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Compile Data Set for Download or QSAR

Found 430 hits from ALLERGAN, INC.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263346
PNG
(US9546162, 4)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F)c23)cc1
Show InChI InChI=1S/C26H21F6NO2/c27-25(28,29)21-12-17(13-22(14-21)26(30,31)32)15-33-11-10-19-3-1-2-18(23(19)33)7-4-16-5-8-20(9-6-16)24(34)35/h1-3,5-6,8-9,12-14H,4,7,10-11,15H2,(H,34,35)
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0.300n/an/an/a 11n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263361
PNG
(US9546162, 19)
Show SMILES COc1cc(CO)cc(c1)S(=O)(=O)N1CCc2cccc(CCc3ccc(cc3)C(O)=O)c12
Show InChI InChI=1S/C25H25NO6S/c1-32-22-13-18(16-27)14-23(15-22)33(30,31)26-12-11-20-4-2-3-19(24(20)26)8-5-17-6-9-21(10-7-17)25(28)29/h2-4,6-7,9-10,13-15,27H,5,8,11-12,16H2,1H3,(H,28,29)
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0.400n/an/an/a 2n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238312
PNG
(US9394273, 1 | US9394273, 2)
Show SMILES OC(Cc1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-25(18-20-7-9-21-3-1-2-4-24(21)17-20)14-12-22-13-16-27(30)26(22)15-8-19-5-10-23(11-6-19)28(31)32/h1-7,9-12,14,17,22,25-26,29H,8,13,15-16,18H2,(H,31,32)/b14-12+/t22-,25?,26+/m0/s1
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0.800n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263357
PNG
(US9546162, 15)
Show SMILES COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C25H23NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-16H,8,11,17H2,1H3,(H,27,28)
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0.800n/an/an/a 1n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238322
PNG
(US9394273, 11 | US9394273, 12)
Show SMILES OC(Cc1cccc(c1)C(F)(F)F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H25F3O4/c26-25(27,28)20-3-1-2-17(14-20)15-21(29)11-9-18-10-13-23(30)22(18)12-6-16-4-7-19(8-5-16)24(31)32/h1-5,7-9,11,14,18,21-22,29H,6,10,12-13,15H2,(H,31,32)/b11-9+/t18-,21?,22+/m0/s1
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1n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25BrO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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1n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238319
PNG
(US9394273, 10 | US9394273, 8 | US9394273, 9)
Show SMILES OC(Cc1cccc(Br)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25BrO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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1n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238316
PNG
(US9394273, 5 | US9394273, 6)
Show SMILES OC(Cc1cccc(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25FO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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2n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238318
PNG
(US9394273, 7)
Show SMILES OC(Cc1cccc(Cl)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25ClO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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2n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263347
PNG
(US9546162, 5)
Show SMILES COc1cc(CO)cc(CN2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C26H27NO4/c1-31-24-14-19(13-20(15-24)17-28)16-27-12-11-22-4-2-3-21(25(22)27)8-5-18-6-9-23(10-7-18)26(29)30/h2-4,6-7,9-10,13-15,28H,5,8,11-12,16-17H2,1H3,(H,29,30)
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2n/an/an/a 11n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263343
PNG
(US9546162, 1)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cccc(F)c4)c23)cc1
Show InChI InChI=1S/C24H22FNO2/c25-22-6-1-3-18(15-22)16-26-14-13-20-5-2-4-19(23(20)26)10-7-17-8-11-21(12-9-17)24(27)28/h1-6,8-9,11-12,15H,7,10,13-14,16H2,(H,27,28)
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2n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263366
PNG
(US9546162, 24)
Show SMILES COc1cc(CN2CCc3cc(F)cc(CCc4ccc(cc4)C(O)=O)c23)cc(OC)c1
Show InChI InChI=1S/C26H26FNO4/c1-31-23-11-18(12-24(15-23)32-2)16-28-10-9-21-14-22(27)13-20(25(21)28)8-5-17-3-6-19(7-4-17)26(29)30/h3-4,6-7,11-15H,5,8-10,16H2,1-2H3,(H,29,30)
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2n/an/an/a 2n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238336
PNG
(US9394273, 25 | US9394273, 26)
Show SMILES OC(Cc1cccc(F)c1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H24F2O4/c25-21-3-1-2-18(23(21)26)14-19(27)11-9-16-10-13-22(28)20(16)12-6-15-4-7-17(8-5-15)24(29)30/h1-5,7-9,11,16,19-20,27H,6,10,12-14H2,(H,29,30)/b11-9+/t16-,19?,20+/m0/s1
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2n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263363
PNG
(US9546162, 21)
Show SMILES COc1cccc(CN2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C25H25NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-13,16H,8,11,14-15,17H2,1H3,(H,27,28)
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23n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238334
PNG
(US9394273, 23 | US9394273, 24)
Show SMILES OC(Cc1ccc(F)c(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H24F2O4/c25-21-11-4-16(14-22(21)26)13-19(27)9-7-17-8-12-23(28)20(17)10-3-15-1-5-18(6-2-15)24(29)30/h1-2,4-7,9,11,14,17,19-20,27H,3,8,10,12-13H2,(H,29,30)/b9-7+/t17-,19?,20+/m0/s1
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3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263343
PNG
(US9546162, 1)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cccc(F)c4)c23)cc1
Show InChI InChI=1S/C24H22FNO2/c25-22-6-1-3-18(15-22)16-26-14-13-20-5-2-4-19(23(20)26)10-7-17-8-11-21(12-9-17)24(27)28/h1-6,8-9,11-12,15H,7,10,13-14,16H2,(H,27,28)
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3n/an/an/a 7.20n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263357
PNG
(US9546162, 15)
Show SMILES COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C25H23NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-16H,8,11,17H2,1H3,(H,27,28)
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3n/an/an/a 11n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238330
PNG
(US9394273, 19 | US9394273, 20)
Show SMILES OC(Cc1ccc(F)cc1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25FO4/c25-20-10-3-17(4-11-20)15-21(26)12-8-18-9-14-23(27)22(18)13-5-16-1-6-19(7-2-16)24(28)29/h1-4,6-8,10-12,18,21-22,26H,5,9,13-15H2,(H,28,29)/b12-8+/t18-,21?,22+/m0/s1
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3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238332
PNG
(US9394273, 21 | US9394273, 22)
Show SMILES OC(Cc1ccccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25FO4/c25-22-4-2-1-3-19(22)15-20(26)12-10-17-11-14-23(27)21(17)13-7-16-5-8-18(9-6-16)24(28)29/h1-6,8-10,12,17,20-21,26H,7,11,13-15H2,(H,28,29)/b12-10+/t17-,20?,21+/m0/s1
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4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238338
PNG
(US9394273, 27 | US9394273, 28)
Show SMILES OC(Cc1cc(F)ccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H24F2O4/c25-19-8-11-22(26)18(13-19)14-20(27)9-6-16-7-12-23(28)21(16)10-3-15-1-4-17(5-2-15)24(29)30/h1-2,4-6,8-9,11,13,16,20-21,27H,3,7,10,12,14H2,(H,29,30)/b9-6+/t16-,20?,21+/m0/s1
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5n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263347
PNG
(US9546162, 5)
Show SMILES COc1cc(CO)cc(CN2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C26H27NO4/c1-31-24-14-19(13-20(15-24)17-28)16-27-12-11-22-4-2-3-21(25(22)27)8-5-18-6-9-23(10-7-18)26(29)30/h2-4,6-7,9-10,13-15,28H,5,8,11-12,16-17H2,1H3,(H,29,30)
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6n/an/an/a 41n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263353
PNG
(US9546162, 11)
Show SMILES COc1cccc(CN2Cc3cccc(CCc4ccc(cc4)C(O)=O)c3C2)c1
Show InChI InChI=1S/C25H25NO3/c1-29-23-7-2-4-19(14-23)15-26-16-22-6-3-5-20(24(22)17-26)11-8-18-9-12-21(13-10-18)25(27)28/h2-7,9-10,12-14H,8,11,15-17H2,1H3,(H,27,28)
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6n/an/an/a 13n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263364
PNG
(US9546162, 22)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cccc(c4)C(F)(F)F)c23)cc1
Show InChI InChI=1S/C25H22F3NO2/c26-25(27,28)22-6-1-3-18(15-22)16-29-14-13-20-5-2-4-19(23(20)29)10-7-17-8-11-21(12-9-17)24(30)31/h1-6,8-9,11-12,15H,7,10,13-14,16H2,(H,30,31)
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7n/an/an/a 15n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263359
PNG
(US9546162, 17)
Show SMILES COc1cccc(CC(=O)N2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C26H25NO4/c1-31-23-7-2-4-19(16-23)17-24(28)27-15-14-21-6-3-5-20(25(21)27)11-8-18-9-12-22(13-10-18)26(29)30/h2-7,9-10,12-13,16H,8,11,14-15,17H2,1H3,(H,29,30)
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8n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238329
PNG
(US9394273, 18)
Show SMILES COc1ccc2ccc(CC(O)\C=C\[C@H]3CCC(=O)[C@@H]3CCc3ccc(cc3)C(O)=O)cc2c1
Show InChI InChI=1S/C29H30O5/c1-34-26-13-10-21-6-4-20(16-24(21)18-26)17-25(30)12-9-22-11-15-28(31)27(22)14-5-19-2-7-23(8-3-19)29(32)33/h2-4,6-10,12-13,16,18,22,25,27,30H,5,11,14-15,17H2,1H3,(H,32,33)/b12-9+/t22-,25?,27+/m0/s1
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9n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238312
PNG
(US9394273, 1 | US9394273, 2)
Show SMILES OC(Cc1ccc2ccccc2c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C28H28O4/c29-25(18-20-7-9-21-3-1-2-4-24(21)17-20)14-12-22-13-16-27(30)26(22)15-8-19-5-10-23(11-6-19)28(31)32/h1-7,9-12,14,17,22,25-26,29H,8,13,15-16,18H2,(H,31,32)/b14-12+/t22-,25?,26+/m0/s1
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10n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263345
PNG
(US9546162, 3)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cc(F)cc(F)c4)c23)cc1
Show InChI InChI=1S/C24H21F2NO2/c25-21-12-17(13-22(26)14-21)15-27-11-10-19-3-1-2-18(23(19)27)7-4-16-5-8-20(9-6-16)24(28)29/h1-3,5-6,8-9,12-14H,4,7,10-11,15H2,(H,28,29)
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12n/an/an/a 12n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263366
PNG
(US9546162, 24)
Show SMILES COc1cc(CN2CCc3cc(F)cc(CCc4ccc(cc4)C(O)=O)c23)cc(OC)c1
Show InChI InChI=1S/C26H26FNO4/c1-31-23-11-18(12-24(15-23)32-2)16-28-10-9-21-14-22(27)13-20(25(21)28)8-5-17-3-6-19(7-4-17)26(29)30/h3-4,6-7,11-15H,5,8-10,16H2,1-2H3,(H,29,30)
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14n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263344
PNG
(US9546162, 2)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4ccc(F)cc4)c23)cc1
Show InChI InChI=1S/C24H22FNO2/c25-22-12-7-18(8-13-22)16-26-15-14-20-3-1-2-19(23(20)26)9-4-17-5-10-21(11-6-17)24(27)28/h1-3,5-8,10-13H,4,9,14-16H2,(H,27,28)
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14n/an/an/a 29n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263347
PNG
(US9546162, 5)
Show SMILES COc1cc(CO)cc(CN2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C26H27NO4/c1-31-24-14-19(13-20(15-24)17-28)16-27-12-11-22-4-2-3-21(25(22)27)8-5-18-6-9-23(10-7-18)26(29)30/h2-4,6-7,9-10,13-15,28H,5,8,11-12,16-17H2,1H3,(H,29,30)
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15n/an/an/a 13n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263352
PNG
(US9546162, 10)
Show SMILES COc1cccc(CCN2Cc3cccc(CCc4ccc(cc4)C(O)=O)c3C2)c1
Show InChI InChI=1S/C26H27NO3/c1-30-24-7-2-4-20(16-24)14-15-27-17-23-6-3-5-21(25(23)18-27)11-8-19-9-12-22(13-10-19)26(28)29/h2-7,9-10,12-13,16H,8,11,14-15,17-18H2,1H3,(H,28,29)
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18n/an/an/a 2n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263361
PNG
(US9546162, 19)
Show SMILES COc1cc(CO)cc(c1)S(=O)(=O)N1CCc2cccc(CCc3ccc(cc3)C(O)=O)c12
Show InChI InChI=1S/C25H25NO6S/c1-32-22-13-18(16-27)14-23(15-22)33(30,31)26-12-11-20-4-2-3-19(24(20)26)8-5-17-6-9-21(10-7-17)25(28)29/h2-4,6-7,9-10,13-15,27H,5,8,11-12,16H2,1H3,(H,28,29)
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18n/an/an/a 36n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263347
PNG
(US9546162, 5)
Show SMILES COc1cc(CO)cc(CN2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C26H27NO4/c1-31-24-14-19(13-20(15-24)17-28)16-27-12-11-22-4-2-3-21(25(22)27)8-5-18-6-9-23(10-7-18)26(29)30/h2-4,6-7,9-10,13-15,28H,5,8,11-12,16-17H2,1H3,(H,29,30)
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19n/an/an/a 3n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263349
PNG
(US9546162, 7)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cc(OCc5ccccc5)cc(OCc5ccccc5)c4)c23)cc1
Show InChI InChI=1S/C38H35NO4/c40-38(41)34-18-15-28(16-19-34)14-17-32-12-7-13-33-20-21-39(37(32)33)25-31-22-35(42-26-29-8-3-1-4-9-29)24-36(23-31)43-27-30-10-5-2-6-11-30/h1-13,15-16,18-19,22-24H,14,17,20-21,25-27H2,(H,40,41)
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20n/an/an/a 161n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263351
PNG
(US9546162, 9)
Show SMILES COc1cc(CN2CCCc3cccc(CCc4ccc(cc4)C(O)=O)c23)cc(OC)c1
Show InChI InChI=1S/C27H29NO4/c1-31-24-15-20(16-25(17-24)32-2)18-28-14-4-7-21-5-3-6-22(26(21)28)11-8-19-9-12-23(13-10-19)27(29)30/h3,5-6,9-10,12-13,15-17H,4,7-8,11,14,18H2,1-2H3,(H,29,30)
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27n/an/an/a 114n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263360
PNG
(US9546162, 18)
Show SMILES COc1cc(OC)cc(c1)C(=O)N1CCc2cccc(CCc3ccc(cc3)C(O)=O)c12
Show InChI InChI=1S/C26H25NO5/c1-31-22-14-21(15-23(16-22)32-2)25(28)27-13-12-19-5-3-4-18(24(19)27)9-6-17-7-10-20(11-8-17)26(29)30/h3-5,7-8,10-11,14-16H,6,9,12-13H2,1-2H3,(H,29,30)
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27n/an/an/a 6n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263349
PNG
(US9546162, 7)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cc(OCc5ccccc5)cc(OCc5ccccc5)c4)c23)cc1
Show InChI InChI=1S/C38H35NO4/c40-38(41)34-18-15-28(16-19-34)14-17-32-12-7-13-33-20-21-39(37(32)33)25-31-22-35(42-26-29-8-3-1-4-9-29)24-36(23-31)43-27-30-10-5-2-6-11-30/h1-13,15-16,18-19,22-24H,14,17,20-21,25-27H2,(H,40,41)
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34n/an/an/a 33n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263343
PNG
(US9546162, 1)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cccc(F)c4)c23)cc1
Show InChI InChI=1S/C24H22FNO2/c25-22-6-1-3-18(15-22)16-26-14-13-20-5-2-4-19(23(20)26)10-7-17-8-11-21(12-9-17)24(27)28/h1-6,8-9,11-12,15H,7,10,13-14,16H2,(H,27,28)
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38n/an/an/a 35n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238316
PNG
(US9394273, 5 | US9394273, 6)
Show SMILES OC(Cc1cccc(F)c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25FO4/c25-20-3-1-2-17(14-20)15-21(26)11-9-18-10-13-23(27)22(18)12-6-16-4-7-19(8-5-16)24(28)29/h1-5,7-9,11,14,18,21-22,26H,6,10,12-13,15H2,(H,28,29)/b11-9+/t18-,21?,22+/m0/s1
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40n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238326
PNG
(US9394273, 15)
Show SMILES OC(Cc1ccc2ccsc2c1)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H26O4S/c27-22(15-18-3-5-20-13-14-31-25(20)16-18)10-8-19-9-12-24(28)23(19)11-4-17-1-6-21(7-2-17)26(29)30/h1-3,5-8,10,13-14,16,19,22-23,27H,4,9,11-12,15H2,(H,29,30)/b10-8+/t19-,22?,23+/m0/s1
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41n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263358
PNG
(US9546162, 16)
Show SMILES COc1cccc(CCN2CCc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1
Show InChI InChI=1S/C26H27NO3/c1-30-24-7-2-4-20(18-24)14-16-27-17-15-22-6-3-5-21(25(22)27)11-8-19-9-12-23(13-10-19)26(28)29/h2-7,9-10,12-13,18H,8,11,14-17H2,1H3,(H,28,29)
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41n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263344
PNG
(US9546162, 2)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4ccc(F)cc4)c23)cc1
Show InChI InChI=1S/C24H22FNO2/c25-22-12-7-18(8-13-22)16-26-15-14-20-3-1-2-19(23(20)26)9-4-17-5-10-21(11-6-17)24(27)28/h1-3,5-8,10-13H,4,9,14-16H2,(H,27,28)
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42n/an/an/a 7n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263355
PNG
(US9546162, 13)
Show SMILES COc1cc(CO)cc(CN2CCc3cccc(CCc4ccc(s4)C(O)=O)c23)c1
Show InChI InChI=1S/C24H25NO4S/c1-29-20-12-16(11-17(13-20)15-26)14-25-10-9-19-4-2-3-18(23(19)25)5-6-21-7-8-22(30-21)24(27)28/h2-4,7-8,11-13,26H,5-6,9-10,14-15H2,1H3,(H,27,28)
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47n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263356
PNG
(US9546162, 14)
Show SMILES COc1cccc(CN2CCc3cccc(CCc4ccc(s4)C(O)=O)c23)c1
Show InChI InChI=1S/C23H23NO3S/c1-27-19-7-2-4-16(14-19)15-24-13-12-18-6-3-5-17(22(18)24)8-9-20-10-11-21(28-20)23(25)26/h2-7,10-11,14H,8-9,12-13,15H2,1H3,(H,25,26)
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50n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263354
PNG
(US9546162, 12)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cccc(CCc3ccc(cc3)C(O)=O)c2C1
Show InChI InChI=1S/C25H25NO4/c1-29-22-12-21(13-23(14-22)30-2)26-15-20-5-3-4-18(24(20)16-26)9-6-17-7-10-19(11-8-17)25(27)28/h3-5,7-8,10-14H,6,9,15-16H2,1-2H3,(H,27,28)
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52n/an/an/a 41n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263346
PNG
(US9546162, 4)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F)c23)cc1
Show InChI InChI=1S/C26H21F6NO2/c27-25(28,29)21-12-17(13-22(14-21)26(30,31)32)15-33-11-10-19-3-1-2-18(23(19)33)7-4-16-5-8-20(9-6-16)24(34)35/h1-3,5-6,8-9,12-14H,4,7,10-11,15H2,(H,34,35)
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52n/an/an/a 71n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263348
PNG
(US9546162, 6)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4ccc5ccccc5c4)c23)cc1
Show InChI InChI=1S/C28H25NO2/c30-28(31)25-14-9-20(10-15-25)8-13-23-6-3-7-24-16-17-29(27(23)24)19-21-11-12-22-4-1-2-5-26(22)18-21/h1-7,9-12,14-15,18H,8,13,16-17,19H2,(H,30,31)
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53n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM263352
PNG
(US9546162, 10)
Show SMILES COc1cccc(CCN2Cc3cccc(CCc4ccc(cc4)C(O)=O)c3C2)c1
Show InChI InChI=1S/C26H27NO3/c1-30-24-7-2-4-20(16-24)14-15-27-17-23-6-3-5-21(25(23)18-27)11-8-19-9-12-22(13-10-19)26(28)29/h2-7,9-10,12-13,16H,8,11,14-15,17-18H2,1H3,(H,28,29)
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56n/an/an/a 23n/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype


(Homo sapiens (Human))
BDBM263346
PNG
(US9546162, 4)
Show SMILES OC(=O)c1ccc(CCc2cccc3CCN(Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F)c23)cc1
Show InChI InChI=1S/C26H21F6NO2/c27-25(28,29)21-12-17(13-22(14-21)26(30,31)32)15-33-11-10-19-3-1-2-18(23(19)33)7-4-16-5-8-20(9-6-16)24(34)35/h1-3,5-6,8-9,12-14H,4,7,10-11,15H2,(H,34,35)
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61n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...


US Patent US9546162 (2017)


Article DOI: 10.1021/jm049354h
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM238332
PNG
(US9394273, 21 | US9394273, 22)
Show SMILES OC(Cc1ccccc1F)\C=C\[C@H]1CCC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H25FO4/c25-22-4-2-1-3-19(22)15-20(26)12-10-17-11-14-23(27)21(17)13-7-16-5-8-18(9-6-16)24(28)29/h1-6,8-10,12,17,20-21,26H,7,11,13-15H2,(H,28,29)/b12-10+/t17-,20?,21+/m0/s1
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64n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buf...


US Patent US9394273 (2016)


BindingDB Entry DOI: 10.7270/Q2SJ1JGJ
More data for this
Ligand-Target Pair
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