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Compile Data Set for Download or QSAR

Found 32 hits from ASKA Pharmaceutical Co., Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046030
PNG
(CHEMBL3310126)
Show SMILES Fc1ccc(cc1)-c1n[nH]c(CCCc2ccccc2)c1-c1ccncc1
Show InChI InChI=1S/C23H20FN3/c24-20-11-9-19(10-12-20)23-22(18-13-15-25-16-14-18)21(26-27-23)8-4-7-17-5-2-1-3-6-17/h1-3,5-6,9-16H,4,7-8H2,(H,26,27)
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n/an/a 0.950n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046053
PNG
(CHEMBL3310146)
Show SMILES Fc1ccc(-c2noc(NC(=O)Cc3ccccc3Cl)c2-c2ccncn2)c(F)c1
Show InChI InChI=1S/C21H13ClF2N4O2/c22-15-4-2-1-3-12(15)9-18(29)27-21-19(17-7-8-25-11-26-17)20(28-30-21)14-6-5-13(23)10-16(14)24/h1-8,10-11H,9H2,(H,27,29)
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n/an/a 2.70n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046056
PNG
(CHEMBL3310149)
Show SMILES Cc1cccc(c1)-c1noc(NC(=O)Cc2ccccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C22H17ClN4O2/c1-14-5-4-7-16(11-14)21-20(18-9-10-24-13-25-18)22(29-27-21)26-19(28)12-15-6-2-3-8-17(15)23/h2-11,13H,12H2,1H3,(H,26,28)
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n/an/a 3.60n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046057
PNG
(CHEMBL3310276)
Show SMILES Cc1ccccc1CC(=O)Nc1onc(c1-c1ccncn1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-5-3-4-6-16(14)12-20(29)27-23-21(19-9-10-25-13-26-19)22(28-30-23)17-7-8-18(24)15(2)11-17/h3-11,13H,12H2,1-2H3,(H,27,29)
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n/an/a 5.5n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046036
PNG
(CHEMBL3310130)
Show SMILES Cn1nc(NC(=O)Cc2ccccc2)c(c1-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H19FN4O/c1-28-22(18-7-9-19(24)10-8-18)21(17-11-13-25-14-12-17)23(27-28)26-20(29)15-16-5-3-2-4-6-16/h2-14H,15H2,1H3,(H,26,27,29)
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n/an/a 5.70n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046048
PNG
(CHEMBL3310141)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2ccccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C21H14ClFN4O2/c22-16-4-2-1-3-14(16)11-18(28)26-21-19(17-9-10-24-12-25-17)20(27-29-21)13-5-7-15(23)8-6-13/h1-10,12H,11H2,(H,26,28)
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n/an/a 6.90n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046050
PNG
(CHEMBL3310143)
Show SMILES Cc1ccc(C)c(CC(=O)Nc2onc(c2-c2ccncn2)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-3-4-15(2)17(11-14)12-20(29)27-23-21(19-9-10-25-13-26-19)22(28-30-23)16-5-7-18(24)8-6-16/h3-11,13H,12H2,1-2H3,(H,27,29)
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n/an/a 8.40n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046052
PNG
(CHEMBL3310145)
Show SMILES Clc1ccc(cc1)-c1noc(NC(=O)Cc2ccccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C21H14Cl2N4O2/c22-15-7-5-13(6-8-15)20-19(17-9-10-24-12-25-17)21(29-27-20)26-18(28)11-14-3-1-2-4-16(14)23/h1-10,12H,11H2,(H,26,28)
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n/an/a 11n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046049
PNG
(CHEMBL3310142)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2c(F)cccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C21H13ClF2N4O2/c22-15-2-1-3-16(24)14(15)10-18(29)27-21-19(17-8-9-25-11-26-17)20(28-30-21)12-4-6-13(23)7-5-12/h1-9,11H,10H2,(H,27,29)
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n/an/a 11n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046033
PNG
(CHEMBL3310128)
Show SMILES Fc1ccc(cc1)-c1n[nH]c(NC(=O)Cc2ccccc2)c1-c1ccncc1
Show InChI InChI=1S/C22H17FN4O/c23-18-8-6-17(7-9-18)21-20(16-10-12-24-13-11-16)22(27-26-21)25-19(28)14-15-4-2-1-3-5-15/h1-13H,14H2,(H2,25,26,27,28)
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n/an/a 17n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046042
PNG
(CHEMBL3310136)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)CCc2ccccc2)c1-c1ccncc1
Show InChI InChI=1S/C23H18FN3O2/c24-19-9-7-18(8-10-19)22-21(17-12-14-25-15-13-17)23(29-27-22)26-20(28)11-6-16-4-2-1-3-5-16/h1-5,7-10,12-15H,6,11H2,(H,26,28)
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n/an/a 23n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046041
PNG
(CHEMBL3310135)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2ccccc2)c1-c1ccncc1
Show InChI InChI=1S/C22H16FN3O2/c23-18-8-6-17(7-9-18)21-20(16-10-12-24-13-11-16)22(28-26-21)25-19(27)14-15-4-2-1-3-5-15/h1-13H,14H2,(H,25,27)
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n/an/a 23n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046047
PNG
(CHEMBL3310140)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2ccccc2F)c1-c1ccncn1
Show InChI InChI=1S/C21H14F2N4O2/c22-15-7-5-13(6-8-15)20-19(17-9-10-24-12-25-17)21(29-27-20)26-18(28)11-14-3-1-2-4-16(14)23/h1-10,12H,11H2,(H,26,28)
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n/an/a 33n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046046
PNG
(CHEMBL3310139)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2ccccc2)c1-c1ccncn1
Show InChI InChI=1S/C21H15FN4O2/c22-16-8-6-15(7-9-16)20-19(17-10-11-23-13-24-17)21(28-26-20)25-18(27)12-14-4-2-1-3-5-14/h1-11,13H,12H2,(H,25,27)
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n/an/a 46n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM19429
PNG
(4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...)
Show SMILES Fc1ccc(cc1)-c1n[nH]cc1-c1ccncc1
Show InChI InChI=1S/C14H10FN3/c15-12-3-1-11(2-4-12)14-13(9-17-18-14)10-5-7-16-8-6-10/h1-9H,(H,17,18)
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n/an/a 67n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046034
PNG
(CHEMBL3310129)
Show SMILES Cn1nc(c(c1N)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C15H13FN4/c1-20-15(17)13(10-6-8-18-9-7-10)14(19-20)11-2-4-12(16)5-3-11/h2-9H,17H2,1H3
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n/an/a 70n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046032
PNG
(CHEMBL3310127)
Show SMILES Nc1[nH]nc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN4/c15-11-3-1-10(2-4-11)13-12(14(16)19-18-13)9-5-7-17-8-6-9/h1-8H,(H3,16,18,19)
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n/an/a 97n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046037
PNG
(CHEMBL3310131)
Show SMILES Nc1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C14H10FN3O/c15-11-3-1-10(2-4-11)13-12(14(16)19-18-13)9-5-7-17-8-6-9/h1-8H,16H2
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n/an/a 105n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046051
PNG
(CHEMBL3310144)
Show SMILES Clc1ccccc1-c1noc(NC(=O)Cc2ccccc2)c1-c1ccncn1
Show InChI InChI=1S/C21H15ClN4O2/c22-16-9-5-4-8-15(16)20-19(17-10-11-23-13-24-17)21(28-26-20)25-18(27)12-14-6-2-1-3-7-14/h1-11,13H,12H2,(H,25,27)
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n/an/a 141n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50046049
PNG
(CHEMBL3310142)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2c(F)cccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C21H13ClF2N4O2/c22-15-2-1-3-16(24)14(15)10-18(29)27-21-19(17-8-9-25-11-26-17)20(28-30-21)12-4-6-13(23)7-5-12/h1-9,11H,10H2,(H,27,29)
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n/an/a 198n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human JNK2 kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046044
PNG
(CHEMBL3310137)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)CCCc2ccccc2)c1-c1ccncc1
Show InChI InChI=1S/C24H20FN3O2/c25-20-11-9-19(10-12-20)23-22(18-13-15-26-16-14-18)24(30-28-23)27-21(29)8-4-7-17-5-2-1-3-6-17/h1-3,5-6,9-16H,4,7-8H2,(H,27,29)
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n/an/a 271n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046054
PNG
(CHEMBL3310147)
Show SMILES Fc1cccc(F)c1-c1noc(NC(=O)Cc2ccccc2)c1-c1ccncn1
Show InChI InChI=1S/C21H14F2N4O2/c22-14-7-4-8-15(23)18(14)20-19(16-9-10-24-12-25-16)21(29-27-20)26-17(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,26,28)
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n/an/a 294n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens)
BDBM50046049
PNG
(CHEMBL3310142)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2c(F)cccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C21H13ClF2N4O2/c22-15-2-1-3-16(24)14(15)10-18(29)27-21-19(17-8-9-25-11-26-17)20(28-30-21)12-4-6-13(23)7-5-12/h1-9,11H,10H2,(H,27,29)
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n/an/a 326n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human p38beta MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50046049
PNG
(CHEMBL3310142)
Show SMILES Fc1ccc(cc1)-c1noc(NC(=O)Cc2c(F)cccc2Cl)c1-c1ccncn1
Show InChI InChI=1S/C21H13ClF2N4O2/c22-15-2-1-3-16(24)14(15)10-18(29)27-21-19(17-8-9-25-11-26-17)20(28-30-21)12-4-6-13(23)7-5-12/h1-9,11H,10H2,(H,27,29)
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n/an/a 572n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human JNK3 kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046045
PNG
(CHEMBL3310138)
Show SMILES Nc1onc(c1-c1ccncn1)-c1ccc(F)cc1
Show InChI InChI=1S/C13H9FN4O/c14-9-3-1-8(2-4-9)12-11(13(15)19-18-12)10-5-6-16-7-17-10/h1-7H,15H2
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n/an/a 792n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046038
PNG
(CHEMBL3310132)
Show SMILES Fc1ccc(cc1)-c1nocc1-c1ccncc1
Show InChI InChI=1S/C14H9FN2O/c15-12-3-1-11(2-4-12)14-13(9-18-17-14)10-5-7-16-8-6-10/h1-9H
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n/an/a 871n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046055
PNG
(CHEMBL3310148)
Show SMILES Clc1cccc(Cl)c1-c1noc(NC(=O)Cc2ccccc2)c1-c1ccncn1
Show InChI InChI=1S/C21H14Cl2N4O2/c22-14-7-4-8-15(23)18(14)20-19(16-9-10-24-12-25-16)21(29-27-20)26-17(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,26,28)
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n/an/a 1.01E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046040
PNG
(CHEMBL3310134)
Show SMILES Fc1ccc(Nc2noc(NC(=O)c3ccccc3)c2-c2ccncc2)cc1
Show InChI InChI=1S/C21H15FN4O2/c22-16-6-8-17(9-7-16)24-19-18(14-10-12-23-13-11-14)21(28-26-19)25-20(27)15-4-2-1-3-5-15/h1-13H,(H,24,26)(H,25,27)
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n/an/a 1.21E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50046039
PNG
(CHEMBL3310133)
Show SMILES CC(=O)Nc1onc(c1-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H12FN3O2/c1-10(21)19-16-14(11-6-8-18-9-7-11)15(20-22-16)12-2-4-13(17)5-3-12/h2-9H,1H3,(H,19,21)
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n/an/a 1.31E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of full length human p38alpha MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (human))
BDBM50046045
PNG
(CHEMBL3310138)
Show SMILES Nc1onc(c1-c1ccncn1)-c1ccc(F)cc1
Show InChI InChI=1S/C13H9FN4O/c14-9-3-1-8(2-4-9)12-11(13(15)19-18-12)10-5-6-16-7-17-10/h1-7H,15H2
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n/an/a 1.48E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human JNK2 kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM50046045
PNG
(CHEMBL3310138)
Show SMILES Nc1onc(c1-c1ccncn1)-c1ccc(F)cc1
Show InChI InChI=1S/C13H9FN4O/c14-9-3-1-8(2-4-9)12-11(13(15)19-18-12)10-5-6-16-7-17-10/h1-7H,15H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human JNK3 kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens)
BDBM50046045
PNG
(CHEMBL3310138)
Show SMILES Nc1onc(c1-c1ccncn1)-c1ccc(F)cc1
Show InChI InChI=1S/C13H9FN4O/c14-9-3-1-8(2-4-9)12-11(13(15)19-18-12)10-5-6-16-7-17-10/h1-7H,15H2
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n/an/a 9.71E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human p38beta MAP kinase by Off-chip mobility shift assay


Bioorg Med Chem 22: 4162-76 (2014)


Article DOI: 10.1016/j.bmc.2014.05.045
BindingDB Entry DOI: 10.7270/Q2C82BXS
More data for this
Ligand-Target Pair