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Compile Data Set for Download or QSAR

Found 12 hits from Targacept, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346176
PNG
(2-(pyridin-3-yl)quinuclidine dihydrochloride | CHE...)
Show SMILES C1CN2CCC1CC2c1cccnc1
Show InChI InChI=1S/C12H16N2/c1-2-11(9-13-5-1)12-8-10-3-6-14(12)7-4-10/h1-2,5,9-10,12H,3-4,6-8H2
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69n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346172
PNG
(2-(pyridin-3-ylmethyl)quinuclidine bis(2,2,2-trifl...)
Show SMILES C(C1CC2CCN1CC2)c1cccnc1
Show InChI InChI=1S/C13H18N2/c1-2-12(10-14-5-1)9-13-8-11-3-6-15(13)7-4-11/h1-2,5,10-11,13H,3-4,6-9H2
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449n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346168
PNG
((R)-3-(pyrrolidin-2-ylethynyl)pyridine hemigalacta...)
Show SMILES O[C@@H]([C@@H](O)[C@H](O)C(O)=O)[C@@H](O)C(O)=O
Show InChI InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-
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733n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346177
PNG
(2-(pyrimidin-5-yl)quinuclidine bis(2,2,2-trifluoro...)
Show SMILES C1CN2CCC1CC2c1cncnc1
Show InChI InChI=1S/C11H15N3/c1-3-14-4-2-9(1)5-11(14)10-6-12-8-13-7-10/h6-9,11H,1-5H2
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1.10E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346178
PNG
(8-methyl-3-(pyridin-3-yl)-8-azabicyclo[3.2.1]oct-2...)
Show SMILES CN1C2CCC1C=C(C2)c1cccnc1
Show InChI InChI=1S/C13H16N2/c1-15-12-4-5-13(15)8-11(7-12)10-3-2-6-14-9-10/h2-3,6-7,9,12-13H,4-5,8H2,1H3
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2.11E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346173
PNG
(2-(pyrimidin-5-ylmethyl)quinuclidine bis(2,2,2-tri...)
Show SMILES C(C1CC2CCN1CC2)c1cncnc1
Show InChI InChI=1S/C12H17N3/c1-3-15-4-2-10(1)5-12(15)6-11-7-13-9-14-8-11/h7-10,12H,1-6H2
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2.59E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346174
PNG
((S)-3-(2-(pyrrolidin-3-yl)vinyl)pyridine bis(2,2,2...)
Show SMILES C1C[C@H](CN1)\C=C\c1cccnc1
Show InChI InChI=1S/C11H14N2/c1-2-10(8-12-6-1)3-4-11-5-7-13-9-11/h1-4,6,8,11,13H,5,7,9H2/b4-3+/t11-/m1/s1
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3.16E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346168
PNG
((R)-3-(pyrrolidin-2-ylethynyl)pyridine hemigalacta...)
Show SMILES O[C@@H]([C@@H](O)[C@H](O)C(O)=O)[C@@H](O)C(O)=O
Show InChI InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-
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5.77E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346179
PNG
(8-methyl-3-(pyrimidin-5-yl)-8-azabicyclo[3.2.1]oct...)
Show SMILES CN1C2CCC1C=C(C2)c1cncnc1
Show InChI InChI=1S/C12H15N3/c1-15-11-2-3-12(15)5-9(4-11)10-6-13-8-14-7-10/h4,6-8,11-12H,2-3,5H2,1H3
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9.10E+3n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346168
PNG
((R)-3-(pyrrolidin-2-ylethynyl)pyridine hemigalacta...)
Show SMILES O[C@@H]([C@@H](O)[C@H](O)C(O)=O)[C@@H](O)C(O)=O
Show InChI InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-
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>1.00E+4n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346168
PNG
((R)-3-(pyrrolidin-2-ylethynyl)pyridine hemigalacta...)
Show SMILES O[C@@H]([C@@H](O)[C@H](O)C(O)=O)[C@@H](O)C(O)=O
Show InChI InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-
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>1.00E+4n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Mus musculus)
BDBM50346168
PNG
((R)-3-(pyrrolidin-2-ylethynyl)pyridine hemigalacta...)
Show SMILES O[C@@H]([C@@H](O)[C@H](O)C(O)=O)[C@@H](O)C(O)=O
Show InChI InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-
PDB

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>1.00E+4n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-bungarotoxin from alpha7 nAChR in C57BL/6J mouse hippocampal membrane


Bioorg Med Chem Lett 19: 4359-63 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.085
BindingDB Entry DOI: 10.7270/Q2DJ5FZP
More data for this
Ligand-Target Pair