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Found 325 hits of Enz. Inhib. data with enzyme = 'Epidermal growth factor receptor' and Substrate = 'EGF-R Substrate'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3585
PNG
(4-[(3-Bromophenyl)amino]benzo[g]quinazoline | Benz...)
Show SMILES Brc1cccc(Nc2ncnc3cc4ccccc4cc23)c1
Show InChI InChI=1S/C18H12BrN3/c19-14-6-3-7-15(10-14)22-18-16-8-12-4-1-2-5-13(12)9-17(16)20-11-21-18/h1-11H,(H,20,21,22)
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Article
PubMed
n/an/a 0.00300n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3556
PNG
(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Show SMILES CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC
Show InChI InChI=1S/C18H18BrN3O2/c1-3-23-16-9-14-15(10-17(16)24-4-2)20-11-21-18(14)22-13-7-5-6-12(19)8-13/h5-11H,3-4H2,1-2H3,(H,20,21,22)
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n/an/a 0.00600n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3604
PNG
(4-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]p...)
Show SMILES CN(C)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C15H14BrN5/c1-21(2)14-7-12-13(8-17-14)18-9-19-15(12)20-11-5-3-4-10(16)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 0.00600n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 1823-35 (1996)


Article DOI: 10.1021/jm049701n
BindingDB Entry DOI: 10.7270/Q2X928GF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3604
PNG
(4-N-(3-bromophenyl)-6-N,6-N-dimethylpyrido[3,4-d]p...)
Show SMILES CN(C)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C15H14BrN5/c1-21(2)14-7-12-13(8-17-14)18-9-19-15(12)20-11-5-3-4-10(16)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 0.00600n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3570
PNG
(8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15/h1-8H,(H,18,19)(H,17,20,21)
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PubMed
n/an/a 0.00800n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3603
PNG
(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Show SMILES CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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PubMed
n/an/a 0.00800n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3603
PNG
(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Show SMILES CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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n/an/a 0.00800n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3603
PNG
(4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimid...)
Show SMILES CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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n/an/a 0.00800n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 1823-35 (1996)


Article DOI: 10.1021/jm049701n
BindingDB Entry DOI: 10.7270/Q2X928GF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3570
PNG
(8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15/h1-8H,(H,18,19)(H,17,20,21)
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n/an/a 0.00800n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3572
PNG
(8-[(3-Bromophenyl)amino]-1-methyl-1H-imidazo[4,5-g...)
Show SMILES Cn1cnc2cc3ncnc(Nc4cccc(Br)c4)c3cc12
Show InChI InChI=1S/C16H12BrN5/c1-22-9-20-14-7-13-12(6-15(14)22)16(19-8-18-13)21-11-4-2-3-10(17)5-11/h2-9H,1H3,(H,18,19,21)
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n/an/a 0.0100n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3574
PNG
(8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g...)
Show SMILES Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc12
Show InChI InChI=1S/C16H12BrN5/c1-22-9-20-14-6-12-13(7-15(14)22)18-8-19-16(12)21-11-4-2-3-10(17)5-11/h2-9H,1H3,(H,18,19,21)
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n/an/a 0.0250n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3568
PNG
(CHEMBL327307 | N-(3,4-dibromophenyl)-6,7-dimethoxy...)
Show SMILES COc1cc2ncnc(Nc3ccc(Br)c(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H13Br2N3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-11(17)12(18)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 0.0720n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3595
PNG
(4-N-(3-bromophenyl)-7-N,7-N-dimethylpyrido[4,3-d]p...)
Show SMILES CN(C)c1cc2ncnc(Nc3cccc(Br)c3)c2cn1
Show InChI InChI=1S/C15H14BrN5/c1-21(2)14-7-13-12(8-17-14)15(19-9-18-13)20-11-5-3-4-10(16)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 0.0910n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 1823-35 (1996)


Article DOI: 10.1021/jm049701n
BindingDB Entry DOI: 10.7270/Q2X928GF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3297
PNG
(4-Anilinoquinazoline deriv. 48 | 4-N-(3-bromopheny...)
Show SMILES Nc1ccc2c(Nc3cccc(Br)c3)ncnc2c1
Show InChI InChI=1S/C14H11BrN4/c15-9-2-1-3-11(6-9)19-14-12-5-4-10(16)7-13(12)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 0.100n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3297
PNG
(4-Anilinoquinazoline deriv. 48 | 4-N-(3-bromopheny...)
Show SMILES Nc1ccc2c(Nc3cccc(Br)c3)ncnc2c1
Show InChI InChI=1S/C14H11BrN4/c15-9-2-1-3-11(6-9)19-14-12-5-4-10(16)7-13(12)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 0.100n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3303
PNG
(4-Anilinoquinazoline deriv. 54 | 4-N-(3-bromopheny...)
Show SMILES Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N
Show InChI InChI=1S/C14H12BrN5/c15-8-2-1-3-9(4-8)20-14-10-5-11(16)12(17)6-13(10)18-7-19-14/h1-7H,16-17H2,(H,18,19,20)
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n/an/a 0.120n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3303
PNG
(4-Anilinoquinazoline deriv. 54 | 4-N-(3-bromopheny...)
Show SMILES Nc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N
Show InChI InChI=1S/C14H12BrN5/c15-8-2-1-3-9(4-8)20-14-10-5-11(16)12(17)6-13(10)18-7-19-14/h1-7H,16-17H2,(H,18,19,20)
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n/an/a 0.120n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3594
PNG
(4-N-(3-bromophenyl)-7-N-methylpyrido[4,3-d]pyrimid...)
Show SMILES CNc1cc2ncnc(Nc3cccc(Br)c3)c2cn1
Show InChI InChI=1S/C14H12BrN5/c1-16-13-6-12-11(7-17-13)14(19-8-18-12)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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n/an/a 0.130n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 1823-35 (1996)


Article DOI: 10.1021/jm049701n
BindingDB Entry DOI: 10.7270/Q2X928GF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3600
PNG
(4-N-(3-bromophenyl)pyrido[3,4-d]pyrimidine-4,6-dia...)
Show SMILES Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C13H10BrN5/c14-8-2-1-3-9(4-8)19-13-10-5-12(15)16-6-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 0.130n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3600
PNG
(4-N-(3-bromophenyl)pyrido[3,4-d]pyrimidine-4,6-dia...)
Show SMILES Nc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C13H10BrN5/c14-8-2-1-3-9(4-8)19-13-10-5-12(15)16-6-11(10)17-7-18-13/h1-7H,(H2,15,16)(H,17,18,19)
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n/an/a 0.130n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 1823-35 (1996)


Article DOI: 10.1021/jm049701n
BindingDB Entry DOI: 10.7270/Q2X928GF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3302
PNG
(4-Anilinoquinazoline deriv. 53 | 4-[(3-bromophenyl...)
Show SMILES Oc1cc2ncnc(Nc3cccc(Br)c3)c2cc1O
Show InChI InChI=1S/C14H10BrN3O2/c15-8-2-1-3-9(4-8)18-14-10-5-12(19)13(20)6-11(10)16-7-17-14/h1-7,19-20H,(H,16,17,18)
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n/an/a 0.170n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 38: 3482-7 (1995)


Article DOI: 10.1021/jm00018a008
BindingDB Entry DOI: 10.7270/Q2319T3K
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3302
PNG
(4-Anilinoquinazoline deriv. 53 | 4-[(3-bromophenyl...)
Show SMILES Oc1cc2ncnc(Nc3cccc(Br)c3)c2cc1O
Show InChI InChI=1S/C14H10BrN3O2/c15-8-2-1-3-9(4-8)18-14-10-5-12(19)13(20)6-11(10)16-7-17-14/h1-7,19-20H,(H,16,17,18)
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n/an/a 0.170n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3557
PNG
(CHEMBL418967 | N-(3-bromophenyl)-6,7-dipropoxyquin...)
Show SMILES CCCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCCC
Show InChI InChI=1S/C20H22BrN3O2/c1-3-8-25-18-11-16-17(12-19(18)26-9-4-2)22-13-23-20(16)24-15-7-5-6-14(21)10-15/h5-7,10-13H,3-4,8-9H2,1-2H3,(H,22,23,24)
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n/an/a 0.170n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3702
PNG
(3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES OCC(O)CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C16H16BrN5O2/c17-10-2-1-3-11(4-10)22-16-13-5-15(18-6-12(24)8-23)19-7-14(13)20-9-21-16/h1-5,7,9,12,23-24H,6,8H2,(H,18,19)(H,20,21,22)
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n/an/a 0.180n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3724
PNG
(4-N-(3-chlorophenyl)-6-N-methylpyrido[3,4-d]pyrimi...)
Show SMILES CNc1cc2c(Nc3cccc(Cl)c3)ncnc2cn1
Show InChI InChI=1S/C14H12ClN5/c1-16-13-6-11-12(7-17-13)18-8-19-14(11)20-10-4-2-3-9(15)5-10/h2-8H,1H3,(H,16,17)(H,18,19,20)
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n/an/a 0.190n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3700
PNG
(2-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES OCCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C15H14BrN5O/c16-10-2-1-3-11(6-10)21-15-12-7-14(17-4-5-22)18-8-13(12)19-9-20-15/h1-3,6-9,22H,4-5H2,(H,17,18)(H,19,20,21)
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n/an/a 0.190n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3701
PNG
(2-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES CN(CCO)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C16H16BrN5O/c1-22(5-6-23)15-8-13-14(9-18-15)19-10-20-16(13)21-12-4-2-3-11(17)7-12/h2-4,7-10,23H,5-6H2,1H3,(H,19,20,21)
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n/an/a 0.220n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3534
PNG
(6,7-dimethoxy-N-[3-(trifluoromethyl)phenyl]quinazo...)
Show SMILES COc1cc2ncnc(Nc3cccc(c3)C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C17H14F3N3O2/c1-24-14-7-12-13(8-15(14)25-2)21-9-22-16(12)23-11-5-3-4-10(6-11)17(18,19)20/h3-9H,1-2H3,(H,21,22,23)
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n/an/a 0.240n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3520
PNG
(4-N-(3-chlorophenyl)quinazoline-4,7-diamine | CHEM...)
Show SMILES Nc1ccc2c(Nc3cccc(Cl)c3)ncnc2c1
Show InChI InChI=1S/C14H11ClN4/c15-9-2-1-3-11(6-9)19-14-12-5-4-10(16)7-13(12)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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n/an/a 0.25n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3690
PNG
(4-[(3-Bromophenyl)amino]-6-[[2-(4-imidazolyl)ethyl...)
Show SMILES Brc1cccc(Nc2ncnc3cnc(NCCc4cnc[nH]4)nc23)c1
Show InChI InChI=1S/C17H15BrN8/c18-11-2-1-3-12(6-11)25-16-15-14(23-10-24-16)8-21-17(26-15)20-5-4-13-7-19-9-22-13/h1-3,6-10H,4-5H2,(H,19,22)(H,20,21,26)(H,23,24,25)
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n/an/a 0.25n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 1820-6 (1997)


Article DOI: 10.1021/jm960879m
BindingDB Entry DOI: 10.7270/Q2J101C8
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3770
PNG
(6-N-(3-bromophenyl)-8-thia-3,5-diazatricyclo[7.4.0...)
Show SMILES Nc1ccc2sc3c(Nc4cccc(Br)c4)ncnc3c2c1
Show InChI InChI=1S/C16H11BrN4S/c17-9-2-1-3-11(6-9)21-16-15-14(19-8-20-16)12-7-10(18)4-5-13(12)22-15/h1-8H,18H2,(H,19,20,21)
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n/an/a 0.270n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3722
PNG
(3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES OC(=O)CCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C16H14BrN5O2/c17-10-2-1-3-11(6-10)22-16-12-7-14(18-5-4-15(23)24)19-8-13(12)20-9-21-16/h1-3,6-9H,4-5H2,(H,18,19)(H,23,24)(H,20,21,22)
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n/an/a 0.270n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3720
PNG
(2-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES OC(=O)CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C15H12BrN5O2/c16-9-2-1-3-10(4-9)21-15-11-5-13(18-7-14(22)23)17-6-12(11)19-8-20-15/h1-6,8H,7H2,(H,17,18)(H,22,23)(H,19,20,21)
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n/an/a 0.280n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3571
PNG
(8-[(3-Bromophenyl)amino]-2-methyl-1H-imidazo[4,5-g...)
Show SMILES Cc1nc2cc3ncnc(Nc4cccc(Br)c4)c3cc2[nH]1
Show InChI InChI=1S/C16H12BrN5/c1-9-20-14-6-12-13(7-15(14)21-9)18-8-19-16(12)22-11-4-2-3-10(17)5-11/h2-8H,1H3,(H,20,21)(H,18,19,22)
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n/an/a 0.290n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3532
PNG
(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 0.310n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3581
PNG
(8-[(3-Bromophenyl)amino]-1H-pyrazolo[3,4-g]quinazo...)
Show SMILES Brc1cccc(Nc2ncnc3cc4cn[nH]c4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-10-2-1-3-11(5-10)20-15-12-6-13-9(7-19-21-13)4-14(12)17-8-18-15/h1-8H,(H,19,21)(H,17,18,20)
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n/an/a 0.340n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3714
PNG
(2-{[3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrim...)
Show SMILES OCCN(CCO)CCCNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C20H25BrN6O2/c21-15-3-1-4-16(11-15)26-20-17-12-19(23-13-18(17)24-14-25-20)22-5-2-6-27(7-9-28)8-10-29/h1,3-4,11-14,28-29H,2,5-10H2,(H,22,23)(H,24,25,26)
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n/an/a 0.350n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3522
PNG
(4-N-(3-iodophenyl)quinazoline-4,7-diamine | CHEMBL...)
Show SMILES Nc1ccc2c(Nc3cccc(I)c3)ncnc2c1
Show InChI InChI=1S/C14H11IN4/c15-9-2-1-3-11(6-9)19-14-12-5-4-10(16)7-13(12)17-8-18-14/h1-8H,16H2,(H,17,18,19)
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Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3583
PNG
(5-[(3-Bromophenyl)amino]-1H-pyrrolo[3,2-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4[nH]ccc4cc23)c1
Show InChI InChI=1S/C16H11BrN4/c17-11-2-1-3-12(7-11)21-16-13-6-10-4-5-18-14(10)8-15(13)19-9-20-16/h1-9,18H,(H,19,20,21)
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n/an/a 0.390n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3582
PNG
(5-[(3-Bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazo...)
Show SMILES Brc1cccc(Nc2ncnc3cc4[nH]ncc4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-10-2-1-3-11(5-10)20-15-12-4-9-7-19-21-13(9)6-14(12)17-8-18-15/h1-8H,(H,19,21)(H,17,18,20)
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n/an/a 0.440n/an/an/an/a7.422



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3582
PNG
(5-[(3-Bromophenyl)amino]-1H-pyrazolo[4,3-g]quinazo...)
Show SMILES Brc1cccc(Nc2ncnc3cc4[nH]ncc4cc23)c1
Show InChI InChI=1S/C15H10BrN5/c16-10-2-1-3-11(5-10)20-15-12-4-9-7-19-21-13(9)6-14(12)17-8-18-15/h1-8H,(H,19,21)(H,17,18,20)
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n/an/a 0.440n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3583
PNG
(5-[(3-Bromophenyl)amino]-1H-pyrrolo[3,2-g]quinazol...)
Show SMILES Brc1cccc(Nc2ncnc3cc4[nH]ccc4cc23)c1
Show InChI InChI=1S/C16H11BrN4/c17-11-2-1-3-12(7-11)21-16-13-6-10-4-5-18-14(10)8-15(13)19-9-20-16/h1-9,18H,(H,19,20,21)
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n/an/a 0.440n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 918-28 (1996)


Article DOI: 10.1021/jm950692f
BindingDB Entry DOI: 10.7270/Q2222RZB
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3721
PNG
(2-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES CN(CC(O)=O)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C16H14BrN5O2/c1-22(8-15(23)24)14-6-12-13(7-18-14)19-9-20-16(12)21-11-4-2-3-10(17)5-11/h2-7,9H,8H2,1H3,(H,23,24)(H,19,20,21)
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n/an/a 0.440n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3727
PNG
(6-(Methylamino)-4-[(3-methylphenyl)amino]pyrido[3,...)
Show SMILES CNc1cc2c(Nc3cccc(C)c3)ncnc2cn1
Show InChI InChI=1S/C15H15N5/c1-10-4-3-5-11(6-10)20-15-12-7-14(16-2)17-8-13(12)18-9-19-15/h3-9H,1-2H3,(H,16,17)(H,18,19,20)
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n/an/a 0.450n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3772
PNG
(6-N-(3-bromophenyl)-8-thia-3,5-diazatricyclo[7.4.0...)
Show SMILES Nc1ccc2c(c1)sc1c(Nc3cccc(Br)c3)ncnc21
Show InChI InChI=1S/C16H11BrN4S/c17-9-2-1-3-11(6-9)21-16-15-14(19-8-20-16)12-5-4-10(18)7-13(12)22-15/h1-8H,18H2,(H,19,20,21)
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n/an/a 0.470n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 5464-74 (1999)


Article DOI: 10.1021/jm9903949
BindingDB Entry DOI: 10.7270/Q28K7783
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3703
PNG
(3-({4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin...)
Show SMILES CN(CC(O)CO)c1cc2c(Nc3cccc(Br)c3)ncnc2cn1
Show InChI InChI=1S/C17H18BrN5O2/c1-23(8-13(25)9-24)16-6-14-15(7-19-16)20-10-21-17(14)22-12-4-2-3-11(18)5-12/h2-7,10,13,24-25H,8-9H2,1H3,(H,20,21,22)
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n/an/a 0.560n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3710
PNG
(4-N-(3-bromophenyl)-6-N-[2-(morpholin-4-yl)ethyl]p...)
Show SMILES Brc1cccc(Nc2ncnc3cnc(NCCN4CCOCC4)cc23)c1
Show InChI InChI=1S/C19H21BrN6O/c20-14-2-1-3-15(10-14)25-19-16-11-18(22-12-17(16)23-13-24-19)21-4-5-26-6-8-27-9-7-26/h1-3,10-13H,4-9H2,(H,21,22)(H,23,24,25)
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n/an/a 0.650n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 742-51 (1998)


Article DOI: 10.1021/jm970641d
BindingDB Entry DOI: 10.7270/Q2DB800T
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3564
PNG
(4-[(3-Bromophenyl)amino]-5,6,7-trimethoxyquinazoli...)
Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2c(OC)c1OC
Show InChI InChI=1S/C17H16BrN3O3/c1-22-13-8-12-14(16(24-3)15(13)23-2)17(20-9-19-12)21-11-6-4-5-10(18)7-11/h4-9H,1-3H3,(H,19,20,21)
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n/an/a 0.670n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3544
PNG
(4-N-(3-bromophenyl)-7-N-methylquinazoline-4,6,7-tr...)
Show SMILES CNc1cc2ncnc(Nc3cccc(Br)c3)c2cc1N
Show InChI InChI=1S/C15H14BrN5/c1-18-14-7-13-11(6-12(14)17)15(20-8-19-13)21-10-4-2-3-9(16)5-10/h2-8,18H,17H2,1H3,(H,19,20,21)
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n/an/a 0.690n/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 39: 267-76 (1996)


Article DOI: 10.1021/bi060184f
BindingDB Entry DOI: 10.7270/Q25T3HPR
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3684
PNG
(4-[(3-Bromophenyl)amino]-6-(methylamino)pyrimido-[...)
Show SMILES CNc1ncc2ncnc(Nc3cccc(Br)c3)c2n1
Show InChI InChI=1S/C13H11BrN6/c1-15-13-16-6-10-11(20-13)12(18-7-17-10)19-9-4-2-3-8(14)5-9/h2-7H,1H3,(H,15,16,20)(H,17,18,19)
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n/an/a 0.760n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 1820-6 (1997)


Article DOI: 10.1021/jm960879m
BindingDB Entry DOI: 10.7270/Q2J101C8
More data for this
Ligand-Target Pair
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