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Compile Data Set for Download or QSAR

Found 129 hits from Advinus Therapeutics Ltd.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231595
PNG
(CHEMBL4092832)
Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(O)c1
Show InChI InChI=1S/C19H22N4O2/c1-2-10-23-18(13-8-5-9-14(24)11-13)22-17-15(19(23)25)20-16(21-17)12-6-3-4-7-12/h5,8-9,11-12,24H,2-4,6-7,10H2,1H3,(H,20,21)
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0.200n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231590
PNG
(CHEMBL4063997)
Show SMILES CCCn1c(Oc2cccnc2C)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C19H23N5O2/c1-3-11-24-18(25)15-17(22-16(21-15)13-7-4-5-8-13)23-19(24)26-14-9-6-10-20-12(14)2/h6,9-10,13H,3-5,7-8,11H2,1-2H3,(H,21,22)
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0.280n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232062
PNG
(CHEMBL4068507)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C27H31F3N8O3/c1-3-9-37-24-22(25(40)38(10-4-2)26(37)41)32-23(33-24)18-15-31-36(16-18)17-21(39)35-13-11-34(12-14-35)20-7-5-19(6-8-20)27(28,29)30/h5-8,15-16H,3-4,9-14,17H2,1-2H3,(H,32,33)
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0.900n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232044
PNG
(CHEMBL4083317)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C26H28F3N7O3/c1-3-9-34-23-21(24(38)35(10-4-2)25(34)39)31-22(32-23)17-12-30-33(15-17)13-16-11-20(37)36(14-16)19-7-5-18(6-8-19)26(27,28)29/h5-8,12,15-16H,3-4,9-11,13-14H2,1-2H3,(H,31,32)
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0.900n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 m...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232060
PNG
(CHEMBL4095766)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H30F3N5O4/c1-3-13-35-26-24(27(39)36(14-4-2)28(35)40)33-25(34-26)19-5-11-22(12-6-19)41-17-18-15-23(38)37(16-18)21-9-7-20(8-10-21)29(30,31)32/h5-12,18H,3-4,13-17H2,1-2H3,(H,33,34)
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1n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232044
PNG
(CHEMBL4083317)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C26H28F3N7O3/c1-3-9-34-23-21(24(38)35(10-4-2)25(34)39)31-22(32-23)17-12-30-33(15-17)13-16-11-20(37)36(14-16)19-7-5-18(6-8-19)26(27,28)29/h5-8,12,15-16H,3-4,9-11,13-14H2,1-2H3,(H,31,32)
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1n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231595
PNG
(CHEMBL4092832)
Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(O)c1
Show InChI InChI=1S/C19H22N4O2/c1-2-10-23-18(13-8-5-9-14(24)11-13)22-17-15(19(23)25)20-16(21-17)12-6-3-4-7-12/h5,8-9,11-12,24H,2-4,6-7,10H2,1H3,(H,20,21)
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1n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232058
PNG
(CHEMBL4092455)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(O)C2CN(C(=O)C2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H30F3N7O4/c1-3-8-35-24-22(25(40)36(9-4-2)26(35)41)32-23(33-24)17-12-31-34(13-17)15-20(38)16-10-21(39)37(14-16)19-7-5-6-18(11-19)27(28,29)30/h5-7,11-13,16,20,38H,3-4,8-10,14-15H2,1-2H3,(H,32,33)
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1.20n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232049
PNG
(CHEMBL4095843)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H31F3N8O3/c1-3-8-37-24-22(25(40)38(9-4-2)26(37)41)32-23(33-24)18-15-31-36(16-18)17-21(39)35-12-10-34(11-13-35)20-7-5-6-19(14-20)27(28,29)30/h5-7,14-16H,3-4,8-13,17H2,1-2H3,(H,32,33)
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1.5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232078
PNG
(CHEMBL4080171)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C26H30ClFN8O3/c1-3-7-35-24-22(25(38)36(8-4-2)26(35)39)30-23(31-24)17-14-29-34(15-17)16-21(37)33-11-9-32(10-12-33)18-5-6-20(28)19(27)13-18/h5-6,13-15H,3-4,7-12,16H2,1-2H3,(H,30,31)
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1.80n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50086170
PNG
((4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-di...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)Nc2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)
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2n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]ABOPX from human adenosine receptor A2b expressed in HEK293 cell membranes after 3 hrs by fluorescence assay


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231589
PNG
(CHEMBL4073088)
Show SMILES CCCn1c(Oc2cncc(Cl)c2)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C18H20ClN5O2/c1-2-7-24-17(25)14-16(22-15(21-14)11-5-3-4-6-11)23-18(24)26-13-8-12(19)9-20-10-13/h8-11H,2-7H2,1H3,(H,21,22)
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2.20n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231597
PNG
(CHEMBL4102409)
Show SMILES CCCn1c(Oc2cccc(OC)c2)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C20H24N4O3/c1-3-11-24-19(25)16-18(22-17(21-16)13-7-4-5-8-13)23-20(24)27-15-10-6-9-14(12-15)26-2/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22)
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2.30n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232089
PNG
(CHEMBL4100199)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CCC2CN(C(=O)C2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H30F3N7O3/c1-3-9-35-24-22(25(39)36(10-4-2)26(35)40)32-23(33-24)18-14-31-34(16-18)11-8-17-12-21(38)37(15-17)20-7-5-6-19(13-20)27(28,29)30/h5-7,13-14,16-17H,3-4,8-12,15H2,1-2H3,(H,32,33)
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2.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232050
PNG
(CHEMBL4065717)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2ccc(cc2)C(F)(F)F)nc1
Show InChI InChI=1S/C28H29F3N6O4/c1-3-11-35-25-23(26(39)36(12-4-2)27(35)40)33-24(34-25)18-5-10-21(32-14-18)41-16-17-13-22(38)37(15-17)20-8-6-19(7-9-20)28(29,30)31/h5-10,14,17H,3-4,11-13,15-16H2,1-2H3,(H,33,34)
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3n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232086
PNG
(CHEMBL4074412)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CCN(C2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C26H30F3N7O2/c1-3-9-35-23-21(24(37)36(10-4-2)25(35)38)31-22(32-23)18-13-30-34(16-18)15-17-8-11-33(14-17)20-7-5-6-19(12-20)26(27,28)29/h5-7,12-13,16-17H,3-4,8-11,14-15H2,1-2H3,(H,31,32)
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3.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231709
PNG
(CHEMBL4083067)
Show SMILES CCCn1c(Oc2cccnc2Cl)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C18H20ClN5O2/c1-2-10-24-17(25)13-16(22-15(21-13)11-6-3-4-7-11)23-18(24)26-12-8-5-9-20-14(12)19/h5,8-9,11H,2-4,6-7,10H2,1H3,(H,21,22)
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3.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232083
PNG
(CHEMBL4088043)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2ccc(F)cc2)nc1
Show InChI InChI=1S/C27H29FN6O4/c1-3-11-32-25-23(26(36)33(12-4-2)27(32)37)30-24(31-25)18-5-10-21(29-14-18)38-16-17-13-22(35)34(15-17)20-8-6-19(28)7-9-20/h5-10,14,17H,3-4,11-13,15-16H2,1-2H3,(H,30,31)
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4n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232045
PNG
(CHEMBL4065629)
Show SMILES CCCn1c(=O)n(CC)c2nc([nH]c2c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(F)cc2)c1
Show InChI InChI=1S/C24H26FN7O3/c1-3-9-31-23(34)20-22(30(4-2)24(31)35)28-21(27-20)16-11-26-29(14-16)12-15-10-19(33)32(13-15)18-7-5-17(25)6-8-18/h5-8,11,14-15H,3-4,9-10,12-13H2,1-2H3,(H,27,28)
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4n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 m...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232047
PNG
(CHEMBL4074253)
Show SMILES CCCn1c(=O)n(CC)c2nc([nH]c2c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N7O3/c1-3-9-34-23(37)20-22(33(4-2)24(34)38)31-21(30-20)16-11-29-32(14-16)12-15-10-19(36)35(13-15)18-7-5-17(6-8-18)25(26,27)28/h5-8,11,14-15H,3-4,9-10,12-13H2,1-2H3,(H,30,31)
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4n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232065
PNG
(CHEMBL4073346)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(c1)C(C)C1CN(C(=O)C1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N7O3/c1-4-9-34-24-22(25(39)35(10-5-2)26(34)40)32-23(33-24)18-13-31-37(15-18)16(3)17-11-21(38)36(14-17)20-8-6-7-19(12-20)27(28,29)30/h6-8,12-13,15-17H,4-5,9-11,14H2,1-3H3,(H,32,33)
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4n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232070
PNG
(CHEMBL4091110)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C26H28F3N7O4/c1-3-9-34-23-21(24(38)35(10-4-2)25(34)39)31-22(32-23)17-12-30-33(15-17)13-16-11-20(37)36(14-16)18-5-7-19(8-6-18)40-26(27,28)29/h5-8,12,15-16H,3-4,9-11,13-14H2,1-2H3,(H,31,32)
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4n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232049
PNG
(CHEMBL4095843)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H31F3N8O3/c1-3-8-37-24-22(25(40)38(9-4-2)26(37)41)32-23(33-24)18-15-31-36(16-18)17-21(39)35-12-10-34(11-13-35)20-7-5-6-19(14-20)27(28,29)30/h5-7,14-16H,3-4,8-13,17H2,1-2H3,(H,32,33)
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4n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 m...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232059
PNG
(CHEMBL4094755)
Show SMILES CCCn1c(=O)n(CC)c2nc([nH]c2c1=O)-c1cnn(CC2CN(C(=O)C2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N7O3/c1-3-8-34-23(37)20-22(33(4-2)24(34)38)31-21(30-20)16-11-29-32(14-16)12-15-9-19(36)35(13-15)18-7-5-6-17(10-18)25(26,27)28/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,30,31)
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4.5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232073
PNG
(CHEMBL4059759)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2cccc(F)c2)nc1
Show InChI InChI=1S/C27H29FN6O4/c1-3-10-32-25-23(26(36)33(11-4-2)27(32)37)30-24(31-25)18-8-9-21(29-14-18)38-16-17-12-22(35)34(15-17)20-7-5-6-19(28)13-20/h5-9,13-14,17H,3-4,10-12,15-16H2,1-2H3,(H,30,31)
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4.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232067
PNG
(CHEMBL4064755)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2ccc(C)cc2)c1
Show InChI InChI=1S/C27H34N8O3/c1-4-10-34-25-23(26(37)35(11-5-2)27(34)38)29-24(30-25)20-16-28-33(17-20)18-22(36)32-14-12-31(13-15-32)21-8-6-19(3)7-9-21/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,29,30)
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5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232075
PNG
(CHEMBL4069458)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C28H30FN5O4/c1-3-13-32-26-24(27(36)33(14-4-2)28(32)37)30-25(31-26)19-5-11-22(12-6-19)38-17-18-15-23(35)34(16-18)21-9-7-20(29)8-10-21/h5-12,18H,3-4,13-17H2,1-2H3,(H,30,31)
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5.40n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231707
PNG
(CHEMBL4085564)
Show SMILES CCCn1c(Oc2cccc3cc[nH]c23)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C21H23N5O2/c1-2-12-26-20(27)17-19(24-18(23-17)14-6-3-4-7-14)25-21(26)28-15-9-5-8-13-10-11-22-16(13)15/h5,8-11,14,22H,2-4,6-7,12H2,1H3,(H,23,24)
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5.5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50229885
PNG
(CHEMBL260331 | CHEMBL506685 | N-(benzo[d][1,3]diox...)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cc(OCC(=O)Nc2ccc3OCOc3c2)nn1C
Show InChI InChI=1S/C24H27N7O6/c1-4-8-30-22-20(23(33)31(9-5-2)24(30)34)26-21(27-22)15-11-19(28-29(15)3)35-12-18(32)25-14-6-7-16-17(10-14)37-13-36-16/h6-7,10-11H,4-5,8-9,12-13H2,1-3H3,(H,25,32)(H,26,27)
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5.5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine receptor A2b expressed in HEK293 cell membranes


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231707
PNG
(CHEMBL4085564)
Show SMILES CCCn1c(Oc2cccc3cc[nH]c23)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C21H23N5O2/c1-2-12-26-20(27)17-19(24-18(23-17)14-6-3-4-7-14)25-21(26)28-15-9-5-8-13-10-11-22-16(13)15/h5,8-11,14,22H,2-4,6-7,12H2,1H3,(H,23,24)
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5.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231588
PNG
(CHEMBL4084453)
Show SMILES CCCn1c(Oc2cccc(c2)C(F)(F)F)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C20H21F3N4O2/c1-2-10-27-18(28)15-17(25-16(24-15)12-6-3-4-7-12)26-19(27)29-14-9-5-8-13(11-14)20(21,22)23/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,24,25)
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5.90n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232076
PNG
(CHEMBL4103446)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CCN(C2=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C26H28F3N7O3/c1-3-9-35-22-20(24(38)36(10-4-2)25(35)39)31-21(32-22)17-13-30-33(15-17)14-16-8-11-34(23(16)37)19-7-5-6-18(12-19)26(27,28)29/h5-7,12-13,15-16H,3-4,8-11,14H2,1-2H3,(H,31,32)
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6n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232048
PNG
(CHEMBL4098127)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CCN(C2=O)c2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C26H28F3N7O4/c1-3-10-35-22-20(24(38)36(11-4-2)25(35)39)31-21(32-22)17-13-30-33(15-17)14-16-9-12-34(23(16)37)18-5-7-19(8-6-18)40-26(27,28)29/h5-8,13,15-16H,3-4,9-12,14H2,1-2H3,(H,31,32)
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6n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232064
PNG
(CHEMBL4099762)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C26H28F3N7O3/c1-3-8-34-23-21(24(38)35(9-4-2)25(34)39)31-22(32-23)17-12-30-33(15-17)13-16-10-20(37)36(14-16)19-7-5-6-18(11-19)26(27,28)29/h5-7,11-12,15-16H,3-4,8-10,13-14H2,1-2H3,(H,31,32)
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6.5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231590
PNG
(CHEMBL4063997)
Show SMILES CCCn1c(Oc2cccnc2C)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C19H23N5O2/c1-3-11-24-18(25)15-17(22-16(21-15)13-7-4-5-8-13)23-19(24)26-14-9-6-10-20-12(14)2/h6,9-10,13H,3-5,7-8,11H2,1-2H3,(H,21,22)
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6.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232057
PNG
(CHEMBL4068421)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H30F3N5O4/c1-3-12-35-26-24(27(39)36(13-4-2)28(35)40)33-25(34-26)19-8-10-22(11-9-19)41-17-18-14-23(38)37(16-18)21-7-5-6-20(15-21)29(30,31)32/h5-11,15,18H,3-4,12-14,16-17H2,1-2H3,(H,33,34)
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7.5n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232055
PNG
(CHEMBL4101208)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(C)cc2)c1
Show InChI InChI=1S/C26H31N7O3/c1-4-10-31-24-22(25(35)32(11-5-2)26(31)36)28-23(29-24)19-13-27-30(16-19)14-18-12-21(34)33(15-18)20-8-6-17(3)7-9-20/h6-9,13,16,18H,4-5,10-12,14-15H2,1-3H3,(H,28,29)
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8n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232047
PNG
(CHEMBL4074253)
Show SMILES CCCn1c(=O)n(CC)c2nc([nH]c2c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C25H26F3N7O3/c1-3-9-34-23(37)20-22(33(4-2)24(34)38)31-21(30-20)16-11-29-32(14-16)12-15-10-19(36)35(13-15)18-7-5-17(6-8-18)25(26,27)28/h5-8,11,14-15H,3-4,9-10,12-13H2,1-2H3,(H,30,31)
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8n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine receptor A2b expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP level preincubated for 15 m...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232056
PNG
(CHEMBL4087139)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2cccc(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C28H29F3N6O4/c1-3-10-35-25-23(26(39)36(11-4-2)27(35)40)33-24(34-25)18-8-9-21(32-14-18)41-16-17-12-22(38)37(15-17)20-7-5-6-19(13-20)28(29,30)31/h5-9,13-14,17H,3-4,10-12,15-16H2,1-2H3,(H,33,34)
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8.70n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232082
PNG
(CHEMBL4061490)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2cccc(OC(F)(F)F)c2)c1
Show InChI InChI=1S/C26H28F3N7O4/c1-3-8-34-23-21(24(38)35(9-4-2)25(34)39)31-22(32-23)17-12-30-33(15-17)13-16-10-20(37)36(14-16)18-6-5-7-19(11-18)40-26(27,28)29/h5-7,11-12,15-16H,3-4,8-10,13-14H2,1-2H3,(H,31,32)
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9n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232092
PNG
(CHEMBL4090483)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC2CN(C(=O)C2)c2cccc(F)c2)cc1
Show InChI InChI=1S/C28H30FN5O4/c1-3-12-32-26-24(27(36)33(13-4-2)28(32)37)30-25(31-26)19-8-10-22(11-9-19)38-17-18-14-23(35)34(16-18)21-7-5-6-20(29)15-21/h5-11,15,18H,3-4,12-14,16-17H2,1-2H3,(H,30,31)
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9n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232088
PNG
(CHEMBL4064289)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(OC)cc2)c1
Show InChI InChI=1S/C26H31N7O4/c1-4-10-31-24-22(25(35)32(11-5-2)26(31)36)28-23(29-24)18-13-27-30(16-18)14-17-12-21(34)33(15-17)19-6-8-20(37-3)9-7-19/h6-9,13,16-17H,4-5,10-12,14-15H2,1-3H3,(H,28,29)
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9n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231593
PNG
(CHEMBL4068469)
Show SMILES CCCn1c(OC2CCC(O)C2)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C18H26N4O3/c1-2-9-22-17(24)14-16(20-15(19-14)11-5-3-4-6-11)21-18(22)25-13-8-7-12(23)10-13/h11-13,23H,2-10H2,1H3,(H,19,20)
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9.60n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232087
PNG
(CHEMBL4072877)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2ccc(F)cc2)c1
Show InChI InChI=1S/C25H28FN7O3/c1-3-9-31-23-21(24(35)32(10-4-2)25(31)36)28-22(29-23)17-12-27-30(15-17)13-16-11-20(34)33(14-16)19-7-5-18(26)6-8-19/h5-8,12,15-16H,3-4,9-11,13-14H2,1-2H3,(H,28,29)
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9.70n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232090
PNG
(CHEMBL4084760)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC2CN(C(=O)C2)c2cccc(C)c2)c1
Show InChI InChI=1S/C26H31N7O3/c1-4-9-31-24-22(25(35)32(10-5-2)26(31)36)28-23(29-24)19-13-27-30(16-19)14-18-12-21(34)33(15-18)20-8-6-7-17(3)11-20/h6-8,11,13,16,18H,4-5,9-10,12,14-15H2,1-3H3,(H,28,29)
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11n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor


(Homo sapiens (Human))
BDBM50232091
PNG
(CHEMBL4098199)
Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cnn(CC(=O)N2CCN(CC2)c2ccc(F)cc2F)c1
Show InChI InChI=1S/C26H30F2N8O3/c1-3-7-35-24-22(25(38)36(8-4-2)26(35)39)30-23(31-24)17-14-29-34(15-17)16-21(37)33-11-9-32(10-12-33)20-6-5-18(27)13-19(20)28/h5-6,13-15H,3-4,7-12,16H2,1-2H3,(H,30,31)
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11n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-MRS-1754 from human adenosine receptor A2b expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting met...


Eur J Med Chem 127: 986-996 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231710
PNG
(CHEMBL4101044)
Show SMILES CCCn1c(Oc2cccc(O)c2)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C19H22N4O3/c1-2-10-23-18(25)15-17(21-16(20-15)12-6-3-4-7-12)22-19(23)26-14-9-5-8-13(24)11-14/h5,8-9,11-12,24H,2-4,6-7,10H2,1H3,(H,20,21)
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11n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231715
PNG
(CHEMBL4088084)
Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H21F3N4O/c1-2-10-27-18(13-8-5-9-14(11-13)20(21,22)23)26-17-15(19(27)28)24-16(25-17)12-6-3-4-7-12/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,24,25)
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12n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231589
PNG
(CHEMBL4073088)
Show SMILES CCCn1c(Oc2cncc(Cl)c2)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C18H20ClN5O2/c1-2-7-24-17(25)14-16(22-15(21-14)11-5-3-4-6-11)23-18(24)26-13-8-12(19)9-20-10-13/h8-11H,2-7H2,1H3,(H,21,22)
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12n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
Adenosine receptor A1/Alpha-2A adrenergic receptor


(Homo sapiens (human))
BDBM50231592
PNG
(CHEMBL4078636)
Show SMILES CCCn1c(OC2CCOCC2)nc2nc([nH]c2c1=O)C1CCCC1
Show InChI InChI=1S/C18H26N4O3/c1-2-9-22-17(23)14-16(20-15(19-14)12-5-3-4-6-12)21-18(22)25-13-7-10-24-11-8-13/h12-13H,2-11H2,1H3,(H,19,20)
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12n/an/an/an/an/an/an/an/a



Advinus Therapeutics Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...


Bioorg Med Chem 25: 1963-1975 (2017)

More data for this
Ligand-Target Pair
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