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Found 55 hits of Enz. Inhib. data with enzyme = 'E3 ubiquitin-protein ligase Mdm2' and Substrate = 'Fl 9mer'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31288
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 2 | BMCL163...)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C28H26Cl2IN3O4/c1-16(21-11-9-19(30)14-23(21)32)34-26(17-5-7-18(29)8-6-17)28(38)33(13-3-2-4-25(35)36)24-12-10-20(31)15-22(24)27(34)37/h5-12,14-16,26H,2-4,13,32H2,1H3,(H,35,36)/t16-,26+/m1/s1
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n/an/a 250n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31288
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 2 | BMCL163...)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C28H26Cl2IN3O4/c1-16(21-11-9-19(30)14-23(21)32)34-26(17-5-7-18(29)8-6-17)28(38)33(13-3-2-4-25(35)36)24-12-10-20(31)15-22(24)27(34)37/h5-12,14-16,26H,2-4,13,32H2,1H3,(H,35,36)/t16-,26+/m1/s1
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n/an/a 250n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31293
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 22 | BMCL16...)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C29H29Cl2IN4O3/c1-18(23-8-6-21(31)16-25(23)33)36-27(19-2-4-20(30)5-3-19)29(38)35(11-10-34-12-14-39-15-13-34)26-9-7-22(32)17-24(26)28(36)37/h2-9,16-18,27H,10-15,33H2,1H3/t18-,27+/m1/s1
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n/an/a 367n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31289
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 21 | BMCL16...)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N([C@H](C)c2ccc(Cl)cc2N)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H28Cl2IN3O4/c1-17(22-9-7-20(30)15-24(22)32)34-26(18-3-5-19(29)6-4-18)28(36)33(11-12-38-14-13-37-2)25-10-8-21(31)16-23(25)27(34)35/h3-10,15-17,26H,11-14,32H2,1-2H3/t17-,26+/m1/s1
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n/an/a 394n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31285
PNG
(BMCL163310 Compound 1 | CHEMBL361103 | benzodiazep...)
Show SMILES OC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)Nc2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H15Cl2IN2O4/c24-14-5-1-12(2-6-14)19-21(29)27-18-10-9-16(26)11-17(18)22(30)28(19)20(23(31)32)13-3-7-15(25)8-4-13/h1-11,19-20H,(H,27,29)(H,31,32)/t19-,20-/m0/s1
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Article
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n/an/a 420n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31328
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 13 | Race...)
Show SMILES OC(=O)CCCCN1c2ccc(I)cc2C(=O)N([C@H](C(O)=O)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H23Cl2IN2O6/c29-18-8-4-16(5-9-18)24-27(37)32(14-2-1-3-23(34)35)22-13-12-20(31)15-21(22)26(36)33(24)25(28(38)39)17-6-10-19(30)11-7-17/h4-13,15,24-25H,1-3,14H2,(H,34,35)(H,38,39)/t24-,25-/m0/s1
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n/an/a 510n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31318
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 2 | Racem...)
Show SMILES OC(=O)C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)Nc2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H17Cl2IN2O4/c25-15-5-1-13(2-6-15)20(12-21(30)31)29-22(14-3-7-16(26)8-4-14)23(32)28-19-10-9-17(27)11-18(19)24(29)33/h1-11,20,22H,12H2,(H,28,32)(H,30,31)/t20-,22+/m1/s1
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n/an/a 540n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31314
PNG
(1,4-benzodiazepine-2,5-dione, 12k)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCN2CCN(C)CC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C31H34Cl2IN5O2/c1-20(25-10-8-23(33)18-27(25)35)39-29(21-4-6-22(32)7-5-21)31(41)38(13-3-12-37-16-14-36(2)15-17-37)28-11-9-24(34)19-26(28)30(39)40/h4-11,18-20,29H,3,12-17,35H2,1-2H3/t20-,29+/m1/s1
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n/an/a 546n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31305
PNG
(1,4-benzodiazepine-2,5-dione, 12b | BMCL163310 Com...)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H25Cl2IN2O4/c1-17(18-5-9-20(29)10-6-18)33-26(19-7-11-21(30)12-8-19)28(37)32(15-3-2-4-25(34)35)24-14-13-22(31)16-23(24)27(33)36/h5-14,16-17,26H,2-4,15H2,1H3,(H,34,35)/t17-,26+/m1/s1
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n/an/a 700n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31289
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 21 | BMCL16...)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N([C@H](C)c2ccc(Cl)cc2N)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H28Cl2IN3O4/c1-17(22-9-7-20(30)15-24(22)32)34-26(18-3-5-19(29)6-4-18)28(36)33(11-12-38-14-13-37-2)25-10-8-21(31)16-23(25)27(34)35/h3-10,15-17,26H,11-14,32H2,1-2H3/t17-,26+/m1/s1
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n/an/a 700n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31338
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 23)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(cc2C1=O)C#C)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H26Cl2N2O4/c1-3-20-7-16-26-25(18-20)29(37)34(19(2)21-8-12-23(31)13-9-21)28(22-10-14-24(32)15-11-22)30(38)33(26)17-5-4-6-27(35)36/h1,7-16,18-19,28H,4-6,17H2,2H3,(H,35,36)/t19-,28+/m1/s1
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n/an/a 710n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31313
PNG
(1,4-benzodiazepine-2,5-dione, 12j)
Show SMILES CC#Cc1ccc2N(CCN3CCOCC3)C(=O)[C@@H](N([C@H](C)c3ccc(Cl)cc3N)C(=O)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H32Cl2N4O3/c1-3-4-22-5-12-29-27(19-22)31(39)38(21(2)26-11-10-25(34)20-28(26)35)30(23-6-8-24(33)9-7-23)32(40)37(29)14-13-36-15-17-41-18-16-36/h5-12,19-21,30H,13-18,35H2,1-2H3/t21-,30+/m1/s1
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n/an/a 787n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31293
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 22 | BMCL16...)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C29H29Cl2IN4O3/c1-18(23-8-6-21(31)16-25(23)33)36-27(19-2-4-20(30)5-3-19)29(38)35(11-10-34-12-14-39-15-13-34)26-9-7-22(32)17-24(26)28(36)37/h2-9,16-18,27H,10-15,33H2,1H3/t18-,27+/m1/s1
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n/an/a 790n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31287
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 52)
Show SMILES Nc1cc(Cl)ccc1CN1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O
Show InChI InChI=1S/C27H24Cl2IN3O4/c28-18-7-4-16(5-8-18)25-27(37)32(12-2-1-3-24(34)35)23-11-10-20(30)14-21(23)26(36)33(25)15-17-6-9-19(29)13-22(17)31/h4-11,13-14,25H,1-3,12,15,31H2,(H,34,35)/t25-/m0/s1
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n/an/a 810n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31320
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 4 | Racem...)
Show SMILES OC(=O)CCNC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)Nc2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H20Cl2IN3O5/c27-16-5-1-14(2-6-16)22(24(35)30-12-11-21(33)34)32-23(15-3-7-17(28)8-4-15)25(36)31-20-10-9-18(29)13-19(20)26(32)37/h1-10,13,22-23H,11-12H2,(H,30,35)(H,31,36)(H,33,34)/t22-,23-/m0/s1
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n/an/a 850n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31305
PNG
(1,4-benzodiazepine-2,5-dione, 12b | BMCL163310 Com...)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H25Cl2IN2O4/c1-17(18-5-9-20(29)10-6-18)33-26(19-7-11-21(30)12-8-19)28(37)32(15-3-2-4-25(34)35)24-14-13-22(31)16-23(24)27(33)36/h5-14,16-17,26H,2-4,15H2,1H3,(H,34,35)/t17-,26+/m1/s1
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n/an/a 856n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31321
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 5 | Racem...)
Show SMILES OC(=O)CCCCNC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)Nc2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H24Cl2IN3O5/c29-18-8-4-16(5-9-18)24(26(37)32-14-2-1-3-23(35)36)34-25(17-6-10-19(30)11-7-17)27(38)33-22-13-12-20(31)15-21(22)28(34)39/h4-13,15,24-25H,1-3,14H2,(H,32,37)(H,33,38)(H,35,36)/t24-,25-/m0/s1
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n/an/a 870n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31336
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 21)
Show SMILES C[C@@H](N1[C@@H](c2ccc(cc2)C(F)(F)F)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25ClF3IN2O4/c1-17(18-7-11-21(30)12-8-18)36-26(19-5-9-20(10-6-19)29(31,32)33)28(40)35(15-3-2-4-25(37)38)24-14-13-22(34)16-23(24)27(36)39/h5-14,16-17,26H,2-4,15H2,1H3,(H,37,38)/t17-,26+/m1/s1
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n/an/a 980n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31337
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 22)
Show SMILES C[C@@H](N1[C@@H](c2ccc(OC(F)(F)F)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25ClF3IN2O5/c1-17(18-5-9-20(30)10-6-18)36-26(19-7-12-22(13-8-19)41-29(31,32)33)28(40)35(15-3-2-4-25(37)38)24-14-11-21(34)16-23(24)27(36)39/h5-14,16-17,26H,2-4,15H2,1H3,(H,37,38)/t17-,26+/m1/s1
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n/an/a 1.04E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31327
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 12 | Race...)
Show SMILES OC(=O)CCN1c2ccc(I)cc2C(=O)N([C@H](C(O)=O)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C26H19Cl2IN2O6/c27-16-5-1-14(2-6-16)22-25(35)30(12-11-21(32)33)20-10-9-18(29)13-19(20)24(34)31(22)23(26(36)37)15-3-7-17(28)8-4-15/h1-10,13,22-23H,11-12H2,(H,32,33)(H,36,37)/t22-,23-/m0/s1
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n/an/a 1.09E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31339
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 24)
Show SMILES CC#Cc1ccc2N(CCCCC(O)=O)C(=O)[C@@H](N([C@H](C)c3ccc(Cl)cc3)C(=O)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H28Cl2N2O4/c1-3-6-21-8-17-27-26(19-21)30(38)35(20(2)22-9-13-24(32)14-10-22)29(23-11-15-25(33)16-12-23)31(39)34(27)18-5-4-7-28(36)37/h8-17,19-20,29H,4-5,7,18H2,1-2H3,(H,36,37)/t20-,29+/m1/s1
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n/an/a 1.11E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31316
PNG
(1,4-benzodiazepine-2,5-dione, 12m)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CC(=O)N2CCNCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C29H28Cl2IN5O3/c1-17(22-8-6-20(31)14-24(22)33)37-27(18-2-4-19(30)5-3-18)29(40)36(16-26(38)35-12-10-34-11-13-35)25-9-7-21(32)15-23(25)28(37)39/h2-9,14-15,17,27,34H,10-13,16,33H2,1H3/t17-,27+/m1/s1
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n/an/a 1.55E+3n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31319
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 3 | Racem...)
Show SMILES OCCNC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)Nc2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2IN3O4/c26-16-5-1-14(2-6-16)21(23(33)29-11-12-32)31-22(15-3-7-17(27)8-4-15)24(34)30-20-10-9-18(28)13-19(20)25(31)35/h1-10,13,21-22,32H,11-12H2,(H,29,33)(H,30,34)/t21-,22-/m0/s1
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n/an/a 2.12E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31331
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 16 | Race...)
Show SMILES CCN(CC)C(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C32H32Cl2IN3O5/c1-3-36(4-2)31(42)28(20-8-12-22(33)13-9-20)38-29(21-10-14-23(34)15-11-21)32(43)37(18-6-5-7-27(39)40)26-17-16-24(35)19-25(26)30(38)41/h8-17,19,28-29H,3-7,18H2,1-2H3,(H,39,40)/t28-,29-/m0/s1
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n/an/a 2.13E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31335
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 20 | Race...)
Show SMILES OC(=O)CCCCN1c2ccc(I)cc2C(=O)N([C@H](C2CC2)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C30H27Cl2IN2O4/c31-21-10-6-19(7-11-21)27(18-4-5-18)35-28(20-8-12-22(32)13-9-20)30(39)34(16-2-1-3-26(36)37)25-15-14-23(33)17-24(25)29(35)38/h6-15,17-18,27-28H,1-5,16H2,(H,36,37)/t27-,28+/m1/s1
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n/an/a 2.15E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31323
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 8 | Racem...)
Show SMILES CN1c2ccc(I)cc2C(=O)N([C@H](C(O)=O)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C24H17Cl2IN2O4/c1-28-19-11-10-17(27)12-18(19)22(30)29(20(23(28)31)13-2-6-15(25)7-3-13)21(24(32)33)14-4-8-16(26)9-5-14/h2-12,20-21H,1H3,(H,32,33)/t20-,21-/m0/s1
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n/an/a 2.18E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31310
PNG
(1,4-benzodiazepine-2,5-dione, 12g)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N([C@H](C)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H27Cl2IN2O4/c1-18(19-3-7-21(29)8-4-19)33-26(20-5-9-22(30)10-6-20)28(35)32(13-14-37-16-15-36-2)25-12-11-23(31)17-24(25)27(33)34/h3-12,17-18,26H,13-16H2,1-2H3/t18-,26+/m1/s1
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n/an/a 2.39E+3n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31290
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 49)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N(Cc2ccc(Cl)cc2O)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C27H25Cl2IN2O5/c1-36-12-13-37-11-10-31-23-9-8-21(30)15-22(23)26(34)32(16-18-4-7-20(29)14-24(18)33)25(27(31)35)17-2-5-19(28)6-3-17/h2-9,14-15,25,33H,10-13,16H2,1H3/t25-/m0/s1
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n/an/a 2.44E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31295
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 27)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1cc(F)c(Cl)cc1N
Show InChI InChI=1S/C29H28Cl2FIN4O3/c1-17(21-15-24(32)23(31)16-25(21)34)37-27(18-2-4-19(30)5-3-18)29(39)36(9-8-35-10-12-40-13-11-35)26-7-6-20(33)14-22(26)28(37)38/h2-7,14-17,27H,8-13,34H2,1H3/t17-,27+/m1/s1
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n/an/a 2.60E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31296
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 28)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1cc(O)c(Cl)cc1N
Show InChI InChI=1S/C29H29Cl2IN4O4/c1-17(21-15-26(37)23(31)16-24(21)33)36-27(18-2-4-19(30)5-3-18)29(39)35(9-8-34-10-12-40-13-11-34)25-7-6-20(32)14-22(25)28(36)38/h2-7,14-17,27,37H,8-13,33H2,1H3/t17-,27+/m1/s1
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n/an/a 2.70E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31306
PNG
(1,4-benzodiazepine-2,5-dione, 12c)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H28Cl2IN3O3/c1-19(20-2-6-22(30)7-3-20)35-27(21-4-8-23(31)9-5-21)29(37)34(13-12-33-14-16-38-17-15-33)26-11-10-24(32)18-25(26)28(35)36/h2-11,18-19,27H,12-17H2,1H3/t19-,27+/m1/s1
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n/an/a 2.70E+3n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31330
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 15 | Race...)
Show SMILES COC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H25Cl2IN2O6/c1-40-29(39)26(18-7-11-20(31)12-8-18)34-25(17-5-9-19(30)10-6-17)28(38)33(15-3-2-4-24(35)36)23-14-13-21(32)16-22(23)27(34)37/h5-14,16,25-26H,2-4,15H2,1H3,(H,35,36)/t25-,26-/m0/s1
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n/an/a 2.82E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31300
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 29)
Show SMILES CN(C)CCCCN1c2ccc(I)cc2C(=O)N(Cc2ccc(Cl)cc2N)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H29Cl2IN4O2/c1-33(2)13-3-4-14-34-25-12-11-22(31)16-23(25)27(36)35(17-19-7-10-21(30)15-24(19)32)26(28(34)37)18-5-8-20(29)9-6-18/h5-12,15-16,26H,3-4,13-14,17,32H2,1-2H3/t26-/m0/s1
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n/an/a 2.83E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31324
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 9 | Racem...)
Show SMILES CNC(=O)CN1c2ccc(I)cc2C(=O)N([C@H](C(O)=O)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C26H20Cl2IN3O5/c1-30-21(33)13-31-20-11-10-18(29)12-19(20)24(34)32(22(25(31)35)14-2-6-16(27)7-3-14)23(26(36)37)15-4-8-17(28)9-5-15/h2-12,22-23H,13H2,1H3,(H,30,33)(H,36,37)/t22-,23-/m0/s1
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n/an/a 3.33E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31294
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 23)
Show SMILES Nc1cc(Cl)ccc1CN1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCN2CCOCC2)c2ccc(I)cc2C1=O
Show InChI InChI=1S/C29H29Cl2IN4O3/c30-21-5-2-19(3-6-21)27-29(38)35(11-1-10-34-12-14-39-15-13-34)26-9-8-23(32)17-24(26)28(37)36(27)18-20-4-7-22(31)16-25(20)33/h2-9,16-17,27H,1,10-15,18,33H2/t27-/m0/s1
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n/an/a 3.60E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31325
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 10 | Race...)
Show SMILES OC(=O)[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(Cc2ccncc2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H20Cl2IN3O4/c30-20-5-1-18(2-6-20)25-28(37)34(16-17-11-13-33-14-12-17)24-10-9-22(32)15-23(24)27(36)35(25)26(29(38)39)19-3-7-21(31)8-4-19/h1-15,25-26H,16H2,(H,38,39)/t25-,26-/m0/s1
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n/an/a 4.35E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31315
PNG
(1,4-benzodiazepine-2,5-dione, 12l)
Show SMILES C[C@@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CC(=O)N2CCOCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H26Cl2IN3O4/c1-18(19-2-6-21(30)7-3-19)35-27(20-4-8-22(31)9-5-20)29(38)34(17-26(36)33-12-14-39-15-13-33)25-11-10-23(32)16-24(25)28(35)37/h2-11,16,18,27H,12-15,17H2,1H3/t18-,27+/m1/s1
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n/an/a 5.40E+3n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31302
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 30)
Show SMILES CN1CCN(CCCN2c3ccc(I)cc3C(=O)N(Cc3ccc(Cl)cc3N)[C@@H](c3ccc(Cl)cc3)C2=O)CC1
Show InChI InChI=1S/C30H32Cl2IN5O2/c1-35-13-15-36(16-14-35)11-2-12-37-27-10-9-24(33)18-25(27)29(39)38(19-21-5-8-23(32)17-26(21)34)28(30(37)40)20-3-6-22(31)7-4-20/h3-10,17-18,28H,2,11-16,19,34H2,1H3/t28-/m0/s1
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n/an/a 5.41E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31303
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 32)
Show SMILES CN1CCN(CCCCN2c3ccc(I)cc3C(=O)N(Cc3ccc(Cl)cc3N)[C@@H](c3ccc(Cl)cc3)C2=O)CC1
Show InChI InChI=1S/C31H34Cl2IN5O2/c1-36-14-16-37(17-15-36)12-2-3-13-38-28-11-10-25(34)19-26(28)30(40)39(20-22-6-9-24(33)18-27(22)35)29(31(38)41)21-4-7-23(32)8-5-21/h4-11,18-19,29H,2-3,12-17,20,35H2,1H3/t29-/m0/s1
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n/an/a 5.66E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31307
PNG
(1,4-benzodiazepine-2,5-dione, 12d)
Show SMILES C[C@@H](N1[C@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H28Cl2IN3O3/c1-19(20-2-6-22(30)7-3-20)35-27(21-4-8-23(31)9-5-21)29(37)34(13-12-33-14-16-38-17-15-33)26-11-10-24(32)18-25(26)28(35)36/h2-11,18-19,27H,12-17H2,1H3/t19-,27-/m1/s1
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n/an/a 6.25E+3n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31332
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 17 | Race...)
Show SMILES OC(=O)CCCCN1c2ccc(I)cc2C(=O)N(Cc2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C27H23Cl2IN2O4/c28-19-8-4-17(5-9-19)16-32-25(18-6-10-20(29)11-7-18)27(36)31(14-2-1-3-24(33)34)23-13-12-21(30)15-22(23)26(32)35/h4-13,15,25H,1-3,14,16H2,(H,33,34)/t25-/m0/s1
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n/an/a 8.22E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31297
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 26)
Show SMILES Fc1cc(Cl)ccc1CN1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O
Show InChI InChI=1S/C28H25Cl2FIN3O3/c29-20-4-1-18(2-5-20)26-28(37)34(10-9-33-11-13-38-14-12-33)25-8-7-22(32)16-23(25)27(36)35(26)17-19-3-6-21(30)15-24(19)31/h1-8,15-16,26H,9-14,17H2/t26-/m0/s1
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n/an/a 8.60E+3n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31326
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 11 | Race...)
Show SMILES OC(=O)CN1c2ccc(I)cc2C(=O)N([C@H](C(O)=O)c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C25H17Cl2IN2O6/c26-15-5-1-13(2-6-15)21-24(34)29(12-20(31)32)19-10-9-17(28)11-18(19)23(33)30(21)22(25(35)36)14-3-7-16(27)8-4-14/h1-11,21-22H,12H2,(H,31,32)(H,35,36)/t21-,22-/m0/s1
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n/an/a 1.02E+4n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31292
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 51)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N(Cc2ccc(Cl)nc2N)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C26H25Cl2IN4O4/c1-36-12-13-37-11-10-32-21-8-7-19(29)14-20(21)25(34)33(15-17-4-9-22(28)31-24(17)30)23(26(32)35)16-2-5-18(27)6-3-16/h2-9,14,23H,10-13,15H2,1H3,(H2,30,31)/t23-/m0/s1
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n/an/a 1.16E+4n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31301
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 31)
Show SMILES CN(C)CCCN1c2ccc(I)cc2C(=O)N(Cc2ccc(Cl)cc2N)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C27H27Cl2IN4O2/c1-32(2)12-3-13-33-24-11-10-21(30)15-22(24)26(35)34(16-18-6-9-20(29)14-23(18)31)25(27(33)36)17-4-7-19(28)8-5-17/h4-11,14-15,25H,3,12-13,16,31H2,1-2H3/t25-/m0/s1
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n/an/a 1.22E+4n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31311
PNG
(1,4-benzodiazepine-2,5-dione, 12h)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N([C@@H](C)c2ccc(Cl)cc2)[C@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C28H27Cl2IN2O4/c1-18(19-3-7-21(29)8-4-19)33-26(20-5-9-22(30)10-6-20)28(35)32(13-14-37-16-15-36-2)25-12-11-23(31)17-24(25)27(33)34/h3-12,17-18,26H,13-16H2,1-2H3/t18-,26+/m0/s1
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n/an/a>1.25E+4n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31291
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 50)
Show SMILES COCCOCCN1c2ccc(I)cc2C(=O)N(Cc2ccc(Cl)cc2OCC=C)[C@@H](c2ccc(Cl)cc2)C1=O
Show InChI InChI=1S/C30H29Cl2IN2O5/c1-3-13-40-27-17-23(32)9-6-21(27)19-35-28(20-4-7-22(31)8-5-20)30(37)34(12-14-39-16-15-38-2)26-11-10-24(33)18-25(26)29(35)36/h3-11,17-18,28H,1,12-16,19H2,2H3/t28-/m0/s1
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n/an/a>1.25E+4n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31309
PNG
(1,4-benzodiazepine-2,5-dione, 12f)
Show SMILES C[C@H](N1[C@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1N
Show InChI InChI=1S/C29H29Cl2IN4O3/c1-18(23-8-6-21(31)16-25(23)33)36-27(19-2-4-20(30)5-3-19)29(38)35(11-10-34-12-14-39-15-13-34)26-9-7-22(32)17-24(26)28(36)37/h2-9,16-18,27H,10-15,33H2,1H3/t18-,27+/m0/s1
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n/an/a 1.31E+4n/an/an/an/a7.423



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3115-20 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.067
BindingDB Entry DOI: 10.7270/Q2ZP44F6
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31333
PNG
(1,4-benzodiazepine-2,5-dione antagonist, 18)
Show SMILES C[C@H](N1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCCCC(O)=O)c2ccc(I)cc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H25Cl2IN2O4/c1-17(18-5-9-20(29)10-6-18)33-26(19-7-11-21(30)12-8-19)28(37)32(15-3-2-4-25(34)35)24-14-13-22(31)16-23(24)27(33)36/h5-14,16-17,26H,2-4,15H2,1H3,(H,34,35)/t17-,26-/m0/s1
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
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UniChem

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Article
PubMed
n/an/a 1.33E+4n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3310-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.055
BindingDB Entry DOI: 10.7270/Q2TX3CP1
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (human))
BDBM31299
PNG
(1,4-benzodiazepine-2,5-dione scaffold, 25)
Show SMILES Cc1cc(Cl)ccc1CN1[C@@H](c2ccc(Cl)cc2)C(=O)N(CCN2CCOCC2)c2ccc(I)cc2C1=O
Show InChI InChI=1S/C29H28Cl2IN3O3/c1-19-16-23(31)7-4-21(19)18-35-27(20-2-5-22(30)6-3-20)29(37)34(11-10-33-12-14-38-15-13-33)26-9-8-24(32)17-25(26)28(35)36/h2-9,16-17,27H,10-15,18H2,1H3/t27-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90E+4n/an/an/an/a7.523



Johnson & Johnson Pharmaceutical



Assay Description
Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...


Bioorg Med Chem Lett 16: 3463-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.009
BindingDB Entry DOI: 10.7270/Q23F4MZJ
More data for this
Ligand-Target Pair
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