BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 38 hits from Aeterna Zentaris GmbH   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (human))
BDBM127596
PNG
(US8791118, 159)
Show SMILES O=C(NCCCCc1ccccc1)Nc1ccc2ncc(nc2n1)-c1cn[nH]c1
Show InChI InChI=1S/C21H21N7O/c29-21(22-11-5-4-8-15-6-2-1-3-7-15)28-19-10-9-17-20(27-19)26-18(14-23-17)16-12-24-25-13-16/h1-3,6-7,9-10,12-14H,4-5,8,11H2,(H,24,25)(H2,22,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127620
PNG
(US8791118, 194)
Show SMILES COc1cc(ccc1C(O)=O)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C26H25N5O4/c1-35-22-15-18(10-11-19(22)25(32)33)21-16-28-20-12-13-23(30-24(20)29-21)31-26(34)27-14-6-5-9-17-7-3-2-4-8-17/h2-4,7-8,10-13,15-16H,5-6,9,14H2,1H3,(H,32,33)(H2,27,29,30,31,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127597
PNG
(US8791118, 160)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C24H23N5O2/c30-19-11-9-18(10-12-19)21-16-26-20-13-14-22(28-23(20)27-21)29-24(31)25-15-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-14,16,30H,4-5,8,15H2,(H2,25,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127593
PNG
(US8791118, 156)
Show SMILES COc1cc(CO)ccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1
Show InChI InChI=1S/C27H29N5O3/c1-18(7-6-10-19-8-4-3-5-9-19)29-27(34)32-25-14-13-22-26(31-25)30-23(16-28-22)21-12-11-20(17-33)15-24(21)35-2/h3-5,8-9,11-16,18,33H,6-7,10,17H2,1-2H3,(H2,29,30,31,32,34)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127621
PNG
(US8791118, 195)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(C[C@H](N)C(O)=O)cc1
Show InChI InChI=1S/C28H30N6O3/c1-18(6-5-9-19-7-3-2-4-8-19)31-28(37)34-25-15-14-23-26(33-25)32-24(17-30-23)21-12-10-20(11-13-21)16-22(29)27(35)36/h2-4,7-8,10-15,17-18,22H,5-6,9,16,29H2,1H3,(H,35,36)(H2,31,32,33,34,37)/t18-,22+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127595
PNG
(US8791118, 158)
Show SMILES COc1c(CO)cccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1
Show InChI InChI=1S/C27H29N5O3/c1-18(8-6-11-19-9-4-3-5-10-19)29-27(34)32-24-15-14-22-26(31-24)30-23(16-28-22)21-13-7-12-20(17-33)25(21)35-2/h3-5,7,9-10,12-16,18,33H,6,8,11,17H2,1-2H3,(H2,29,30,31,32,34)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127594
PNG
(US8791118, 157)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1ccncc1
Show InChI InChI=1S/C24H24N6O/c1-17(6-5-9-18-7-3-2-4-8-18)27-24(31)30-22-11-10-20-23(29-22)28-21(16-26-20)19-12-14-25-15-13-19/h2-4,7-8,10-17H,5-6,9H2,1H3,(H2,27,28,29,30,31)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127601
PNG
(US8791118, 164)
Show SMILES CC(CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O/c1-16(7-6-10-17-8-4-3-5-9-17)26-23(31)29-21-12-11-19-22(28-21)27-20(14-24-19)18-13-25-30(2)15-18/h3-5,8-9,11-16H,6-7,10H2,1-2H3,(H2,26,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127600
PNG
(US8791118, 163)
Show SMILES FC(F)Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C23H23F2N7O/c24-20(25)15-32-14-17(12-28-32)19-13-27-18-9-10-21(30-22(18)29-19)31-23(33)26-11-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,9-10,12-14,20H,4-5,8,11,15H2,(H2,26,29,30,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127599
PNG
(US8791118, 162)
Show SMILES OCCCn1cc(cn1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C24H27N7O2/c32-14-6-13-31-17-19(15-27-31)21-16-26-20-10-11-22(29-23(20)28-21)30-24(33)25-12-5-4-9-18-7-2-1-3-8-18/h1-3,7-8,10-11,15-17,32H,4-6,9,12-14H2,(H2,25,28,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127598
PNG
(US8791118, 161)
Show SMILES COc1ncccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1
Show InChI InChI=1S/C25H26N6O2/c1-17(8-6-11-18-9-4-3-5-10-18)28-25(32)31-22-14-13-20-23(30-22)29-21(16-27-20)19-12-7-15-26-24(19)33-2/h3-5,7,9-10,12-17H,6,8,11H2,1-2H3,(H2,28,29,30,31,32)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127606
PNG
(US8791118, 169)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCCC(C)(C)c3ccccc3)nc2n1
Show InChI InChI=1S/C24H27N7O/c1-24(2,18-8-5-4-6-9-18)12-7-13-25-23(32)30-21-11-10-19-22(29-21)28-20(15-26-19)17-14-27-31(3)16-17/h4-6,8-11,14-16H,7,12-13H2,1-3H3,(H2,25,28,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127624
PNG
(US8791118, 198)
Show SMILES OC(=O)c1cccc(c1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C25H23N5O3/c31-24(32)19-11-6-10-18(15-19)21-16-27-20-12-13-22(29-23(20)28-21)30-25(33)26-14-5-4-9-17-7-2-1-3-8-17/h1-3,6-8,10-13,15-16H,4-5,9,14H2,(H,31,32)(H2,26,28,29,30,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127605
PNG
(US8791118, 168)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C28H34N8O2/c1-21(6-5-9-22-7-3-2-4-8-22)31-28(37)34-26-11-10-24-27(33-26)32-25(19-29-24)23-18-30-36(20-23)13-12-35-14-16-38-17-15-35/h2-4,7-8,10-11,18-21H,5-6,9,12-17H2,1H3,(H2,31,32,33,34,37)/t21-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127604
PNG
(US8791118, 167)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1ccc(CO)cc1
Show InChI InChI=1S/C26H27N5O2/c1-18(6-5-9-19-7-3-2-4-8-19)28-26(33)31-24-15-14-22-25(30-24)29-23(16-27-22)21-12-10-20(17-32)11-13-21/h2-4,7-8,10-16,18,32H,5-6,9,17H2,1H3,(H2,28,29,30,31,33)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127603
PNG
(US8791118, 166)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)N1CCOCC1
Show InChI InChI=1S/C23H28N6O2/c1-17(6-5-9-18-7-3-2-4-8-18)25-23(30)27-20-11-10-19-22(26-20)28-21(16-24-19)29-12-14-31-15-13-29/h2-4,7-8,10-11,16-17H,5-6,9,12-15H2,1H3,(H2,25,26,27,28,30)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127602
PNG
(US8791118, 165)
Show SMILES OP(O)(=O)Oc1ccc(cc1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C24H24N5O5P/c30-24(25-15-5-4-8-17-6-2-1-3-7-17)29-22-14-13-20-23(28-22)27-21(16-26-20)18-9-11-19(12-10-18)34-35(31,32)33/h1-3,6-7,9-14,16H,4-5,8,15H2,(H2,31,32,33)(H2,25,27,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127592
PNG
(US8791118, 155)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C22H23N7O/c1-29-15-17(13-25-29)19-14-24-18-10-11-20(27-21(18)26-19)28-22(30)23-12-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,10-11,13-15H,5-6,9,12H2,1H3,(H2,23,26,27,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127590
PNG
(US8791118, 108)
Show SMILES CCn1cc(cn1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C23H25N7O/c1-2-30-16-18(14-26-30)20-15-25-19-11-12-21(28-22(19)27-20)29-23(31)24-13-7-6-10-17-8-4-3-5-9-17/h3-5,8-9,11-12,14-16H,2,6-7,10,13H2,1H3,(H2,24,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127622
PNG
(US8791118, 196)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(c1)C(O)=O
Show InChI InChI=1S/C26H25N5O3/c1-17(7-5-10-18-8-3-2-4-9-18)28-26(34)31-23-14-13-21-24(30-23)29-22(16-27-21)19-11-6-12-20(15-19)25(32)33/h2-4,6,8-9,11-17H,5,7,10H2,1H3,(H,32,33)(H2,28,29,30,31,34)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127608
PNG
(US8791118, 171)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cn[nH]c1
Show InChI InChI=1S/C22H23N7O/c1-15(6-5-9-16-7-3-2-4-8-16)26-22(30)29-20-11-10-18-21(28-20)27-19(14-23-18)17-12-24-25-13-17/h2-4,7-8,10-15H,5-6,9H2,1H3,(H,24,25)(H2,26,27,28,29,30)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127607
PNG
(US8791118, 170)
Show SMILES CCCn1cc(cn1)-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1
Show InChI InChI=1S/C25H29N7O/c1-3-14-32-17-20(15-27-32)22-16-26-21-12-13-23(30-24(21)29-22)31-25(33)28-18(2)8-7-11-19-9-5-4-6-10-19/h4-6,9-10,12-13,15-18H,3,7-8,11,14H2,1-2H3,(H2,28,29,30,31,33)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127619
PNG
(US8791118, 189)
Show SMILES OCCn1cc(cn1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C23H25N7O2/c31-13-12-30-16-18(14-26-30)20-15-25-19-9-10-21(28-22(19)27-20)29-23(32)24-11-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-10,14-16,31H,4-5,8,11-13H2,(H2,24,27,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127610
PNG
(US8791118, 173)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)N1CCCC1
Show InChI InChI=1S/C23H28N6O/c1-17(8-7-11-18-9-3-2-4-10-18)25-23(30)27-20-13-12-19-22(26-20)28-21(16-24-19)29-14-5-6-15-29/h2-4,9-10,12-13,16-17H,5-8,11,14-15H2,1H3,(H2,25,26,27,28,30)/t17-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127609
PNG
(US8791118, 172)
Show SMILES O=C(NCCCCc1ccccc1)Nc1ccc2ncc(nc2n1)N1CCCC1
Show InChI InChI=1S/C22H26N6O/c29-22(23-13-5-4-10-17-8-2-1-3-9-17)26-19-12-11-18-21(25-19)27-20(16-24-18)28-14-6-7-15-28/h1-3,8-9,11-12,16H,4-7,10,13-15H2,(H2,23,25,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127591
PNG
(US8791118, 127)
Show SMILES O=C(NCCCCc1ccccc1)Nc1ccc2ncc(nc2n1)-c1cnn(CCN2CCOCC2)c1
Show InChI InChI=1S/C27H32N8O2/c36-27(28-11-5-4-8-21-6-2-1-3-7-21)33-25-10-9-23-26(32-25)31-24(19-29-23)22-18-30-35(20-22)13-12-34-14-16-37-17-15-34/h1-3,6-7,9-10,18-20H,4-5,8,11-17H2,(H2,28,31,32,33,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127623
PNG
(US8791118, 197)
Show SMILES N[C@@H](Cc1ccc(cc1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1)C(O)=O
Show InChI InChI=1S/C27H28N6O3/c28-21(26(34)35)16-19-9-11-20(12-10-19)23-17-30-22-13-14-24(32-25(22)31-23)33-27(36)29-15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-14,17,21H,4-5,8,15-16,28H2,(H,34,35)(H2,29,31,32,33,36)/t21-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127617
PNG
(US8791118, 180)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O/c1-16(7-6-10-17-8-4-3-5-9-17)26-23(31)29-21-12-11-19-22(28-21)27-20(14-24-19)18-13-25-30(2)15-18/h3-5,8-9,11-16H,6-7,10H2,1-2H3,(H2,26,27,28,29,31)/t16-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127618
PNG
(US8791118, 181)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1cccc(CO)c1
Show InChI InChI=1S/C26H27N5O2/c1-18(7-5-10-19-8-3-2-4-9-19)28-26(33)31-24-14-13-22-25(30-24)29-23(16-27-22)21-12-6-11-20(15-21)17-32/h2-4,6,8-9,11-16,18,32H,5,7,10,17H2,1H3,(H2,28,29,30,31,33)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127614
PNG
(US8791118, 177)
Show SMILES C[C@H](CCCc1ccccc1)NC(=O)Nc1ccc2ncc(nc2n1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C24H27N7O/c1-15(8-7-11-18-9-5-4-6-10-18)26-24(32)29-21-13-12-19-23(28-21)27-20(14-25-19)22-16(2)30-31-17(22)3/h4-6,9-10,12-15H,7-8,11H2,1-3H3,(H,30,31)(H2,26,27,28,29,32)/t15-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127613
PNG
(US8791118, 176)
Show SMILES O=C(NCCCCc1ccccc1)Nc1ccc2ncc(nc2n1)N1CCOCC1
Show InChI InChI=1S/C22H26N6O2/c29-22(23-11-5-4-8-17-6-2-1-3-7-17)26-19-10-9-18-21(25-19)27-20(16-24-18)28-12-14-30-15-13-28/h1-3,6-7,9-10,16H,4-5,8,11-15H2,(H2,23,25,26,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127612
PNG
(US8791118, 175)
Show SMILES OCc1cccc(c1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C25H25N5O2/c31-17-19-10-6-11-20(15-19)22-16-27-21-12-13-23(29-24(21)28-22)30-25(32)26-14-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-13,15-16,31H,4-5,9,14,17H2,(H2,26,28,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127615
PNG
(US8791118, 178)
Show SMILES COc1ccc(cc1OC)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C26H27N5O3/c1-33-22-13-11-19(16-23(22)34-2)21-17-28-20-12-14-24(30-25(20)29-21)31-26(32)27-15-7-6-10-18-8-4-3-5-9-18/h3-5,8-9,11-14,16-17H,6-7,10,15H2,1-2H3,(H2,27,29,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127611
PNG
(US8791118, 174)
Show SMILES Oc1ccc(cc1F)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C24H22FN5O2/c25-18-14-17(9-11-21(18)31)20-15-27-19-10-12-22(29-23(19)28-20)30-24(32)26-13-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,9-12,14-15,31H,4-5,8,13H2,(H2,26,28,29,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127616
PNG
(US8791118, 179)
Show SMILES COc1ccccc1-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1
Show InChI InChI=1S/C26H27N5O2/c1-18(9-8-12-19-10-4-3-5-11-19)28-26(32)31-24-16-15-21-25(30-24)29-22(17-27-21)20-13-6-7-14-23(20)33-2/h3-7,10-11,13-18H,8-9,12H2,1-2H3,(H2,28,29,30,31,32)/t18-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127627
PNG
(US8791118, 203)
Show SMILES COCc1cccc(c1)-c1cnc2ccc(NC(=O)N[C@H](C)CCCc3ccccc3)nc2n1
Show InChI InChI=1S/C27H29N5O2/c1-19(8-6-11-20-9-4-3-5-10-20)29-27(33)32-25-15-14-23-26(31-25)30-24(17-28-23)22-13-7-12-21(16-22)18-34-2/h3-5,7,9-10,12-17,19H,6,8,11,18H2,1-2H3,(H2,29,30,31,32,33)/t19-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127625
PNG
(US8791118, 201)
Show SMILES OCCOCCOc1ccc(cc1)-c1cnc2ccc(NC(=O)NCCCCc3ccccc3)nc2n1
Show InChI InChI=1S/C28H31N5O4/c34-16-17-36-18-19-37-23-11-9-22(10-12-23)25-20-30-24-13-14-26(32-27(24)31-25)33-28(35)29-15-5-4-8-21-6-2-1-3-7-21/h1-3,6-7,9-14,20,34H,4-5,8,15-19H2,(H2,29,31,32,33,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 39n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM127626
PNG
(US8791118, 202)
Show SMILES O=C(NCCCCc1ccccc1)Nc1ccc2ncc(nc2n1)-c1ccc(OCCN2CCOCC2)cc1
Show InChI InChI=1S/C30H34N6O3/c37-30(31-15-5-4-8-23-6-2-1-3-7-23)35-28-14-13-26-29(34-28)33-27(22-32-26)24-9-11-25(12-10-24)39-21-18-36-16-19-38-20-17-36/h1-3,6-7,9-14,22H,4-5,8,15-21H2,(H2,31,33,34,35,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 41n/an/an/an/an/an/a



Aeterna Zentaris GmbH

US Patent


Assay Description
The inhibitory effect of the compounds according to the invention was tested on various serine/threonine, tyrosine and lipid kinases in enzymatic ass...


US Patent US8791118 (2014)


BindingDB Entry DOI: 10.7270/Q2TT4PNN
More data for this
Ligand-Target Pair