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Compile Data Set for Download or QSAR

Found 300 hits from AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycine transporter 1


(Homo sapiens (Human))
BDBM133255
PNG
(US8846741, 1 | US8846741, 2)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1ccc2CCC(C(Cc3ccccc3)c2c1)N1CC2CC2C1
Show InChI InChI=1S/C27H32N4O2S/c1-30-17-27(28-18-30)34(32,33)29-14-20-7-8-21-9-10-26(31-15-22-13-23(22)16-31)25(24(21)12-20)11-19-5-3-2-4-6-19/h2-8,12,17-18,22-23,25-26,29H,9-11,13-16H2,1H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand Binding Assays Using Recombinant CHO Cell Membranes Expressing Human GlyT1:Radioligand binding to human GlyT1c transporter-expressing mem...


US Patent US8846741 (2014)


BindingDB Entry DOI: 10.7270/Q23T9FW8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM133255
PNG
(US8846741, 1 | US8846741, 2)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1ccc2CCC(C(Cc3ccccc3)c2c1)N1CC2CC2C1
Show InChI InChI=1S/C27H32N4O2S/c1-30-17-27(28-18-30)34(32,33)29-14-20-7-8-21-9-10-26(31-15-22-13-23(22)16-31)25(24(21)12-20)11-19-5-3-2-4-6-19/h2-8,12,17-18,22-23,25-26,29H,9-11,13-16H2,1H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand Binding Assays Using Recombinant CHO Cell Membranes Expressing Human GlyT1:Radioligand binding to human GlyT1c transporter-expressing mem...


US Patent US8846741 (2014)


BindingDB Entry DOI: 10.7270/Q23T9FW8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM133257
PNG
(US8846741, 3)
Show SMILES Cn1cc(cn1)S(=O)(=O)NCCOc1ccc2CCC(C(Cc3ccccc3)c2c1)N1CC2CC2C1
Show InChI InChI=1S/C28H34N4O3S/c1-31-19-25(16-29-31)36(33,34)30-11-12-35-24-9-7-21-8-10-28(32-17-22-14-23(22)18-32)27(26(21)15-24)13-20-5-3-2-4-6-20/h2-7,9,15-16,19,22-23,27-28,30H,8,10-14,17-18H2,1H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand Binding Assays Using Recombinant CHO Cell Membranes Expressing Human GlyT1:Radioligand binding to human GlyT1c transporter-expressing mem...


US Patent US8846741 (2014)


BindingDB Entry DOI: 10.7270/Q23T9FW8
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199970
PNG
(US9227930, 210)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1cc2C(Cc3ccccc3)C(N)Cc2cc1F
Show InChI InChI=1S/C21H23FN4O2S/c1-26-12-21(24-13-26)29(27,28)25-11-16-8-17-15(9-19(16)22)10-20(23)18(17)7-14-5-3-2-4-6-14/h2-6,8-9,12-13,18,20,25H,7,10-11,23H2,1H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199955
PNG
(US9227930, 202)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCCOc1ccc2CC(C(Cc3ccccc3)c2c1)N1CCC1
Show InChI InChI=1S/C25H30N4O3S/c1-28-17-25(26-18-28)33(30,31)27-10-13-32-21-9-8-20-15-24(29-11-5-12-29)23(22(20)16-21)14-19-6-3-2-4-7-19/h2-4,6-9,16-18,23-24,27H,5,10-15H2,1H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199969
PNG
(BDBM199971 | US9227930, 209a)
Show SMILES CNC1Cc2cc(F)c(CNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Show InChI InChI=1S/C22H25FN4O2S/c1-24-21-11-16-10-20(23)17(12-26-30(28,29)22-13-27(2)14-25-22)9-18(16)19(21)8-15-6-4-3-5-7-15/h3-7,9-10,13-14,19,21,24,26H,8,11-12H2,1-2H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199969
PNG
(BDBM199971 | US9227930, 209a)
Show SMILES CNC1Cc2cc(F)c(CNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Show InChI InChI=1S/C22H25FN4O2S/c1-24-21-11-16-10-20(23)17(12-26-30(28,29)22-13-27(2)14-25-22)9-18(16)19(21)8-15-6-4-3-5-7-15/h3-7,9-10,13-14,19,21,24,26H,8,11-12H2,1-2H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199952
PNG
(US9227930, 199)
Show SMILES CNC1Cc2ccc(OCCNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Show InChI InChI=1S/C23H28N4O3S/c1-24-22-13-18-8-9-19(14-20(18)21(22)12-17-6-4-3-5-7-17)30-11-10-26-31(28,29)23-15-27(2)16-25-23/h3-9,14-16,21-22,24,26H,10-13H2,1-2H3
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<10n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141253
PNG
(US8653100, 147)
Show SMILES Nc1ccc(cc1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClN3O3S/c28-21-5-3-20(4-6-21)27(13-1-14-27)26-25-18-23(9-2-19(25)12-15-30-26)34-17-16-31-35(32,33)24-10-7-22(29)8-11-24/h2-11,18,26,30-31H,1,12-17,29H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141254
PNG
(US8653100, 148 | US8653100, 151 | US8653100, 159 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCNC3)cc12
Show InChI InChI=1S/C25H32ClN3O3S/c26-20-5-3-19(4-6-20)25(10-1-11-25)24-23-16-21(7-2-18(23)8-13-28-24)32-15-14-29-33(30,31)22-9-12-27-17-22/h2-7,16,22,24,27-29H,1,8-15,17H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141255
PNG
(US8653100, 149)
Show SMILES CN(C)CCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H34ClN3O3S/c1-29(2)15-17-33(30,31)28-14-16-32-22-9-4-19-10-13-27-24(23(19)18-22)25(11-3-12-25)20-5-7-21(26)8-6-20/h4-9,18,24,27-28H,3,10-17H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141256
PNG
(US8653100, 150)
Show SMILES Nc1ncc(cn1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H28ClN5O3S/c26-19-5-3-18(4-6-19)25(9-1-10-25)23-22-14-20(7-2-17(22)8-11-28-23)34-13-12-31-35(32,33)21-15-29-24(27)30-16-21/h2-7,14-16,23,28,31H,1,8-13H2,(H2,27,29,30)
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141254
PNG
(US8653100, 148 | US8653100, 151 | US8653100, 159 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCNC3)cc12
Show InChI InChI=1S/C25H32ClN3O3S/c26-20-5-3-19(4-6-20)25(10-1-11-25)24-23-16-21(7-2-18(23)8-13-28-24)32-15-14-29-33(30,31)22-9-12-27-17-22/h2-7,16,22,24,27-29H,1,8-15,17H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141259
PNG
(US8653100, 153)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)c3cn[nH]c3)cc12
Show InChI InChI=1S/C24H27ClN4O3S/c25-19-5-3-18(4-6-19)24(9-1-10-24)23-22-14-20(7-2-17(22)8-11-26-23)32-13-12-29-33(30,31)21-15-27-28-16-21/h2-7,14-16,23,26,29H,1,8-13H2,(H,27,28)
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141261
PNG
(US8653100, 155)
Show SMILES CC(C)(C)CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H35ClN2O3S/c1-25(2,3)18-33(30,31)29-15-16-32-22-10-5-19-11-14-28-24(23(19)17-22)26(12-4-13-26)20-6-8-21(27)9-7-20/h5-10,17,24,28-29H,4,11-16,18H2,1-3H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141262
PNG
(US8653100, 156)
Show SMILES COc1ccc(cn1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClN3O4S/c1-34-25-10-9-23(18-30-25)36(32,33)31-15-16-35-22-8-3-19-11-14-29-26(24(19)17-22)27(12-2-13-27)20-4-6-21(28)7-5-20/h3-10,17-18,26,29,31H,2,11-16H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141263
PNG
(US8653100, 157)
Show SMILES Nc1cccc(c1)S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClN3O3S/c28-21-8-6-20(7-9-21)27(12-2-13-27)26-25-18-23(10-5-19(25)11-14-30-26)34-16-15-31-35(32,33)24-4-1-3-22(29)17-24/h1,3-10,17-18,26,30-31H,2,11-16,29H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141252
PNG
(US8653100, 146 | US8653100, 152 | US8653100, 154 |...)
Show SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H30ClN3O3S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-12-26-22)30-14-13-27-31(28,29)15-11-25/h2-7,16,22,26-27H,1,8-15,25H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141254
PNG
(US8653100, 148 | US8653100, 151 | US8653100, 159 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCNC3)cc12
Show InChI InChI=1S/C25H32ClN3O3S/c26-20-5-3-19(4-6-20)25(10-1-11-25)24-23-16-21(7-2-18(23)8-13-28-24)32-15-14-29-33(30,31)22-9-12-27-17-22/h2-7,16,22,24,27-29H,1,8-15,17H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141126
PNG
(US8653100, 160 | US8653100, 164 | US8653100, 192 |...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CCCNC3)cc12
Show InChI InChI=1S/C26H34ClN3O3S/c27-21-7-5-20(6-8-21)26(11-2-12-26)25-24-17-22(9-4-19(24)10-14-29-25)33-16-15-30-34(31,32)23-3-1-13-28-18-23/h4-9,17,23,25,28-30H,1-3,10-16,18H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199950
PNG
(US9227930, 197)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCCOc1ccc2CC(N)C(Cc3ccccc3)c2c1
Show InChI InChI=1S/C22H26N4O3S/c1-26-14-22(24-15-26)30(27,28)25-9-10-29-18-8-7-17-12-21(23)20(19(17)13-18)11-16-5-3-2-4-6-16/h2-8,13-15,20-21,25H,9-12,23H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199953
PNG
(US9227930, 200)
Show SMILES CNC1Cc2cc(F)c(OCCNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Show InChI InChI=1S/C23H27FN4O3S/c1-25-21-12-17-11-20(24)22(13-18(17)19(21)10-16-6-4-3-5-7-16)31-9-8-27-32(29,30)23-14-28(2)15-26-23/h3-7,11,13-15,19,21,25,27H,8-10,12H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199954
PNG
(US9227930, 201)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCCOc1cc2C(Cc3ccccc3)C(Cc2cc1F)N1CCC1
Show InChI InChI=1S/C25H29FN4O3S/c1-29-16-25(27-17-29)34(31,32)28-8-11-33-24-15-20-19(13-22(24)26)14-23(30-9-5-10-30)21(20)12-18-6-3-2-4-7-18/h2-4,6-7,13,15-17,21,23,28H,5,8-12,14H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199956
PNG
(US9227930, 203)
Show SMILES CC1CN(C1)C1Cc2cc(F)c(OCCNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Show InChI InChI=1S/C26H31FN4O3S/c1-18-14-31(15-18)24-12-20-11-23(27)25(13-21(20)22(24)10-19-6-4-3-5-7-19)34-9-8-29-35(32,33)26-16-30(2)17-28-26/h3-7,11,13,16-18,22,24,29H,8-10,12,14-15H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199957
PNG
(US9227930, 204)
Show SMILES CC1CN(C1)C1Cc2ccc(OCCNS(=O)(=O)c3cn(C)cn3)cc2C1Cc1ccccc1
Show InChI InChI=1S/C26H32N4O3S/c1-19-15-30(16-19)25-13-21-8-9-22(14-23(21)24(25)12-20-6-4-3-5-7-20)33-11-10-28-34(31,32)26-17-29(2)18-27-26/h3-9,14,17-19,24-25,28H,10-13,15-16H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199958
PNG
(US9227930, 205)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCCOc1ccc2CC(C(Cc3ccccc3)c2c1)N1CC(C)(C)C1
Show InChI InChI=1S/C27H34N4O3S/c1-27(2)17-31(18-27)25-14-21-9-10-22(15-23(21)24(25)13-20-7-5-4-6-8-20)34-12-11-29-35(32,33)26-16-30(3)19-28-26/h4-10,15-16,19,24-25,29H,11-14,17-18H2,1-3H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine Transporter 1 (GlyT1)


(Homo sapiens (Human))
BDBM199962
PNG
(US9227930, 206)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCCOc1cc2C(Cc3ccccc3)C(Cc2cc1F)N1CC(C)(O)C1
Show InChI InChI=1S/C26H31FN4O4S/c1-26(32)15-31(16-26)23-12-19-11-22(27)24(13-20(19)21(23)10-18-6-4-3-5-7-18)35-9-8-29-36(33,34)25-14-30(2)17-28-25/h3-7,11,13-14,17,21,23,29,32H,8-10,12,15-16H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was determined as described in Mezler et al., Molecular Pharmacology 74:1705-171...


US Patent US9227930 (2016)


BindingDB Entry DOI: 10.7270/Q2DZ0737
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM133262
PNG
(US8846741, 9)
Show SMILES O=S(=O)(CC1CC1)NCc1ccc2CCC(NC3(COC3)C#N)C(Cc3ccccc3)c2c1
Show InChI InChI=1S/C26H31N3O3S/c27-16-26(17-32-18-26)29-25-11-10-22-9-8-21(14-28-33(30,31)15-20-6-7-20)13-23(22)24(25)12-19-4-2-1-3-5-19/h1-5,8-9,13,20,24-25,28-29H,6-7,10-12,14-15,17-18H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand Binding Assays Using Recombinant CHO Cell Membranes Expressing Human GlyT1:Radioligand binding to human GlyT1c transporter-expressing mem...


US Patent US8846741 (2014)


BindingDB Entry DOI: 10.7270/Q23T9FW8
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141042
PNG
(US8653100, 2)
Show SMILES CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H27ClN2O3S/c1-29(26,27)25-13-14-28-19-8-3-16-9-12-24-21(20(16)15-19)22(10-2-11-22)17-4-6-18(23)7-5-17/h3-8,15,21,24-25H,2,9-14H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141044
PNG
(US8653100, 4)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H31ClN2O3S/c1-2-16-31(28,29)27-14-15-30-21-9-4-18-10-13-26-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h4-9,17,23,26-27H,2-3,10-16H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141047
PNG
(US8653100, 7)
Show SMILES CCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O3S/c1-2-30(27,28)26-14-15-29-20-9-4-17-10-13-25-22(21(17)16-20)23(11-3-12-23)18-5-7-19(24)8-6-18/h4-9,16,22,25-26H,2-3,10-15H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141048
PNG
(US8653100, 8)
Show SMILES CC(C)CS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H33ClN2O3S/c1-18(2)17-32(29,30)28-14-15-31-22-9-4-19-10-13-27-24(23(19)16-22)25(11-3-12-25)20-5-7-21(26)8-6-20/h4-9,16,18,24,27-28H,3,10-15,17H2,1-2H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141049
PNG
(US8653100, 10 | US8653100, 141 | US8653100, 182 | ...)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)c3cccnc3)cc12
Show InChI InChI=1S/C26H28ClN3O3S/c27-21-7-5-20(6-8-21)26(11-2-12-26)25-24-17-22(9-4-19(24)10-14-29-25)33-16-15-30-34(31,32)23-3-1-13-28-18-23/h1,3-9,13,17-18,25,29-30H,2,10-12,14-16H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141060
PNG
(US8653100, 14)
Show SMILES Fc1cc2CCNC(c2cc1OCCNS(=O)(=O)c1cccnc1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClFN3O3S/c27-20-6-4-19(5-7-20)26(9-2-10-26)25-22-16-24(23(28)15-18(22)8-12-30-25)34-14-13-31-35(32,33)21-3-1-11-29-17-21/h1,3-7,11,15-17,25,30-31H,2,8-10,12-14H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141061
PNG
(US8653100, 15)
Show SMILES CCCS(=O)(=O)NCCOc1cc2C(NCCc2cc1F)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H30ClFN2O3S/c1-2-14-32(29,30)28-12-13-31-22-16-20-17(15-21(22)26)8-11-27-23(20)24(9-3-10-24)18-4-6-19(25)7-5-18/h4-7,15-16,23,27-28H,2-3,8-14H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141062
PNG
(US8653100, 16)
Show SMILES CCCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H33ClN2O3S/c1-2-3-17-32(29,30)28-15-16-31-22-10-5-19-11-14-27-24(23(19)18-22)25(12-4-13-25)20-6-8-21(26)9-7-20/h5-10,18,24,27-28H,2-4,11-17H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141072
PNG
(US8653100, 28)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(OCCNS(=O)(=O)C3CC3)cc12
Show InChI InChI=1S/C24H29ClN2O3S/c25-19-5-3-18(4-6-19)24(11-1-12-24)23-22-16-20(7-2-17(22)10-13-26-23)30-15-14-27-31(28,29)21-8-9-21/h2-7,16,21,23,26-27H,1,8-15H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141134
PNG
(US8653100, 65)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(F)cc1
Show InChI InChI=1S/C24H31FN2O3S/c1-2-16-31(28,29)27-14-15-30-21-9-4-18-10-13-26-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h4-9,17,23,26-27H,2-3,10-16H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141177
PNG
(US8653100, 88)
Show SMILES C\C=C\S(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H29ClN2O3S/c1-2-16-31(28,29)27-14-15-30-21-9-4-18-10-13-26-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h2,4-9,16-17,23,26-27H,3,10-15H2,1H3/b16-2+
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141178
PNG
(US8653100, 89)
Show SMILES CCCS(=O)(=O)NCCNc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H32ClN3O2S/c1-2-16-31(29,30)28-15-14-26-21-9-4-18-10-13-27-23(22(18)17-21)24(11-3-12-24)19-5-7-20(25)8-6-19/h4-9,17,23,26-28H,2-3,10-16H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141179
PNG
(US8653100, 90)
Show SMILES CCCS(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O2S/c1-2-14-29(27,28)26-16-17-4-5-18-10-13-25-22(21(18)15-17)23(11-3-12-23)19-6-8-20(24)9-7-19/h4-9,15,22,25-26H,2-3,10-14,16H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141180
PNG
(US8653100, 91)
Show SMILES Cn1cc(cn1)S(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O2S/c1-29-16-21(15-27-29)32(30,31)28-14-17-3-4-18-9-12-26-23(22(18)13-17)24(10-2-11-24)19-5-7-20(25)8-6-19/h3-8,13,15-16,23,26,28H,2,9-12,14H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141181
PNG
(US8653100, 92)
Show SMILES Clc1ccc(cc1)C1(CCC1)C1NCCc2ccc(cc12)C#N
Show InChI InChI=1S/C20H19ClN2/c21-17-6-4-16(5-7-17)20(9-1-10-20)19-18-12-14(13-22)2-3-15(18)8-11-23-19/h2-7,12,19,23H,1,8-11H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141182
PNG
(US8653100, 93)
Show SMILES Cn1cnc(c1)S(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H27ClN4O2S/c1-29-15-22(27-16-29)32(30,31)28-14-17-3-4-18-9-12-26-23(21(18)13-17)24(10-2-11-24)19-5-7-20(25)8-6-19/h3-8,13,15-16,23,26,28H,2,9-12,14H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141183
PNG
(US8653100, 94)
Show SMILES FCCCS(=O)(=O)NCc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H28ClFN2O2S/c24-20-7-5-19(6-8-20)23(10-1-11-23)22-21-15-17(3-4-18(21)9-13-26-22)16-27-30(28,29)14-2-12-25/h3-8,15,22,26-27H,1-2,9-14,16H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141184
PNG
(US8653100, 95)
Show SMILES CCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1cccc(F)c1
Show InChI InChI=1S/C24H31FN2O3S/c1-2-15-31(28,29)27-13-14-30-21-8-7-18-9-12-26-23(22(18)17-21)24(10-4-11-24)19-5-3-6-20(25)16-19/h3,5-8,16-17,23,26-27H,2,4,9-15H2,1H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141185
PNG
(US8653100, 96)
Show SMILES CCCS(=O)(=O)NCc1ccc2CCNC(c2c1)C(C)(C)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H29ClN2O2S/c1-4-13-28(26,27)25-15-16-5-6-17-11-12-24-21(20(17)14-16)22(2,3)18-7-9-19(23)10-8-18/h5-10,14,21,24-25H,4,11-13,15H2,1-3H3
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
Glycine transporter 1


(Homo sapiens (Human))
BDBM141186
PNG
(US8653100, 97)
Show SMILES OCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H29ClN2O4S/c24-19-5-3-18(4-6-19)23(9-1-10-23)22-21-16-20(7-2-17(21)8-11-25-22)30-14-12-26-31(28,29)15-13-27/h2-7,16,22,25-27H,1,8-15H2
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<100n/an/an/an/an/an/an/an/a



AbbVie Inc.; AbbVie Deutschland GmbH & Co. KG

US Patent


Assay Description
Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...


US Patent US8653100 (2014)


BindingDB Entry DOI: 10.7270/Q2JD4VH9
More data for this
Ligand-Target Pair
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