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Compile Data Set for Download or QSAR

Found 52 hits of Enz. Inhib. data with enzyme = 'Egl nine homolog 1' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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US Patent
n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292143
PNG
(2-(2-((2,3-dihydrobenzo[b][1,4]dioxo-6-yl)oxy)-5-h...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc4OCCOc4c3)nc12
Show InChI InChI=1S/C20H17N3O7/c1-10-17-12(19(26)18(22-10)20(27)21-9-16(24)25)3-5-15(23-17)30-11-2-4-13-14(8-11)29-7-6-28-13/h2-5,8,26H,6-7,9H2,1H3,(H,21,27)(H,24,25)
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n/an/a 210n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292144
PNG
(2-(2-([1,1′-biphenyl]-4-oxo)-5-hydroxy-8-met...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)-c3ccccc3)nc12
Show InChI InChI=1S/C24H19N3O5/c1-14-21-18(23(30)22(26-14)24(31)25-13-20(28)29)11-12-19(27-21)32-17-9-7-16(8-10-17)15-5-3-2-4-6-15/h2-12,30H,13H2,1H3,(H,25,31)(H,28,29)
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n/an/a 230n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 240n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292141
PNG
((2-(2-(4-bromophenoxy)-5-hydroxy-8-methyl-1,7-naph...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(Br)cc3)nc12
Show InChI InChI=1S/C18H14BrN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)6-7-13(22-15)27-11-4-2-10(19)3-5-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
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n/an/a 330n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301825
PNG
(US9598370, Example 00149)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/a 400n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 410n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 440n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292142
PNG
(2-(2-(3-(tert-butyl)phenoxy)-5-hydroxy-8-methyl-1,...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cccc(c3)C(C)(C)C)nc12
Show InChI InChI=1S/C22H23N3O5/c1-12-18-15(20(28)19(24-12)21(29)23-11-17(26)27)8-9-16(25-18)30-14-7-5-6-13(10-14)22(2,3)4/h5-10,28H,11H2,1-4H3,(H,23,29)(H,26,27)
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n/an/a 510n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 650n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107711
PNG
(US8598210, Table XV, 17 | US8722895, 17: 5-(3-Chlo...)
Show SMILES CNC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3/c1-17-13(21)8-19-15(22)14-12(20)6-10(7-18-14)9-3-2-4-11(16)5-9/h2-7,20H,8H2,1H3,(H,17,21)(H,19,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292145
PNG
(2-(5-hydroxy-2-(4-methoxyphenoxy)-8-methyl-1,7-nap...)
Show SMILES COc1ccc(Oc2ccc3c(O)c(nc(C)c3n2)C(=O)NCC(O)=O)cc1
Show InChI InChI=1S/C19H17N3O6/c1-10-16-13(18(25)17(21-10)19(26)20-9-15(23)24)7-8-14(22-16)28-12-5-3-11(27-2)4-6-12/h3-8,25H,9H2,1-2H3,(H,20,26)(H,23,24)
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n/an/a 1.40E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM227555
PNG
(US9340511, 4 | US9708269, 4f)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2cccc(Oc3ccccc3)c12
Show InChI InChI=1S/C19H16N2O5/c1-11-16-13(18(24)17(21-11)19(25)20-10-15(22)23)8-5-9-14(16)26-12-6-3-2-4-7-12/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
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n/an/a 1.40E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107709
PNG
(US8598210, Table XV, 15 | US8722895, 15: {[5-(4-Is...)
Show SMILES CC(C)Oc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O5/c1-10(2)24-13-5-3-11(4-6-13)12-7-14(20)16(18-8-12)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM261512
PNG
(2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carb...)
Show SMILES OC(=O)CNC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C18H14N2O5/c21-15(22)10-20-18(24)16-17(23)14-7-6-13(8-11(14)9-19-16)25-12-4-2-1-3-5-12/h1-9,23H,10H2,(H,20,24)(H,21,22)
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n/an/a 2.10E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM227556
PNG
(US9340511, 5 | US9708269, 5f)
Show SMILES COc1ccc(Oc2ccc3c(O)c(nc(C)c3c2)C(=O)NCC(O)=O)cc1
Show InChI InChI=1S/C20H18N2O6/c1-11-16-9-14(28-13-5-3-12(27-2)4-6-13)7-8-15(16)19(25)18(22-11)20(26)21-10-17(23)24/h3-9,25H,10H2,1-2H3,(H,21,26)(H,23,24)
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n/an/a 2.20E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM227558
PNG
(US9340511, 7 | US9708269, 7f)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cc(F)cc(F)c3)cc12
Show InChI InChI=1S/C19H14F2N2O5/c1-9-15-7-12(28-13-5-10(20)4-11(21)6-13)2-3-14(15)18(26)17(23-9)19(27)22-8-16(24)25/h2-7,26H,8H2,1H3,(H,22,27)(H,24,25)
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n/an/a 2.20E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292135
PNG
(2-(2-(4-cyanophenoxy)-5-hydroxy-8-methyl-1,7-napht...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C#N)nc12
Show InChI InChI=1S/C19H14N4O5/c1-10-16-13(18(26)17(22-10)19(27)21-9-15(24)25)6-7-14(23-16)28-12-4-2-11(8-20)3-5-12/h2-7,26H,9H2,1H3,(H,21,27)(H,24,25)
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n/an/a 2.20E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107716
PNG
(US8598210, Table XV, 22 | US8722895, 22: ({3-Hydro...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C20H21N3O5/c1-28-17(25)12-22-19(26)18-16(24)10-15(11-21-18)13-5-4-6-14(9-13)20(27)23-7-2-3-8-23/h4-6,9-11,24H,2-3,7-8,12H2,1H3,(H,22,26)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107710
PNG
(US8598210, Table XV, 16 | US8722895, 16: {[5-(2-Me...)
Show SMILES Cc1ccc(Cl)cc1-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-8-2-3-10(16)5-11(8)9-4-12(19)14(17-6-9)15(22)18-7-13(20)21/h2-6,19H,7H2,1H3,(H,18,22)(H,20,21)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301820
PNG
(US9598370, Example 00144)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C16H14N6O4/c1-26-13(24)8-18-16(25)14-12(23)6-11(7-17-14)9-3-2-4-10(5-9)15-19-21-22-20-15/h2-7,23H,8H2,1H3,(H,18,25)(H,19,20,21,22)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107695
PNG
(US8598210, Table XV, 1 | US8722895, 1: {[5-(3-chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-3-2-4-11(16)5-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM227554
PNG
(US9340511, 2 | US9708269, 2f)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C19H16N2O5/c1-11-14-8-7-13(26-12-5-3-2-4-6-12)9-15(14)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
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n/an/a 3.50E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107696
PNG
(US8598210, Table XV, 2 | US8722895, 2: {[5-(4-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-10(7-17-14)9-2-4-11(16)5-3-9/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292138
PNG
(2-(2-(4-chlorophenoxy)-5-hydroxy-8-methyl-1,7-naph...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(Cl)cc3)nc12
Show InChI InChI=1S/C18H14ClN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)6-7-13(22-15)27-11-4-2-10(19)3-5-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
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n/an/a 4.00E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107700
PNG
(US8598210, Table XV, 6 | US8722895, 6: [(3-Hydroxy...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C16H16N2O4/c1-10-3-5-11(6-4-10)12-7-13(19)15(17-8-12)16(21)18-9-14(20)22-2/h3-8,19H,9H2,1-2H3,(H,18,21)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301819
PNG
(US9598370, Example 00143)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-3-10(5-11)7-17/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292140
PNG
(2-(2-(3-cyanophenoxy)-5-hydroxy-8-methyl-1,7-napht...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cccc(c3)C#N)nc12
Show InChI InChI=1S/C19H14N4O5/c1-10-16-13(18(26)17(22-10)19(27)21-9-15(24)25)5-6-14(23-16)28-12-4-2-3-11(7-12)8-20/h2-7,26H,9H2,1H3,(H,21,27)(H,24,25)
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n/an/a 5.10E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM227557
PNG
(US9340511, 6 | US9708269, 6f)
Show SMILES COc1ccc(Oc2ccc3c(C)nc(C(=O)NCC(O)=O)c(O)c3c2)cc1
Show InChI InChI=1S/C20H18N2O6/c1-11-15-8-7-14(28-13-5-3-12(27-2)4-6-13)9-16(15)19(25)18(22-11)20(26)21-10-17(23)24/h3-9,25H,10H2,1-2H3,(H,21,26)(H,23,24)
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n/an/a 5.20E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301787
PNG
(US9598370, Example 00128)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C16H13N3O4/c1-23-14(21)9-19-16(22)15-13(20)6-12(8-18-15)11-4-2-10(7-17)3-5-11/h2-6,8,20H,9H2,1H3,(H,19,22)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107701
PNG
(US8598210, Table XV, 7 | US8722895, 7: {[5-(2-Chlo...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13(20)8-18-15(21)14-12(19)6-9(7-17-14)10-4-2-3-5-11(10)16/h2-7,19H,8H2,1H3,(H,18,21)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292137
PNG
(2-(5-hydroxy-2-phenoxy-1,7-naphthyridine-6-formami...)
Show SMILES OC(=O)CNC(=O)c1ncc2nc(Oc3ccccc3)ccc2c1O
Show InChI InChI=1S/C17H13N3O5/c21-14(22)9-19-17(24)15-16(23)11-6-7-13(20-12(11)8-18-15)25-10-4-2-1-3-5-10/h1-8,23H,9H2,(H,19,24)(H,21,22)
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n/an/a 6.90E+3n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM227553
PNG
(US9340511, 1 | US9708269, 1f)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2c(Oc3ccccc3)cccc12
Show InChI InChI=1S/C19H16N2O5/c1-11-13-8-5-9-14(26-12-6-3-2-4-7-12)16(13)18(24)17(21-11)19(25)20-10-15(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
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n/an/a 7.90E+3n/an/an/an/a7.4n/a



FibroGen, Inc.

US Patent


Assay Description
Ketoglutaric acid α-[1-14C]-sodium salt, alpha-ketoglutaric acid sodium salt, and HPLC purified peptide were obtained from commercial sources, e...


US Patent US9708269 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107719
PNG
(US8598210, Table XV, 25 | US8722895, 25: ({5-[3-(c...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(NC(=O)C2CC2)c1
Show InChI InChI=1S/C19H19N3O5/c1-27-16(24)10-21-19(26)17-15(23)8-13(9-20-17)12-3-2-4-14(7-12)22-18(25)11-5-6-11/h2-4,7-9,11,23H,5-6,10H2,1H3,(H,21,26)(H,22,25)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107715
PNG
(US8598210, Table XV, 21 | US8722895, 21: {[5-(3-Ca...)
Show SMILES COC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(N)=O
Show InChI InChI=1S/C16H15N3O5/c1-24-13(21)8-19-16(23)14-12(20)6-11(7-18-14)9-3-2-4-10(5-9)15(17)22/h2-7,20H,8H2,1H3,(H2,17,22)(H,19,23)
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n/an/a 1.12E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306798
PNG
(US10149841, Compound 9)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2cccc(F)c2F)cc1O
Show InChI InChI=1S/C14H10F2N2O5/c15-8-2-1-3-10(12(8)16)23-7-4-9(19)13(17-5-7)14(22)18-6-11(20)21/h1-5,19H,6H2,(H,18,22)(H,20,21)
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n/an/a 1.50E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107699
PNG
(US8598210, Table XV, 5 | US8722895, 5: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1ccc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C16H15NO4/c1-10-2-4-11(5-3-10)12-6-7-13(14(18)8-12)16(21)17-9-15(19)20/h2-8,18H,9H2,1H3,(H,17,21)(H,19,20)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292132
PNG
(2-(5-hydroxy-8-methyl-2-phenoxy-1,7-naphthyridine-...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccccc3)nc12
Show InChI InChI=1S/C18H15N3O5/c1-10-15-12(17(24)16(20-10)18(25)19-9-14(22)23)7-8-13(21-15)26-11-5-3-2-4-6-11/h2-8,24H,9H2,1H3,(H,19,25)(H,22,23)
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US Patent
n/an/a 3.30E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292139
PNG
((2-5-hydroxy-8-methyl-2-(4-(trifluoromethyl)phenox...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C(F)(F)F)nc12
Show InChI InChI=1S/C19H14F3N3O5/c1-9-15-12(17(28)16(24-9)18(29)23-8-14(26)27)6-7-13(25-15)30-11-4-2-10(3-5-11)19(20,21)22/h2-7,28H,8H2,1H3,(H,23,29)(H,26,27)
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n/an/a 3.60E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292134
PNG
(2-(2-(3-chlorophenoxy)-5-hydroxy-8-methyl-1,7-naph...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3cccc(Cl)c3)nc12
Show InChI InChI=1S/C18H14ClN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)5-6-13(22-15)27-11-4-2-3-10(19)7-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
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n/an/a 4.80E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292136
PNG
(2-(2-(4-(tert-butyl)phenoxy)-5-hydroxy-8-methyl-1,...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C(C)(C)C)nc12
Show InChI InChI=1S/C22H23N3O5/c1-12-18-15(20(28)19(24-12)21(29)23-11-17(26)27)9-10-16(25-18)30-14-7-5-13(6-8-14)22(2,3)4/h5-10,28H,11H2,1-4H3,(H,23,29)(H,26,27)
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n/an/a 5.90E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306799
PNG
(US10149841, Compound 19)
Show SMILES Cc1ccc(Oc2cnc(C(=O)NCC(O)=O)c(O)c2)c(C)c1
Show InChI InChI=1S/C16H16N2O5/c1-9-3-4-13(10(2)5-9)23-11-6-12(19)15(17-7-11)16(22)18-8-14(20)21/h3-7,19H,8H2,1-2H3,(H,18,22)(H,20,21)
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n/an/a 6.30E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM292133
PNG
((2-(2-(4-fluorophenoxy)-5-hydroxy-8-methyl-1,7-nap...)
Show SMILES Cc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(F)cc3)nc12
Show InChI InChI=1S/C18H14FN3O5/c1-9-15-12(17(25)16(21-9)18(26)20-8-14(23)24)6-7-13(22-15)27-11-4-2-10(19)3-5-11/h2-7,25H,8H2,1H3,(H,20,26)(H,23,24)
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n/an/a 7.30E+4n/an/an/an/an/a25



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
To a NETN (20 mM Tris.HCl, 100 mM NaCl, 1 mM EDTA, 0.5% NP-40, 1 mM PMSF) buffer containing 200 μM ascorbic acid, 20 μM α-ketoglutaric...


US Patent US10100051 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306795
PNG
(US10149841, Compound 1)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2ccccc2)cc1O
Show InChI InChI=1S/C14H12N2O5/c17-11-6-10(21-9-4-2-1-3-5-9)7-15-13(11)14(20)16-8-12(18)19/h1-7,17H,8H2,(H,16,20)(H,18,19)
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n/an/a 8.40E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM306797
PNG
(US10149841, Compound 8)
Show SMILES OC(=O)CNC(=O)c1ncc(Oc2ccc3ccccc3c2)cc1O
Show InChI InChI=1S/C18H14N2O5/c21-15-8-14(9-19-17(15)18(24)20-10-16(22)23)25-13-6-5-11-3-1-2-4-12(11)7-13/h1-9,21H,10H2,(H,20,24)(H,22,23)
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n/an/a 9.10E+4n/an/an/an/an/an/a



SHENYANG SUNSHINE PHARMACEUTICAL CO. LTD.

US Patent


Assay Description
The interaction between hypoxia-inducible factor HIF-1α and VBC complex (von Hippel-Lindau protein-Elongin B-Elongin C, VBC) was detected by Flu...


US Patent US10149841 (2018)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301799
PNG
(US9598370, Example 00133)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 9.90E+4n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)

More data for this
Ligand-Target Pair
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