13,17H,7-12H2,1-2H3/t17-,21-/s2
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95.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371840
PNG
(US10239870, Example 31 | US10239870, Example 34 | ...)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(CC3c3ccc(F)cc3F)C2)n1C
Show InChI InChI=1/C22H25F2N5OS/c1-14-19(30-13-25-14)20-26-27-21(28(20)2)31-9-3-7-29-8-6-22(12-29)11-17(22)16-5-4-15(23)10-18(16)24/h4-5,10,13,17H,3,6-9,11-12H2,1-2H3/t17?,22-/s2
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95.5n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM301845
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccncc2)CC1
Show InChI InChI=1S/C27H39F3N8O/c1-26(2,3)24-33-22(27(28,29)30)20-23(34-24)37-14-12-35(13-15-37)11-5-4-8-32-25(39)38-18-16-36(17-19-38)21-6-9-31-10-7-21/h6-7,9-10,20H,4-5,8,11-19H2,1-3H3,(H,32,39)
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97.4n/an/an/an/an/an/an/an/a



Southern Research Institute

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50192243
PNG
(CHEMBL3978613 | US10239870, Example 234)
Show SMILES Cc1cc(on1)-c1nnc(SCCCN2CC[C@]3(C[C@@H]3c3ccc(cc3)C(F)(F)F)C2)n1C
Show InChI InChI=1/C23H26F3N5OS/c1-15-12-19(32-29-15)20-27-28-21(30(20)2)33-11-3-9-31-10-8-22(14-31)13-18(22)16-4-6-17(7-5-16)23(24,25)26/h4-7,12,18H,3,8-11,13-14H2,1-2H3/t18-,22+/s2
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97.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382343
PNG
(US10273244, Example 233)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@H]3CCCN([C@H]3C2)c2ccc(cc2)C(F)(F)F)n1C
Show InChI InChI=1S/C24H29F3N6OS/c1-16-21(34-15-28-16)22-29-30-23(31(22)2)35-12-4-10-32-13-17-5-3-11-33(20(17)14-32)19-8-6-18(7-9-19)24(25,26)27/h6-9,15,17,20H,3-5,10-14H2,1-2H3/t17-,20+/m1/s1
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97.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371892
PNG
(US10239870, Example 114 | US10239870, Example 115)
Show SMILES Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3)C(F)(F)F)C2)nnc1N1CCOCC1
Show InChI InChI=1/C23H30F3N5OS/c1-29-20(31-10-12-32-13-11-31)27-28-21(29)33-14-2-8-30-9-7-22(16-30)15-19(22)17-3-5-18(6-4-17)23(24,25)26/h3-6,19H,2,7-16H2,1H3/t19?,22-/s2
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US Patent
97.7n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM301861
PNG
(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)N3CCC(CC3)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C26H34Cl2N4O/c27-23-9-6-10-24(25(23)28)31-19-17-30(18-20-31)14-5-4-13-29-26(33)32-15-11-22(12-16-32)21-7-2-1-3-8-21/h1-3,6-10,22H,4-5,11-20H2,(H,29,33)
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US Patent
102n/an/an/an/an/an/an/an/a



Southern Research Institute

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154888
PNG
(CHEMBL3774996 | US10273244, Example 95)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)nnc1-c1cnccn1
Show InChI InChI=1/C22H26FN7S/c1-28-21(19-13-24-8-9-25-19)26-27-22(28)31-12-2-10-29-14-16-7-11-30(20(16)15-29)18-5-3-17(23)4-6-18/h3-6,8-9,13,16,20H,2,7,10-12,14-15H2,1H3
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US Patent
105n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371967
PNG
(US10239870, Example 211)
Show SMILES Cn1c(SCCCN2CC[C@@]3(C[C@@H]3c3ccc(cc3)C(F)(F)F)C2)nnc1-c1ccncn1
Show InChI InChI=1/C23H25F3N6S/c1-31-20(19-7-9-27-15-28-19)29-30-21(31)33-12-2-10-32-11-8-22(14-32)13-18(22)16-3-5-17(6-4-16)23(24,25)26/h3-7,9,15,18H,2,8,10-14H2,1H3/t18-,22-/s2
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107n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371914
PNG
(US10239870, Example 140 | US10239870, Example 141)
Show SMILES Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3)C(F)(F)F)C2)nnc1-c1ccccn1
Show InChI InChI=1/C24H26F3N5S/c1-31-21(20-5-2-3-11-28-20)29-30-22(31)33-14-4-12-32-13-10-23(16-32)15-19(23)17-6-8-18(9-7-17)24(25,26)27/h2-3,5-9,11,19H,4,10,12-16H2,1H3/t19?,23-/s2
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US Patent
107n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154867
PNG
(CHEMBL3775810 | US10273244, Example 134)
Show SMILES Cn1c(SCCCN2CC3CCN(C3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncn1
Show InChI InChI=1/C23H26F3N7S/c1-31-21(19-7-9-27-15-28-19)29-30-22(31)34-12-2-10-32-13-16-8-11-33(20(16)14-32)18-5-3-17(4-6-18)23(24,25)26/h3-7,9,15-16,20H,2,8,10-14H2,1H3
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US Patent
112n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50154850
PNG
(CHEMBL3774588 | US10273244, Example 22)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC3CCN(C3C2)c2ccc(F)cc2)n1C
Show InChI InChI=1/C22H27FN6OS/c1-15-20(30-14-24-15)21-25-26-22(27(21)2)31-11-3-9-28-12-16-8-10-29(19(16)13-28)18-6-4-17(23)5-7-18/h4-7,14,16,19H,3,8-13H2,1-2H3
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US Patent
115n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM382268
PNG
(US10273244, Example 137)
Show SMILES Cn1c(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)nnc1-c1ccncn1
Show InChI InChI=1S/C23H26F3N7S/c1-31-21(19-7-9-27-15-28-19)29-30-22(31)34-12-2-10-32-13-16-8-11-33(20(16)14-32)18-5-3-17(4-6-18)23(24,25)26/h3-7,9,15-16,20H,2,8,10-14H2,1H3/t16-,20+/m0/s1
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117n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...


US Patent US10273244 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371845
PNG
(US10239870, Example 40 | US10239870, Example 43 | ...)
Show SMILES Cc1ncoc1-c1nnc(SCCCN2CC[C@]3(CC3c3ccc(F)cc3)C2)n1C
Show InChI InChI=1/C22H26FN5OS/c1-15-19(29-14-24-15)20-25-26-21(27(20)2)30-11-3-9-28-10-8-22(13-28)12-18(22)16-4-6-17(23)7-5-16/h4-7,14,18H,3,8-13H2,1-2H3/t18?,22-/s2
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US Patent
117n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM371965
PNG
(US10239870, Example 207 | US10239870, Example 212)
Show SMILES Cn1c(SCCCN2CC[C@]3(CC3c3ccc(cc3)C(F)(F)F)C2)nnc1-c1ccncn1
Show InChI InChI=1/C23H25F3N6S/c1-31-20(19-7-9-27-15-28-19)29-30-21(31)33-12-2-10-32-11-8-22(14-32)13-18(22)16-3-5-17(6-4-16)23(24,25)26/h3-7,9,15,18H,2,8,10-14H2,1H3/t18?,22-/s2
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117n/an/an/an/an/an/an/an/a



Indivior UK Limited

US Patent


Assay Description
CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...


US Patent US10239870 (2019)

More data for this
Ligand-Target Pair
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