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Found 139 hits from ACETYLON PHARMACEUTICALS, INC.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 6


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002 | US9884850, Compound 2)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
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n/an/a 2.40n/an/an/an/a7.425



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM249364
PNG
(US9464073, 001 | US9884850, Compound 1)
Show SMILES ONC(=O)c1cnc(NC2(CCCCC2)c2cc(F)cc(F)c2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-13-6-12(7-14(19)8-13)17(4-2-1-3-5-17)22-16-20-9-11(10-21-16)15(24)23-25/h6-10,25H,1-5H2,(H,23,24)(H,20,21,22)
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n/an/a 2.90n/an/an/an/a7.425



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182737
PNG
(US9145412, Table 1, Compound 3)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C27H27N5OS/c28-21-7-5-18(24-2-1-13-34-24)15-22(21)31-27(33)20-14-19-6-8-23(32-11-9-29-10-12-32)25(17-3-4-17)26(19)30-16-20/h1-2,5-8,13-17,29H,3-4,9-12,28H2,(H,31,33)
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n/an/a 3.10n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM249366
PNG
(US9464073, 003 | US9884850, Compound 3)
Show SMILES ONC(=O)c1cnc(NC2(CCC(F)(F)CC2)c2ccccc2)nc1
Show InChI InChI=1S/C17H18F2N4O2/c18-17(19)8-6-16(7-9-17,13-4-2-1-3-5-13)22-15-20-10-12(11-21-15)14(24)23-25/h1-5,10-11,25H,6-9H2,(H,23,24)(H,20,21,22)
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n/an/a 3.70n/an/an/an/a7.425



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (human))
BDBM249367
PNG
(US9464073, 004 | US9884850, Compound 4)
Show SMILES ONC(=O)c1cnc(NC2(CCC3(CC2)OCCO3)c2cccc(F)c2)nc1
Show InChI InChI=1S/C19H21FN4O4/c20-15-3-1-2-14(10-15)18(4-6-19(7-5-18)27-8-9-28-19)23-17-21-11-13(12-22-17)16(25)24-26/h1-3,10-12,26H,4-9H2,(H,24,25)(H,21,22,23)
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n/an/a 3.90n/an/an/an/a7.425



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182757
PNG
(US9145412, Table 1, Compound 23)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C24H23N5OS/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29/h1-8,13-15,26H,9-12,25H2,(H,28,30)
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n/an/a 4n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182760
PNG
(US9145412, Table 1, Compound 47)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1cccs1
Show InChI InChI=1S/C27H29N5O2S/c28-22-6-5-19(25-2-1-13-35-25)15-23(22)30-27(33)21-14-20-16-24(18-3-4-18)32(26(20)29-17-21)8-7-31-9-11-34-12-10-31/h1-2,5-6,13-18H,3-4,7-12,28H2,(H,30,33)
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n/an/a 6n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182753
PNG
(US9145412, Table 1, Compound 19)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)ccc2c1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c27-23-7-6-20(19-4-2-1-3-5-19)17-24(23)29-26(32)22-16-21-8-9-31(25(21)28-18-22)11-10-30-12-14-33-15-13-30/h1-9,16-18H,10-15,27H2,(H,29,32)
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n/an/a 6.80n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182756
PNG
(US9145412, Table 1, Compound 22)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nc(cnc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C23H22N6OS/c24-17-5-3-15(21-2-1-11-31-21)12-19(17)28-23(30)16-4-6-18-20(13-16)26-14-22(27-18)29-9-7-25-8-10-29/h1-6,11-14,25H,7-10,24H2,(H,28,30)
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n/an/a 7n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182752
PNG
(US9145412, Table 1, Compound 18)
Show SMILES CN1CCN(CCn2ncc3cc(ccc23)C(=O)Nc2cc(ccc2N)-c2ccccc2)CC1
Show InChI InChI=1S/C27H30N6O/c1-31-11-13-32(14-12-31)15-16-33-26-10-8-22(17-23(26)19-29-33)27(34)30-25-18-21(7-9-24(25)28)20-5-3-2-4-6-20/h2-10,17-19H,11-16,28H2,1H3,(H,30,34)
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n/an/a 7.10n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182751
PNG
(US9145412, Table 1, Compound 17)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2n(CCN3CCOCC3)ncc2c1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c27-23-8-6-20(19-4-2-1-3-5-19)17-24(23)29-26(32)21-7-9-25-22(16-21)18-28-31(25)11-10-30-12-14-33-15-13-30/h1-9,16-18H,10-15,27H2,(H,29,32)
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n/an/a 7.40n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182741
PNG
(US9145412, Table 1, Compound 7)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N5O/c30-24-10-8-21(19-4-2-1-3-5-19)17-25(24)33-29(35)23-16-22-9-11-26(34-14-12-31-13-15-34)27(20-6-7-20)28(22)32-18-23/h1-5,8-11,16-18,20,31H,6-7,12-15,30H2,(H,33,35)
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n/an/a 7.80n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182752
PNG
(US9145412, Table 1, Compound 18)
Show SMILES CN1CCN(CCn2ncc3cc(ccc23)C(=O)Nc2cc(ccc2N)-c2ccccc2)CC1
Show InChI InChI=1S/C27H30N6O/c1-31-11-13-32(14-12-31)15-16-33-26-10-8-22(17-23(26)19-29-33)27(34)30-25-18-21(7-9-24(25)28)20-5-3-2-4-6-20/h2-10,17-19H,11-16,28H2,1H3,(H,30,34)
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n/an/a 11n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182754
PNG
(US9145412, Table 1, Compound 20)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nn(CCN3CCOCC3)cc2c1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c27-23-8-6-20(19-4-2-1-3-5-19)17-25(23)28-26(32)21-7-9-24-22(16-21)18-31(29-24)11-10-30-12-14-33-15-13-30/h1-9,16-18H,10-15,27H2,(H,28,32)
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n/an/a 11n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182756
PNG
(US9145412, Table 1, Compound 22)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nc(cnc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C23H22N6OS/c24-17-5-3-15(21-2-1-11-31-21)12-19(17)28-23(30)16-4-6-18-20(13-16)26-14-22(27-18)29-9-7-25-8-10-29/h1-6,11-14,25H,7-10,24H2,(H,28,30)
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n/an/a 12n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182737
PNG
(US9145412, Table 1, Compound 3)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C27H27N5OS/c28-21-7-5-18(24-2-1-13-34-24)15-22(21)31-27(33)20-14-19-6-8-23(32-11-9-29-10-12-32)25(17-3-4-17)26(19)30-16-20/h1-2,5-8,13-17,29H,3-4,9-12,28H2,(H,31,33)
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n/an/a 14n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182741
PNG
(US9145412, Table 1, Compound 7)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N5O/c30-24-10-8-21(19-4-2-1-3-5-19)17-25(24)33-29(35)23-16-22-9-11-26(34-14-12-31-13-15-34)27(20-6-7-20)28(22)32-18-23/h1-5,8-11,16-18,20,31H,6-7,12-15,30H2,(H,33,35)
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n/an/a 15n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182757
PNG
(US9145412, Table 1, Compound 23)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C24H23N5OS/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29/h1-8,13-15,26H,9-12,25H2,(H,28,30)
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n/an/a 15n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182758
PNG
(US9145412, Table 1, Compound 33)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1ccccc1
Show InChI InChI=1S/C30H32N4O2/c31-26-10-8-23(21-4-2-1-3-5-21)19-27(26)32-30(35)24-9-11-28-25(18-24)20-29(22-6-7-22)34(28)13-12-33-14-16-36-17-15-33/h1-5,8-11,18-20,22H,6-7,12-17,31H2,(H,32,35)
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n/an/a 15n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182751
PNG
(US9145412, Table 1, Compound 17)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2n(CCN3CCOCC3)ncc2c1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c27-23-8-6-20(19-4-2-1-3-5-19)17-24(23)29-26(32)21-7-9-25-22(16-21)18-28-31(25)11-10-30-12-14-33-15-13-30/h1-9,16-18H,10-15,27H2,(H,29,32)
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n/an/a 19n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182754
PNG
(US9145412, Table 1, Compound 20)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nn(CCN3CCOCC3)cc2c1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c27-23-8-6-20(19-4-2-1-3-5-19)17-25(23)28-26(32)21-7-9-24-22(16-21)18-31(29-24)11-10-30-12-14-33-15-13-30/h1-9,16-18H,10-15,27H2,(H,28,32)
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n/an/a 23n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182759
PNG
(US9145412, Table 1, Compound 48)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1ccncc1
Show InChI InChI=1S/C28H30N6O2/c29-24-4-3-21(19-5-7-30-8-6-19)16-25(24)32-28(35)23-15-22-17-26(20-1-2-20)34(27(22)31-18-23)10-9-33-11-13-36-14-12-33/h3-8,15-18,20H,1-2,9-14,29H2,(H,32,35)
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n/an/a 24n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182759
PNG
(US9145412, Table 1, Compound 48)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1ccncc1
Show InChI InChI=1S/C28H30N6O2/c29-24-4-3-21(19-5-7-30-8-6-19)16-25(24)32-28(35)23-15-22-17-26(20-1-2-20)34(27(22)31-18-23)10-9-33-11-13-36-14-12-33/h3-8,15-18,20H,1-2,9-14,29H2,(H,32,35)
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n/an/a 27n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172766
PNG
(US9096549, M)
Show SMILES Nc1cc(F)ccc1NC(=O)c1cc2ccc(N3CCNCC3)c(C3CC3)c2cn1
Show InChI InChI=1S/C23H24FN5O/c24-16-4-5-19(18(25)12-16)28-23(30)20-11-15-3-6-21(29-9-7-26-8-10-29)22(14-1-2-14)17(15)13-27-20/h3-6,11-14,26H,1-2,7-10,25H2,(H,28,30)
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n/an/a 30n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182753
PNG
(US9145412, Table 1, Compound 19)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)ccc2c1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2/c27-23-7-6-20(19-4-2-1-3-5-19)17-24(23)29-26(32)22-16-21-8-9-31(25(21)28-18-22)11-10-30-12-14-33-15-13-30/h1-9,16-18H,10-15,27H2,(H,29,32)
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n/an/a 31n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172765
PNG
(US9096549, L)
Show SMILES Nc1ccccc1NC(=O)c1cc2ccc(N3CCNCC3)c(C3CC3)c2cn1
Show InChI InChI=1S/C23H25N5O/c24-18-3-1-2-4-19(18)27-23(29)20-13-16-7-8-21(28-11-9-25-10-12-28)22(15-5-6-15)17(16)14-26-20/h1-4,7-8,13-15,25H,5-6,9-12,24H2,(H,27,29)
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n/an/a 33n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182760
PNG
(US9145412, Table 1, Compound 47)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1cccs1
Show InChI InChI=1S/C27H29N5O2S/c28-22-6-5-19(25-2-1-13-35-25)15-23(22)30-27(33)21-14-20-16-24(18-3-4-18)32(26(20)29-17-21)8-7-31-9-11-34-12-10-31/h1-2,5-6,13-18H,3-4,7-12,28H2,(H,30,33)
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n/an/a 36n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172764
PNG
(US9096549, K)
Show SMILES Nc1ccccc1NC(=O)c1cc2ccc(cc2cn1)N1CCNCC1
Show InChI InChI=1S/C20H21N5O/c21-17-3-1-2-4-18(17)24-20(26)19-12-14-5-6-16(11-15(14)13-23-19)25-9-7-22-8-10-25/h1-6,11-13,22H,7-10,21H2,(H,24,26)
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n/an/a 38n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172755
PNG
(US9096549, B)
Show SMILES Nc1ccccc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1
Show InChI InChI=1S/C23H25N5O/c24-18-3-1-2-4-19(18)27-23(29)17-13-16-7-8-20(28-11-9-25-10-12-28)21(15-5-6-15)22(16)26-14-17/h1-4,7-8,13-15,25H,5-6,9-12,24H2,(H,27,29)
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n/an/a 53n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182755
PNG
(US9145412, Table 1, Compound 21)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(N3CCNCC3)c(ccc2c1)C1CC1)-c1ccccc1
Show InChI InChI=1S/C29H29N5O/c30-25-11-9-21(19-4-2-1-3-5-19)17-26(25)33-29(35)23-16-22-8-10-24(20-6-7-20)28(27(22)32-18-23)34-14-12-31-13-15-34/h1-5,8-11,16-18,20,31H,6-7,12-15,30H2,(H,33,35)
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n/an/a 56n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172762
PNG
(US9096549, I)
Show SMILES Nc1cc(F)ccc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1
Show InChI InChI=1S/C23H24FN5O/c24-17-4-5-19(18(25)12-17)28-23(30)16-11-15-3-6-20(29-9-7-26-8-10-29)21(14-1-2-14)22(15)27-13-16/h3-6,11-14,26H,1-2,7-10,25H2,(H,28,30)
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n/an/a 57n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172754
PNG
(US9096549, A)
Show SMILES Nc1ccc(F)cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1
Show InChI InChI=1S/C23H24FN5O/c24-17-4-5-18(25)19(12-17)28-23(30)16-11-15-3-6-20(29-9-7-26-8-10-29)21(14-1-2-14)22(15)27-13-16/h3-6,11-14,26H,1-2,7-10,25H2,(H,28,30)
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n/an/a 59n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172758
PNG
(US9096549, E)
Show SMILES CN1CCN(CC1)c1ccc2cc(cnc2c1C1CC1)C(=O)Nc1ccc(F)cc1N
Show InChI InChI=1S/C24H26FN5O/c1-29-8-10-30(11-9-29)21-7-4-16-12-17(14-27-23(16)22(21)15-2-3-15)24(31)28-20-6-5-18(25)13-19(20)26/h4-7,12-15H,2-3,8-11,26H2,1H3,(H,28,31)
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n/an/a 68n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182758
PNG
(US9145412, Table 1, Compound 33)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1ccccc1
Show InChI InChI=1S/C30H32N4O2/c31-26-10-8-23(21-4-2-1-3-5-21)19-27(26)32-30(35)24-9-11-28-25(18-24)20-29(22-6-7-22)34(28)13-12-33-14-16-36-17-15-33/h1-5,8-11,18-20,22H,6-7,12-17,31H2,(H,32,35)
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n/an/a 70n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182756
PNG
(US9145412, Table 1, Compound 22)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nc(cnc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C23H22N6OS/c24-17-5-3-15(21-2-1-11-31-21)12-19(17)28-23(30)16-4-6-18-20(13-16)26-14-22(27-18)29-9-7-25-8-10-29/h1-6,11-14,25H,7-10,24H2,(H,28,30)
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n/an/a 71n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182745
PNG
(US9145412, Table 1, Compound 11)
Show SMILES COCCNc1cc2ncc(cc2cc1C1CC1)C(=O)Nc1cc(ccc1N)-c1cccs1
Show InChI InChI=1S/C26H26N4O2S/c1-32-9-8-28-23-14-22-18(12-20(23)16-4-5-16)11-19(15-29-22)26(31)30-24-13-17(6-7-21(24)27)25-3-2-10-33-25/h2-3,6-7,10-16,28H,4-5,8-9,27H2,1H3,(H,30,31)
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n/an/a 89n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182737
PNG
(US9145412, Table 1, Compound 3)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C27H27N5OS/c28-21-7-5-18(24-2-1-13-34-24)15-22(21)31-27(33)20-14-19-6-8-23(32-11-9-29-10-12-32)25(17-3-4-17)26(19)30-16-20/h1-2,5-8,13-17,29H,3-4,9-12,28H2,(H,31,33)
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n/an/a 99n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182755
PNG
(US9145412, Table 1, Compound 21)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(N3CCNCC3)c(ccc2c1)C1CC1)-c1ccccc1
Show InChI InChI=1S/C29H29N5O/c30-25-11-9-21(19-4-2-1-3-5-19)17-26(25)33-29(35)23-16-22-8-10-24(20-6-7-20)28(27(22)32-18-23)34-14-12-31-13-15-34/h1-5,8-11,16-18,20,31H,6-7,12-15,30H2,(H,33,35)
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n/an/a 103n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182735
PNG
(US9145412, Table 1, Compound 1)
Show SMILES Nc1ccccc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1
Show InChI InChI=1S/C20H21N5O/c21-16-3-1-2-4-18(16)24-20(26)15-5-7-17-14(13-15)6-8-19(23-17)25-11-9-22-10-12-25/h1-8,13,22H,9-12,21H2,(H,24,26)
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n/an/a 104n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002 | US9884850, Compound 2)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
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n/an/a 108n/an/an/an/a7.425



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182757
PNG
(US9145412, Table 1, Compound 23)
Show SMILES Nc1ccc(cc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1)-c1cccs1
Show InChI InChI=1S/C24H23N5OS/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29/h1-8,13-15,26H,9-12,25H2,(H,28,30)
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n/an/a 114n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM182749
PNG
(US9145412, Table 1, Compound 15)
Show SMILES COCCNc1ccc2cc(cnc2c1C1CC1)C(=O)Nc1cc(ccc1N)-c1ccccc1
Show InChI InChI=1S/C28H28N4O2/c1-34-14-13-30-24-12-10-21-15-22(17-31-27(21)26(24)19-7-8-19)28(33)32-25-16-20(9-11-23(25)29)18-5-3-2-4-6-18/h2-6,9-12,15-17,19,30H,7-8,13-14,29H2,1H3,(H,32,33)
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n/an/a 115n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM249365
PNG
(US9464073, 002 | US9884850, Compound 2)
Show SMILES ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Show InChI InChI=1S/C16H16F2N4O3/c17-11-1-2-13(18)12(7-11)16(3-5-25-6-4-16)21-15-19-8-10(9-20-15)14(23)22-24/h1-2,7-9,24H,3-6H2,(H,22,23)(H,19,20,21)
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n/an/a 117n/an/an/an/a7.425



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9884850 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182741
PNG
(US9145412, Table 1, Compound 7)
Show SMILES Nc1ccc(cc1NC(=O)c1cnc2c(C3CC3)c(ccc2c1)N1CCNCC1)-c1ccccc1
Show InChI InChI=1S/C29H29N5O/c30-24-10-8-21(19-4-2-1-3-5-19)17-25(24)33-29(35)23-16-22-9-11-26(34-14-12-31-13-15-34)27(20-6-7-20)28(22)32-18-23/h1-5,8-11,16-18,20,31H,6-7,12-15,30H2,(H,33,35)
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n/an/a 164n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182742
PNG
(US9145412, Table 1, Compound 8)
Show SMILES Nc1sc(cc1NC(=O)c1cnc2cc(ccc2c1)N1CCNCC1)-c1ccccc1
Show InChI InChI=1S/C24H23N5OS/c25-23-21(14-22(31-23)16-4-2-1-3-5-16)28-24(30)18-12-17-6-7-19(13-20(17)27-15-18)29-10-8-26-9-11-29/h1-7,12-15,26H,8-11,25H2,(H,28,30)
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n/an/a 171n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM182752
PNG
(US9145412, Table 1, Compound 18)
Show SMILES CN1CCN(CCn2ncc3cc(ccc23)C(=O)Nc2cc(ccc2N)-c2ccccc2)CC1
Show InChI InChI=1S/C27H30N6O/c1-31-11-13-32(14-12-31)15-16-33-26-10-8-22(17-23(26)19-29-33)27(34)30-25-18-21(7-9-24(25)28)20-5-3-2-4-6-20/h2-10,17-19H,11-16,28H2,1H3,(H,30,34)
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n/an/a 175n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM172760
PNG
(US9096549, G)
Show SMILES Nc1cc(F)ccc1NC(=O)c1cnc2n(CCN3CCOCC3)ccc2c1
Show InChI InChI=1S/C20H22FN5O2/c21-16-1-2-18(17(22)12-16)24-20(27)15-11-14-3-4-26(19(14)23-13-15)6-5-25-7-9-28-10-8-25/h1-4,11-13H,5-10,22H2,(H,24,27)
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n/an/a 193n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM182742
PNG
(US9145412, Table 1, Compound 8)
Show SMILES Nc1sc(cc1NC(=O)c1cnc2cc(ccc2c1)N1CCNCC1)-c1ccccc1
Show InChI InChI=1S/C24H23N5OS/c25-23-21(14-22(31-23)16-4-2-1-3-5-16)28-24(30)18-12-17-6-7-19(13-20(17)27-15-18)29-10-8-26-9-11-29/h1-7,12-15,26H,8-11,25H2,(H,28,30)
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n/an/a 193n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9145412 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NQT
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM172765
PNG
(US9096549, L)
Show SMILES Nc1ccccc1NC(=O)c1cc2ccc(N3CCNCC3)c(C3CC3)c2cn1
Show InChI InChI=1S/C23H25N5O/c24-18-3-1-2-4-19(18)27-23(29)20-13-16-7-8-21(28-11-9-25-10-12-28)22(15-5-6-15)17(16)14-26-20/h1-4,7-8,13-15,25H,5-6,9-12,24H2,(H,27,29)
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n/an/a 212n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM172765
PNG
(US9096549, L)
Show SMILES Nc1ccccc1NC(=O)c1cc2ccc(N3CCNCC3)c(C3CC3)c2cn1
Show InChI InChI=1S/C23H25N5O/c24-18-3-1-2-4-19(18)27-23(29)20-13-16-7-8-21(28-11-9-25-10-12-28)22(15-5-6-15)17(16)14-26-20/h1-4,7-8,13-15,25H,5-6,9-12,24H2,(H,27,29)
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n/an/a 228n/an/an/an/a7.4n/a



ACETYLON PHARMACEUTICALS, INC.

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US9096549 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TRV
More data for this
Ligand-Target Pair
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