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Compile Data Set for Download or QSAR

Found 95 hits from AbbVie Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231837
PNG
(CHEMBL4079307)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ccncc1
Show InChI InChI=1S/C29H36FN5/c1-22-5-4-6-28(30)26(22)19-33-20-27(29(21-33)32(2)3)23-7-9-24(10-8-23)34-15-17-35(18-16-34)25-11-13-31-14-12-25/h4-14,27,29H,15-21H2,1-3H3/t27-,29+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231837
PNG
(CHEMBL4079307)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ccncc1
Show InChI InChI=1S/C29H36FN5/c1-22-5-4-6-28(30)26(22)19-33-20-27(29(21-33)32(2)3)23-7-9-24(10-8-23)34-15-17-35(18-16-34)25-11-13-31-14-12-25/h4-14,27,29H,15-21H2,1-3H3/t27-,29+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231868
PNG
(CHEMBL4093911)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H36ClFN4O/c1-22-5-4-6-29(33)27(22)19-35-20-28(30(21-35)34(2)3)23-9-13-26(14-10-23)36-15-17-37(18-16-36)31(38)24-7-11-25(32)12-8-24/h4-14,28,30H,15-21H2,1-3H3/t28-,30+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231862
PNG
(CHEMBL4081745)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C26H38FN5O2S/c1-20-7-6-8-25(27)23(20)17-30-18-24(26(19-30)28(2)3)21-9-11-22(12-10-21)31-13-15-32(16-14-31)35(33,34)29(4)5/h6-12,24,26H,13-19H2,1-5H3/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231841
PNG
(CHEMBL4093192)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H40FN5O/c1-22-7-6-8-27(30)25(22)19-32-20-26(28(21-32)31(2)3)23-9-11-24(12-10-23)33-15-17-35(18-16-33)29(36)34-13-4-5-14-34/h6-12,26,28H,4-5,13-21H2,1-3H3/t26-,28+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231865
PNG
(CHEMBL4102534)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1nccs1
Show InChI InChI=1S/C27H34FN5S/c1-20-5-4-6-25(28)23(20)17-31-18-24(26(19-31)30(2)3)21-7-9-22(10-8-21)32-12-14-33(15-13-32)27-29-11-16-34-27/h4-11,16,24,26H,12-15,17-19H2,1-3H3/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231877
PNG
(CHEMBL4064647)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(cc1)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C
Show InChI InChI=1S/C26H35FN4O2/c1-19-6-5-7-24(27)22(19)16-29-17-23(25(18-29)28(2)3)20-8-10-21(11-9-20)30-12-14-31(15-13-30)26(32)33-4/h5-11,23,25H,12-18H2,1-4H3/t23-,25+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231866
PNG
(CHEMBL4094795)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C28H35FN6/c1-21-6-4-7-26(29)24(21)18-33-19-25(27(20-33)32(2)3)22-8-10-23(11-9-22)34-14-16-35(17-15-34)28-30-12-5-13-31-28/h4-13,25,27H,14-20H2,1-3H3/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231831
PNG
(CHEMBL4086155)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C30H36F2N4O2S/c1-22-6-4-9-29(32)27(22)19-34-20-28(30(21-34)33(2)3)23-10-12-25(13-11-23)35-14-16-36(17-15-35)39(37,38)26-8-5-7-24(31)18-26/h4-13,18,28,30H,14-17,19-21H2,1-3H3/t28-,30+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231864
PNG
(CHEMBL4094127)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C29H41FN4O/c1-22-5-4-6-28(30)26(22)19-32-20-27(29(21-32)31(2)3)23-7-9-24(10-8-23)33-13-11-25(12-14-33)34-15-17-35-18-16-34/h4-10,25,27,29H,11-21H2,1-3H3/t27-,29+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231877
PNG
(CHEMBL4064647)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(cc1)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C
Show InChI InChI=1S/C26H35FN4O2/c1-19-6-5-7-24(27)22(19)16-29-17-23(25(18-29)28(2)3)20-8-10-21(11-9-20)30-12-14-31(15-13-30)26(32)33-4/h5-11,23,25H,12-18H2,1-4H3/t23-,25+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231867
PNG
(CHEMBL4067345)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)C(=O)N(C)C
Show InChI InChI=1S/C28H39FN4O/c1-20-7-6-8-26(29)24(20)17-32-18-25(27(19-32)30(2)3)21-9-11-23(12-10-21)33-15-13-22(14-16-33)28(34)31(4)5/h6-12,22,25,27H,13-19H2,1-5H3/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231834
PNG
(CHEMBL4059817)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)NC(C)=O
Show InChI InChI=1S/C27H37FN4O/c1-19-6-5-7-26(28)24(19)16-31-17-25(27(18-31)30(3)4)21-8-10-23(11-9-21)32-14-12-22(13-15-32)29-20(2)33/h5-11,22,25,27H,12-18H2,1-4H3,(H,29,33)/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231871
PNG
(CHEMBL4072445)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C27H39FN4/c1-20-7-6-8-26(28)24(20)17-31-18-25(27(19-31)30(4)5)21-9-11-23(12-10-21)32-15-13-22(14-16-32)29(2)3/h6-12,22,25,27H,13-19H2,1-5H3/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231868
PNG
(CHEMBL4093911)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H36ClFN4O/c1-22-5-4-6-29(33)27(22)19-35-20-28(30(21-35)34(2)3)23-9-13-26(14-10-23)36-15-17-37(18-16-36)31(38)24-7-11-25(32)12-8-24/h4-14,28,30H,15-21H2,1-3H3/t28-,30+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231865
PNG
(CHEMBL4102534)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1nccs1
Show InChI InChI=1S/C27H34FN5S/c1-20-5-4-6-25(28)23(20)17-31-18-24(26(19-31)30(2)3)21-7-9-22(10-8-21)32-12-14-33(15-13-32)27-29-11-16-34-27/h4-11,16,24,26H,12-15,17-19H2,1-3H3/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231836
PNG
(CHEMBL4097336)
Show SMILES CC1CCN(CC1)c1ccc(cc1)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C
Show InChI InChI=1S/C26H36FN3/c1-19-12-14-30(15-13-19)22-10-8-21(9-11-22)24-17-29(18-26(24)28(3)4)16-23-20(2)6-5-7-25(23)27/h5-11,19,24,26H,12-18H2,1-4H3/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231841
PNG
(CHEMBL4093192)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C29H40FN5O/c1-22-7-6-8-27(30)25(22)19-32-20-26(28(21-32)31(2)3)23-9-11-24(12-10-23)33-15-17-35(18-16-33)29(36)34-13-4-5-14-34/h6-12,26,28H,4-5,13-21H2,1-3H3/t26-,28+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231831
PNG
(CHEMBL4086155)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C30H36F2N4O2S/c1-22-6-4-9-29(32)27(22)19-34-20-28(30(21-34)33(2)3)23-10-12-25(13-11-23)35-14-16-36(17-15-35)39(37,38)26-8-5-7-24(31)18-26/h4-13,18,28,30H,14-17,19-21H2,1-3H3/t28-,30+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231835
PNG
(CHEMBL4071195)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C30H37FN4/c1-23-8-7-11-29(31)27(23)20-33-21-28(30(22-33)32(2)3)24-12-14-26(15-13-24)35-18-16-34(17-19-35)25-9-5-4-6-10-25/h4-15,28,30H,16-22H2,1-3H3/t28-,30+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231832
PNG
(CHEMBL4068385)
Show SMILES CNC(=O)C1CCN(CC1)c1ccc(cc1)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C
Show InChI InChI=1S/C27H37FN4O/c1-19-6-5-7-25(28)23(19)16-31-17-24(26(18-31)30(3)4)20-8-10-22(11-9-20)32-14-12-21(13-15-32)27(33)29-2/h5-11,21,24,26H,12-18H2,1-4H3,(H,29,33)/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231875
PNG
(CHEMBL4085432)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C31H39FN4O2S/c1-23-8-14-27(15-9-23)39(37,38)36-18-16-35(17-19-36)26-12-10-25(11-13-26)29-21-34(22-31(29)33(3)4)20-28-24(2)6-5-7-30(28)32/h5-15,29,31H,16-22H2,1-4H3/t29-,31+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231844
PNG
(CHEMBL4062781)
Show SMILES CCN1CCN(CC1=O)c1ccc(cc1)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C
Show InChI InChI=1S/C26H35FN4O/c1-5-30-13-14-31(18-26(30)32)21-11-9-20(10-12-21)23-16-29(17-25(23)28(3)4)15-22-19(2)7-6-8-24(22)27/h6-12,23,25H,5,13-18H2,1-4H3/t23-,25+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231863
PNG
(CHEMBL4066590)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC2(CNC(=O)O2)CC1
Show InChI InChI=1S/C27H35FN4O2/c1-19-5-4-6-24(28)22(19)15-31-16-23(25(17-31)30(2)3)20-7-9-21(10-8-20)32-13-11-27(12-14-32)18-29-26(33)34-27/h4-10,23,25H,11-18H2,1-3H3,(H,29,33)/t23-,25+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231864
PNG
(CHEMBL4094127)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C29H41FN4O/c1-22-5-4-6-28(30)26(22)19-32-20-27(29(21-32)31(2)3)23-7-9-24(10-8-23)33-13-11-25(12-14-33)34-15-17-35-18-16-34/h4-10,25,27,29H,11-21H2,1-3H3/t27-,29+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231862
PNG
(CHEMBL4081745)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(=O)(=O)N(C)C
Show InChI InChI=1S/C26H38FN5O2S/c1-20-7-6-8-25(27)23(20)17-30-18-24(26(19-30)28(2)3)21-9-11-22(12-10-21)31-13-15-32(16-14-31)35(33,34)29(4)5/h6-12,24,26H,13-19H2,1-5H3/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231860
PNG
(CHEMBL4075246)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCc2ccncc2)c(C)c1
Show InChI InChI=1S/C28H33FN4O/c1-19-6-5-7-26(29)24(19)16-33-17-25(27(18-33)32(3)4)22-8-9-23(20(2)14-22)28(34)31-15-21-10-12-30-13-11-21/h5-14,25,27H,15-18H2,1-4H3,(H,31,34)/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231869
PNG
(CHEMBL4080065)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCc2ccccn2)c(C)c1
Show InChI InChI=1S/C28H33FN4O/c1-19-8-7-10-26(29)24(19)16-33-17-25(27(18-33)32(3)4)21-11-12-23(20(2)14-21)28(34)31-15-22-9-5-6-13-30-22/h5-14,25,27H,15-18H2,1-4H3,(H,31,34)/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231867
PNG
(CHEMBL4067345)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)C(=O)N(C)C
Show InChI InChI=1S/C28H39FN4O/c1-20-7-6-8-26(29)24(20)17-32-18-25(27(19-32)30(2)3)21-9-11-23(12-10-21)33-15-13-22(14-16-33)28(34)31(4)5/h6-12,22,25,27H,13-19H2,1-5H3/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231842
PNG
(CHEMBL4063855)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCn2ccnc2C1
Show InChI InChI=1S/C26H32FN5/c1-19-5-4-6-24(27)22(19)15-30-16-23(25(17-30)29(2)3)20-7-9-21(10-8-20)32-14-13-31-12-11-28-26(31)18-32/h4-12,23,25H,13-18H2,1-3H3/t23-,25+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231880
PNG
(CHEMBL4073232)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ccccc1S(C)(=O)=O
Show InChI InChI=1S/C31H39FN4O2S/c1-23-8-7-9-28(32)26(23)20-34-21-27(30(22-34)33(2)3)24-12-14-25(15-13-24)35-16-18-36(19-17-35)29-10-5-6-11-31(29)39(4,37)38/h5-15,27,30H,16-22H2,1-4H3/t27-,30+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231839
PNG
(CHEMBL4094876)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)C#N
Show InChI InChI=1S/C26H33FN4/c1-19-5-4-6-25(27)23(19)16-30-17-24(26(18-30)29(2)3)21-7-9-22(10-8-21)31-13-11-20(15-28)12-14-31/h4-10,20,24,26H,11-14,16-18H2,1-3H3/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231866
PNG
(CHEMBL4094795)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C28H35FN6/c1-21-6-4-7-26(29)24(21)18-33-19-25(27(20-33)32(2)3)22-8-10-23(11-9-22)34-14-16-35(17-15-34)28-30-12-5-13-31-28/h4-13,25,27H,14-20H2,1-3H3/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231853
PNG
(CHEMBL4074364)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCCC2CCCN2C)c(C)c1
Show InChI InChI=1S/C29H41FN4O/c1-20-8-6-10-27(30)25(20)17-34-18-26(28(19-34)32(3)4)22-11-12-24(21(2)16-22)29(35)31-14-13-23-9-7-15-33(23)5/h6,8,10-12,16,23,26,28H,7,9,13-15,17-19H2,1-5H3,(H,31,35)/t23?,26-,28+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231858
PNG
(CHEMBL4066626)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)Nc2cccnc2)c(C)c1
Show InChI InChI=1S/C27H31FN4O/c1-18-7-5-9-25(28)23(18)15-32-16-24(26(17-32)31(3)4)20-10-11-22(19(2)13-20)27(33)30-21-8-6-12-29-14-21/h5-14,24,26H,15-17H2,1-4H3,(H,30,33)/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231838
PNG
(CHEMBL4068481)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)N1CCCC1=O
Show InChI InChI=1S/C29H39FN4O/c1-21-6-4-7-27(30)25(21)18-32-19-26(28(20-32)31(2)3)22-9-11-23(12-10-22)33-16-13-24(14-17-33)34-15-5-8-29(34)35/h4,6-7,9-12,24,26,28H,5,8,13-20H2,1-3H3/t26-,28+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231854
PNG
(CHEMBL4101104)
Show SMILES CN(C)CCNC(=O)c1ccc(cc1C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C
Show InChI InChI=1S/C26H37FN4O/c1-18-8-7-9-24(27)22(18)15-31-16-23(25(17-31)30(5)6)20-10-11-21(19(2)14-20)26(32)28-12-13-29(3)4/h7-11,14,23,25H,12-13,15-17H2,1-6H3,(H,28,32)/t23-,25+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231855
PNG
(CHEMBL4069338)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)Nc2ccncc2)c(C)c1
Show InChI InChI=1S/C27H31FN4O/c1-18-6-5-7-25(28)23(18)15-32-16-24(26(17-32)31(3)4)20-8-9-22(19(2)14-20)27(33)30-21-10-12-29-13-11-21/h5-14,24,26H,15-17H2,1-4H3,(H,29,30,33)/t24-,26+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231859
PNG
(CHEMBL4087938)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCc2cccnc2)c(C)c1
Show InChI InChI=1S/C28H33FN4O/c1-19-7-5-9-26(29)24(19)16-33-17-25(27(18-33)32(3)4)22-10-11-23(20(2)13-22)28(34)31-15-21-8-6-12-30-14-21/h5-14,25,27H,15-18H2,1-4H3,(H,31,34)/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231869
PNG
(CHEMBL4080065)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCc2ccccn2)c(C)c1
Show InChI InChI=1S/C28H33FN4O/c1-19-8-7-10-26(29)24(19)16-33-17-25(27(18-33)32(3)4)21-11-12-23(20(2)14-21)28(34)31-15-22-9-5-6-13-30-22/h5-14,25,27H,15-18H2,1-4H3,(H,31,34)/t25-,27+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231875
PNG
(CHEMBL4085432)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C31H39FN4O2S/c1-23-8-14-27(15-9-23)39(37,38)36-18-16-35(17-19-36)26-12-10-25(11-13-26)29-21-34(22-31(29)33(3)4)20-28-24(2)6-5-7-30(28)32/h5-15,29,31H,16-22H2,1-4H3/t29-,31+/m1/s1
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AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231879
PNG
(CHEMBL4098240)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C27H39FN4/c1-20-7-6-8-26(28)24(20)17-32-18-25(27(19-32)29(2)3)21-9-11-22(12-10-21)31(5)23-13-15-30(4)16-14-23/h6-12,23,25,27H,13-19H2,1-5H3/t25-,27+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231835
PNG
(CHEMBL4071195)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C30H37FN4/c1-23-8-7-11-29(31)27(23)20-33-21-28(30(22-33)32(2)3)24-12-14-26(15-13-24)35-18-16-34(17-19-35)25-9-5-4-6-10-25/h4-15,28,30H,16-22H2,1-3H3/t28-,30+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231833
PNG
(CHEMBL4089538)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CC[C@@H](C1)NC(C)=O
Show InChI InChI=1S/C26H35FN4O/c1-18-6-5-7-25(27)23(18)15-30-16-24(26(17-30)29(3)4)20-8-10-22(11-9-20)31-13-12-21(14-31)28-19(2)32/h5-11,21,24,26H,12-17H2,1-4H3,(H,28,32)/t21-,24+,26-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231855
PNG
(CHEMBL4069338)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)Nc2ccncc2)c(C)c1
Show InChI InChI=1S/C27H31FN4O/c1-18-6-5-7-25(28)23(18)15-32-16-24(26(17-32)31(3)4)20-8-9-22(19(2)14-20)27(33)30-21-10-12-29-13-11-21/h5-14,24,26H,15-17H2,1-4H3,(H,29,30,33)/t24-,26+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231870
PNG
(CHEMBL4096569)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCCN2CCN(C)CC2)c(C)c1
Show InChI InChI=1S/C29H42FN5O/c1-21-7-6-8-27(30)25(21)18-35-19-26(28(20-35)32(3)4)23-9-10-24(22(2)17-23)29(36)31-11-12-34-15-13-33(5)14-16-34/h6-10,17,26,28H,11-16,18-20H2,1-5H3,(H,31,36)/t26-,28+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231842
PNG
(CHEMBL4063855)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCn2ccnc2C1
Show InChI InChI=1S/C26H32FN5/c1-19-5-4-6-24(27)22(19)15-30-16-23(25(17-30)29(2)3)20-7-9-21(10-8-20)32-14-13-31-12-11-28-26(31)18-32/h4-12,23,25H,13-18H2,1-3H3/t23-,25+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231843
PNG
(CHEMBL4090732)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CC2CCCCN2C(=O)C1
Show InChI InChI=1S/C28H37FN4O/c1-20-7-6-9-26(29)24(20)16-31-17-25(27(18-31)30(2)3)21-10-12-22(13-11-21)32-15-23-8-4-5-14-33(23)28(34)19-32/h6-7,9-13,23,25,27H,4-5,8,14-19H2,1-3H3/t23?,25-,27+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by assay explorer integrated Lanth...


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231871
PNG
(CHEMBL4072445)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(cc1)N1CCC(CC1)N(C)C
Show InChI InChI=1S/C27H39FN4/c1-20-7-6-8-26(28)24(20)17-31-18-25(27(19-31)30(4)5)21-9-11-23(12-10-21)32-15-13-22(14-16-32)29(2)3/h6-12,22,25,27H,13-19H2,1-5H3/t25-,27+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
Polycomb protein EED (EED)


(Homo sapiens (Human))
BDBM50231859
PNG
(CHEMBL4087938)
Show SMILES CN(C)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1c1ccc(C(=O)NCc2cccnc2)c(C)c1
Show InChI InChI=1S/C28H33FN4O/c1-19-7-5-9-26(29)24(19)16-33-17-25(27(18-33)32(3)4)22-10-11-23(20(2)13-22)28(34)31-15-21-8-6-12-30-14-21/h5-14,25,27H,15-18H2,1-4H3,(H,31,34)/t25-,27+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



AbbVie Inc.

Curated by ChEMBL


Assay Description
Inhibition of pyrrolidine inhibitor-based oregon-green probe binding to GST-tagged EED (unknown origin) after 1 hr by LanthaScreen TR-FRET assay


ACS Med Chem Lett 8: 461-465 (2017)

More data for this
Ligand-Target Pair
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