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Found 22 hits from Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50207140
PNG
(CHEMBL131352)
Show SMILES CCC(CC)(CCC#N)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClN7O/c1-3-23(4-2,12-6-13-25)21(30-20(32)17-8-10-18(24)11-9-17)31-22(28-16-26)29-19-7-5-14-27-15-19/h5,7-11,14-15,21H,3-4,6,12H2,1-2H3,(H,30,32)(H2,28,29,31)
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n/an/an/an/a 5.01E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50211663
PNG
(CHEMBL128831)
Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C17H15BrCl2N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50207690
PNG
(CHEMBL239512)
Show SMILES CC(Cl)(Cl)[C@H](N\C(Nc1cccnc1)=N\C#N)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)/t15-/m0/s1
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n/an/an/an/a 316n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208312
PNG
(CHEMBL421903)
Show SMILES Clc1ccc(cc1)C(=O)NC(NC(=S)Nc1cccnc1)C(Cl)(Cl)Cl
Show InChI InChI=1S/C15H12Cl4N4OS/c16-10-5-3-9(4-6-10)12(24)22-13(15(17,18)19)23-14(25)21-11-2-1-7-20-8-11/h1-8,13H,(H,22,24)(H2,21,23,25)
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n/an/an/an/a 794n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208313
PNG
(CHEMBL131347)
Show SMILES CC(C)(C)C(N\C(S)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H21ClN4OS/c1-18(2,3)16(22-15(24)12-6-8-13(19)9-7-12)23-17(25)21-14-5-4-10-20-11-14/h4-11,16H,1-3H3,(H,22,24)(H2,21,23,25)
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n/an/an/an/a 2.51E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208316
PNG
(CHEMBL1788243)
Show SMILES CC(Cl)(Cl)[C@@H](N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)/t15-/m1/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208348
PNG
(CHEMBL339992)
Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C17H14Cl2F2N6O/c1-17(18,19)15(26-14(28)10-5-11(20)7-12(21)6-10)27-16(24-9-22)25-13-3-2-4-23-8-13/h2-8,15H,1H3,(H,26,28)(H2,24,25,27)
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n/an/an/an/a 3.98E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208349
PNG
(CHEMBL128096)
Show SMILES Clc1ccc(cc1)C(=O)NC(\N=C(/NC#N)Nc1cccnc1)C(Cl)(Cl)Cl
Show InChI InChI=1S/C16H12Cl4N6O/c17-11-5-3-10(4-6-11)13(27)25-14(16(18,19)20)26-15(23-9-21)24-12-2-1-7-22-8-12/h1-8,14H,(H,25,27)(H2,23,24,26)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208350
PNG
(CHEMBL128062)
Show SMILES Cc1cccc(c1)C(=O)NC(\N=C(/NC#N)Nc1cccnc1)C(C)(Cl)Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-12-5-3-6-13(9-12)15(27)25-16(18(2,19)20)26-17(23-11-21)24-14-7-4-8-22-10-14/h3-10,16H,1-2H3,(H,25,27)(H2,23,24,26)
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n/an/an/an/a 5.01E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208351
PNG
(CHEMBL128767)
Show SMILES CCCCC(C)(C)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H27ClN6O/c1-4-5-12-22(2,3)20(28-19(30)16-8-10-17(23)11-9-16)29-21(26-15-24)27-18-7-6-13-25-14-18/h6-11,13-14,20H,4-5,12H2,1-3H3,(H,28,30)(H2,26,27,29)
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n/an/an/an/a<1.00E+5n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208352
PNG
(CHEMBL129080)
Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-2-5-12(18)8-11)26-16(23-10-21)24-13-6-3-7-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50208424
PNG
(CHEMBL127164)
Show SMILES CC(C)(C)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN6O/c1-19(2,3)17(25-16(27)13-6-8-14(20)9-7-13)26-18(23-12-21)24-15-5-4-10-22-11-15/h4-11,17H,1-3H3,(H,25,27)(H2,23,24,26)
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n/an/an/an/a 6.31E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM86249
PNG
(ZD 6169 | ZD-6169)
Show SMILES C[C@](O)(C(=O)Nc1ccc(cc1)C(=O)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C17H14F3NO3/c1-16(24,17(18,19)20)15(23)21-13-9-7-12(8-10-13)14(22)11-5-3-2-4-6-11/h2-10,24H,1H3,(H,21,23)/t16-/m0/s1
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n/an/an/an/a 398n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50209291
PNG
(CHEMBL131453)
Show SMILES CC(C)(C)C(N\C(N[N+]([O-])=O)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H21ClN6O3/c1-18(2,3)16(22-15(26)12-6-8-13(19)9-7-12)23-17(24-25(27)28)21-14-5-4-10-20-11-14/h4-11,16H,1-3H3,(H,22,26)(H2,21,23,24)
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n/an/an/an/a 3.16E+4n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50209793
PNG
(CHEMBL335172)
Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15Cl3N6O/c1-17(19,20)15(25-14(27)11-4-6-12(18)7-5-11)26-16(23-10-21)24-13-3-2-8-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)
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n/an/an/an/a 2.00E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50210059
PNG
(CHEMBL127612)
Show SMILES CC(C)(C)C(N\C(Nc1cccnc1)=C\[N+]([O-])=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H22ClN5O3/c1-19(2,3)18(24-17(26)13-6-8-14(20)9-7-13)23-16(12-25(27)28)22-15-5-4-10-21-11-15/h4-12,18,22-23H,1-3H3,(H,24,26)/b16-12+
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n/an/an/an/a<1.00E+5n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50210168
PNG
(CHEMBL130622)
Show SMILES CN(C)S(=O)(=O)N\C(Nc1cccnc1)=N/C(NC(=O)c1ccc(Cl)cc1)C(C)(C)C
Show InChI InChI=1S/C20H27ClN6O3S/c1-20(2,3)18(24-17(28)14-8-10-15(21)11-9-14)25-19(26-31(29,30)27(4)5)23-16-7-6-12-22-13-16/h6-13,18H,1-5H3,(H,24,28)(H2,23,25,26)
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n/an/an/an/a<1.00E+5n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50210172
PNG
(CHEMBL340330)
Show SMILES CC(Cl)(Cl)C(N\C(NC#N)=N\c1cccnc1)NC(=O)c1cccc(F)c1
Show InChI InChI=1S/C17H15Cl2FN6O/c1-17(18,19)15(25-14(27)11-4-2-5-12(20)8-11)26-16(23-10-21)24-13-6-3-7-22-9-13/h2-9,15H,1H3,(H,25,27)(H2,23,24,26)
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PubMed
n/an/an/an/a 3.98E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50210355
PNG
(CHEMBL132277)
Show SMILES CC(C)(CC=C)C(NC(=O)c1ccc(Cl)cc1)N\C(NC#N)=N\c1cccnc1
Show InChI InChI=1S/C21H23ClN6O/c1-4-11-21(2,3)19(27-18(29)15-7-9-16(22)10-8-15)28-20(25-14-23)26-17-6-5-12-24-13-17/h4-10,12-13,19H,1,11H2,2-3H3,(H,27,29)(H2,25,26,28)
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PubMed
n/an/an/an/a 2.00E+4n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50211661
PNG
(CHEMBL128862)
Show SMILES Cc1ccc(cc1)C(=O)NC(\N=C(/NC#N)Nc1cccnc1)C(C)(Cl)Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-12-5-7-13(8-6-12)15(27)25-16(18(2,19)20)26-17(23-11-21)24-14-4-3-9-22-10-14/h3-10,16H,1-2H3,(H,25,27)(H2,23,24,26)
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PubMed
n/an/an/an/a 2.51E+3n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50211662
PNG
(CHEMBL131993)
Show SMILES CC(C)(C)C(N\C(NS(N)(=O)=O)=N\c1cccnc1)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H23ClN6O3S/c1-18(2,3)16(23-15(26)12-6-8-13(19)9-7-12)24-17(25-29(20,27)28)22-14-5-4-10-21-11-14/h4-11,16H,1-3H3,(H,23,26)(H2,20,27,28)(H2,22,24,25)
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PubMed
n/an/an/an/a<1.00E+5n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2


(Homo sapiens-HUMAN)
BDBM50207429
PNG
(CHEMBL130849)
Show SMILES CC(C)(CC(NC(=O)c1ccc(Cl)cc1)N\C(NC#N)=N\c1cccnc1)C=C
Show InChI InChI=1S/C21H23ClN6O/c1-4-21(2,3)12-18(27-19(29)15-7-9-16(22)10-8-15)28-20(25-14-23)26-17-6-5-11-24-13-17/h4-11,13,18H,1,12H2,2-3H3,(H,27,29)(H2,25,26,28)
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PubMed
n/an/an/an/a 1.00E+4n/an/an/an/a



Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. arturo.perezmedrano@abbott.com

Curated by ChEMBL


Assay Description
In vitro ATP-sensitive potassium channel (KATP) activity in cells expressing human KATP channels Kir6.2 and sulfonylurea receptor 2B


Bioorg Med Chem Lett 14: 397-400 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.063
More data for this
Ligand-Target Pair