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Compile Data Set for Download or QSAR

Found 34 hits from AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186195
PNG
(US9163013, 12)
Show SMILES OC(=O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(cc34)-c3cccc(F)c3F)CC2)n1
Show InChI InChI=1S/C25H23F2N5O4/c26-18-3-1-2-16(22(18)27)15-4-5-19-17(10-15)23(31-30-19)24(33)28-11-14-6-8-32(9-7-14)12-21-29-20(13-36-21)25(34)35/h1-5,10,13-14H,6-9,11-12H2,(H,28,33)(H,30,31)(H,34,35)
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n/an/a 10n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186202
PNG
(US9163013, 19)
Show SMILES OC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(cc34)-c3cccc(F)c3F)CC2)o1
Show InChI InChI=1S/C26H24F2N4O4/c27-20-3-1-2-18(23(20)28)16-4-6-21-19(12-16)24(31-30-21)25(33)29-13-15-8-10-32(11-9-15)14-17-5-7-22(36-17)26(34)35/h1-7,12,15H,8-11,13-14H2,(H,29,33)(H,30,31)(H,34,35)
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n/an/a 10n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186204
PNG
(US9163013, 21)
Show SMILES COc1ccncc1-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C26H27N5O5/c1-35-22-6-9-27-14-20(22)17-2-4-21-19(12-17)24(30-29-21)25(32)28-13-16-7-10-31(11-8-16)15-18-3-5-23(36-18)26(33)34/h2-6,9,12,14,16H,7-8,10-11,13,15H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 10n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186203
PNG
(US9163013, 20)
Show SMILES OC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(cc34)-c3ccccc3F)CC2)o1
Show InChI InChI=1S/C26H25FN4O4/c27-21-4-2-1-3-19(21)17-5-7-22-20(13-17)24(30-29-22)25(32)28-14-16-9-11-31(12-10-16)15-18-6-8-23(35-18)26(33)34/h1-8,13,16H,9-12,14-15H2,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 20n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186200
PNG
(US9163013, 17)
Show SMILES COc1ccc(cn1)-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C26H27N5O5/c1-35-23-7-3-18(14-27-23)17-2-5-21-20(12-17)24(30-29-21)25(32)28-13-16-8-10-31(11-9-16)15-19-4-6-22(36-19)26(33)34/h2-7,12,14,16H,8-11,13,15H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 20n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186190
PNG
(US9163013, 7)
Show SMILES COC(=O)c1csc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)n1
Show InChI InChI=1S/C21H25N5O4S/c1-29-14-3-4-16-15(9-14)19(25-24-16)20(27)22-10-13-5-7-26(8-6-13)11-18-23-17(12-31-18)21(28)30-2/h3-4,9,12-13H,5-8,10-11H2,1-2H3,(H,22,27)(H,24,25)
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n/an/a 130n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186191
PNG
(US9163013, 8)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4nc(cs4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C20H23N5O4S/c1-29-13-2-3-15-14(8-13)18(24-23-15)19(26)21-9-12-4-6-25(7-5-12)10-17-22-16(11-30-17)20(27)28/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,21,26)(H,23,24)(H,27,28)
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n/an/a 170n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186205
PNG
(US9163013, 22)
Show SMILES OC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)o1
Show InChI InChI=1S/C20H21BrN4O4/c21-13-1-3-16-15(9-13)18(24-23-16)19(26)22-10-12-5-7-25(8-6-12)11-14-2-4-17(29-14)20(27)28/h1-4,9,12H,5-8,10-11H2,(H,22,26)(H,23,24)(H,27,28)
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n/an/a 210n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186192
PNG
(US9163013, 9)
Show SMILES COC(=O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)n1
Show InChI InChI=1S/C21H25N5O5/c1-29-14-3-4-16-15(9-14)19(25-24-16)20(27)22-10-13-5-7-26(8-6-13)11-18-23-17(12-31-18)21(28)30-2/h3-4,9,12-13H,5-8,10-11H2,1-2H3,(H,22,27)(H,24,25)
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n/an/a 210n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186197
PNG
(US9163013, 14)
Show SMILES COC(=O)c1ccoc1CN1CCC(CNC(=O)c2n[nH]c3ccc(OC)cc23)CC1
Show InChI InChI=1S/C22H26N4O5/c1-29-15-3-4-18-17(11-15)20(25-24-18)21(27)23-12-14-5-8-26(9-6-14)13-19-16(7-10-31-19)22(28)30-2/h3-4,7,10-11,14H,5-6,8-9,12-13H2,1-2H3,(H,23,27)(H,24,25)
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n/an/a 230n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186198
PNG
(US9163013, 15)
Show SMILES CCOC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)o1
Show InChI InChI=1S/C22H25BrN4O4/c1-2-30-22(29)19-6-4-16(31-19)13-27-9-7-14(8-10-27)12-24-21(28)20-17-11-15(23)3-5-18(17)25-26-20/h3-6,11,14H,2,7-10,12-13H2,1H3,(H,24,28)(H,25,26)
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n/an/a 260n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186201
PNG
(US9163013, 18)
Show SMILES COc1ccc(cc1)-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C27H28N4O5/c1-35-20-5-2-18(3-6-20)19-4-8-23-22(14-19)25(30-29-23)26(32)28-15-17-10-12-31(13-11-17)16-21-7-9-24(36-21)27(33)34/h2-9,14,17H,10-13,15-16H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 300n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186210
PNG
(US9163013, 27)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCC4CCCC(C)C4)CC3)c2c1
Show InChI InChI=1S/C24H36N4O2/c1-17-4-3-5-18(14-17)8-11-28-12-9-19(10-13-28)16-25-24(29)23-21-15-20(30-2)6-7-22(21)26-27-23/h6-7,15,17-19H,3-5,8-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 310n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186193
PNG
(US9163013, 10)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4nc(co4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C20H23N5O5/c1-29-13-2-3-15-14(8-13)18(24-23-15)19(26)21-9-12-4-6-25(7-5-12)10-17-22-16(11-30-17)20(27)28/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,21,26)(H,23,24)(H,27,28)
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n/an/a 310n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186186
PNG
(US9163013, 3)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(Cl)cc4Cl)CC3)c2c1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-30-17-4-5-20-18(11-17)21(27-26-20)22(29)25-12-14-6-8-28(9-7-14)13-15-2-3-16(23)10-19(15)24/h2-5,10-11,14H,6-9,12-13H2,1H3,(H,25,29)(H,26,27)
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n/an/a 310n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186213
PNG
(US9163013, 30)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4noc(n4)C(N)=O)CC3)c2c1
Show InChI InChI=1S/C19H23N7O4/c1-29-12-2-3-14-13(8-12)16(24-23-14)18(28)21-9-11-4-6-26(7-5-11)10-15-22-19(17(20)27)30-25-15/h2-3,8,11H,4-7,9-10H2,1H3,(H2,20,27)(H,21,28)(H,23,24)
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n/an/a 310n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186212
PNG
(US9163013, 29)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(nc4)C([O-])=O)CC3)c2c1
Show InChI InChI=1S/C22H25N5O4/c1-31-16-3-5-18-17(10-16)20(26-25-18)21(28)24-11-14-6-8-27(9-7-14)13-15-2-4-19(22(29)30)23-12-15/h2-5,10,12,14H,6-9,11,13H2,1H3,(H,24,28)(H,25,26)(H,29,30)/p-1
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n/an/a 320n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186206
PNG
(US9163013, 23)
Show SMILES CCOC(=O)c1ccc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)o1
Show InChI InChI=1S/C23H28N4O5/c1-3-31-23(29)20-7-5-17(32-20)14-27-10-8-15(9-11-27)13-24-22(28)21-18-12-16(30-2)4-6-19(18)25-26-21/h4-7,12,15H,3,8-11,13-14H2,1-2H3,(H,24,28)(H,25,26)
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n/an/a 330n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186184
PNG
(US9163013, 1)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-30-19-6-7-21-20(14-19)22(26-25-21)23(29)24-15-17-9-12-27(13-10-17)11-8-16-2-4-18(28)5-3-16/h2-7,14,17,28H,8-13,15H2,1H3,(H,24,29)(H,25,26)
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n/an/a 350n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186188
PNG
(US9163013, 5)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(OCc5ccccc5)cc4)CC3)c2c1
Show InChI InChI=1S/C29H32N4O3/c1-35-25-11-12-27-26(17-25)28(32-31-27)29(34)30-18-21-13-15-33(16-14-21)19-22-7-9-24(10-8-22)36-20-23-5-3-2-4-6-23/h2-12,17,21H,13-16,18-20H2,1H3,(H,30,34)(H,31,32)
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n/an/a 350n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186194
PNG
(US9163013, 11)
Show SMILES COC(=O)c1coc(CN2CCC(CNC(=O)c3n[nH]c4ccc(Br)cc34)CC2)n1
Show InChI InChI=1S/C20H22BrN5O4/c1-29-20(28)16-11-30-17(23-16)10-26-6-4-12(5-7-26)9-22-19(27)18-14-8-13(21)2-3-15(14)24-25-18/h2-3,8,11-12H,4-7,9-10H2,1H3,(H,22,27)(H,24,25)
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n/an/a 360n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186199
PNG
(US9163013, 16)
Show SMILES COc1ncccc1-c1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C26H27N5O5/c1-35-25-19(3-2-10-27-25)17-4-6-21-20(13-17)23(30-29-21)24(32)28-14-16-8-11-31(12-9-16)15-18-5-7-22(36-18)26(33)34/h2-7,10,13,16H,8-9,11-12,14-15H2,1H3,(H,28,32)(H,29,30)(H,33,34)
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n/an/a 360n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186189
PNG
(US9163013, 6)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C22H26N4O3/c1-29-18-6-7-20-19(12-18)21(25-24-20)22(28)23-13-15-8-10-26(11-9-15)14-16-2-4-17(27)5-3-16/h2-7,12,15,27H,8-11,13-14H2,1H3,(H,23,28)(H,24,25)
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n/an/a 400n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186207
PNG
(US9163013, 24)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(o4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C21H24N4O5/c1-29-14-2-4-17-16(10-14)19(24-23-17)20(26)22-11-13-6-8-25(9-7-13)12-15-3-5-18(30-15)21(27)28/h2-5,10,13H,6-9,11-12H2,1H3,(H,22,26)(H,23,24)(H,27,28)
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n/an/a 400n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186211
PNG
(US9163013, 28)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccnc(c4)C(O)=O)CC3)c2c1
Show InChI InChI=1S/C22H25N5O4/c1-31-16-2-3-18-17(11-16)20(26-25-18)21(28)24-12-14-5-8-27(9-6-14)13-15-4-7-23-19(10-15)22(29)30/h2-4,7,10-11,14H,5-6,8-9,12-13H2,1H3,(H,24,28)(H,25,26)(H,29,30)
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n/an/a 450n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186185
PNG
(US9163013, 2)
Show SMILES COc1ccc(CCN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)cc1
Show InChI InChI=1S/C24H30N4O3/c1-30-19-5-3-17(4-6-19)9-12-28-13-10-18(11-14-28)16-25-24(29)23-21-15-20(31-2)7-8-22(21)26-27-23/h3-8,15,18H,9-14,16H2,1-2H3,(H,25,29)(H,26,27)
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n/an/a 560n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186187
PNG
(US9163013, 4)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(Cc4ccc(cc4)C(F)(F)F)CC3)c2c1
Show InChI InChI=1S/C23H25F3N4O2/c1-32-18-6-7-20-19(12-18)21(29-28-20)22(31)27-13-15-8-10-30(11-9-15)14-16-2-4-17(5-3-16)23(24,25)26/h2-7,12,15H,8-11,13-14H2,1H3,(H,27,31)(H,28,29)
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n/an/a 640n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186196
PNG
(US9163013, 13)
Show SMILES CCOC(=O)c1nc(CN2CCC(CNC(=O)c3n[nH]c4ccc(OC)cc34)CC2)cs1
Show InChI InChI=1S/C22H27N5O4S/c1-3-31-22(29)21-24-15(13-32-21)12-27-8-6-14(7-9-27)11-23-20(28)19-17-10-16(30-2)4-5-18(17)25-26-19/h4-5,10,13-14H,3,6-9,11-12H2,1-2H3,(H,23,28)(H,25,26)
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n/an/a 950n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186208
PNG
(US9163013, 25)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCN4C[C@H](C)O[C@H](C)C4)CC3)c2c1
Show InChI InChI=1S/C23H35N5O3/c1-16-14-28(15-17(2)31-16)11-10-27-8-6-18(7-9-27)13-24-23(29)22-20-12-19(30-3)4-5-21(20)25-26-22/h4-5,12,16-18H,6-11,13-15H2,1-3H3,(H,24,29)(H,25,26)/t16-,17+
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n/an/a 1.40E+3n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PCTAIRE-1


(Homo sapiens (Human))
BDBM186184
PNG
(US9163013, 1)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-30-19-6-7-21-20(14-19)22(26-25-21)23(29)24-15-17-9-12-27(13-10-17)11-8-16-2-4-18(28)5-3-16/h2-7,14,17,28H,8-13,15H2,1H3,(H,24,29)(H,25,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Compound 1 was also assayed to determine the IC50 values for three different kinases (PCTAIRE1, DYRK1a, and CDK2) in comparison to Gsk3beta. The ass...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186209
PNG
(US9163013, 26)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCCN4C[C@H](C)O[C@H](C)C4)CC3)c2c1
Show InChI InChI=1S/C24H37N5O3/c1-17-15-29(16-18(2)32-17)10-4-9-28-11-7-19(8-12-28)14-25-24(30)23-21-13-20(31-3)5-6-22(21)26-27-23/h5-6,13,17-19H,4,7-12,14-16H2,1-3H3,(H,25,30)(H,26,27)/t17-,18+
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n/an/a 2.10E+3n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (human))
BDBM186184
PNG
(US9163013, 1)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-30-19-6-7-21-20(14-19)22(26-25-21)23(29)24-15-17-9-12-27(13-10-17)11-8-16-2-4-18(28)5-3-16/h2-7,14,17,28H,8-13,15H2,1H3,(H,24,29)(H,25,26)
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n/an/a 2.90E+3n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Compound 1 was also assayed to determine the IC50 values for three different kinases (PCTAIRE1, DYRK1a, and CDK2) in comparison to Gsk3beta. The ass...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM186214
PNG
(US9163013, 31)
Show SMILES [O-][N+](=O)c1cccc(CN2CCC(CNC(=O)c3n[nH]c4ccccc34)CC2)c1
Show InChI InChI=1S/C21H23N5O3/c27-21(20-18-6-1-2-7-19(18)23-24-20)22-13-15-8-10-25(11-9-15)14-16-4-3-5-17(12-16)26(28)29/h1-7,12,15H,8-11,13-14H2,(H,22,27)(H,23,24)
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n/an/a 7.20E+3n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Activity on human GSK-3beta was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screenin...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (human))
BDBM186184
PNG
(US9163013, 1)
Show SMILES COc1ccc2[nH]nc(C(=O)NCC3CCN(CCc4ccc(O)cc4)CC3)c2c1
Show InChI InChI=1S/C23H28N4O3/c1-30-19-6-7-21-20(14-19)22(26-25-21)23(29)24-15-17-9-12-27(13-10-17)11-8-16-2-4-18(28)5-3-16/h2-7,14,17,28H,8-13,15H2,1H3,(H,24,29)(H,25,26)
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n/an/a 3.60E+4n/an/an/an/an/an/a



AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.

US Patent


Assay Description
Compound 1 was also assayed to determine the IC50 values for three different kinases (PCTAIRE1, DYRK1a, and CDK2) in comparison to Gsk3beta. The ass...


US Patent US9163013 (2015)


BindingDB Entry DOI: 10.7270/Q2PN94DT
More data for this
Ligand-Target Pair