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Compile Data Set for Download or QSAR

Found 94 hits from Cephalon, Inc   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (human))
BDBM50334080
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)cc2CCCC1=O
Show InChI InChI=1S/C22H21ClN6O2/c1-29-18-10-9-14(11-13(18)5-4-8-19(29)30)26-22-25-12-16(23)21(28-22)27-17-7-3-2-6-15(17)20(24)31/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,24,31)(H2,25,26,27,28)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334604
PNG
(2-(7-(5-chloro-4-(2-methoxy-4-(2-methoxyethoxy)phe...)
Show SMILES COCCOc1ccc(Nc2nc(Nc3cc4CCN(CC(=O)N(C)C)CCc4cc3OC)ncc2Cl)c(OC)c1
Show InChI InChI=1S/C29H37ClN6O5/c1-35(2)27(37)18-36-10-8-19-14-24(25(39-4)15-20(19)9-11-36)33-29-31-17-22(30)28(34-29)32-23-7-6-21(16-26(23)40-5)41-13-12-38-3/h6-7,14-17H,8-13,18H2,1-5H3,(H2,31,32,33,34)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334601
PNG
(2-(7-(5-chloro-4-(2-methoxyphenylamino)pyrimidin-2...)
Show SMILES COc1ccccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O3/c1-32(2)24(34)16-33-11-9-17-13-21(23(36-4)14-18(17)10-12-33)30-26-28-15-19(27)25(31-26)29-20-7-5-6-8-22(20)35-3/h5-8,13-15H,9-12,16H2,1-4H3,(H2,28,29,30,31)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334595
PNG
(5-chloro-N2,N4-bis(2-methoxy-4-morpholinophenyl)py...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccc(cc2OC)N2CCOCC2)n1)N1CCOCC1
Show InChI InChI=1S/C26H31ClN6O4/c1-34-23-15-18(32-7-11-36-12-8-32)3-5-21(23)29-25-20(27)17-28-26(31-25)30-22-6-4-19(16-24(22)35-2)33-9-13-37-14-10-33/h3-6,15-17H,7-14H2,1-2H3,(H2,28,29,30,31)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334593
PNG
(2-(7-(5-chloro-4-(2-methoxy-4-morpholinophenylamin...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl)N1CCOCC1
Show InChI InChI=1S/C30H38ClN7O4/c1-36(2)28(39)19-37-9-7-20-15-25(26(40-3)16-21(20)8-10-37)34-30-32-18-23(31)29(35-30)33-24-6-5-22(17-27(24)41-4)38-11-13-42-14-12-38/h5-6,15-18H,7-14,19H2,1-4H3,(H2,32,33,34,35)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334594
PNG
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334606
PNG
(2-(7-(5-chloro-4-(2,4-dimethoxyphenylamino)pyrimid...)
Show SMILES COc1ccc(Nc2nc(Nc3cc4CCN(CC(=O)N(C)C)CCc4cc3OC)ncc2Cl)c(OC)c1
Show InChI InChI=1S/C27H33ClN6O4/c1-33(2)25(35)16-34-10-8-17-12-22(23(37-4)13-18(17)9-11-34)31-27-29-15-20(28)26(32-27)30-21-7-6-19(36-3)14-24(21)38-5/h6-7,12-15H,8-11,16H2,1-5H3,(H2,29,30,31,32)
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n/an/a 5n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334602
PNG
(4-(5-chloro-2-(3-(2-(dimethylamino)-2-oxoethyl)-8-...)
Show SMILES COc1cc2CCN(CC(=O)N(C)C)CCc2cc1Nc1ncc(Cl)c(Nc2ccc(cc2OC)C(N)=O)n1
Show InChI InChI=1S/C27H32ClN7O4/c1-34(2)24(36)15-35-9-7-16-11-21(23(39-4)12-17(16)8-10-35)32-27-30-14-19(28)26(33-27)31-20-6-5-18(25(29)37)13-22(20)38-3/h5-6,11-14H,7-10,15H2,1-4H3,(H2,29,37)(H2,30,31,32,33)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334081
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334603
PNG
(2-(7-(5-chloro-4-(2-methoxy-4-morpholinophenylamin...)
Show SMILES CNC(=O)CN1CCc2cc(Nc3ncc(Cl)c(Nc4ccc(cc4OC)N4CCOCC4)n3)c(OC)cc2CC1
Show InChI InChI=1S/C29H36ClN7O4/c1-31-27(38)18-36-8-6-19-14-24(25(39-2)15-20(19)7-9-36)34-29-32-17-22(30)28(35-29)33-23-5-4-21(16-26(23)40-3)37-10-12-41-13-11-37/h4-5,14-17H,6-13,18H2,1-3H3,(H,31,38)(H2,32,33,34,35)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334597
PNG
(5-chloro-N2-(8-methoxy-3-(2-methoxyethyl)-2,3,4,5-...)
Show SMILES COCCN1CCc2cc(Nc3ncc(Cl)c(Nc4ccc(cc4OC)N4CCOCC4)n3)c(OC)cc2CC1
Show InChI InChI=1S/C29H37ClN6O4/c1-37-13-10-35-8-6-20-16-25(26(38-2)17-21(20)7-9-35)33-29-31-19-23(30)28(34-29)32-24-5-4-22(18-27(24)39-3)36-11-14-40-15-12-36/h4-5,16-19H,6-15H2,1-3H3,(H2,31,32,33,34)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334080
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)cc2CCCC1=O
Show InChI InChI=1S/C22H21ClN6O2/c1-29-18-10-9-14(11-13(18)5-4-8-19(29)30)26-22-25-12-16(23)21(28-22)27-17-7-3-2-6-15(17)20(24)31/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,24,31)(H2,25,26,27,28)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334605
PNG
(2-(7-(5-chloro-4-(4-cyano-2-methoxyphenylamino)pyr...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl)C#N
Show InChI InChI=1S/C27H30ClN7O3/c1-34(2)25(36)16-35-9-7-18-12-22(24(38-4)13-19(18)8-10-35)32-27-30-15-20(28)26(33-27)31-21-6-5-17(14-29)11-23(21)37-3/h5-6,11-13,15H,7-10,16H2,1-4H3,(H2,30,31,32,33)
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n/an/a 7n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334082
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NCC#C)n3)cc2CCCC1=O
Show InChI InChI=1S/C25H23ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h1,4-5,8-9,11-12,14-15H,6-7,10,13H2,2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334599
PNG
(5-chloro-N2-(8-methoxy-3-(2-(methylsulfonyl)ethyl)...)
Show SMILES COc1cc2CCN(CCS(C)(=O)=O)CCc2cc1Nc1ncc(Cl)c(Nc2ccc(cc2OC)N2CCOCC2)n1
Show InChI InChI=1S/C29H37ClN6O5S/c1-39-26-17-21-7-9-35(12-15-42(3,37)38)8-6-20(21)16-25(26)33-29-31-19-23(30)28(34-29)32-24-5-4-22(18-27(24)40-2)36-10-13-41-14-11-36/h4-5,16-19H,6-15H2,1-3H3,(H2,31,32,33,34)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334085
PNG
(2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...)
Show SMILES CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O
Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334081
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334084
PNG
(2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334083
PNG
(2-{5-Chloro-2-[1-(2-methoxy-ethyl)-2-oxo-2,3,4,5-t...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)N(CCOC)c3c2)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O3/c1-28-24(35)17-6-4-7-19(27)22(17)31-23-18(26)14-29-25(32-23)30-16-10-9-15-5-3-8-21(34)33(11-12-36-2)20(15)13-16/h4,6-7,9-10,13-14H,3,5,8,11-12H2,1-2H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 10n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334086
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CCCNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h4-5,8-9,11-12,14-15H,3,6-7,10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334082
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NCC#C)n3)cc2CCCC1=O
Show InChI InChI=1S/C25H23ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h1,4-5,8-9,11-12,14-15H,6-7,10,13H2,2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 17n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334087
PNG
(2-{5-Chloro-2-[1-(2-methoxy-ethyl)-5,5-dimethyl-2-...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CCOC)C(=O)CCC3(C)C)ncc1Cl
Show InChI InChI=1S/C27H30ClFN6O3/c1-27(2)11-10-22(36)35(12-13-38-4)21-14-16(8-9-18(21)27)32-26-31-15-19(28)24(34-26)33-23-17(25(37)30-3)6-5-7-20(23)29/h5-9,14-15H,10-13H2,1-4H3,(H,30,37)(H2,31,32,33,34)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334081
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)
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n/an/a 23n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334594
PNG
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)
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n/an/a 25n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334593
PNG
(2-(7-(5-chloro-4-(2-methoxy-4-morpholinophenylamin...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl)N1CCOCC1
Show InChI InChI=1S/C30H38ClN7O4/c1-36(2)28(39)19-37-9-7-20-15-25(26(40-3)16-21(20)8-10-37)34-30-32-18-23(31)29(35-30)33-24-6-5-22(17-27(24)41-4)38-11-13-42-14-12-38/h5-6,15-18H,7-14,19H2,1-4H3,(H2,32,33,34,35)
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334088
PNG
(2-(5-chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3NC(=O)CCC(C)(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O2/c1-24(2)11-10-20(32)29-19-9-8-14(12-16(19)24)28-23-27-13-17(25)21(31-23)30-18-7-5-4-6-15(18)22(33)26-3/h4-9,12-13H,10-11H2,1-3H3,(H,26,33)(H,29,32)(H2,27,28,30,31)
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334089
PNG
(2-[5-Chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)Nc3c2)ncc1Cl
Show InChI InChI=1S/C22H20ClFN6O2/c1-25-21(32)14-5-3-6-16(24)19(14)29-20-15(23)11-26-22(30-20)27-13-9-8-12-4-2-7-18(31)28-17(12)10-13/h3,5-6,8-11H,2,4,7H2,1H3,(H,25,32)(H,28,31)(H2,26,27,29,30)
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n/an/a 30n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334596
PNG
(7-(5-chloro-4-(2-methoxy-4-morpholinophenylamino)p...)
Show SMILES CCN1c2ccc(Nc3ncc(Cl)c(Nc4ccc(cc4OC)N4CCOCC4)n3)c(OC)c2CCCC1=O
Show InChI InChI=1S/C28H33ClN6O4/c1-4-35-23-11-10-22(26(38-3)19(23)6-5-7-25(35)36)32-28-30-17-20(29)27(33-28)31-21-9-8-18(16-24(21)37-2)34-12-14-39-15-13-34/h8-11,16-17H,4-7,12-15H2,1-3H3,(H2,30,31,32,33)
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n/an/a 34n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334090
PNG
(CHEMBL1644801 | N-Butyl-2-[5-chloro-2-(1-methyl-2-...)
Show SMILES CCCCNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C26H29ClN6O2/c1-3-4-14-28-25(35)19-9-5-6-10-21(19)31-24-20(27)16-29-26(32-24)30-18-12-13-22-17(15-18)8-7-11-23(34)33(22)2/h5-6,9-10,12-13,15-16H,3-4,7-8,11,14H2,1-2H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 34n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of IR kinase


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334082
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NCC#C)n3)cc2CCCC1=O
Show InChI InChI=1S/C25H23ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h1,4-5,8-9,11-12,14-15H,6-7,10,13H2,2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 38n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334604
PNG
(2-(7-(5-chloro-4-(2-methoxy-4-(2-methoxyethoxy)phe...)
Show SMILES COCCOc1ccc(Nc2nc(Nc3cc4CCN(CC(=O)N(C)C)CCc4cc3OC)ncc2Cl)c(OC)c1
Show InChI InChI=1S/C29H37ClN6O5/c1-35(2)27(37)18-36-10-8-19-14-24(25(39-4)15-20(19)9-11-36)33-29-31-17-22(30)28(34-29)32-23-7-6-21(16-26(23)40-5)41-13-12-38-3/h6-7,14-17H,8-13,18H2,1-5H3,(H2,31,32,33,34)
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n/an/a 40n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334606
PNG
(2-(7-(5-chloro-4-(2,4-dimethoxyphenylamino)pyrimid...)
Show SMILES COc1ccc(Nc2nc(Nc3cc4CCN(CC(=O)N(C)C)CCc4cc3OC)ncc2Cl)c(OC)c1
Show InChI InChI=1S/C27H33ClN6O4/c1-33(2)25(35)16-34-10-8-17-12-22(23(37-4)13-18(17)9-11-34)31-27-29-15-20(28)26(32-27)30-21-7-6-19(36-3)14-24(21)38-5/h6-7,12-15H,8-11,16H2,1-5H3,(H2,29,30,31,32)
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n/an/a 40n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334085
PNG
(2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...)
Show SMILES CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O
Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)
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n/an/a 44n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334091
PNG
(2-(5-chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3NC(=O)CCC(C)(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-8-7-13(11-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 45n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334600
PNG
(2-(7-(5-chloro-4-(4-morpholinophenylamino)pyrimidi...)
Show SMILES COc1cc2CCN(CC(=O)N(C)C)CCc2cc1Nc1ncc(Cl)c(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C29H36ClN7O3/c1-35(2)27(38)19-36-10-8-20-16-25(26(39-3)17-21(20)9-11-36)33-29-31-18-24(30)28(34-29)32-22-4-6-23(7-5-22)37-12-14-40-15-13-37/h4-7,16-18H,8-15,19H2,1-3H3,(H2,31,32,33,34)
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n/an/a 49n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334594
PNG
(2-(5-chloro-2-(2-methoxy-4-morpholinophenylamino)p...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl
Show InChI InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29)
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n/an/a 50n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334084
PNG
(2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl
Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)
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n/an/a 54n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334088
PNG
(2-(5-chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3NC(=O)CCC(C)(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O2/c1-24(2)11-10-20(32)29-19-9-8-14(12-16(19)24)28-23-27-13-17(25)21(31-23)30-18-7-5-4-6-15(18)22(33)26-3/h4-9,12-13H,10-11H2,1-3H3,(H,26,33)(H,29,32)(H2,27,28,30,31)
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n/an/a 54n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334092
PNG
(2-(5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...)
Show SMILES CCN1c2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc2C(C)(C)CCC1=O
Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-10-9-15(13-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)
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n/an/a 56n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334598
PNG
(5-chloro-N2-(3-(2,2-difluoroethyl)-8-methoxy-2,3,4...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc3CCN(CC(F)F)CCc3cc2OC)ncc1Cl)N1CCOCC1
Show InChI InChI=1S/C28H33ClF2N6O3/c1-38-24-14-19-6-8-36(17-26(30)31)7-5-18(19)13-23(24)34-28-32-16-21(29)27(35-28)33-22-4-3-20(15-25(22)39-2)37-9-11-40-12-10-37/h3-4,13-16,26H,5-12,17H2,1-2H3,(H2,32,33,34,35)
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n/an/a 58n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334083
PNG
(2-{5-Chloro-2-[1-(2-methoxy-ethyl)-2-oxo-2,3,4,5-t...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)N(CCOC)c3c2)ncc1Cl
Show InChI InChI=1S/C25H26ClFN6O3/c1-28-24(35)17-6-4-7-19(27)22(17)31-23-18(26)14-29-25(32-23)30-16-10-9-15-5-3-8-21(34)33(11-12-36-2)20(15)13-16/h4,6-7,9-10,13-14H,3,5,8,11-12H2,1-2H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 61n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50334601
PNG
(2-(7-(5-chloro-4-(2-methoxyphenylamino)pyrimidin-2...)
Show SMILES COc1ccccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O3/c1-32(2)24(34)16-33-11-9-17-13-21(23(36-4)14-18(17)10-12-33)30-26-28-15-19(27)25(31-26)29-20-7-5-6-8-22(20)35-3/h5-8,13-15H,9-12,16H2,1-4H3,(H2,28,29,30,31)
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n/an/a 62n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin receptor


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334092
PNG
(2-(5-chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...)
Show SMILES CCN1c2ccc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)cc2C(C)(C)CCC1=O
Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-10-9-15(13-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)
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n/an/a 64n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334605
PNG
(2-(7-(5-chloro-4-(4-cyano-2-methoxyphenylamino)pyr...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl)C#N
Show InChI InChI=1S/C27H30ClN7O3/c1-34(2)25(36)16-35-9-7-18-12-22(24(38-4)13-19(18)8-10-35)32-27-30-15-20(28)26(33-27)31-21-6-5-17(14-29)11-23(21)37-3/h5-6,11-13,15H,7-10,16H2,1-4H3,(H2,30,31,32,33)
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n/an/a 65n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334601
PNG
(2-(7-(5-chloro-4-(2-methoxyphenylamino)pyrimidin-2...)
Show SMILES COc1ccccc1Nc1nc(Nc2cc3CCN(CC(=O)N(C)C)CCc3cc2OC)ncc1Cl
Show InChI InChI=1S/C26H31ClN6O3/c1-32(2)24(34)16-33-11-9-17-13-21(23(36-4)14-18(17)10-12-33)30-26-28-15-19(27)25(31-26)29-20-7-5-6-8-22(20)35-3/h5-8,13-15H,9-12,16H2,1-4H3,(H2,28,29,30,31)
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n/an/a 65n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50334602
PNG
(4-(5-chloro-2-(3-(2-(dimethylamino)-2-oxoethyl)-8-...)
Show SMILES COc1cc2CCN(CC(=O)N(C)C)CCc2cc1Nc1ncc(Cl)c(Nc2ccc(cc2OC)C(N)=O)n1
Show InChI InChI=1S/C27H32ClN7O4/c1-34(2)24(36)15-35-9-7-16-11-21(23(39-4)12-17(16)8-10-35)32-27-30-14-19(28)26(33-27)31-20-6-5-18(25(29)37)13-22(20)38-3/h5-6,11-14H,7-10,15H2,1-4H3,(H2,29,37)(H2,30,31,32,33)
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n/an/a 65n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of ALK by cell based assay


Bioorg Med Chem Lett 21: 463-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.115
BindingDB Entry DOI: 10.7270/Q27081QN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334086
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CCCNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl
Show InChI InChI=1S/C25H27ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h4-5,8-9,11-12,14-15H,3,6-7,10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)
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n/an/a 73n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334088
PNG
(2-(5-chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...)
Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3NC(=O)CCC(C)(C)c3c2)ncc1Cl
Show InChI InChI=1S/C24H25ClN6O2/c1-24(2)11-10-20(32)29-19-9-8-14(12-16(19)24)28-23-27-13-17(25)21(31-23)30-18-7-5-4-6-15(18)22(33)26-3/h4-9,12-13H,10-11H2,1-3H3,(H,26,33)(H,29,32)(H2,27,28,30,31)
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n/an/a 80n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334093
PNG
(2-[5-Chloro-2-(1-isobutyl-5,5-dimethyl-2-oxo-2,3,4...)
Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)N(CC(C)C)C(=O)CCC3(C)C)ncc1Cl
Show InChI InChI=1S/C28H32ClFN6O2/c1-16(2)15-36-22-13-17(9-10-19(22)28(3,4)12-11-23(36)37)33-27-32-14-20(29)25(35-27)34-24-18(26(38)31-5)7-6-8-21(24)30/h6-10,13-14,16H,11-12,15H2,1-5H3,(H,31,38)(H2,32,33,34,35)
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n/an/a 84n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50334080
PNG
(2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...)
Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)cc2CCCC1=O
Show InChI InChI=1S/C22H21ClN6O2/c1-29-18-10-9-14(11-13(18)5-4-8-19(29)30)26-22-25-12-16(23)21(28-22)27-17-7-3-2-6-15(17)20(24)31/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,24,31)(H2,25,26,27,28)
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n/an/a 85n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human c-Met in human GTL16 cells by cell-based assay


Bioorg Med Chem Lett 21: 164-7 (2010)

Checked by Author
Article DOI: 10.1016/j.bmcl.2010.11.045
BindingDB Entry DOI: 10.7270/Q28W3F85
More data for this
Ligand-Target Pair
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