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Compile Data Set for Download or QSAR

Found 146 hits from E. I. du Pont de Nemours& Company, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(RAT)
BDBM50226528
PNG
(CHEMBL284425)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(NC(=O)c2ccccc2S(O)(=O)=O)cc1
Show InChI InChI=1S/C23H26ClN3O5S/c1-3-4-9-21-26-22(24)19(15-32-2)27(21)14-16-10-12-17(13-11-16)25-23(28)18-7-5-6-8-20(18)33(29,30)31/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,25,28)(H,29,30,31)
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n/an/a 12n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229469
PNG
(CHEMBL315094)
Show SMILES CCCCc1nc(c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N6O/c1-2-3-8-20-27-21(23(24,25)26)19(14-33)32(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-28-30-31-29-22/h4-7,9-12,33H,2-3,8,13-14H2,1H3,(H,28,29,30,31)
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n/an/a 12n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226522
PNG
(CHEMBL1744348)
Show SMILES C1CCC(CC1)NC1CCCCC1.CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2c(Cl)ccc(Cl)c2C(O)=O)cc1
Show InChI InChI=1S/C25H24Cl3N3O5.C12H23N/c1-3-4-5-19-30-23(28)18(12-20(32)36-2)31(19)13-14-6-8-15(9-7-14)29-24(33)21-16(26)10-11-17(27)22(21)25(34)35;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h6-11H,3-5,12-13H2,1-2H3,(H,29,33)(H,34,35);11-13H,1-10H2
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n/an/a 18n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 19n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229433
PNG
(CHEMBL85692)
Show SMILES CCCCc1nc(Br)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H23BrN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 19n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50211282
PNG
(CHEMBL308493)
Show SMILES CCCCc1nc(Cl)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,25,26,27,28)
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n/an/a 20n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229443
PNG
(CHEMBL313715)
Show SMILES CCCCc1nc(I)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H23IN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 20n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229435
PNG
(CHEMBL87755)
Show SMILES CCCCc1ncc(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H24N6O/c1-2-3-8-21-23-13-18(15-29)28(21)14-16-9-11-17(12-10-16)19-6-4-5-7-20(19)22-24-26-27-25-22/h4-7,9-13,29H,2-3,8,14-15H2,1H3,(H,24,25,26,27)
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n/an/a 29n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229453
PNG
(CHEMBL87343)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C23H25ClN6O/c1-3-4-9-21-25-22(24)20(15-31-2)30(21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23-26-28-29-27-23/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,26,27,28,29)
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n/an/a 32n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226421
PNG
(CHEMBL281589)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2c(C)cccc2C(O)=O)cc1
Show InChI InChI=1S/C26H28ClN3O5/c1-4-5-9-21-29-24(27)20(14-22(31)35-3)30(21)15-17-10-12-18(13-11-17)28-25(32)23-16(2)7-6-8-19(23)26(33)34/h6-8,10-13H,4-5,9,14-15H2,1-3H3,(H,28,32)(H,33,34)
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n/an/a 32n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226467
PNG
(CHEMBL276956)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(NC(=O)c2c(Cl)ccc(Cl)c2C(O)=O)cc1
Show InChI InChI=1S/C24H24Cl3N3O4/c1-3-4-5-19-29-22(27)18(13-34-2)30(19)12-14-6-8-15(9-7-14)28-23(31)20-16(25)10-11-17(26)21(20)24(32)33/h6-11H,3-5,12-13H2,1-2H3,(H,28,31)(H,32,33)
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n/an/a 42n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229455
PNG
(CHEMBL313779)
Show SMILES CCCCc1nc(Cl)c(CNC(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C24H26ClN7O2/c1-3-4-9-21-27-22(25)20(14-26-24(33)34-2)32(21)15-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23-28-30-31-29-23/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,26,33)(H,28,29,30,31)
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n/an/a 60n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229465
PNG
(CHEMBL315594)
Show SMILES CCCCc1nc(I)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23IN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 61n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229431
PNG
(CHEMBL313928)
Show SMILES CCCCc1nc(c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C23H23F3N2O3/c1-2-3-8-20-27-21(23(24,25)26)19(14-29)28(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(30)31/h4-7,9-12,29H,2-3,8,13-14H2,1H3,(H,30,31)
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n/an/a 62n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50087583
PNG
(CHEMBL25031)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2c(OC)cccc2C(O)=O)cc1
Show InChI InChI=1S/C27H28N2O6/c30-24-16-15-23(29(24)18-21-8-4-1-5-9-21)26(33)28-22(27(34)35)17-20-13-11-19(12-14-20)7-3-2-6-10-25(31)32/h1,4-5,8-9,11-14,22-23H,2,6,10,15-18H2,(H,28,33)(H,31,32)(H,34,35)/t22-,23-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229476
PNG
(CHEMBL85984)
Show SMILES CC\C=C\c1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H21ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h3-12,26H,2,13-14H2,1H3,(H,27,28)/b8-3+
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n/an/a 80n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229477
PNG
(CHEMBL86041)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C22H23ClF3N3O3S/c1-2-3-8-20-27-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)28-33(31,32)22(24,25)26/h4-7,9-12,28,30H,2-3,8,13-14H2,1H3
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n/an/a 83n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229474
PNG
(CHEMBL87315)
Show SMILES CCCCc1nc(Br)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23BrN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 90n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50009505
PNG
(2-Butyl-3-(2'-carboxy-biphenyl-4-ylmethyl)-5-chlor...)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H21ClN2O4/c1-2-3-8-18-24-20(23)19(22(28)29)25(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21(26)27/h4-7,9-12H,2-3,8,13H2,1H3,(H,26,27)(H,28,29)
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n/an/a 92n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229454
PNG
(CHEMBL314673)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H25ClN2O3/c1-3-4-9-21-25-22(24)20(15-29-2)26(21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23(27)28/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,27,28)
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n/an/a 99n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229440
PNG
(CHEMBL85435)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1cc(OC)ccc1-c1nn[nH]n1
Show InChI InChI=1S/C23H25ClN6O2/c1-3-4-5-21-25-22(24)20(14-31)30(21)13-15-6-8-16(9-7-15)19-12-17(32-2)10-11-18(19)23-26-28-29-27-23/h6-12,31H,3-5,13-14H2,1-2H3,(H,26,27,28,29)
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n/an/a 120n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50015270
PNG
(CHEMBL262958 | N-[4-(2-Butyl-4-chloro-5-methoxycar...)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1
Show InChI InChI=1S/C25H26ClN3O5/c1-3-4-9-21-28-23(26)20(14-22(30)34-2)29(21)15-16-10-12-17(13-11-16)27-24(31)18-7-5-6-8-19(18)25(32)33/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,27,31)(H,32,33)
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n/an/a 140n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50009447
PNG
(CHEMBL86067 | N-[4'-(2-Butyl-4-chloro-5-hydroxymet...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C28H28ClN3O4S/c1-2-3-13-26-30-27(29)25(19-33)32(26)18-20-14-16-21(17-15-20)23-11-7-8-12-24(23)28(34)31-37(35,36)22-9-5-4-6-10-22/h4-12,14-17,33H,2-3,13,18-19H2,1H3,(H,31,34)
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n/an/a 140n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229479
PNG
(CHEMBL88017)
Show SMILES CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H22ClN3O3/c1-2-3-8-18-25-20(23)19(21(24)27)26(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)22(28)29/h4-7,9-12H,2-3,8,13H2,1H3,(H2,24,27)(H,28,29)
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n/an/a 150n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229430
PNG
(CHEMBL87339)
Show SMILES CCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C21H21ClN2O3/c1-2-5-19-23-20(22)18(13-25)24(19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21(26)27/h3-4,6-11,25H,2,5,12-13H2,1H3,(H,26,27)
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n/an/a 160n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226532
PNG
(CHEMBL282491)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2ccccc2C(O)=O)cc1
Show InChI InChI=1S/C31H30ClN3O5/c1-3-4-13-27-34-29(32)26(18-28(36)40-2)35(27)19-20-14-16-21(17-15-20)33-30(37)24-11-7-5-9-22(24)23-10-6-8-12-25(23)31(38)39/h5-12,14-17H,3-4,13,18-19H2,1-2H3,(H,33,37)(H,38,39)
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n/an/a 190n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229488
PNG
(CHEMBL85601)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(cc1)-c1ccccc1NS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H25ClF3N3O3S/c1-3-4-9-21-28-22(24)20(15-33-2)30(21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)29-34(31,32)23(25,26)27/h5-8,10-13,29H,3-4,9,14-15H2,1-2H3
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n/an/a 190n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226428
PNG
(CHEMBL28011)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2cccc(C)c2NS(=O)(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C26H28ClF3N4O5S/c1-4-5-9-21-32-24(27)20(14-22(35)39-3)34(21)15-17-10-12-18(13-11-17)31-25(36)19-8-6-7-16(2)23(19)33-40(37,38)26(28,29)30/h6-8,10-13,33H,4-5,9,14-15H2,1-3H3,(H,31,36)
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n/an/a 190n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229456
PNG
(CHEMBL314363)
Show SMILES CCCCc1nc(Cl)c(CNC(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C25H28ClN3O4/c1-3-5-10-22-28-23(26)21(15-27-25(32)33-4-2)29(22)16-17-11-13-18(14-12-17)19-8-6-7-9-20(19)24(30)31/h6-9,11-14H,3-5,10,15-16H2,1-2H3,(H,27,32)(H,30,31)
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n/an/a 200n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229467
PNG
(CHEMBL83505)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(cc1)-c1ccccc1C(=O)NNS(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N4O4S/c1-3-4-9-21-29-22(25)20(15-36-2)32(21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23(33)30-31-37(34,35)24(26,27)28/h5-8,10-13,31H,3-4,9,14-15H2,1-2H3,(H,30,33)
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n/an/a 200n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 230n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229471
PNG
(CHEMBL446095)
Show SMILES CCCCc1nc(Cl)c(CNC(=O)NC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H27ClN4O3/c1-3-4-9-21-28-22(25)20(14-27-24(32)26-2)29(21)15-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23(30)31/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,30,31)(H2,26,27,32)
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n/an/a 240n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226525
PNG
(CHEMBL26652)
Show SMILES CCCCCc1nccn1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1
Show InChI InChI=1S/C23H25N3O3/c1-2-3-4-9-21-24-14-15-26(21)16-17-10-12-18(13-11-17)25-22(27)19-7-5-6-8-20(19)23(28)29/h5-8,10-15H,2-4,9,16H2,1H3,(H,25,27)(H,28,29)
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n/an/a 240n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin ll receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229489
PNG
(CHEMBL83409)
Show SMILES CCCCc1nc(Cl)c(CNC(=O)OC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H26ClN3O4/c1-3-4-9-21-27-22(25)20(14-26-24(31)32-2)28(21)15-16-10-12-17(13-11-16)18-7-5-6-8-19(18)23(29)30/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,26,31)(H,29,30)
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n/an/a 250n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229483
PNG
(CHEMBL313130)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1[nH]nnc1C(=O)OC
Show InChI InChI=1S/C25H26ClN5O3/c1-3-4-9-21-27-24(26)20(15-32)31(21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)22-23(25(33)34-2)29-30-28-22/h5-8,10-13,32H,3-4,9,14-15H2,1-2H3,(H,28,29,30)
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n/an/a 260n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229473
PNG
(CHEMBL315724)
Show SMILES CCCCc1nc(c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O)[N+]([O-])=O
Show InChI InChI=1S/C22H23N3O5/c1-2-3-8-20-23-21(25(29)30)19(14-26)24(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 260n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229445
PNG
(CHEMBL86120)
Show SMILES CCCCc1ncc(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H24N2O3/c1-2-3-8-21-23-13-18(15-25)24(21)14-16-9-11-17(12-10-16)19-6-4-5-7-20(19)22(26)27/h4-7,9-13,25H,2-3,8,14-15H2,1H3,(H,26,27)
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n/an/a 270n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229436
PNG
(CHEMBL86207)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1[nH]nnc1C#N
Show InChI InChI=1S/C24H23ClN6O/c1-2-3-8-22-27-24(25)21(15-32)31(22)14-16-9-11-17(12-10-16)18-6-4-5-7-19(18)23-20(13-26)28-30-29-23/h4-7,9-12,32H,2-3,8,14-15H2,1H3,(H,28,29,30)
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n/an/a 280n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50023646
PNG
(CHEMBL24364)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1
Show InChI InChI=1S/C15H16N3O10P/c19-11-5-13(28-12(11)7-27-29(24,25)26)17-6-10(14(20)16-15(17)21)8-1-3-9(4-2-8)18(22)23/h1-4,6,11-13,19H,5,7H2,(H,16,20,21)(H2,24,25,26)/p-2
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n/an/a 280n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229449
PNG
(CHEMBL310619)
Show SMILES CCCCc1nc(Cl)c(\C=N\NC2=NCCN2)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C25H27ClN10/c1-2-3-8-22-30-23(26)21(15-29-33-25-27-13-14-28-25)36(22)16-17-9-11-18(12-10-17)19-6-4-5-7-20(19)24-31-34-35-32-24/h4-7,9-12,15H,2-3,8,13-14,16H2,1H3,(H2,27,28,33)(H,31,32,34,35)/b29-15+
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n/an/a 290n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229434
PNG
(CHEMBL312950)
Show SMILES CCCCc1nc(Cl)c(COC)n1Cc1ccc(cc1)-c1ccccc1Cc1nnn[nH]1
Show InChI InChI=1S/C24H27ClN6O/c1-3-4-9-23-26-24(25)21(16-32-2)31(23)15-17-10-12-18(13-11-17)20-8-6-5-7-19(20)14-22-27-29-30-28-22/h5-8,10-13H,3-4,9,14-16H2,1-2H3,(H,27,28,29,30)
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n/an/a 300n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229444
PNG
(CHEMBL315386)
Show SMILES CCCCc1nc(Cl)c(COC(C)=O)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C24H25ClN2O4/c1-3-4-9-22-26-23(25)21(15-31-16(2)28)27(22)14-17-10-12-18(13-11-17)19-7-5-6-8-20(19)24(29)30/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,29,30)
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n/an/a 330n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229464
PNG
(CHEMBL87553)
Show SMILES CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C23H23ClN2O4/c1-3-4-9-19-25-21(24)20(23(29)30-2)26(19)14-15-10-12-16(13-11-15)17-7-5-6-8-18(17)22(27)28/h5-8,10-13H,3-4,9,14H2,1-2H3,(H,27,28)
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n/an/a 340n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50087614
PNG
(CHEMBL27981)
Show SMILES CCCCCCc1nccn1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1
Show InChI InChI=1S/C22H22N2O6/c25-20-9-7-17(24(20)12-14-4-2-1-3-5-14)21(26)23-16(22(27)28)10-15-6-8-18-19(11-15)30-13-29-18/h1-6,8,11,16-17H,7,9-10,12-13H2,(H,23,26)(H,27,28)/t16-,17-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin ll receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229466
PNG
(CHEMBL312831)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1n[nH]c(n1)C(F)(F)F
Show InChI InChI=1S/C24H23ClF3N5O/c1-2-3-8-20-29-21(25)19(14-34)33(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-30-23(32-31-22)24(26,27)28/h4-7,9-12,34H,2-3,8,13-14H2,1H3,(H,30,31,32)
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n/an/a 370n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229486
PNG
(CHEMBL314818)
Show SMILES CCCCc1nc(Cl)c(CNC(=O)c2cc3c(OCC(O)CNC(C)C)cccc3[nH]2)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C37H42ClN5O5/c1-4-5-13-34-42-35(38)32(43(34)21-24-14-16-25(17-15-24)27-9-6-7-10-28(27)37(46)47)20-40-36(45)31-18-29-30(41-31)11-8-12-33(29)48-22-26(44)19-39-23(2)3/h6-12,14-18,23,26,39,41,44H,4-5,13,19-22H2,1-3H3,(H,40,45)(H,46,47)
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n/an/a 380n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50226523
PNG
(CHEMBL283071)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2cc(C)ccc2C(O)=O)cc1
Show InChI InChI=1S/C26H28ClN3O5/c1-4-5-6-22-29-24(27)21(14-23(31)35-3)30(22)15-17-8-10-18(11-9-17)28-25(32)20-13-16(2)7-12-19(20)26(33)34/h7-13H,4-6,14-15H2,1-3H3,(H,28,32)(H,33,34)
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n/an/a 380n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229481
PNG
(CHEMBL82799)
Show SMILES CCCCc1nc(Cl)c(CNC(=O)OCC=C)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C26H28ClN3O4/c1-3-5-10-23-29-24(27)22(16-28-26(33)34-15-4-2)30(23)17-18-11-13-19(14-12-18)20-8-6-7-9-21(20)25(31)32/h4,6-9,11-14H,2-3,5,10,15-17H2,1H3,(H,28,33)(H,31,32)
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n/an/a 390n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50108642
PNG
(CHEMBL27725)
Show SMILES CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2cccc(c2C(O)=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C23H23F3N2OS/c24-23(25,26)20-13-17(12-18(14-20)21-28-10-11-30-21)15-29-16-22(6-8-27-9-7-22)19-4-2-1-3-5-19/h1-5,10-14,27H,6-9,15-16H2
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n/an/a 400n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor


J Med Chem 33: 1312-29 (1990)


Article DOI: 10.1021/jm00167a007
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50229482
PNG
(CHEMBL82445)
Show SMILES CCCCc1nc(Cl)c(C(O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C28H27ClN6O/c1-2-3-13-24-30-27(29)25(26(36)21-9-5-4-6-10-21)35(24)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)28-31-33-34-32-28/h4-12,14-17,26,36H,2-3,13,18H2,1H3,(H,31,32,33,34)
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n/an/a 410n/an/an/an/an/an/a



E. I. du Pont de Nemours& Company, Inc.

Curated by ChEMBL


Assay Description
Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of rat adrenal cortical membrane


J Med Chem 34: 2525-47 (1991)


Article DOI: 10.1021/jm00112a031
More data for this
Ligand-Target Pair
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