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Compile Data Set for Download or QSAR

Found 24 hits from A Subsidiary of Agouron Pharmaceuticals, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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20n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075917
PNG
(8N-(2-aminoethyl)-15-oxo-9a,10,11,12,13,13a,14,15-...)
Show SMILES NCCNC(=O)c1c2N[C@@H]3CCCC[C@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,30-31H,3-4,7-10,25H2,(H,26,32)/t14-,15-/m1/s1
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45n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50403725
PNG
(CHEMBL2112326)
Show SMILES NCCNC(=O)c1c2N[C@H]3CCCC[C@@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,29-30H,3-4,7-10,25H2,(H,26,32)/t14-,15-/m0/s1
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75n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075918
PNG
(8N-[2-amino-(1R,2R)-cyclohexyl]-15-oxo-(9aS,13aS)-...)
Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)c1c2N[C@H]3CCCC[C@@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,33,35H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m1/s1
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86n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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110n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075917
PNG
(8N-(2-aminoethyl)-15-oxo-9a,10,11,12,13,13a,14,15-...)
Show SMILES NCCNC(=O)c1c2N[C@@H]3CCCC[C@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,30-31H,3-4,7-10,25H2,(H,26,32)/t14-,15-/m1/s1
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160n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075918
PNG
(8N-[2-amino-(1R,2R)-cyclohexyl]-15-oxo-(9aS,13aS)-...)
Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)c1c2N[C@H]3CCCC[C@@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,33,35H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m1/s1
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180n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50403725
PNG
(CHEMBL2112326)
Show SMILES NCCNC(=O)c1c2N[C@H]3CCCC[C@@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,29-30H,3-4,7-10,25H2,(H,26,32)/t14-,15-/m0/s1
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200n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075921
PNG
(8N-(2-aminoethyl)-15-oxo-(9aR,13aS)-11,12,13,15-te...)
Show SMILES NCCNC(=O)c1c2N[C@@H]3CCCC[C@@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,30-31H,3-4,7-10,25H2,(H,26,32)/t14-,15+/m0/s1
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270n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075924
PNG
(13-Oxo-10,11,12,13-tetrahydro-9H-5,7,9,12-tetraaza...)
Show SMILES NCCNC(=O)c1c2NCCN=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C20H18N6O2/c21-5-6-24-20(28)14-16-12-13(17-18(14)23-8-7-22-17)19(27)11-4-2-1-3-10(11)15(12)25-9-26-16/h1-4,9,23,27H,5-8,21H2,(H,24,28)
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650n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075921
PNG
(8N-(2-aminoethyl)-15-oxo-(9aR,13aS)-11,12,13,15-te...)
Show SMILES NCCNC(=O)c1c2N[C@@H]3CCCC[C@@H]3N=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C24H24N6O2/c25-9-10-26-24(32)18-20-16-17(21-22(18)30-15-8-4-3-7-14(15)29-21)23(31)13-6-2-1-5-12(13)19(16)27-11-28-20/h1-2,5-6,11,14-15,30-31H,3-4,7-10,25H2,(H,26,32)/t14-,15+/m0/s1
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830n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (human))
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075924
PNG
(13-Oxo-10,11,12,13-tetrahydro-9H-5,7,9,12-tetraaza...)
Show SMILES NCCNC(=O)c1c2NCCN=c2c2c(O)c3ccccc3c3ncnc1c23
Show InChI InChI=1S/C20H18N6O2/c21-5-6-24-20(28)14-16-12-13(17-18(14)23-8-7-22-17)19(27)11-4-2-1-3-10(11)15(12)25-9-26-16/h1-4,9,23,27H,5-8,21H2,(H,24,28)
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2.05E+3n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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3.20E+3n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine D2 receptor


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 1


(HUMAN)
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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4.20E+3n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity against Neuropeptide Y receptor type 1 using [125I]-PYY


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075923
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R...)
Show SMILES N[C@H]1CCCC[C@H]1NC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C22H20N4O2/c23-16-7-3-4-8-17(16)26-22(28)15-10-9-14-18-19(24-11-25-20(15)18)12-5-1-2-6-13(12)21(14)27/h1-2,5-6,9-11,16-17H,3-4,7-8,23H2,(H,26,28)/t16-,17+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075920
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R...)
Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C22H20N4O2/c23-16-7-3-4-8-17(16)26-22(28)15-10-9-14-18-19(24-11-25-20(15)18)12-5-1-2-6-13(12)21(14)27/h1-2,5-6,9-11,16-17H,3-4,7-8,23H2,(H,26,28)/t16-,17-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50075919
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid (2-a...)
Show SMILES NCCNC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C18H14N4O2/c19-7-8-20-18(24)13-6-5-12-14-15(21-9-22-16(13)14)10-3-1-2-4-11(10)17(12)23/h1-6,9H,7-8,19H2,(H,20,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075919
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid (2-a...)
Show SMILES NCCNC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C18H14N4O2/c19-7-8-20-18(24)13-6-5-12-14-15(21-9-22-16(13)14)10-3-1-2-4-11(10)17(12)23/h1-6,9H,7-8,19H2,(H,20,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 6 receptor


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075925
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid dime...)
Show SMILES CN(C)C(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C18H13N3O2/c1-21(2)18(23)13-8-7-12-14-15(19-9-20-16(13)14)10-5-3-4-6-11(10)17(12)22/h3-9H,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075923
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R...)
Show SMILES N[C@H]1CCCC[C@H]1NC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C22H20N4O2/c23-16-7-3-4-8-17(16)26-22(28)15-10-9-14-18-19(24-11-25-20(15)18)12-5-1-2-6-13(12)21(14)27/h1-2,5-6,9-11,16-17H,3-4,7-8,23H2,(H,26,28)/t16-,17+/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM50075920
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid ((1R...)
Show SMILES N[C@@H]1CCCC[C@H]1NC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C22H20N4O2/c23-16-7-3-4-8-17(16)26-22(28)15-10-9-14-18-19(24-11-25-20(15)18)12-5-1-2-6-13(12)21(14)27/h1-2,5-6,9-11,16-17H,3-4,7-8,23H2,(H,26,28)/t16-,17-/m1/s1
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PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 2


(Mus musculus)
BDBM32001
PNG
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
Show SMILES OC(=O)c1ccc2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C16H8N2O3/c19-15-9-4-2-1-3-8(9)13-12-10(15)5-6-11(16(20)21)14(12)18-7-17-13/h1-7H,(H,20,21)
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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta (30% inhibition at 100 uM)


Bioorg Med Chem Lett 9: 765-70 (1999)


Article DOI: 10.1016/s0960-894x(99)00075-x
BindingDB Entry DOI: 10.7270/Q2TD9WJJ
More data for this
Ligand-Target Pair