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Compile Data Set for Download or QSAR

Found 2 hits of Enz. Inhib. data with enzyme = 'E3 ubiquitin-protein ligase Mdm2' and Substrate = 'CREB-binding protein/p53'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31272
PNG
(NSC 333003 | NSC-333003)
Show SMILES c1ccc(cc1)C(N=Nc1nc2ccccc2s1)c1ccccn1
Show InChI InChI=1S/C19H14N4S/c1-2-8-14(9-3-1)18(16-11-6-7-13-20-16)22-23-19-21-15-10-4-5-12-17(15)24-19/h1-13,18H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/a7.424



H. Lee Moffitt Cancer Center



Assay Description
When two proteins interact (one of which is conjugated to the donor bead and the other to the acceptor bead) the beads are brought into close proximi...


Bioorg Med Chem Lett 19: 3756-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.124
BindingDB Entry DOI: 10.7270/Q2MC8XC4
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31284
PNG
(CHEMBL361676 | NSC 279287)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(cc1)N=Nc1c(O)n(-c2ccccc2)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C31H27N5O6S/c1-21(2)42-26-17-13-22(14-18-26)29(37)34-43(40,41)27-19-15-23(16-20-27)32-33-28-30(38)35(24-9-5-3-6-10-24)36(31(28)39)25-11-7-4-8-12-25/h3-21,38H,1-2H3,(H,34,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.18E+4n/an/an/an/a7.637



Virginia Commonwealth University



Assay Description
ELISA plates were coated with equivalent amounts of either glutathione S-transferase (GST) protein or GST-MDM2 (1-188) fusion protein and incubated o...


J Med Chem 47: 4163-5 (2004)


Article DOI: 10.1021/jm034182u
BindingDB Entry DOI: 10.7270/Q2BZ64DP
More data for this
Ligand-Target Pair