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Found 93 hits of Enz. Inhib. data with enzyme = 'Epidermal growth factor receptor' and Substrate = 'poly(E, A, Y)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4001
PNG
(1 H-indole-3-alkanamide deriv. 10j | N-benzyl-3-[2...)
Show SMILES O=C(CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)NCc2ccccc2)[nH]c2ccccc12)NCc1ccccc1
Show InChI InChI=1S/C36H34N4O2S2/c41-33(37-23-25-11-3-1-4-12-25)21-19-29-27-15-7-9-17-31(27)39-35(29)43-44-36-30(28-16-8-10-18-32(28)40-36)20-22-34(42)38-24-26-13-5-2-6-14-26/h1-18,39-40H,19-24H2,(H,37,41)(H,38,42)
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n/an/a 850n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4042
PNG
(1-methyl-N-phenyl-2-sulfanylidene-2,3-dihydro-1H-i...)
Show SMILES CN1C(=S)C(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C16H14N2OS/c1-18-13-10-6-5-9-12(13)14(16(18)20)15(19)17-11-7-3-2-4-8-11/h2-10,14H,1H3,(H,17,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3985
PNG
(2,2 -Dithiobis(7-methyl-1H-indole-3-propanoic acid...)
Show SMILES Cc1cccc2c(CCC(O)=O)c(SSc3[nH]c4c(C)cccc4c3CCC(O)=O)[nH]c12
Show InChI InChI=1S/C24H24N2O4S2/c1-13-5-3-7-15-17(9-11-19(27)28)23(25-21(13)15)31-32-24-18(10-12-20(29)30)16-8-4-6-14(2)22(16)26-24/h3-8,25-26H,9-12H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3960
PNG
(2,3-Dihydro-2-thioxo-1H-indole-3-propanoic Acid | ...)
Show SMILES OC(=O)CCC1C(=S)Nc2ccccc12
Show InChI InChI=1S/C11H11NO2S/c13-10(14)6-5-8-7-3-1-2-4-9(7)12-11(8)15/h1-4,8H,5-6H2,(H,12,15)(H,13,14)
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n/an/a 1.62E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3973
PNG
(N-[(E)-2-(2,5-dihydroxyphenyl)ethenyl]formamide | ...)
Show SMILES Oc1ccc(O)c(\C=C\NC=O)c1
Show InChI InChI=1S/C9H9NO3/c11-6-10-4-3-7-5-8(12)1-2-9(7)13/h1-6,12-13H,(H,10,11)/b4-3+
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n/an/a 2.00E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3984
PNG
(2,2 -Dithiobis(6-methyl-1H-indole-3-propanoic acid...)
Show SMILES Cc1ccc2c(CCC(O)=O)c(SSc3[nH]c4cc(C)ccc4c3CCC(O)=O)[nH]c2c1
Show InChI InChI=1S/C24H24N2O4S2/c1-13-3-5-15-17(7-9-21(27)28)23(25-19(15)11-13)31-32-24-18(8-10-22(29)30)16-6-4-14(2)12-20(16)26-24/h3-6,11-12,25-26H,7-10H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3980
PNG
(2,2 -Dithiobis(1-methyl-1H-indole-3-propanoic acid...)
Show SMILES Cn1c(SSc2c(CCC(O)=O)c3ccccc3n2C)c(CCC(O)=O)c2ccccc12
Show InChI InChI=1S/C24H24N2O4S2/c1-25-19-9-5-3-7-15(19)17(11-13-21(27)28)23(25)31-32-24-18(12-14-22(29)30)16-8-4-6-10-20(16)26(24)2/h3-10H,11-14H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 3.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4033
PNG
(6-methoxy-2-{[6-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1ccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4ccc(OC)cc4n3C)n(C)c2c1
Show InChI InChI=1S/C34H30N4O4S2/c1-37-27-19-23(41-3)15-17-25(27)29(31(39)35-21-11-7-5-8-12-21)33(37)43-44-34-30(32(40)36-22-13-9-6-10-14-22)26-18-16-24(42-4)20-28(26)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 3.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3979
PNG
(2,2 -Dithiobis(1H-indole-3-propanoic acid) | 3-(2-...)
Show SMILES OC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(O)=O)[nH]c2ccccc12
Show InChI InChI=1S/C22H20N2O4S2/c25-19(26)11-9-15-13-5-1-3-7-17(13)23-21(15)29-30-22-16(10-12-20(27)28)14-6-2-4-8-18(14)24-22/h1-8,23-24H,9-12H2,(H,25,26)(H,27,28)
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4022
PNG
(5-chloro-2-{[5-chloro-1-methyl-3-(phenylcarbamoyl)...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(Cl)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(Cl)ccc12
Show InChI InChI=1S/C32H24Cl2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 4.30E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3979
PNG
(2,2 -Dithiobis(1H-indole-3-propanoic acid) | 3-(2-...)
Show SMILES OC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(O)=O)[nH]c2ccccc12
Show InChI InChI=1S/C22H20N2O4S2/c25-19(26)11-9-15-13-5-1-3-7-17(13)23-21(15)29-30-22-16(10-12-20(27)28)14-6-2-4-8-18(14)24-22/h1-8,23-24H,9-12H2,(H,25,26)(H,27,28)
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n/an/a 4.80E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4030
PNG
(1-methyl-2-{[1-methyl-5-nitro-3-(phenylcarbamoyl)-...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(ccc3n2C)[N+]([O-])=O)c(C(=O)Nc2ccccc2)c2cc(ccc12)[N+]([O-])=O
Show InChI InChI=1S/C32H24N6O6S2/c1-35-25-15-13-21(37(41)42)17-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)45-46-32-28(30(40)34-20-11-7-4-8-12-20)24-18-22(38(43)44)14-16-26(24)36(32)2/h3-18H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 5.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4026
PNG
(2-{[5-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1ccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4cc(OC(C)=O)ccc4n3C)c(C(=O)Nc3ccccc3)c2c1
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-25-15-17-29-27(19-25)31(33(43)37-23-11-7-5-8-12-23)35(39(29)3)47-48-36-32(34(44)38-24-13-9-6-10-14-24)28-20-26(46-22(2)42)16-18-30(28)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 5.30E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4038
PNG
(7-methoxy-2-{[7-methoxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES COc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(OC)c4n3C)n(C)c12
Show InChI InChI=1S/C34H30N4O4S2/c1-37-29-23(17-11-19-25(29)41-3)27(31(39)35-21-13-7-5-8-14-21)33(37)43-44-34-28(32(40)36-22-15-9-6-10-16-22)24-18-12-20-26(42-4)30(24)38(34)2/h5-20H,1-4H3,(H,35,39)(H,36,40)
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3964
PNG
(2,3-Dihydro-2-thioxo-1H-indole-3-butanoic Acid | 2...)
Show SMILES OC(=O)CCCC1C(=S)Nc2ccccc12
Show InChI InChI=1S/C12H13NO2S/c14-11(15)7-3-5-9-8-4-1-2-6-10(8)13-12(9)16/h1-2,4,6,9H,3,5,7H2,(H,13,16)(H,14,15)
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n/an/a 6.70E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3961
PNG
(2,3-Dihydro-1-methyl-2-thioxo-1H-indole-3-propanoi...)
Show SMILES CN1C(=S)C(CCC(O)=O)c2ccccc12
Show InChI InChI=1S/C12H13NO2S/c1-13-10-5-3-2-4-8(10)9(12(13)16)6-7-11(14)15/h2-5,9H,6-7H2,1H3,(H,14,15)
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n/an/a 6.70E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4003
PNG
(1 H-indole-3-alkanamide deriv. 10l | 2,2 -Dithiobi...)
Show SMILES OC(=O)c1ccc(CNC(=O)CCc2c(SSc3[nH]c4ccccc4c3CCC(=O)NCc3ccc(cc3)C(O)=O)[nH]c3ccccc23)cc1
Show InChI InChI=1S/C38H34N4O6S2/c43-33(39-21-23-9-13-25(14-10-23)37(45)46)19-17-29-27-5-1-3-7-31(27)41-35(29)49-50-36-30(28-6-2-4-8-32(28)42-36)18-20-34(44)40-22-24-11-15-26(16-12-24)38(47)48/h1-16,41-42H,17-22H2,(H,39,43)(H,40,44)(H,45,46)(H,47,48)
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n/an/a 7.40E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3351
PNG
(2-amino-3-[2-({3-[2-amino-2-(benzylcarbamoyl)ethyl...)
Show SMILES NC(Cc1c(SSc2[nH]c3ccccc3c2CC(N)C(=O)NCc2ccccc2)[nH]c2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C36H36N6O2S2/c37-29(33(43)39-21-23-11-3-1-4-12-23)19-27-25-15-7-9-17-31(25)41-35(27)45-46-36-28(26-16-8-10-18-32(26)42-36)20-30(38)34(44)40-22-24-13-5-2-6-14-24/h1-18,29-30,41-42H,19-22,37-38H2,(H,39,43)(H,40,44)
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n/an/a 7.60E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3987
PNG
(2,2 -Dithiobis(1-methyl-1H-indole-3-butanoic acid)...)
Show SMILES Cn1c(SSc2c(CCCC(O)=O)c3ccccc3n2C)c(CCCC(O)=O)c2ccccc12
Show InChI InChI=1S/C26H28N2O4S2/c1-27-21-13-5-3-9-17(21)19(11-7-15-23(29)30)25(27)33-34-26-20(12-8-16-24(31)32)18-10-4-6-14-22(18)28(26)2/h3-6,9-10,13-14H,7-8,11-12,15-16H2,1-2H3,(H,29,30)(H,31,32)
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n/an/a 8.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3983
PNG
(2,2 -Dithiobis(5-methyl-1H-indole-3-propanoic acid...)
Show SMILES Cc1ccc2[nH]c(SSc3[nH]c4ccc(C)cc4c3CCC(O)=O)c(CCC(O)=O)c2c1
Show InChI InChI=1S/C24H24N2O4S2/c1-13-3-7-19-17(11-13)15(5-9-21(27)28)23(25-19)31-32-24-16(6-10-22(29)30)18-12-14(2)4-8-20(18)26-24/h3-4,7-8,11-12,25-26H,5-6,9-10H2,1-2H3,(H,27,28)(H,29,30)
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n/an/a 8.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4005
PNG
(1 H-indole-3-alkanamide deriv. 10n | 2,2 -Dithiobi...)
Show SMILES OC(=O)c1ccc(CNC(=O)CCc2c(SSc3[nH]c4ccccc4c3CCC(=O)NCc3ccc(C(O)=O)c(O)c3)[nH]c3ccccc23)cc1O
Show InChI InChI=1S/C38H34N4O8S2/c43-31-17-21(9-11-27(31)37(47)48)19-39-33(45)15-13-25-23-5-1-3-7-29(23)41-35(25)51-52-36-26(24-6-2-4-8-30(24)42-36)14-16-34(46)40-20-22-10-12-28(38(49)50)32(44)18-22/h1-12,17-18,41-44H,13-16,19-20H2,(H,39,45)(H,40,46)(H,47,48)(H,49,50)
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n/an/a 8.50E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3977
PNG
(2,2 -Trithiobis( 1H-indole-3-acetic acid) | 2-[2-(...)
Show SMILES OC(=O)Cc1c(SSSc2[nH]c3ccccc3c2CC(O)=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H16N2O4S3/c23-17(24)9-13-11-5-1-3-7-15(11)21-19(13)27-29-28-20-14(10-18(25)26)12-6-2-4-8-16(12)22-20/h1-8,21-22H,9-10H2,(H,23,24)(H,25,26)
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n/an/a 9.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3997
PNG
(1 H-indole-3-alkanamide deriv. 10f | N-methyl-3-[2...)
Show SMILES CNC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)NC)[nH]c2ccccc12
Show InChI InChI=1S/C24H26N4O2S2/c1-25-21(29)13-11-17-15-7-3-5-9-19(15)27-23(17)31-32-24-18(12-14-22(30)26-2)16-8-4-6-10-20(16)28-24/h3-10,27-28H,11-14H2,1-2H3,(H,25,29)(H,26,30)
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n/an/a 9.40E+3n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4039
PNG
(2-{[7-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1cccc2c(C(=O)Nc3ccccc3)c(SSc3c(C(=O)Nc4ccccc4)c4cccc(OC(C)=O)c4n3C)n(C)c12
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-27-19-11-17-25-29(33(43)37-23-13-7-5-8-14-23)35(39(3)31(25)27)47-48-36-30(34(44)38-24-15-9-6-10-16-24)26-18-12-20-28(46-22(2)42)32(26)40(36)4/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 9.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4016
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-indol...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccccc3n2C)c(C(=O)Nc2ccccc2)c2ccccc12
Show InChI InChI=1S/C32H26N4O2S2/c1-35-25-19-11-9-17-23(25)27(29(37)33-21-13-5-3-6-14-21)31(35)39-40-32-28(24-18-10-12-20-26(24)36(32)2)30(38)34-22-15-7-4-8-16-22/h3-20H,1-2H3,(H,33,37)(H,34,38)
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n/an/a 1.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3971
PNG
(2,2 -Dithiobis(1H-indole-3-acetic acid) | 2-(2-{[3...)
Show SMILES OC(=O)Cc1c(SSc2[nH]c3ccccc3c2CC(O)=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H16N2O4S2/c23-17(24)9-13-11-5-1-3-7-15(11)21-19(13)27-28-20-14(10-18(25)26)12-6-2-4-8-16(12)22-20/h1-8,21-22H,9-10H2,(H,23,24)(H,25,26)
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n/an/a 1.02E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4023
PNG
(5-bromo-2-{[5-bromo-1-methyl-3-(phenylcarbamoyl)-1...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(Br)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(Br)ccc12
Show InChI InChI=1S/C32H24Br2N4O2S2/c1-37-25-15-13-19(33)17-23(25)27(29(39)35-21-9-5-3-6-10-21)31(37)41-42-32-28(30(40)36-22-11-7-4-8-12-22)24-18-20(34)14-16-26(24)38(32)2/h3-18H,1-2H3,(H,35,39)(H,36,40)
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n/an/a 1.14E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3999
PNG
(1 H-indole-3-alkanamide deriv. 10h | 3-[2-({3-[2-(...)
Show SMILES CN(C)C(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)N(C)C)[nH]c2ccccc12
Show InChI InChI=1S/C26H30N4O2S2/c1-29(2)23(31)15-13-19-17-9-5-7-11-21(17)27-25(19)33-34-26-20(14-16-24(32)30(3)4)18-10-6-8-12-22(18)28-26/h5-12,27-28H,13-16H2,1-4H3
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n/an/a 1.20E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4011
PNG
(1 H-indole-3-alkanamide deriv. 10t | 2,2 -Dithiobi...)
Show SMILES OC(Cc1c(SSc2[nH]c3ccccc3c2CC(O)C(=O)NCc2ccccc2)[nH]c2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C36H34N4O4S2/c41-31(33(43)37-21-23-11-3-1-4-12-23)19-27-25-15-7-9-17-29(25)39-35(27)45-46-36-28(26-16-8-10-18-30(26)40-36)20-32(42)34(44)38-22-24-13-5-2-6-14-24/h1-18,31-32,39-42H,19-22H2,(H,37,43)(H,38,44)
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n/an/a 1.40E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3956
PNG
((2-thioxo-2,3-dihydro-1H-indol-3-yl)acetic acid | ...)
Show SMILES OC(=O)CC1C(=S)Nc2ccccc12
Show InChI InChI=1S/C10H9NO2S/c12-9(13)5-7-6-3-1-2-4-8(6)11-10(7)14/h1-4,7H,5H2,(H,11,14)(H,12,13)
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n/an/a 1.49E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3996
PNG
(1 H-indole-3-alkanamide deriv. 10e | 2,2 -Dithiobi...)
Show SMILES NC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(N)=O)[nH]c2ccccc12
Show InChI InChI=1S/C22H22N4O2S2/c23-19(27)11-9-15-13-5-1-3-7-17(13)25-21(15)29-30-22-16(10-12-20(24)28)14-6-2-4-8-18(14)26-22/h1-8,25-26H,9-12H2,(H2,23,27)(H2,24,28)
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n/an/a 1.60E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3974
PNG
(Dimethyl 2,2 -Dithiobis(1H-indole-3-acetate) | dit...)
Show SMILES COC(=O)Cc1c(SSc2[nH]c3ccccc3c2CC(=O)OC)[nH]c2ccccc12
Show InChI InChI=1S/C22H20N2O4S2/c1-27-19(25)11-15-13-7-3-5-9-17(13)23-21(15)29-30-22-16(12-20(26)28-2)14-8-4-6-10-18(14)24-22/h3-10,23-24H,11-12H2,1-2H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3986
PNG
(2,2 -Dithiobis(1H-indole-3-butanoic acid) | 4-(2-{...)
Show SMILES OC(=O)CCCc1c(SSc2[nH]c3ccccc3c2CCCC(O)=O)[nH]c2ccccc12
Show InChI InChI=1S/C24H24N2O4S2/c27-21(28)13-5-9-17-15-7-1-3-11-19(15)25-23(17)31-32-24-18(10-6-14-22(29)30)16-8-2-4-12-20(16)26-24/h1-4,7-8,11-12,25-26H,5-6,9-10,13-14H2,(H,27,28)(H,29,30)
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4020
PNG
(2-{[4-(acetyloxy)-1-methyl-3-(phenylcarbamoyl)-1H-...)
Show SMILES CC(=O)Oc1cccc2n(C)c(SSc3c(C(=O)Nc4ccccc4)c4c(OC(C)=O)cccc4n3C)c(C(=O)Nc3ccccc3)c12
Show InChI InChI=1S/C36H30N4O6S2/c1-21(41)45-27-19-11-17-25-29(27)31(33(43)37-23-13-7-5-8-14-23)35(39(25)3)47-48-36-32(34(44)38-24-15-9-6-10-16-24)30-26(40(36)4)18-12-20-28(30)46-22(2)42/h5-20H,1-4H3,(H,37,43)(H,38,44)
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n/an/a 2.00E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3981
PNG
(1 H-indole-3-alkanamide deriv. 7 | Dimethyl 2,2 -D...)
Show SMILES COC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)OC)[nH]c2ccccc12
Show InChI InChI=1S/C24H24N2O4S2/c1-29-21(27)13-11-17-15-7-3-5-9-19(15)25-23(17)31-32-24-18(12-14-22(28)30-2)16-8-4-6-10-20(16)26-24/h3-10,25-26H,11-14H2,1-2H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3981
PNG
(1 H-indole-3-alkanamide deriv. 7 | Dimethyl 2,2 -D...)
Show SMILES COC(=O)CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)OC)[nH]c2ccccc12
Show InChI InChI=1S/C24H24N2O4S2/c1-29-21(27)13-11-17-15-7-3-5-9-19(15)25-23(17)31-32-24-18(12-14-22(28)30-2)16-8-4-6-10-20(16)26-24/h3-10,25-26H,11-14H2,1-2H3
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n/an/a 2.10E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4014
PNG
(1 H-indole-3-alkanamide deriv. 11e | 2,3-Dihydro-2...)
Show SMILES NC(=O)CCC1C(=S)Nc2ccccc12
Show InChI InChI=1S/C11H12N2OS/c12-10(14)6-5-8-7-3-1-2-4-9(7)13-11(8)15/h1-4,8H,5-6H2,(H2,12,14)(H,13,15)
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n/an/a 2.20E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4041
PNG
(1-methyl-2-{[1-methyl-3-(phenylcarbamoyl)-1H-pyrro...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cccnc3n2C)c(C(=O)Nc2ccccc2)c2cccnc12
Show InChI InChI=1S/C30H24N6O2S2/c1-35-25-21(15-9-17-31-25)23(27(37)33-19-11-5-3-6-12-19)29(35)39-40-30-24(22-16-10-18-32-26(22)36(30)2)28(38)34-20-13-7-4-8-14-20/h3-18H,1-2H3,(H,33,37)(H,34,38)
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n/an/a 2.23E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4006
PNG
(1 H-indole-3-alkanamide deriv. 10o | N-(2-phenylet...)
Show SMILES O=C(CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)NCCc2ccccc2)[nH]c2ccccc12)NCCc1ccccc1
Show InChI InChI=1S/C38H38N4O2S2/c43-35(39-25-23-27-11-3-1-4-12-27)21-19-31-29-15-7-9-17-33(29)41-37(31)45-46-38-32(30-16-8-10-18-34(30)42-38)20-22-36(44)40-26-24-28-13-5-2-6-14-28/h1-18,41-42H,19-26H2,(H,39,43)(H,40,44)
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n/an/a 2.40E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4000
PNG
(1 H-indole-3-alkanamide deriv. 10i | 2,2-Dithiobis...)
Show SMILES O=C(CCc1c(SSc2[nH]c3ccccc3c2CCC(=O)Nc2ccccc2)[nH]c2ccccc12)Nc1ccccc1
Show InChI InChI=1S/C34H30N4O2S2/c39-31(35-23-11-3-1-4-12-23)21-19-27-25-15-7-9-17-29(25)37-33(27)41-42-34-28(26-16-8-10-18-30(26)38-34)20-22-32(40)36-24-13-5-2-6-14-24/h1-18,37-38H,19-22H2,(H,35,39)(H,36,40)
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n/an/a 2.50E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4010
PNG
(1 H-indole-3-alkanamide deriv. 10s | 1-(benzylcarb...)
Show SMILES CC(=O)OC(Cc1c(SSc2[nH]c3ccccc3c2CC(OC(C)=O)C(=O)NCc2ccccc2)[nH]c2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C40H38N4O6S2/c1-25(45)49-35(37(47)41-23-27-13-5-3-6-14-27)21-31-29-17-9-11-19-33(29)43-39(31)51-52-40-32(30-18-10-12-20-34(30)44-40)22-36(50-26(2)46)38(48)42-24-28-15-7-4-8-16-28/h3-20,35-36,43-44H,21-24H2,1-2H3,(H,41,47)(H,42,48)
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n/an/a 2.80E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3991
PNG
(1 H-indole-3-alkanamide deriv. 10b | 2-(2-{[3-(cya...)
Show SMILES N#CCc1c(SSc2[nH]c3ccccc3c2CC#N)[nH]c2ccccc12
Show InChI InChI=1S/C20H14N4S2/c21-11-9-15-13-5-1-3-7-17(13)23-19(15)25-26-20-16(10-12-22)14-6-2-4-8-18(14)24-20/h1-8,23-24H,9-10H2
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n/an/a 3.20E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3975
PNG
(Dimethyl 2,2 -Dithiobis(1-methyl-1H-indole-3-aceta...)
Show SMILES COC(=O)Cc1c(SSc2c(CC(=O)OC)c3ccccc3n2C)n(C)c2ccccc12
Show InChI InChI=1S/C24H24N2O4S2/c1-25-19-11-7-5-9-15(19)17(13-21(27)29-3)23(25)31-32-24-18(14-22(28)30-4)16-10-6-8-12-20(16)26(24)2/h5-12H,13-14H2,1-4H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3978
PNG
(Dimethyl 2,2 -Trithiobis(1H-indole-3-acetate) | di...)
Show SMILES COC(=O)Cc1c(SSSc2[nH]c3ccccc3c2CC(=O)OC)[nH]c2ccccc12
Show InChI InChI=1S/C22H20N2O4S3/c1-27-19(25)11-15-13-7-3-5-9-17(13)23-21(15)29-31-30-22-16(12-20(26)28-2)14-8-4-6-10-18(14)24-22/h3-10,23-24H,11-12H2,1-2H3
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 36: 2459-69 (1993)


Article DOI: 10.1021/jm00069a003
BindingDB Entry DOI: 10.7270/Q2RJ4GNS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3990
PNG
(1 H-indole-3-alkanamide deriv. 10a | N-benzyl-2-[2...)
Show SMILES O=C(Cc1c(SSc2[nH]c3ccccc3c2CC(=O)NCc2ccccc2)[nH]c2ccccc12)NCc1ccccc1
Show InChI InChI=1S/C34H30N4O2S2/c39-31(35-21-23-11-3-1-4-12-23)19-27-25-15-7-9-17-29(25)37-33(27)41-42-34-28(26-16-8-10-18-30(26)38-34)20-32(40)36-22-24-13-5-2-6-14-24/h1-18,37-38H,19-22H2,(H,35,39)(H,36,40)
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n/an/a 3.80E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4027
PNG
(2,2 -Dithiobis( 5-hydroxy- 1-methyl-N-phenylindole...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3cc(O)ccc3n2C)c(C(=O)Nc2ccccc2)c2cc(O)ccc12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-25-15-13-21(37)17-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)41-42-32-28(30(40)34-20-11-7-4-8-12-20)24-18-22(38)14-16-26(24)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 4.05E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4002
PNG
(1 H-indole-3-alkanamide deriv. 10k | 2,2 -dithiobi...)
Show SMILES COC(=O)c1ccc(CNC(=O)CCc2c(SSc3[nH]c4ccccc4c3CCC(=O)NCc3ccc(cc3)C(=O)OC)[nH]c3ccccc23)cc1
Show InChI InChI=1S/C40H38N4O6S2/c1-49-39(47)27-15-11-25(12-16-27)23-41-35(45)21-19-31-29-7-3-5-9-33(29)43-37(31)51-52-38-32(30-8-4-6-10-34(30)44-38)20-22-36(46)42-24-26-13-17-28(18-14-26)40(48)50-2/h3-18,43-44H,19-24H2,1-2H3,(H,41,45)(H,42,46)
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n/an/a 4.40E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4035
PNG
(6-hydroxy-2-{[6-hydroxy-1-methyl-3-(phenylcarbamoy...)
Show SMILES Cn1c(SSc2c(C(=O)Nc3ccccc3)c3ccc(O)cc3n2C)c(C(=O)Nc2ccccc2)c2ccc(O)cc12
Show InChI InChI=1S/C32H26N4O4S2/c1-35-25-17-21(37)13-15-23(25)27(29(39)33-19-9-5-3-6-10-19)31(35)41-42-32-28(30(40)34-20-11-7-4-8-12-20)24-16-14-22(38)18-26(24)36(32)2/h3-18,37-38H,1-2H3,(H,33,39)(H,34,40)
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n/an/a 4.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 2033-42 (1994)


Article DOI: 10.1021/jm00039a016
BindingDB Entry DOI: 10.7270/Q2H41PMC
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3994
PNG
(1 H-indole-3-alkanamide deriv. 10c | 3-(2-{[3-(2-c...)
Show SMILES N#CCCc1c(SSc2[nH]c3ccccc3c2CCC#N)[nH]c2ccccc12
Show InChI InChI=1S/C22H18N4S2/c23-13-5-9-17-15-7-1-3-11-19(15)25-21(17)27-28-22-18(10-6-14-24)16-8-2-4-12-20(16)26-22/h1-4,7-8,11-12,25-26H,5-6,9-10H2
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n/an/a 4.70E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4007
PNG
(1 H-indole-3-alkanamide deriv. 10p | 2,2 -Dithiobi...)
Show SMILES CC(=O)NC(Cc1c(SSc2[nH]c3ccccc3c2CC(NC(C)=O)C(=O)NCc2ccccc2)[nH]c2ccccc12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C40H40N6O4S2/c1-25(47)43-35(37(49)41-23-27-13-5-3-6-14-27)21-31-29-17-9-11-19-33(29)45-39(31)51-52-40-32(30-18-10-12-20-34(30)46-40)22-36(44-26(2)48)38(50)42-24-28-15-7-4-8-16-28/h3-20,35-36,45-46H,21-24H2,1-2H3,(H,41,49)(H,42,50)(H,43,47)(H,44,48)
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n/an/a 5.10E+4n/an/an/an/a7.422



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 37: 598-609 (1994)


Article DOI: 10.1021/jm00031a009
BindingDB Entry DOI: 10.7270/Q2MS3QZH
More data for this
Ligand-Target Pair
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