BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 15 hits from 'Alexandru Ioan Cuza' University of Iasi   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189292
PNG
(CHEMBL3828157)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2ccccc12
Show InChI InChI=1S/C27H22N2O3S/c1-3-32-27(31)19-17-23(29-15-7-6-8-20(19)29)24(30)14-12-18-11-13-22-26(16-18)33-25-10-5-4-9-21(25)28(22)2/h4-17H,3H2,1-2H3/b14-12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189293
PNG
(CHEMBL3827279)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2c(C)cccc12
Show InChI InChI=1S/C28H24N2O3S/c1-4-33-28(32)20-17-24(30-18(2)8-7-10-21(20)30)25(31)15-13-19-12-14-23-27(16-19)34-26-11-6-5-9-22(26)29(23)3/h5-17H,4H2,1-3H3/b15-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 23n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189295
PNG
(CHEMBL3828384)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2ccc(C)cc12
Show InChI InChI=1S/C28H24N2O3S/c1-4-33-28(32)20-17-24(30-14-13-18(2)15-23(20)30)25(31)12-10-19-9-11-22-27(16-19)34-26-8-6-5-7-21(26)29(22)3/h5-17H,4H2,1-3H3/b12-10+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 155n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50059863
PNG
((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Show SMILES CCCCCCCCCCCCCC\C(C(O)=O)=C(/C)C(O)=O
Show InChI InChI=1S/C19H34O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-17(19(22)23)16(2)18(20)21/h3-15H2,1-2H3,(H,20,21)(H,22,23)/b17-16-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189304
PNG
(CHEMBL3827991)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(Br)cc2)n2ccc(OC)cc12
Show InChI InChI=1S/C21H18BrNO4/c1-3-27-21(25)17-13-19(23-11-10-16(26-2)12-18(17)23)20(24)9-6-14-4-7-15(22)8-5-14/h4-13H,3H2,1-2H3/b9-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 602n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189297
PNG
(CHEMBL3828545)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc3N(C)c4ccccc4Sc3c2)n2ccc(OC)cc12
Show InChI InChI=1S/C28H24N2O4S/c1-4-34-28(32)20-17-24(30-14-13-19(33-3)16-23(20)30)25(31)12-10-18-9-11-22-27(15-18)35-26-8-6-5-7-21(26)29(22)2/h5-17H,4H2,1-3H3/b12-10+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 711n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189301
PNG
(CHEMBL3827237)
Show SMILES COc1cc(\C=C\C(=O)c2ccc3c(C)cc(C)cn23)cc(OC)c1OC
Show InChI InChI=1S/C22H23NO4/c1-14-10-15(2)17-7-8-18(23(17)13-14)19(24)9-6-16-11-20(25-3)22(27-5)21(12-16)26-4/h6-13H,1-5H3/b9-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 726n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189302
PNG
(CHEMBL3827637)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(Cl)cc2)n2ccc(OC)cc12
Show InChI InChI=1S/C21H18ClNO4/c1-3-27-21(25)17-13-19(23-11-10-16(26-2)12-18(17)23)20(24)9-6-14-4-7-15(22)8-5-14/h4-13H,3H2,1-2H3/b9-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 931n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189300
PNG
(CHEMBL3826996)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(cc2)-c2ccccc2)n2ccc(OC)cc12
Show InChI InChI=1S/C27H23NO4/c1-3-32-27(30)23-18-25(28-16-15-22(31-2)17-24(23)28)26(29)14-11-19-9-12-21(13-10-19)20-7-5-4-6-8-20/h4-18H,3H2,1-2H3/b14-11+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.32E+3n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189303
PNG
(CHEMBL3828130)
Show SMILES COc1ccn2c(cc(C(O)=O)c2c1)C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C19H14ClNO4/c1-25-14-8-9-21-16(10-14)15(19(23)24)11-17(21)18(22)7-4-12-2-5-13(20)6-3-12/h2-11H,1H3,(H,23,24)/b7-4+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.33E+3n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189299
PNG
(CHEMBL3828274)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2ccc(cc2)C#N)n2ccc(OC)cc12
Show InChI InChI=1S/C22H18N2O4/c1-3-28-22(26)18-13-20(24-11-10-17(27-2)12-19(18)24)21(25)9-8-15-4-6-16(14-23)7-5-15/h4-13H,3H2,1-2H3/b9-8+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.74E+3n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189294
PNG
(CHEMBL3827132)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)n2ccc(OC)cc12
Show InChI InChI=1S/C24H25NO7/c1-6-32-24(27)17-14-19(25-10-9-16(28-2)13-18(17)25)20(26)8-7-15-11-21(29-3)23(31-5)22(12-15)30-4/h7-14H,6H2,1-5H3/b8-7+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.16E+4n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189296
PNG
(CHEMBL3827509)
Show SMILES COc1cc(\C=C\C(=O)c2cc(C(O)=O)c3c(C)cc(C)cn23)cc(OC)c1OC
Show InChI InChI=1S/C23H23NO6/c1-13-8-14(2)21-16(23(26)27)11-17(24(21)12-13)18(25)7-6-15-9-19(28-3)22(30-5)20(10-15)29-4/h6-12H,1-5H3,(H,26,27)/b7-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.59E+4n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50189298
PNG
(CHEMBL3826985)
Show SMILES CCOC(=O)c1cc(C(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)n2ccccc12
Show InChI InChI=1S/C23H23NO6/c1-5-30-23(26)16-14-18(24-11-7-6-8-17(16)24)19(25)10-9-15-12-20(27-2)22(29-4)21(13-15)28-3/h6-14H,5H2,1-4H3/b10-9+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.93E+4n/an/an/an/an/an/a



'Alexandru Ioan Cuza' University of Iasi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant farnesyltransferase using farnesylpyrophosphate and dansyl-GCVLS as substrate measured for 15 mins by fluorescence as...


Bioorg Med Chem Lett 26: 3730-4 (2016)


Article DOI: 10.1016/j.bmcl.2016.05.074
BindingDB Entry DOI: 10.7270/Q2DR2XFP
More data for this
Ligand-Target Pair