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Compile Data Set for Download or QSAR

Found 199 hits from Akebia Therapeutics, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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US Patent
n/an/a 83n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 83n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 83n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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US Patent
n/an/a 83n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107702
PNG
(US8598210, Table XV, 8 | US8722895, 8: {[5-(4-Cyan...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-9(3-5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 99n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 180n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 180n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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US Patent
n/an/a 180n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 180n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
PDB
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n/an/a 190n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107714
PNG
(US8598210, Table XV, 20 | US8722895, 20: {[5-(3-Cy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-3-9(5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
PDB
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n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM400041
PNG
(USRE47437, Example {[5-(3-Cyanophenyl)-3-hydroxypy...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-2-1-3-10(4-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 190n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
PDB
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n/an/a 240n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
PDB
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n/an/a 240n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
PDB
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n/an/a 240n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107703
PNG
(US8598210, Table XV, 9 | US8722895, 9: {[5-(4-Chlo...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
PDB
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n/an/a 240n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/a 300n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107717
PNG
(US8598210, Table XV, 23 | US8722895, 23: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C19H19N3O5/c23-15-9-14(10-20-17(15)18(26)21-11-16(24)25)12-4-3-5-13(8-12)19(27)22-6-1-2-7-22/h3-5,8-10,23H,1-2,6-7,11H2,(H,21,26)(H,24,25)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 300n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107708
PNG
(US8598210, Table XV, 14 | US8722895, 14: {[5-(4-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(F)cc1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-1-8(2-4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 300n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107706
PNG
(US8598210, Table XV, 12 | US8722895, 12: {[5-(2-Ch...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccccc1Cl
Show InChI InChI=1S/C14H11ClN2O4/c15-10-4-2-1-3-9(10)8-5-11(18)13(16-6-8)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 390n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301825
PNG
(US9598370, Example 00149 | USRE47437, Example ({3-...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/a 400n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107718
PNG
(US8598210, Table XV, 24 | US8722895, 24: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/a 400n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM301825
PNG
(US9598370, Example 00149 | USRE47437, Example ({3-...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nn[nH]n1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/a 400n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107718
PNG
(US8598210, Table XV, 24 | US8722895, 24: ({3-Hydro...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C15H12N6O4/c22-11-5-10(6-16-13(11)15(25)17-7-12(23)24)8-2-1-3-9(4-8)14-18-20-21-19-14/h1-6,22H,7H2,(H,17,25)(H,23,24)(H,18,19,20,21)
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n/an/a 400n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 410n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 410n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 410n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107704
PNG
(US8598210, 119 | US8598210, Table XV, 10 | US85982...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Show InChI InChI=1S/C14H11ClN2O4/c15-10-3-1-2-8(4-10)9-5-11(18)13(16-6-9)14(21)17-7-12(19)20/h1-6,18H,7H2,(H,17,21)(H,19,20)
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n/an/a 410n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 440n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 440n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 440n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107707
PNG
(US8598210, Table XV, 13 | US8722895, 13: {[5-(4-Is...)
Show SMILES CC(C)c1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C17H18N2O4/c1-10(2)11-3-5-12(6-4-11)13-7-14(20)16(18-8-13)17(23)19-9-15(21)22/h3-8,10,20H,9H2,1-2H3,(H,19,23)(H,21,22)
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n/an/a 440n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM301799
PNG
(US9598370, Example 00133 | USRE47437, Example {[5-...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent USRE47437 (2019)

More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107702
PNG
(US8598210, Table XV, 8 | US8722895, 8: {[5-(4-Cyan...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-9(3-5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/a25



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8722895 (2014)


BindingDB Entry DOI: 10.7270/Q25Q4TRQ
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM301799
PNG
(US9598370, Example 00133 | USRE47437, Example {[5-...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c16-6-9-1-3-10(4-2-9)11-5-12(19)14(17-7-11)15(22)18-8-13(20)21/h1-5,7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
HEK293 cells are seeded in 96-well poly-lysine coated plates at 20,000 cells per well in DMEM (10% FBS, 1% NEAA, 0.1% glutamine). Following overnight...


US Patent US9598370 (2017)


Article DOI: 10.1016/j.bmcl.2007.07.009
BindingDB Entry DOI: 10.7270/Q20G3N64
More data for this
Ligand-Target Pair
Egl nine homolog 3


(Homo sapiens (Human))
BDBM107702
PNG
(US8598210, Table XV, 8 | US8722895, 8: {[5-(4-Cyan...)
Show SMILES OC(=O)CNC(=O)c1ncc(cc1O)-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H11N3O4/c1-16-11-4-2-9(3-5-11)10-6-12(19)14(17-7-10)15(22)18-8-13(20)21/h2-7,19H,8H2,(H,18,22)(H,20,21)
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n/an/a 560n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM107698
PNG
(US8598210, Table XV, 4 | US8722895, 4: [(3-Hydroxy...)
Show SMILES Cc1ccc(cc1)-c1cnc(C(=O)NCC(O)=O)c(O)c1
Show InChI InChI=1S/C15H14N2O4/c1-9-2-4-10(5-3-9)11-6-12(18)14(16-7-11)15(21)17-8-13(19)20/h2-7,18H,8H2,1H3,(H,17,21)(H,19,20)
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n/an/a 650n/an/an/an/an/an/a



Akebia Therapeutics, Inc.

US Patent


Assay Description
The EGLN-1 (or EGLN-3) enzyme activity is determined using mass spectrometry (matrix-assisted laser desorption ionization, time-of-flight MS, MALDI-T...


US Patent US8598210 (2013)


BindingDB Entry DOI: 10.7270/Q2M04428
More data for this
Ligand-Target Pair
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