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Found 3973 hits from ACTELION PHARMACEUTICALS LTD.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184008
PNG
(US9150566, 45)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC[C@H]1Cc1cccc(c1)-c1cccs1)-n1nccn1
Show InChI InChI=1S/C25H24N4O2S/c1-18-7-8-23(29-26-9-10-27-29)22(14-18)25(30)28-11-12-31-17-21(28)16-19-4-2-5-20(15-19)24-6-3-13-32-24/h2-10,13-15,21H,11-12,16-17H2,1H3/t21-/m1/s1
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US Patent
n/an/a 0.100n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205858
PNG
(US9255090, 327)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1CCOc2cc(F)ccc12
Show InChI InChI=1S/C30H29F2NO5/c1-2-37-27-13-18(14-30(35)36)3-5-24(27)22-7-8-26(32)23-9-11-33(17-25(22)23)29(34)15-19-10-12-38-28-16-20(31)4-6-21(19)28/h3-8,13,16,19H,2,9-12,14-15,17H2,1H3,(H,35,36)
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n/an/a 0.200n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205626
PNG
(US9255090, 95)
Show SMILES COc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)C1CC1c1ccccc1C(F)(F)F
Show InChI InChI=1S/C29H25F4NO4/c1-38-26-9-6-16(13-27(35)36)12-21(26)17-7-8-25(30)19-10-11-34(15-23(17)19)28(37)22-14-20(22)18-4-2-3-5-24(18)29(31,32)33/h2-9,12,20,22H,10-11,13-15H2,1H3,(H,35,36)
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n/an/a 0.220n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205728
PNG
(US9255090, 197)
Show SMILES CCCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H28FNO5/c1-2-14-34-26-11-8-20(16-27(31)32)15-23(26)21-9-10-25(29)22-12-13-30(17-24(21)22)28(33)35-18-19-6-4-3-5-7-19/h3-11,15H,2,12-14,16-18H2,1H3,(H,31,32)
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n/an/a 0.280n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205727
PNG
(US9255090, 196)
Show SMILES OC(=O)Cc1ccc(OCC2CC2)c(c1)-c1ccc(F)c2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H28FNO5/c30-26-10-9-22(24-14-21(15-28(32)33)8-11-27(24)35-17-20-6-7-20)25-16-31(13-12-23(25)26)29(34)36-18-19-4-2-1-3-5-19/h1-5,8-11,14,20H,6-7,12-13,15-18H2,(H,32,33)
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n/an/a 0.280n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205766
PNG
(US9255090, 235)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1COc2ccccc12
Show InChI InChI=1S/C29H28FNO5/c1-2-35-27-13-18(14-29(33)34)7-8-23(27)21-9-10-25(30)22-11-12-31(16-24(21)22)28(32)15-19-17-36-26-6-4-3-5-20(19)26/h3-10,13,19H,2,11-12,14-17H2,1H3,(H,33,34)
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n/an/a 0.300n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184006
PNG
(US9150566, 43)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC[C@H]1Cc1cccc(c1)-c1nccs1)-n1nccn1
Show InChI InChI=1S/C24H23N5O2S/c1-17-5-6-22(29-26-7-8-27-29)21(13-17)24(30)28-10-11-31-16-20(28)15-18-3-2-4-19(14-18)23-25-9-12-32-23/h2-9,12-14,20H,10-11,15-16H2,1H3/t20-/m1/s1
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n/an/a 0.300n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205768
PNG
(US9255090, 237)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC(C)(C)c1ccc(F)cc1
Show InChI InChI=1S/C30H31F2NO4/c1-4-37-27-15-19(16-29(35)36)5-10-24(27)22-11-12-26(32)23-13-14-33(18-25(22)23)28(34)17-30(2,3)20-6-8-21(31)9-7-20/h5-12,15H,4,13-14,16-18H2,1-3H3,(H,35,36)
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n/an/a 0.300n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM183960
PNG
(US9150566, Ref. 4)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCCC[C@H]1Cc1cccc(c1)-n1nccn1)-n1nccn1
Show InChI InChI=1S/C24H25N7O/c1-18-8-9-23(31-27-12-13-28-31)22(15-18)24(32)29-14-3-2-6-20(29)16-19-5-4-7-21(17-19)30-25-10-11-26-30/h4-5,7-13,15,17,20H,2-3,6,14,16H2,1H3/t20-/m0/s1
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n/an/a 0.300n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184041
PNG
(US9150566, 79)
Show SMILES Cc1cc(C(=O)N2CCOC[C@H]2Cc2ccc(C)c(c2)-c2ncon2)c(cc1C)-n1nccn1
Show InChI InChI=1S/C25H26N6O3/c1-16-4-5-19(13-21(16)24-26-15-34-29-24)12-20-14-33-9-8-30(20)25(32)22-10-17(2)18(3)11-23(22)31-27-6-7-28-31/h4-7,10-11,13,15,20H,8-9,12,14H2,1-3H3/t20-/m1/s1
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n/an/a 0.400n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM257871
PNG
(US9493446, 340)
Show SMILES COc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1
Show InChI InChI=1S/C24H23FN6O3/c1-14-12-17(20(13-15(14)2)31-26-9-10-27-31)24(32)30-11-5-8-19(30)22-28-23(34-29-22)16-6-4-7-18(25)21(16)33-3/h4,6-7,9-10,12-13,19H,5,8,11H2,1-3H3/t19-/m0/s1
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n/an/a 0.400n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...


US Patent US9493446 (2016)


BindingDB Entry DOI: 10.7270/Q2DR2TD0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205714
PNG
(US9255090, 183)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CCc1cn(C)c2ccccc12
Show InChI InChI=1S/C30H29FN2O4/c1-32-17-20(21-5-3-4-6-27(21)32)8-12-29(34)33-14-13-23-25(18-33)22(10-11-26(23)31)24-9-7-19(16-30(35)36)15-28(24)37-2/h3-7,9-11,15,17H,8,12-14,16,18H2,1-2H3,(H,35,36)
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n/an/a 0.460n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205730
PNG
(US9255090, 199)
Show SMILES COCCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H28FNO6/c1-34-13-14-35-26-10-7-20(16-27(31)32)15-23(26)21-8-9-25(29)22-11-12-30(17-24(21)22)28(33)36-18-19-5-3-2-4-6-19/h2-10,15H,11-14,16-18H2,1H3,(H,31,32)
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n/an/a 0.490n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM183962
PNG
(US9150566, Ref. 2)
Show SMILES Cc1ccc(c(c1)C(=O)N1CCC[C@H]1Cc1cccc(c1)-n1nccn1)-n1nccn1
Show InChI InChI=1S/C23H23N7O/c1-17-7-8-22(30-26-11-12-27-30)21(14-17)23(31)28-13-3-6-19(28)15-18-4-2-5-20(16-18)29-24-9-10-25-29/h2,4-5,7-12,14,16,19H,3,6,13,15H2,1H3/t19-/m0/s1
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n/an/a 0.5n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184009
PNG
(US9150566, 46)
Show SMILES O=C(N1CCOC[C@H]1Cc1cccc(c1)-c1cccs1)c1ccccc1-n1nccn1
Show InChI InChI=1S/C24H22N4O2S/c29-24(21-7-1-2-8-22(21)28-25-10-11-26-28)27-12-13-30-17-20(27)16-18-5-3-6-19(15-18)23-9-4-14-31-23/h1-11,14-15,20H,12-13,16-17H2/t20-/m1/s1
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n/an/a 0.5n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM183973
PNG
(US9150566, 10)
Show SMILES COc1ccc(C[C@@H]2COCCN2C(=O)c2ccccc2-n2nccn2)cc1-c1cccs1
Show InChI InChI=1S/C25H24N4O3S/c1-31-23-9-8-18(16-21(23)24-7-4-14-33-24)15-19-17-32-13-12-28(19)25(30)20-5-2-3-6-22(20)29-26-10-11-27-29/h2-11,14,16,19H,12-13,15,17H2,1H3/t19-/m1/s1
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n/an/a 0.5n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM257862
PNG
(US9493446, 331)
Show SMILES CCOc1ncccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1
Show InChI InChI=1S/C24H25N7O3/c1-4-33-22-17(7-5-9-25-22)23-28-21(29-34-23)19-8-6-12-30(19)24(32)18-13-15(2)16(3)14-20(18)31-26-10-11-27-31/h5,7,9-11,13-14,19H,4,6,8,12H2,1-3H3/t19-/m0/s1
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n/an/a 0.5n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...


US Patent US9493446 (2016)


BindingDB Entry DOI: 10.7270/Q2DR2TD0
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205880
PNG
(US9255090, 349)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CCc1ccccn1
Show InChI InChI=1S/C27H27FN2O4/c1-2-34-25-15-18(16-27(32)33)6-8-22(25)20-9-10-24(28)21-12-14-30(17-23(20)21)26(31)11-7-19-5-3-4-13-29-19/h3-6,8-10,13,15H,2,7,11-12,14,16-17H2,1H3,(H,32,33)
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n/an/a 0.5n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205719
PNG
(US9255090, 188)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC(C)(C)c1ccccc1
Show InChI InChI=1S/C29H30FNO4/c1-29(2,20-7-5-4-6-8-20)17-27(32)31-14-13-22-24(18-31)21(11-12-25(22)30)23-10-9-19(16-28(33)34)15-26(23)35-3/h4-12,15H,13-14,16-18H2,1-3H3,(H,33,34)
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n/an/a 0.530n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM240183
PNG
(US9403813, 88)
Show SMILES COc1cc(C(=O)N2CC[C@H]2c2noc(n2)-c2cccc(F)c2OC)c(cc1C)-n1nccn1
Show InChI InChI=1S/C23H21FN6O4/c1-13-11-18(30-25-8-9-26-30)15(12-19(13)32-2)23(31)29-10-7-17(29)21-27-22(34-28-21)14-5-4-6-16(24)20(14)33-3/h4-6,8-9,11-12,17H,7,10H2,1-3H3/t17-/m0/s1
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n/an/a 0.600n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9403813 (2016)


BindingDB Entry DOI: 10.7270/Q2QF8RS2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205731
PNG
(US9255090, 200 | US9255090, 201 | US9255090, 359)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1CCOc2ccccc12
Show InChI InChI=1S/C29H28FNO5/c1-35-27-14-18(15-29(33)34)6-7-23(27)21-8-9-25(30)22-10-12-31(17-24(21)22)28(32)16-19-11-13-36-26-5-3-2-4-20(19)26/h2-9,14,19H,10-13,15-17H2,1H3,(H,33,34)
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n/an/a 0.600n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205769
PNG
(US9255090, 238)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC(C)(C)c1ccccc1
Show InChI InChI=1S/C30H32FNO4/c1-4-36-27-16-20(17-29(34)35)10-11-24(27)22-12-13-26(31)23-14-15-32(19-25(22)23)28(33)18-30(2,3)21-8-6-5-7-9-21/h5-13,16H,4,14-15,17-19H2,1-3H3,(H,34,35)
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n/an/a 0.600n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205902
PNG
(US9255090, 371)
Show SMILES CCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)OCc1cccc(C)n1
Show InChI InChI=1S/C27H27FN2O5/c1-3-34-25-10-7-18(14-26(31)32)13-22(25)20-8-9-24(28)21-11-12-30(15-23(20)21)27(33)35-16-19-6-4-5-17(2)29-19/h4-10,13H,3,11-12,14-16H2,1-2H3,(H,31,32)
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n/an/a 0.600n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205861
PNG
(US9255090, 330)
Show SMILES CCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)C1CC1c1ccccn1
Show InChI InChI=1S/C28H27FN2O4/c1-2-35-26-9-6-17(14-27(32)33)13-21(26)18-7-8-24(29)19-10-12-31(16-23(18)19)28(34)22-15-20(22)25-5-3-4-11-30-25/h3-9,11,13,20,22H,2,10,12,14-16H2,1H3,(H,32,33)
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n/an/a 0.600n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205763
PNG
(US9255090, 232)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1COCc2ccccc12
Show InChI InChI=1S/C30H30FNO5/c1-2-37-28-13-19(14-30(34)35)7-8-25(28)23-9-10-27(31)24-11-12-32(16-26(23)24)29(33)15-21-18-36-17-20-5-3-4-6-22(20)21/h3-10,13,21H,2,11-12,14-18H2,1H3,(H,34,35)
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n/an/a 0.600n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM240186
PNG
(US9403813, 91)
Show SMILES CCOc1ncccc1-c1nc(no1)[C@@H]1CCN1C(=O)c1cc(C)c(C)cc1-n1nccn1
Show InChI InChI=1S/C23H23N7O3/c1-4-32-21-16(6-5-8-24-21)22-27-20(28-33-22)18-7-11-29(18)23(31)17-12-14(2)15(3)13-19(17)30-25-9-10-26-30/h5-6,8-10,12-13,18H,4,7,11H2,1-3H3/t18-/m0/s1
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n/an/a 0.600n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9403813 (2016)


BindingDB Entry DOI: 10.7270/Q2QF8RS2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205691
PNG
(US9255090, 160)
Show SMILES OC(=O)COc1ccc(OC(F)(F)F)c(c1)-c1ccc(F)c2CCN(Cc12)C(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C28H23F4NO5/c29-24-8-7-18(21-12-17(37-15-26(34)35)6-9-25(21)38-28(30,31)32)23-14-33(11-10-19(23)24)27(36)22-13-20(22)16-4-2-1-3-5-16/h1-9,12,20,22H,10-11,13-15H2,(H,34,35)/t20-,22+/m0/s1
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n/an/a 0.670n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205723
PNG
(US9255090, 192)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CCOc1ccc(F)cc1
Show InChI InChI=1S/C27H25F2NO5/c1-34-25-14-17(15-27(32)33)2-7-22(25)20-8-9-24(29)21-10-12-30(16-23(20)21)26(31)11-13-35-19-5-3-18(28)4-6-19/h2-9,14H,10-13,15-16H2,1H3,(H,32,33)
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n/an/a 0.690n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184022
PNG
(US9150566, 60)
Show SMILES COc1ccc(C[C@@H]2COCCN2C(=O)c2ccc(C)cc2-n2nccn2)cc1-c1ncon1
Show InChI InChI=1S/C24H24N6O4/c1-16-3-5-19(21(11-16)30-26-7-8-27-30)24(31)29-9-10-33-14-18(29)12-17-4-6-22(32-2)20(13-17)23-25-15-34-28-23/h3-8,11,13,15,18H,9-10,12,14H2,1-2H3/t18-/m1/s1
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n/an/a 0.700n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205736
PNG
(US9255090, 205 | US9255090, 206 | US9255090, 229)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1OCCc2ccccc12
Show InChI InChI=1S/C30H30FNO5/c1-2-36-27-15-19(16-30(34)35)7-8-24(27)22-9-10-26(31)23-11-13-32(18-25(22)23)29(33)17-28-21-6-4-3-5-20(21)12-14-37-28/h3-10,15,28H,2,11-14,16-18H2,1H3,(H,34,35)
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n/an/a 0.700n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184090
PNG
(US9150566, 128)
Show SMILES Cc1cc(C(=O)N2CCOC[C@H]2Cc2cc(ccc2F)-n2nccn2)c(cc1C)-n1nccn1
Show InChI InChI=1S/C24H24FN7O2/c1-16-11-21(23(12-17(16)2)32-28-7-8-29-32)24(33)30-9-10-34-15-20(30)14-18-13-19(3-4-22(18)25)31-26-5-6-27-31/h3-8,11-13,20H,9-10,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 0.700n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 2


(Homo sapiens (Human))
BDBM50108622
PNG
(CHEMBL3597964 | US9403813, 111)
Show SMILES COc1cc(C(=O)N2CC[C@H]2c2noc(n2)-c2cccc(Cl)c2OC)c(cc1C)-n1nccn1
Show InChI InChI=1S/C23H21ClN6O4/c1-13-11-18(30-25-8-9-26-30)15(12-19(13)32-2)23(31)29-10-7-17(29)21-27-22(34-28-21)14-5-4-6-16(24)20(14)33-3/h4-6,8-9,11-12,17H,7,10H2,1-3H3/t17-/m0/s1
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n/an/a 0.700n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9403813 (2016)


BindingDB Entry DOI: 10.7270/Q2QF8RS2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184065
PNG
(US9150566, 103)
Show SMILES Cc1cc(c(cc1Cl)C(=O)N1CCOC[C@H]1Cc1cccc(c1)-n1nccn1)-n1nccn1
Show InChI InChI=1S/C23H22ClN7O2/c1-16-11-22(31-27-7-8-28-31)20(14-21(16)24)23(32)29-9-10-33-15-19(29)13-17-3-2-4-18(12-17)30-25-5-6-26-30/h2-8,11-12,14,19H,9-10,13,15H2,1H3/t19-/m1/s1
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n/an/a 0.700n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184020
PNG
(US9150566, 58)
Show SMILES COc1ccc(C[C@@H]2COCCN2C(=O)c2cc(C)ccc2-n2nccn2)cc1-c1ncon1
Show InChI InChI=1S/C24H24N6O4/c1-16-3-5-21(30-26-7-8-27-30)19(11-16)24(31)29-9-10-33-14-18(29)12-17-4-6-22(32-2)20(13-17)23-25-15-34-28-23/h3-8,11,13,15,18H,9-10,12,14H2,1-2H3/t18-/m1/s1
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n/an/a 0.700n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205965
PNG
(US9255090, 434)
Show SMILES CCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C27H26F2N2O4/c1-2-35-25-10-5-18(14-26(32)33)13-22(25)20-8-9-24(29)21-11-12-31(16-23(20)21)27(34)30-15-17-3-6-19(28)7-4-17/h3-10,13H,2,11-12,14-16H2,1H3,(H,30,34)(H,32,33)
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n/an/a 0.700n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205725
PNG
(US9255090, 194)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CCc1ccccc1C
Show InChI InChI=1S/C28H28FNO4/c1-18-5-3-4-6-20(18)8-12-27(31)30-14-13-22-24(17-30)21(10-11-25(22)29)23-9-7-19(16-28(32)33)15-26(23)34-2/h3-7,9-11,15H,8,12-14,16-17H2,1-2H3,(H,32,33)
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n/an/a 0.75n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205944
PNG
(US9255090, 413)
Show SMILES OC(=O)Cc1ccc(OCC(F)F)c(c1)-c1ccc(F)c2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C27H24F3NO5/c28-23-8-7-19(21-12-18(13-26(32)33)6-9-24(21)35-16-25(29)30)22-14-31(11-10-20(22)23)27(34)36-15-17-4-2-1-3-5-17/h1-9,12,25H,10-11,13-16H2,(H,32,33)
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n/an/a 0.800n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205767
PNG
(US9255090, 236)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1CCOc2ccccc12
Show InChI InChI=1S/C30H30FNO5/c1-2-36-28-15-19(16-30(34)35)7-8-24(28)22-9-10-26(31)23-11-13-32(18-25(22)23)29(33)17-20-12-14-37-27-6-4-3-5-21(20)27/h3-10,15,20H,2,11-14,16-18H2,1H3,(H,34,35)
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ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205921
PNG
(US9255090, 390)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)OCc1cccc(C)n1
Show InChI InChI=1S/C27H27FN2O5/c1-3-34-25-13-18(14-26(31)32)7-8-22(25)20-9-10-24(28)21-11-12-30(15-23(20)21)27(33)35-16-19-6-4-5-17(2)29-19/h4-10,13H,3,11-12,14-16H2,1-2H3,(H,31,32)
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n/an/a 0.800n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205827
PNG
(US9255090, 296)
Show SMILES CC(C)Oc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1COCc2ccccc12
Show InChI InChI=1S/C31H32FNO5/c1-19(2)38-29-10-7-20(14-31(35)36)13-26(29)24-8-9-28(32)25-11-12-33(16-27(24)25)30(34)15-22-18-37-17-21-5-3-4-6-23(21)22/h3-10,13,19,22H,11-12,14-18H2,1-2H3,(H,35,36)
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n/an/a 0.800n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205718
PNG
(US9255090, 187)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CCCc1ccccc1
Show InChI InChI=1S/C28H28FNO4/c1-34-26-16-20(17-28(32)33)10-11-23(26)21-12-13-25(29)22-14-15-30(18-24(21)22)27(31)9-5-8-19-6-3-2-4-7-19/h2-4,6-7,10-13,16H,5,8-9,14-15,17-18H2,1H3,(H,32,33)
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US Patent
n/an/a 0.890n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205715
PNG
(US9255090, 184)
Show SMILES COc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C28H26FNO4/c1-34-26-13-17(14-27(31)32)7-8-21(26)19-9-10-25(29)20-11-12-30(16-24(19)20)28(33)23-15-22(23)18-5-3-2-4-6-18/h2-10,13,22-23H,11-12,14-16H2,1H3,(H,31,32)/t22-,23+/m0/s1
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US Patent
n/an/a 0.900n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205866
PNG
(US9255090, 335)
Show SMILES CCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1CCOc2cc(F)ccc12
Show InChI InChI=1S/C30H29F2NO5/c1-2-37-27-8-3-18(14-30(35)36)13-24(27)22-6-7-26(32)23-9-11-33(17-25(22)23)29(34)15-19-10-12-38-28-16-20(31)4-5-21(19)28/h3-8,13,16,19H,2,9-12,14-15,17H2,1H3,(H,35,36)
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US Patent
n/an/a 0.900n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205765
PNG
(US9255090, 234)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)C[C@@H](C)c1ccccc1
Show InChI InChI=1S/C29H30FNO4/c1-3-35-27-16-20(17-29(33)34)9-10-24(27)22-11-12-26(30)23-13-14-31(18-25(22)23)28(32)15-19(2)21-7-5-4-6-8-21/h4-12,16,19H,3,13-15,17-18H2,1-2H3,(H,33,34)/t19-/m1/s1
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US Patent
n/an/a 0.900n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM184031
PNG
(US9150566, 69)
Show SMILES C[C@@H]1COC[C@@H](Cc2cccc(c2)-n2nccn2)N1C(=O)c1ccc(C)cc1-n1nccn1
Show InChI InChI=1S/C24H25N7O2/c1-17-6-7-22(23(12-17)31-27-10-11-28-31)24(32)29-18(2)15-33-16-21(29)14-19-4-3-5-20(13-19)30-25-8-9-26-30/h3-13,18,21H,14-16H2,1-2H3/t18-,21-/m1/s1
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Similars

US Patent
n/an/a 0.900n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...


US Patent US9150566 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TJ3
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205738
PNG
(US9255090, 207 | US9255090, 208 | US9255090, 227)
Show SMILES CCOc1ccc(CC(O)=O)cc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1COc2ccccc12
Show InChI InChI=1S/C29H28FNO5/c1-2-35-27-10-7-18(14-29(33)34)13-23(27)21-8-9-25(30)22-11-12-31(16-24(21)22)28(32)15-19-17-36-26-6-4-3-5-20(19)26/h3-10,13,19H,2,11-12,14-17H2,1H3,(H,33,34)
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US Patent
n/an/a 0.900n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205855
PNG
(US9255090, 324)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1COc2ccccc2C1
Show InChI InChI=1S/C30H30FNO5/c1-2-36-28-14-19(16-30(34)35)7-8-24(28)22-9-10-26(31)23-11-12-32(17-25(22)23)29(33)15-20-13-21-5-3-4-6-27(21)37-18-20/h3-10,14,20H,2,11-13,15-18H2,1H3,(H,34,35)
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n/an/a 0.900n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205875
PNG
(US9255090, 344)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC(C)c1ccccn1
Show InChI InChI=1S/C28H29FN2O4/c1-3-35-26-15-19(16-28(33)34)7-8-22(26)20-9-10-24(29)21-11-13-31(17-23(20)21)27(32)14-18(2)25-6-4-5-12-30-25/h4-10,12,15,18H,3,11,13-14,16-17H2,1-2H3,(H,33,34)
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US Patent
n/an/a 0.900n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
G protein-coupled receptor 44


(Homo sapiens (Human))
BDBM205761
PNG
(US9255090, 230)
Show SMILES CCOc1cc(CC(O)=O)ccc1-c1ccc(F)c2CCN(Cc12)C(=O)CC1(CC1)c1ccccc1
Show InChI InChI=1S/C30H30FNO4/c1-2-36-27-16-20(17-29(34)35)8-9-24(27)22-10-11-26(31)23-12-15-32(19-25(22)23)28(33)18-30(13-14-30)21-6-4-3-5-7-21/h3-11,16H,2,12-15,17-19H2,1H3,(H,34,35)
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US Patent
n/an/a 1n/an/an/an/a7.025



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Binding assay was performed in a final assay volume of 250 ul. First, 25 ul of test compound, previously diluted in Binding-Buffer (Binding-Buffer: 5...


US Patent US9255090 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60B2
More data for this
Ligand-Target Pair
Orexin receptor type 1


(Homo sapiens (Human))
BDBM202953
PNG
(US9242970, 100)
Show SMILES COc1cccc(OC)c1C1CCCCC(=O)N1Cc1cccc(c1)-c1ncc(C)s1
Show InChI InChI=1S/C25H28N2O3S/c1-17-15-26-25(31-17)19-9-6-8-18(14-19)16-27-20(10-4-5-13-23(27)28)24-21(29-2)11-7-12-22(24)30-3/h6-9,11-12,14-15,20H,4-5,10,13,16H2,1-3H3
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US Patent
n/an/a 1n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
In Vitro Assay: Intracellular Calcium Measurements:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 re...


US Patent US9242970 (2016)


BindingDB Entry DOI: 10.7270/Q2R49PK4
More data for this
Ligand-Target Pair
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