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Compile Data Set for Download or QSAR

Found 69 hits from AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186202
PNG
(US9163013, 19)
Show SMILES OC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(cc34)-c3cccc(F)c3F)CC2)o1
Show InChI InChI=1S/C26H24F2N4O4/c27-20-3-1-2-18(23(20)28)16-4-6-21-19(12-16)24(31-30-21)25(33)29-13-15-8-10-32(11-9-15)14-17-5-7-22(36-17)26(34)35/h1-7,12,15H,8-11,13-14H2,(H,29,33)(H,30,31)(H,34,35)
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n/an/a 10n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186195
PNG
(US9163013, 12)
Show SMILES OC(=O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(cc34)-c3cccc(F)c3F)CC2)n1
Show InChI InChI=1S/C25H23F2N5O4/c26-18-3-1-2-16(22(18)27)15-4-5-19-17(10-15)23(31-30-19)24(33)28-11-14-6-8-32(9-7-14)12-21-29-20(13-36-21)25(34)35/h1-5,10,13-14H,6-9,11-12H2,(H,28,33)(H,30,31)(H,34,35)
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n/an/a 10n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186204
PNG
(US9163013, 21)
Show SMILES COc1ccncc1-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C26H27N5O5/c1-35-22-6-9-27-14-20(22)17-2-4-21-19(12-17)24(30-29-21)25(32)28-13-16-7-10-31(11-8-16)15-18-3-5-23(36-18)26(33)34/h2-6,9,12,14,16H,7-8,10-11,13,15H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 10n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50134187
PNG
(CHEMBL3735506 | US9611249, Compound 8)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1
Show InChI InChI=1S/C23H26F2N4O2/c1-31-12-11-29-9-7-15(8-10-29)14-26-23(30)22-18-13-16(5-6-20(18)27-28-22)17-3-2-4-19(24)21(17)25/h2-6,13,15H,7-12,14H2,1H3,(H,26,30)(H,27,28)
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US Patent
n/an/a 20n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186203
PNG
(US9163013, 20)
Show SMILES OC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(cc34)-c3ccccc3F)CC2)o1
Show InChI InChI=1S/C26H25FN4O4/c27-21-4-2-1-3-19(21)17-5-7-22-20(13-17)24(30-29-22)25(32)28-14-16-9-11-31(12-10-16)15-18-6-8-23(35-18)26(33)34/h1-8,13,16H,9-12,14-15H2,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 20n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314399
PNG
(US9611249, Compound 30 | {4-[({[5-(5-methoxypyridi...)
Show SMILES COc1cncc(c1)-c1ccc2[nH]nc(C(=O)NCC3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C22H25N5O4/c1-31-17-8-16(11-23-12-17)15-2-3-19-18(9-15)21(26-25-19)22(30)24-10-14-4-6-27(7-5-14)13-20(28)29/h2-3,8-9,11-12,14H,4-7,10,13H2,1H3,(H,24,30)(H,25,26)(H,28,29)
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n/an/a 20n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186200
PNG
(US9163013, 17)
Show SMILES COc1ccc(cn1)-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C26H27N5O5/c1-35-23-7-3-18(14-27-23)17-2-5-21-20(12-17)24(30-29-21)25(32)28-13-16-8-10-31(11-9-16)15-19-4-6-22(36-19)26(33)34/h2-7,12,14,16H,8-11,13,15H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 20n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314398
PNG
(US9611249, Compound 29 | {4-[({[5-(2,3-difluorophe...)
Show SMILES OC(=O)CN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2F)CC1
Show InChI InChI=1S/C22H22F2N4O3/c23-17-3-1-2-15(20(17)24)14-4-5-18-16(10-14)21(27-26-18)22(31)25-11-13-6-8-28(9-7-13)12-19(29)30/h1-5,10,13H,6-9,11-12H2,(H,25,31)(H,26,27)(H,29,30)
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n/an/a 30n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314382
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(5...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cncc(OC)c2)CC1
Show InChI InChI=1S/C23H29N5O3/c1-30-10-9-28-7-5-16(6-8-28)13-25-23(29)22-20-12-17(3-4-21(20)26-27-22)18-11-19(31-2)15-24-14-18/h3-4,11-12,14-16H,5-10,13H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 30n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314371
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(p...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccnc2)CC1
Show InChI InChI=1S/C22H27N5O2/c1-29-12-11-27-9-6-16(7-10-27)14-24-22(28)21-19-13-17(4-5-20(19)25-26-21)18-3-2-8-23-15-18/h2-5,8,13,15-16H,6-7,9-12,14H2,1H3,(H,24,28)(H,25,26)
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n/an/a 30n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314374
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(4...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cnccc2OC)CC1
Show InChI InChI=1S/C23H29N5O3/c1-30-12-11-28-9-6-16(7-10-28)14-25-23(29)22-18-13-17(3-4-20(18)26-27-22)19-15-24-8-5-21(19)31-2/h3-5,8,13,15-16H,6-7,9-12,14H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314387
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(6...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccc(OC)nc2)CC1
Show InChI InChI=1S/C23H29N5O3/c1-30-12-11-28-9-7-16(8-10-28)14-25-23(29)22-19-13-17(3-5-20(19)26-27-22)18-4-6-21(31-2)24-15-18/h3-6,13,15-16H,7-12,14H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314378
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(6...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccc(C)nc2)CC1
Show InChI InChI=1S/C23H29N5O2/c1-16-3-4-19(15-24-16)18-5-6-21-20(13-18)22(27-26-21)23(29)25-14-17-7-9-28(10-8-17)11-12-30-2/h3-6,13,15,17H,7-12,14H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 60n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314377
PNG
(5-(2-fluorophenyl)-N-{[1-(2- methoxyethyl)piperidi...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccccc2F)CC1
Show InChI InChI=1S/C23H27FN4O2/c1-30-13-12-28-10-8-16(9-11-28)15-25-23(29)22-19-14-17(6-7-21(19)26-27-22)18-4-2-3-5-20(18)24/h2-7,14,16H,8-13,15H2,1H3,(H,25,29)(H,26,27)
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n/an/a 70n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314396
PNG
(US9611249, Compound 27 | {4-[({[5-(2,3-dichlorophe...)
Show SMILES OC(=O)CN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(Cl)c2Cl)CC1
Show InChI InChI=1S/C22H22Cl2N4O3/c23-17-3-1-2-15(20(17)24)14-4-5-18-16(10-14)21(27-26-18)22(31)25-11-13-6-8-28(9-7-13)12-19(29)30/h1-5,10,13H,6-9,11-12H2,(H,25,31)(H,26,27)(H,29,30)
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n/an/a 100n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314397
PNG
(US9611249, Compound 28 | {4-[({[5-(3-fluorophenyl)...)
Show SMILES OC(=O)CN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cccc(F)c2)CC1
Show InChI InChI=1S/C22H23FN4O3/c23-17-3-1-2-15(10-17)16-4-5-19-18(11-16)21(26-25-19)22(30)24-12-14-6-8-27(9-7-14)13-20(28)29/h1-5,10-11,14H,6-9,12-13H2,(H,24,30)(H,25,26)(H,28,29)
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n/an/a 110n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186190
PNG
(US9163013, 7)
Show SMILES COC(=O)c1csc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)n1
Show InChI InChI=1S/C21H25N5O4S/c1-29-14-3-4-16-15(9-14)19(25-24-16)20(27)22-10-13-5-7-26(8-6-13)11-18-23-17(12-31-18)21(28)30-2/h3-4,9,12-13H,5-8,10-11H2,1-2H3,(H,22,27)(H,24,25)
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n/an/a 130n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186191
PNG
(US9163013, 8)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4nc(cs4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C20H23N5O4S/c1-29-13-2-3-15-14(8-13)18(24-23-15)19(26)21-9-12-4-6-25(7-5-12)10-17-22-16(11-30-17)20(27)28/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,21,26)(H,23,24)(H,27,28)
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n/an/a 170n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314381
PNG
(N-{[1-(2-methoxyethyl)pipendin-4- yl]methyl}-5-phe...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccccc2)CC1
Show InChI InChI=1S/C23H28N4O2/c1-29-14-13-27-11-9-17(10-12-27)16-24-23(28)22-20-15-19(7-8-21(20)25-26-22)18-5-3-2-4-6-18/h2-8,15,17H,9-14,16H2,1H3,(H,24,28)(H,25,26)
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n/an/a 200n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186205
PNG
(US9163013, 22)
Show SMILES OC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)o1
Show InChI InChI=1S/C20H21BrN4O4/c21-13-1-3-16-15(9-13)18(24-23-16)19(26)22-10-12-5-7-25(8-6-12)11-14-2-4-17(29-14)20(27)28/h1-4,9,12H,5-8,10-11H2,(H,22,26)(H,23,24)(H,27,28)
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n/an/a 210n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186192
PNG
(US9163013, 9)
Show SMILES COC(=O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)n1
Show InChI InChI=1S/C21H25N5O5/c1-29-14-3-4-16-15(9-14)19(25-24-16)20(27)22-10-13-5-7-26(8-6-13)11-18-23-17(12-31-18)21(28)30-2/h3-4,9,12-13H,5-8,10-11H2,1-2H3,(H,22,27)(H,24,25)
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n/an/a 210n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314391
PNG
(US9611249, Compound 25 | US9611249, Compound 25b |...)
Show SMILES OC(=O)CN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cncnc2)CC1
Show InChI InChI=1S/C20H22N6O3/c27-18(28)11-26-5-3-13(4-6-26)8-23-20(29)19-16-7-14(1-2-17(16)24-25-19)15-9-21-12-22-10-15/h1-2,7,9-10,12-13H,3-6,8,11H2,(H,23,29)(H,24,25)(H,27,28)
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n/an/a 220n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186197
PNG
(US9163013, 14)
Show SMILES COC(=O)c1ccoc1CN1CCC(CNC(=O)c2n[nH]c3ccc(OC)cc23)CC1
Show InChI InChI=1S/C22H26N4O5/c1-29-15-3-4-18-17(11-15)20(25-24-18)21(27)23-12-14-5-8-26(9-6-14)13-19-16(7-10-31-19)22(28)30-2/h3-4,7,10-11,14H,5-6,8-9,12-13H2,1-2H3,(H,23,27)(H,24,25)
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n/an/a 230n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186198
PNG
(US9163013, 15)
Show SMILES CCOC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)o1
Show InChI InChI=1S/C22H25BrN4O4/c1-2-30-22(29)19-6-4-16(31-19)13-27-9-7-14(8-10-27)12-24-21(28)20-17-11-15(23)3-5-18(17)25-26-20/h3-6,11,14H,2,7-10,12-13H2,1H3,(H,24,28)(H,25,26)
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n/an/a 260n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186201
PNG
(US9163013, 18)
Show SMILES COc1ccc(cc1)-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H28N4O5/c1-35-20-5-2-18(3-6-20)19-4-8-23-22(14-19)25(30-29-23)26(32)28-15-17-10-12-31(13-11-17)16-21-7-9-24(36-21)27(33)34/h2-9,14,17H,10-13,15-16H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 300n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186213
PNG
(US9163013, 30)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4noc(n4)C(N)=O)CC3)c2c1
Show InChI InChI=1S/C19H23N7O4/c1-29-12-2-3-14-13(8-12)16(24-23-14)18(28)21-9-11-4-6-26(7-5-11)10-15-22-19(17(20)27)30-25-15/h2-3,8,11H,4-7,9-10H2,1H3,(H2,20,27)(H,21,28)(H,23,24)
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n/an/a 310n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186193
PNG
(US9163013, 10)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4nc(co4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C20H23N5O5/c1-29-13-2-3-15-14(8-13)18(24-23-15)19(26)21-9-12-4-6-25(7-5-12)10-17-22-16(11-30-17)20(27)28/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,21,26)(H,23,24)(H,27,28)
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n/an/a 310n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186210
PNG
(US9163013, 27)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCC4CCCC(C)C4)CC3)c2c1
Show InChI InChI=1/C24H36N4O2/c1-17-4-3-5-18(14-17)8-11-28-12-9-19(10-13-28)16-25-24(29)23-21-15-20(30-2)6-7-22(21)26-27-23/h6-7,15,17-19H,3-5,8-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 310n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186186
PNG
(US9163013, 3)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(Cl)cc4Cl)CC3)c2c1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-30-17-4-5-20-18(11-17)21(27-26-20)22(29)25-12-14-6-8-28(9-7-14)13-15-2-3-16(23)10-19(15)24/h2-5,10-11,14H,6-9,12-13H2,1H3,(H,25,29)(H,26,27)
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n/an/a 310n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186212
PNG
(US9163013, 29)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(nc4)C([O-])=O)CC3)c2c1
Show InChI InChI=1S/C22H25N5O4/c1-31-16-3-5-18-17(10-16)20(26-25-18)21(28)24-11-14-6-8-27(9-7-14)13-15-2-4-19(22(29)30)23-12-15/h2-5,10,12,14H,6-9,11,13H2,1H3,(H,24,28)(H,25,26)(H,29,30)/p-1
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n/an/a 320n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186206
PNG
(US9163013, 23)
Show SMILES CCOC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)o1
Show InChI InChI=1S/C23H28N4O5/c1-3-31-23(29)20-7-5-17(32-20)14-27-10-8-15(9-11-27)13-24-22(28)21-18-12-16(30-2)4-6-19(18)25-26-21/h4-7,12,15H,3,8-11,13-14H2,1-2H3,(H,24,28)(H,25,26)
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n/an/a 330n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186188
PNG
(US9163013, 5)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(OCc5ccccc5)cc4)CC3)c2c1
Show InChI InChI=1S/C29H32N4O3/c1-35-25-11-12-27-26(17-25)28(32-31-27)29(34)30-18-21-13-15-33(16-14-21)19-22-7-9-24(10-8-22)36-20-23-5-3-2-4-6-23/h2-12,17,21H,13-16,18-20H2,1H3,(H,30,34)(H,31,32)
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n/an/a 350n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186184
PNG
(US9163013, 1)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-30-19-6-7-21-20(14-19)22(26-25-21)23(29)24-15-17-9-12-27(13-10-17)11-8-16-2-4-18(28)5-3-16/h2-7,14,17,28H,8-13,15H2,1H3,(H,24,29)(H,25,26)
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n/an/a 350n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186199
PNG
(US9163013, 16)
Show SMILES COc1ncccc1-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C26H27N5O5/c1-35-25-19(3-2-10-27-25)17-4-6-21-20(13-17)23(30-29-21)24(32)28-14-16-8-11-31(12-9-16)15-18-5-7-22(36-18)26(33)34/h2-7,10,13,16H,8-9,11-12,14-15H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 360n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186194
PNG
(US9163013, 11)
Show SMILES COC(=O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)n1
Show InChI InChI=1S/C20H22BrN5O4/c1-29-20(28)16-11-30-17(23-16)10-26-6-4-12(5-7-26)9-22-19(27)18-14-8-13(21)2-3-15(14)24-25-18/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,22,27)(H,24,25)
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n/an/a 360n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186207
PNG
(US9163013, 24)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C21H24N4O5/c1-29-14-2-4-17-16(10-14)19(24-23-17)20(26)22-11-13-6-8-25(9-7-13)12-15-3-5-18(30-15)21(27)28/h2-5,10,13H,6-9,11-12H2,1H3,(H,22,26)(H,23,24)(H,27,28)
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n/an/a 400n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186189
PNG
(US9163013, 6)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C22H26N4O3/c1-29-18-6-7-20-19(12-18)21(25-24-20)22(28)23-13-15-8-10-26(11-9-15)14-16-2-4-17(27)5-3-16/h2-7,12,15,27H,8-11,13-14H2,1H3,(H,23,28)(H,24,25)
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n/an/a 400n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186211
PNG
(US9163013, 28)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccnc(c4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C22H25N5O4/c1-31-16-2-3-18-17(11-16)20(26-25-18)21(28)24-12-14-5-8-27(9-6-14)13-15-4-7-23-19(10-15)22(29)30/h2-4,7,10-11,14H,5-6,8-9,12-13H2,1H3,(H,24,28)(H,25,26)(H,29,30)
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n/an/a 450n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314391
PNG
(US9611249, Compound 25 | US9611249, Compound 25b |...)
Show SMILES OC(=O)CN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2cncnc2)CC1
Show InChI InChI=1S/C20H22N6O3/c27-18(28)11-26-5-3-13(4-6-26)8-23-20(29)19-16-7-14(1-2-17(16)24-25-19)15-9-21-12-22-10-15/h1-2,7,9-10,12-13H,3-6,8,11H2,(H,23,29)(H,24,25)(H,27,28)
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n/an/a 530n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314385
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(4...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccc(C)cc2)CC1
Show InChI InChI=1S/C24H30N4O2/c1-17-3-5-19(6-4-17)20-7-8-22-21(15-20)23(27-26-22)24(29)25-16-18-9-11-28(12-10-18)13-14-30-2/h3-8,15,18H,9-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 560n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314384
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(4...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccc(OC)cc2)CC1
Show InChI InChI=1S/C24H30N4O3/c1-30-14-13-28-11-9-17(10-12-28)16-25-24(29)23-21-15-19(5-8-22(21)26-27-23)18-3-6-20(31-2)7-4-18/h3-8,15,17H,9-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 560n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186185
PNG
(US9163013, 2)
Show SMILES COc1ccc(CCN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)cc1
Show InChI InChI=1S/C24H30N4O3/c1-30-19-5-3-17(4-6-19)9-12-28-13-10-18(11-14-28)16-25-24(29)23-21-15-20(31-2)7-8-22(21)26-27-23/h3-8,15,18H,9-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 560n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314388
PNG
(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(2...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccccc2C)CC1
Show InChI InChI=1S/C24H30N4O2/c1-17-5-3-4-6-20(17)19-7-8-22-21(15-19)23(27-26-22)24(29)25-16-18-9-11-28(12-10-18)13-14-30-2/h3-8,15,18H,9-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 580n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM186187
PNG
(US9163013, 4)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(cc4)C(F)(F)F)CC3)c2c1
Show InChI InChI=1S/C23H25F3N4O2/c1-32-18-6-7-20-19(12-18)21(29-28-20)22(31)27-13-15-8-10-30(11-9-15)14-16-2-4-17(5-3-16)23(24,25)26/h2-7,12,15H,8-11,13-14H2,1H3,(H,27,31)(H,28,29)
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n/an/a 640n/an/an/an/an/a22



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314324
PNG
(US9611249, Compound 1 | [4-({[(5-methoxy-1H-indazo...)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CC(O)=O)CC3)c2c1
Show InChI InChI=1S/C17H22N4O4/c1-25-12-2-3-14-13(8-12)16(20-19-14)17(24)18-9-11-4-6-21(7-5-11)10-15(22)23/h2-3,8,11H,4-7,9-10H2,1H3,(H,18,24)(H,19,20)(H,22,23)
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n/an/a 670n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314370
PNG
(US9611249, Compound 3 | [4-({[(5-methoxy-1H-indazo...)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCC(O)=O)CC3)c2c1
Show InChI InChI=1S/C18H24N4O4/c1-26-13-2-3-15-14(10-13)17(21-20-15)18(25)19-11-12-4-7-22(8-5-12)9-6-16(23)24/h2-3,10,12H,4-9,11H2,1H3,(H,19,25)(H,20,21)(H,23,24)
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n/an/a 690n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314407
PNG
(N-[(1-{3-[(2E)-but-2-enoylamino]propyl} piperidin-...)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCCNC(=O)\C=C\C)CC3)c2c1
Show InChI InChI=1S/C22H31N5O3/c1-3-5-20(28)23-10-4-11-27-12-8-16(9-13-27)15-24-22(29)21-18-14-17(30-2)6-7-19(18)25-26-21/h3,5-7,14,16H,4,8-13,15H2,1-2H3,(H,23,28)(H,24,29)(H,25,26)/b5-3+
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n/an/a 780n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314368
PNG
(5-methoxy-N-{[1-(2-methoxyethyl)- piperidin-4-yl]m...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(OC)cc23)CC1
Show InChI InChI=1S/C18H26N4O3/c1-24-10-9-22-7-5-13(6-8-22)12-19-18(23)17-15-11-14(25-2)3-4-16(15)20-21-17/h3-4,11,13H,5-10,12H2,1-2H3,(H,19,23)(H,20,21)
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n/an/a 870n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314409
PNG
(N-({1-[3-(but-2-ynoylamino)propyl] piperidin-4-yl}...)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCCNC(=O)C#CC)CC3)c2c1
Show InChI InChI=1S/C22H29N5O3/c1-3-5-20(28)23-10-4-11-27-12-8-16(9-13-27)15-24-22(29)21-18-14-17(30-2)6-7-19(18)25-26-21/h6-7,14,16H,4,8-13,15H2,1-2H3,(H,23,28)(H,24,29)(H,25,26)
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n/an/a 880n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM314383
PNG
(5-(4-hydroxyphenyl)-N-{[1-(2- methoxyethyl)piperid...)
Show SMILES COCCN1CCC(CNC(=O)c2n[nH]c3ccc(cc23)-c2ccc(O)cc2)CC1
Show InChI InChI=1S/C23H28N4O3/c1-30-13-12-27-10-8-16(9-11-27)15-24-23(29)22-20-14-18(4-7-21(20)25-26-22)17-2-5-19(28)6-3-17/h2-7,14,16,28H,8-13,15H2,1H3,(H,24,29)(H,25,26)
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n/an/a 890n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...


US Patent US9611249 (2017)


Article DOI: 10.1016/j.bmcl.2007.10.043
BindingDB Entry DOI: 10.7270/Q2JH3P79
More data for this
Ligand-Target Pair
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