BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 12 hits from A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124560
PNG
(CHEMBL3623706)
Show SMILES Cl.OC(=O)[C@H](CNC(=O)CCNC(=O)c1ccc2CCNCc2c1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H26N4O6S.ClH/c27-20(9-11-24-21(28)16-7-6-15-8-10-23-13-17(15)12-16)25-14-19(22(29)30)26-33(31,32)18-4-2-1-3-5-18;/h1-7,12,19,23,26H,8-11,13-14H2,(H,24,28)(H,25,27)(H,29,30);1H/t19-;/m0./s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.20n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 open form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124522
PNG
(CHEMBL3623709)
Show SMILES Cl.Cl.NCCCC(=O)Nc1ccc2nc([nH]c(=O)c2c1)N1CCNCC1
Show InChI InChI=1S/C16H22N6O2.2ClH/c17-5-1-2-14(23)19-11-3-4-13-12(10-11)15(24)21-16(20-13)22-8-6-18-7-9-22;;/h3-4,10,18H,1-2,5-9,17H2,(H,19,23)(H,20,21,24);2*1H
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 closed form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregatio...


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124559
PNG
(CHEMBL3623707)
Show SMILES Cl.OC(=O)[C@@H](CNC(=O)CCNC(=O)c1ccc2CCNCc2c1)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H26N4O6S.ClH/c27-20(9-11-24-21(28)16-7-6-15-8-10-23-13-17(15)12-16)25-14-19(22(29)30)26-33(31,32)18-4-2-1-3-5-18;/h1-7,12,19,23,26H,8-11,13-14H2,(H,24,28)(H,25,27)(H,29,30);1H/t19-;/m1./s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 25n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 open form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50004058
PNG
((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Show SMILES CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O
Show InChI InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 open form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50004058
PNG
((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Show SMILES CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O
Show InChI InChI=1S/C22H36N2O5S/c1-2-3-16-30(27,28)24-21(22(25)26)17-19-7-9-20(10-8-19)29-15-5-4-6-18-11-13-23-14-12-18/h7-10,18,21,23-24H,2-6,11-17H2,1H3,(H,25,26)/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 closed form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregatio...


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124573
PNG
(CHEMBL1472460)
Show SMILES NCC(=O)Nc1cccc(c1)-c1nn2c(nc(cc2=O)N2CCNCC2)s1
Show InChI InChI=1S/C17H19N7O2S/c18-10-14(25)20-12-3-1-2-11(8-12)16-22-24-15(26)9-13(21-17(24)27-16)23-6-4-19-5-7-23/h1-3,8-9,19H,4-7,10,18H2,(H,20,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 96n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 in human platelet rich plasma


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124510
PNG
(CHEMBL3623710)
Show SMILES Cl.Cl.O=C(Nc1ccc2nc([nH]c(=O)c2c1)N1CCNCC1)C1CCNCC1
Show InChI InChI=1S/C18H24N6O2.2ClH/c25-16(12-3-5-19-6-4-12)21-13-1-2-15-14(11-13)17(26)23-18(22-15)24-9-7-20-8-10-24;;/h1-2,11-12,19-20H,3-10H2,(H,21,25)(H,22,23,26);2*1H
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 closed form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregatio...


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124558
PNG
(CHEMBL3623708)
Show SMILES Cl.Cl.NCCC(=O)Nc1ccc2nc([nH]c(=O)c2c1)N1CCNCC1
Show InChI InChI=1S/C15H20N6O2.2ClH/c16-4-3-13(22)18-10-1-2-12-11(9-10)14(23)20-15(19-12)21-7-5-17-6-8-21;;/h1-2,9,17H,3-8,16H2,(H,18,22)(H,19,20,23);2*1H
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 closed form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregatio...


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124571
PNG
(CHEMBL3623501)
Show SMILES Cl.CCCCS(=O)(=O)N[C@@H](CNC(=O)CCNC(=O)c1ccc2CCNCc2c1)C(O)=O
Show InChI InChI=1S/C20H30N4O6S.ClH/c1-2-3-10-31(29,30)24-17(20(27)28)13-23-18(25)7-9-22-19(26)15-5-4-14-6-8-21-12-16(14)11-15;/h4-5,11,17,21,24H,2-3,6-10,12-13H2,1H3,(H,22,26)(H,23,25)(H,27,28);1H/t17-;/m0./s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 open form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124561
PNG
(CHEMBL3621231)
Show SMILES Cl.CCCCS(=O)(=O)N[C@H](CNC(=O)CCNC(=O)c1ccc2CCNCc2c1)C(O)=O
Show InChI InChI=1S/C20H30N4O6S.ClH/c1-2-3-10-31(29,30)24-17(20(27)28)13-23-18(25)7-9-22-19(26)15-5-4-14-6-8-21-12-16(14)11-15;/h4-5,11,17,21,24H,2-3,6-10,12-13H2,1H3,(H,22,26)(H,23,25)(H,27,28);1H/t17-;/m1./s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 670n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 open form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50063698
PNG
(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Show SMILES NC(N)=Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 in human platelet rich plasma


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair
Integrin alpha-2/beta-3


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50124572
PNG
(CHEMBL1234739)
Show SMILES CCc1nn2c(nc(cc2=O)N2CCNCC2)s1
Show InChI InChI=1S/C11H15N5OS/c1-2-9-14-16-10(17)7-8(13-11(16)18-9)15-5-3-12-4-6-15/h7,12H,2-6H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



A.V. Bogatsky Physico-Chemical Institute of National Academy of Sciences of Ukraine

Curated by ChEMBL


Assay Description
Antagonist activity against integrin alpha2bbeta3 in human platelet rich plasma


J Med Chem 58: 7681-94 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00865
BindingDB Entry DOI: 10.7270/Q2QN68MB
More data for this
Ligand-Target Pair