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Compile Data Set for Download or QSAR

Found 22 hits from Alantos Pharmaceuticals AG   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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n/an/a 0.0300n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP13 using MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 as substrate preincubated for 10 mins measured by fluorescence analys...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP13 using MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH2 as substrate preincubated for 10 mins measured by fluorescence analys...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aggrecanase 1 using aggrecan-IGD as substrate measured after 15 mins by ELISA


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP8 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant aggrecanase 1 using aggrecan-IGD as substrate measured after 15 mins by ELISA


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP3 using MCAArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)-NH2 as substrate preincubated for 10 mins measured by fluo...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP3 using MCAArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(DNP)-NH2 as substrate preincubated for 10 mins measured by fluo...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP9 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-12 (MMP12)


(Homo sapiens (Human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP12 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP14 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TACE using MCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate preincubated for 10 mins measured by ...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP8 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TACE using MCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate preincubated for 10 mins measured by ...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP1 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7)


(Homo sapiens (Human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP7 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50386429
PNG
(CHEMBL2047537)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4c(F)cnn34)C(=O)NCc3ccc(F)c(c3)C(F)(F)F)c2ccc1C(O)=O
Show InChI InChI=1S/C27H20F5N5O4/c1-12-14-5-7-20(16(14)4-3-15(12)26(40)41)36-25(39)22-9-21(35-23-19(29)11-34-37(22)23)24(38)33-10-13-2-6-18(28)17(8-13)27(30,31)32/h2-4,6,8-9,11,20H,5,7,10H2,1H3,(H,33,38)(H,36,39)(H,40,41)/t20-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP14 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence a...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50386430
PNG
(CHEMBL2047536)
Show SMILES Cc1c2CC[C@H](NC(=O)c3cc(nc4ccnn34)C(=O)NCc3ccc4OCC(=O)Nc4c3)c2ccc1C(O)=O
Show InChI InChI=1S/C28H24N6O6/c1-14-16-5-6-19(18(16)4-3-17(14)28(38)39)33-27(37)22-11-21(31-24-8-9-30-34(22)24)26(36)29-12-15-2-7-23-20(10-15)32-25(35)13-40-23/h2-4,7-11,19H,5-6,12-13H2,1H3,(H,29,36)(H,32,35)(H,33,37)(H,38,39)/t19-/m0/s1
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Alantos Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP1 using MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins measured by fluorescence an...


J Med Chem 55: 709-16 (2012)


Article DOI: 10.1021/jm201152u
BindingDB Entry DOI: 10.7270/Q2668F73
More data for this
Ligand-Target Pair