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Found 30 hits from 'Al. I. Cuza' University of Iasi   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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PC sid
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n/an/a 1.40n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 22: 6896-902 (2012)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50485735
PNG
(CHEMBL2159815)
Show SMILES Cc1c2C(=O)c3ccccc3-c2nn1CC(=O)N1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C25H17N3O2S/c1-15-23-24(16-8-2-3-9-17(16)25(23)30)26-27(15)14-22(29)28-18-10-4-6-12-20(18)31-21-13-7-5-11-19(21)28/h2-13H,14H2,1H3
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n/an/a 3.35E+3n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FTase using dansyl-GCVLS as substrate after 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 22: 6896-902 (2012)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50485736
PNG
(CHEMBL2159814)
Show SMILES C\C(=N/NC(=O)CCN1c2ccccc2Sc2ccccc12)C1=C(O)c2ccccc2C1=O
Show InChI InChI=1S/C26H21N3O3S/c1-16(24-25(31)17-8-2-3-9-18(17)26(24)32)27-28-23(30)14-15-29-19-10-4-6-12-21(19)33-22-13-7-5-11-20(22)29/h2-13,31H,14-15H2,1H3,(H,28,30)/b27-16+
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n/an/a 3.73E+3n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FTase using dansyl-GCVLS as substrate after 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 22: 6896-902 (2012)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493668
PNG
(CHEMBL2434996)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)N1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C25H19N5OS/c1-28(2)19-11-13-29(14-12-19)22(15-18(16-26)17-27)25(31)30-20-7-3-5-9-23(20)32-24-10-6-4-8-21(24)30/h3-15H,1-2H3
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n/an/a 4.67E+3n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493679
PNG
(CHEMBL2435003)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H15ClN4O/c1-23(2)17-7-9-24(10-8-17)18(11-14(12-21)13-22)19(25)15-3-5-16(20)6-4-15/h3-11H,1-2H3
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n/an/a 1.25E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493666
PNG
(CHEMBL2434999)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C20H18N4O/c1-15-4-6-17(7-5-15)20(25)19(12-16(13-21)14-22)24-10-8-18(9-11-24)23(2)3/h4-12H,1-3H3
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n/an/a 1.45E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493675
PNG
(CHEMBL2435012)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)[C-](C=C(C#N)C#N)[n+]1ccc(cc1)N(C)C
Show InChI InChI=1S/C22H22N4O4/c1-25(2)17-6-8-26(9-7-17)18(10-15(13-23)14-24)21(27)16-11-19(28-3)22(30-5)20(12-16)29-4/h6-12H,1-5H3
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n/an/a 1.56E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50485737
PNG
(CHEMBL2160039)
Show SMILES Nc1c(cnn1CC(=O)N1c2ccccc2Sc2ccccc12)C#N
Show InChI InChI=1S/C18H13N5OS/c19-9-12-10-21-22(18(12)20)11-17(24)23-13-5-1-3-7-15(13)25-16-8-4-2-6-14(16)23/h1-8,10H,11,20H2
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n/an/a 1.72E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FTase using dansyl-GCVLS as substrate after 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 22: 6896-902 (2012)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493664
PNG
(CHEMBL2435005)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C19H15BrN4O/c1-23(2)17-7-9-24(10-8-17)18(11-14(12-21)13-22)19(25)15-3-5-16(20)6-4-15/h3-11H,1-2H3
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n/an/a 1.97E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493670
PNG
(CHEMBL2435024)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)[C-](C=C(C#N)C#N)[n+]1cc(C)cc(C)c1
Show InChI InChI=1S/C22H21N3O4/c1-14-6-15(2)13-25(12-14)18(7-16(10-23)11-24)21(26)17-8-19(27-3)22(29-5)20(9-17)28-4/h6-9,12-13H,1-5H3
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n/an/a 2.01E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493657
PNG
(CHEMBL2435021)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(OC)c(OC)c1)[n+]1ccc(OC)cc1)\C#N
Show InChI InChI=1S/C22H22N2O6/c1-5-30-22(26)16(14-23)12-18(24-10-8-17(27-2)9-11-24)21(25)15-6-7-19(28-3)20(13-15)29-4/h6-13H,5H2,1-4H3/b16-12+
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n/an/a 2.08E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493671
PNG
(CHEMBL2435009)
Show SMILES COc1ccc(cc1)C(=O)[C-](C=C(C#N)C#N)[n+]1ccc(cc1)N(C)C
Show InChI InChI=1S/C20H18N4O2/c1-23(2)17-8-10-24(11-9-17)19(12-15(13-21)14-22)20(25)16-4-6-18(26-3)7-5-16/h4-12H,1-3H3
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n/an/a 2.22E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493674
PNG
(CHEMBL2435001)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN4O/c1-23(2)17-7-9-24(10-8-17)18(11-14(12-21)13-22)19(25)15-3-5-16(20)6-4-15/h3-11H,1-2H3
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n/an/a 2.36E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493676
PNG
(CHEMBL2435007)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C20H15N5O/c1-24(2)18-7-9-25(10-8-18)19(11-16(13-22)14-23)20(26)17-5-3-15(12-21)4-6-17/h3-11H,1-2H3
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n/an/a 2.39E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493660
PNG
(CHEMBL2435014)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc2OCC(=O)Nc2c1
Show InChI InChI=1S/C21H17N5O3/c1-25(2)16-5-7-26(8-6-16)18(9-14(11-22)12-23)21(28)15-3-4-19-17(10-15)24-20(27)13-29-19/h3-10H,13H2,1-2H3,(H,24,27)
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n/an/a 2.59E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493681
PNG
(CHEMBL2435018)
Show SMILES COc1ccc(cc1)C(=O)[C-](C=C(C#N)C#N)[n+]1ccc(OC)cc1
Show InChI InChI=1S/C19H15N3O3/c1-24-16-5-3-15(4-6-16)19(23)18(11-14(12-20)13-21)22-9-7-17(25-2)8-10-22/h3-11H,1-2H3
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n/an/a 2.73E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493669
PNG
(CHEMBL2435022)
Show SMILES COc1ccc(cc1)C(=O)[C-](C=C(C#N)C#N)[n+]1cc(C)cc(C)c1
Show InChI InChI=1S/C20H17N3O2/c1-14-8-15(2)13-23(12-14)19(9-16(10-21)11-22)20(24)17-4-6-18(25-3)7-5-17/h4-9,12-13H,1-3H3
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n/an/a 2.74E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493661
PNG
(CHEMBL2435011)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H15N5O3/c1-22(2)16-7-9-23(10-8-16)18(11-14(12-20)13-21)19(25)15-3-5-17(6-4-15)24(26)27/h3-11H,1-2H3
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n/an/a 2.82E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493667
PNG
(CHEMBL2434998)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccccc1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C21H21N3O3/c1-4-27-21(26)17(15-22)14-19(20(25)16-8-6-5-7-9-16)24-12-10-18(11-13-24)23(2)3/h5-14H,4H2,1-3H3/b17-14+
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n/an/a 3.09E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493658
PNG
(CHEMBL2435020)
Show SMILES COc1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H17N3O4/c1-25-16-6-8-23(9-7-16)17(10-14(12-21)13-22)20(24)15-4-5-18(26-2)19(11-15)27-3/h4-11H,1-3H3
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n/an/a 3.14E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493665
PNG
(CHEMBL2435004)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(Cl)cc1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C21H20ClN3O3/c1-4-28-21(27)16(14-23)13-19(20(26)15-5-7-17(22)8-6-15)25-11-9-18(10-12-25)24(2)3/h5-13H,4H2,1-3H3/b16-13+
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n/an/a 3.19E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493680
PNG
(CHEMBL2435006)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(Br)cc1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C21H20BrN3O3/c1-4-28-21(27)16(14-23)13-19(20(26)15-5-7-17(22)8-6-15)25-11-9-18(10-12-25)24(2)3/h5-13H,4H2,1-3H3/b16-13+
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n/an/a 3.64E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493656
PNG
(CHEMBL2435025)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1cc(OC)c(OC)c(OC)c1)[n+]1cc(C)cc(C)c1)\C#N
Show InChI InChI=1S/C24H26N2O6/c1-7-32-24(28)18(12-25)9-19(26-13-15(2)8-16(3)14-26)22(27)17-10-20(29-4)23(31-6)21(11-17)30-5/h8-11,13-14H,7H2,1-6H3/b18-9+
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n/an/a 4.35E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493672
PNG
(CHEMBL2435000)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(C)cc1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C22H23N3O3/c1-5-28-22(27)18(15-23)14-20(21(26)17-8-6-16(2)7-9-17)25-12-10-19(11-13-25)24(3)4/h6-14H,5H2,1-4H3/b18-14+
PDB
MMDB

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n/an/a 4.36E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493663
PNG
(CHEMBL2435008)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(cc1)C#N)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C22H20N4O3/c1-4-29-22(28)18(15-24)13-20(26-11-9-19(10-12-26)25(2)3)21(27)17-7-5-16(14-23)6-8-17/h5-13H,4H2,1-3H3/b18-13+
PDB
MMDB

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n/an/a 4.62E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493678
PNG
(CHEMBL2434997)
Show SMILES CN(C)c1cc[n+](cc1)[C-](C=C(C#N)C#N)C(=O)c1ccccc1
Show InChI InChI=1S/C19H16N4O/c1-22(2)17-8-10-23(11-9-17)18(12-15(13-20)14-21)19(24)16-6-4-3-5-7-16/h3-12H,1-2H3
PDB
MMDB

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n/an/a 4.62E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493673
PNG
(CHEMBL2435013)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1cc(OC)c(OC)c(OC)c1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C24H27N3O6/c1-7-33-24(29)17(15-25)12-19(27-10-8-18(9-11-27)26(2)3)22(28)16-13-20(30-4)23(32-6)21(14-16)31-5/h8-14H,7H2,1-6H3/b17-12+
PDB
MMDB

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n/an/a 4.80E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493659
PNG
(CHEMBL2435015)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc2OCC(=O)Nc2c1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C23H22N4O5/c1-4-31-23(30)16(13-24)12-19(27-9-7-17(8-10-27)26(2)3)22(29)15-5-6-20-18(11-15)25-21(28)14-32-20/h5-12H,4,14H2,1-3H3,(H,25,28)/b16-12+
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n/an/a 5.52E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493677
PNG
(CHEMBL2435002)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(F)cc1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C21H20FN3O3/c1-4-28-21(27)16(14-23)13-19(20(26)15-5-7-17(22)8-6-15)25-11-9-18(10-12-25)24(2)3/h5-13H,4H2,1-3H3/b16-13+
PDB
MMDB

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n/an/a 6.23E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50493662
PNG
(CHEMBL2435010)
Show SMILES CCOC(=O)C(=C\[C-](C(=O)c1ccc(OC)cc1)[n+]1ccc(cc1)N(C)C)\C#N
Show InChI InChI=1S/C22H23N3O4/c1-5-29-22(27)17(15-23)14-20(25-12-10-18(11-13-25)24(2)3)21(26)16-6-8-19(28-4)9-7-16/h6-14H,5H2,1-4H3/b17-14+
PDB
MMDB

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n/an/a 6.27E+4n/an/an/an/an/an/a



'Al. I. Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of recombinant human farnesyltransferase using Dansyl-GCVLS as substrate measured for 15 mins by fluorimetric analysis


Bioorg Med Chem Lett 23: 5887-92 (2013)

More data for this
Ligand-Target Pair