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Compile Data Set for Download or QSAR

Found 96 hits from Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM77064
PNG
(US9695197, 4)
Show SMILES CNC1=N[C@H]2[C@@H](S1)S[C@H](CO)[C@@H](O)[C@@H]2O
Show InChI InChI=1S/C8H14N2O3S2/c1-9-8-10-4-6(13)5(12)3(2-11)14-7(4)15-8/h3-7,11-13H,2H2,1H3,(H,9,10)/t3-,4-,5-,6-,7-/m1/s1
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0.110n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9695197 (2017)


BindingDB Entry DOI: 10.7270/Q247481J
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240645
PNG
(US9409924, (3aR,5R,6R,7S,7aR)-2-(dimethylamino)-7-...)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1
Show InChI InChI=1S/C9H15FN2O3S/c1-12(2)9-11-6-5(10)7(14)4(3-13)15-8(6)16-9/h4-8,13-14H,3H2,1-2H3/t4-,5+,6-,7-,8-/m1/s1
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0.300n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240657
PNG
(US9409924, 34)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@H]2F)S1
Show InChI InChI=1S/C9H15FN2O3S/c1-3(13)7-6(14)4(10)5-8(15-7)16-9(11-2)12-5/h3-8,13-14H,1-2H3,(H,11,12)/t3-,4-,5+,6-,7+,8+/m0/s1
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0.300n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205418
PNG
(US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H16N2O4S/c1-11(2)9-10-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,3H2,1-2H3/t4-,5-,6-,7-,8-/m1/s1
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0.300n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240644
PNG
(US9409924, (3aR,5R,6R,7S,7aR)-2-(ethylamino)-7-flu...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2F)S1
Show InChI InChI=1S/C9H15FN2O3S/c1-2-11-9-12-6-5(10)7(14)4(3-13)15-8(6)16-9/h4-8,13-14H,2-3H2,1H3,(H,11,12)/t4-,5+,6-,7-,8-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM50323697
PNG
((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9695197 (2017)


BindingDB Entry DOI: 10.7270/Q247481J
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM50323697
PNG
((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205423
PNG
(US9243020, 17)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CF)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C8H13FN2O3S/c1-10-8-11-4-6(13)5(12)3(2-9)14-7(4)15-8/h3-7,12-13H,2H2,1H3,(H,10,11)/t3-,4-,5-,6-,7-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267947
PNG
((3aR,5R,6S,7R,7aR)-5- ((cyclopentylamino)methyl)-2...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNC3CCCC3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C13H23N3O3S/c1-14-13-16-9-11(18)10(17)8(19-12(9)20-13)6-15-7-4-2-3-5-7/h7-12,15,17-18H,2-6H2,1H3,(H,14,16)/t8-,9-,10-,11-,12-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM255774
PNG
((3aR,5R,6S,7S,7aR)-5- (hydroxymethyl)-2-(methylami...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2O)S1
Show InChI InChI=1S/C8H14N2O4S/c1-9-8-10-4-6(13)5(12)3(2-11)14-7(4)15-8/h3-7,11-13H,2H2,1H3,(H,9,10)/t3-,4-,5-,6+,7-/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
A variety of tissue culture cell lines, expressing endogenous levels of O-GlcNAcase, can be utilized; examples include rat PC-12, and human U-87, or ...


US Patent US9701693 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240659
PNG
(US9409924, 38)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@H]2F)S1
Show InChI InChI=1S/C9H12F4N2O3S/c1-14-8-15-3-2(10)4(16)5(18-7(3)19-8)6(17)9(11,12)13/h2-7,16-17H,1H3,(H,14,15)/t2-,3+,4-,5-,6+,7+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193649
PNG
(US9199949, 6)
Show SMILES O[C@@H]1[C@H]2N=C(O[C@H]2C[C@H](C(F)F)[C@H]1O)N1CCC1
Show InChI InChI=1S/C11H16F2N2O3/c12-10(13)5-4-6-7(9(17)8(5)16)14-11(18-6)15-2-1-3-15/h5-10,16-17H,1-4H2/t5-,6-,7-,8+,9+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9199949 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NR8
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240646
PNG
(US9409924, 1)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@@H]2F)S1
Show InChI InChI=1S/C9H15FN2O3S/c1-3(13)7-6(14)4(10)5-8(15-7)16-9(11-2)12-5/h3-8,13-14H,1-2H3,(H,11,12)/t3-,4+,5+,6-,7+,8+/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193648
PNG
(US9199949, 4)
Show SMILES O[C@@H]1[C@H]2N=C(O[C@H]2C[C@H](CF)[C@H]1O)N1CCC1
Show InChI InChI=1S/C11H17FN2O3/c12-5-6-4-7-8(10(16)9(6)15)13-11(17-7)14-2-1-3-14/h6-10,15-16H,1-5H2/t6-,7+,8+,9-,10-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9199949 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NR8
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267944
PNG
((3aR,5R,6S,7R,7aR)-5- ((cyclopropylamino)methyl)-2...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNC3CC3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C11H19N3O3S/c1-12-11-14-7-9(16)8(15)6(17-10(7)18-11)4-13-5-2-3-5/h5-10,13,15-16H,2-4H2,1H3,(H,12,14)/t6-,7-,8-,9-,10-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205422
PNG
(US9243020, 9)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2F)S1
Show InChI InChI=1S/C8H13FN2O3S/c1-10-8-11-5-4(9)6(13)3(2-12)14-7(5)15-8/h3-7,12-13H,2H2,1H3,(H,10,11)/t3-,4-,5-,6-,7-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205425
PNG
(US9243020, 20)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H14F2N2O3S/c1-13(2)9-12-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,1-2H3/t3-,4-,5+,6+,8-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM77047
PNG
(US9695197, 3)
Show SMILES CCCNC1=N[C@H]2[C@@H](S1)S[C@H](CO)[C@@H](O)[C@@H]2O
Show InChI InChI=1S/C10H18N2O3S2/c1-2-3-11-10-12-6-8(15)7(14)5(4-13)16-9(6)17-10/h5-9,13-15H,2-4H2,1H3,(H,11,12)/t5-,6-,7-,8-,9-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9695197 (2017)


BindingDB Entry DOI: 10.7270/Q247481J
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267946
PNG
((3aR,5R,6S,7R,7aR)-5- ((cyclobutylamino)methyl)-2-...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNC3CCC3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C12H21N3O3S/c1-13-12-15-8-10(17)9(16)7(18-11(8)19-12)5-14-6-3-2-4-6/h6-11,14,16-17H,2-5H2,1H3,(H,13,15)/t7-,8-,9-,10-,11-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193650
PNG
(US9199949, 8)
Show SMILES CNC1=N[C@H]2[C@H](C[C@H](C(F)F)[C@@H](O)[C@@H]2O)O1
Show InChI InChI=1S/C9H14F2N2O3/c1-12-9-13-5-4(16-9)2-3(8(10)11)6(14)7(5)15/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5-,6+,7+/m0/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9199949 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NR8
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267936
PNG
(((3aR,5R,6S,7R,7aR)-6,7-dihydroxy- 2-(methylamino)...)
Show SMILES CCN(CC)C(=O)OC[C@H]1O[C@@H]2SC(NC)=N[C@@H]2[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H23N3O5S/c1-4-16(5-2)13(19)20-6-7-9(17)10(18)8-11(21-7)22-12(14-3)15-8/h7-11,17-18H,4-6H2,1-3H3,(H,14,15)/t7-,8-,9-,10-,11-/m1/s1
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2.70n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267938
PNG
((3aR,5R,6S,7R,7aR)-2- (methylamino)-5- ((methylami...)
Show SMILES CNC[C@H]1O[C@@H]2SC(NC)=N[C@@H]2[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C9H17N3O3S/c1-10-3-4-6(13)7(14)5-8(15-4)16-9(11-2)12-5/h4-8,10,13-14H,3H2,1-2H3,(H,11,12)/t4-,5-,6-,7-,8-/m1/s1
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2.80n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193647
PNG
(US9199949, 2)
Show SMILES CNC1=N[C@H]2[C@H](C[C@H](CF)[C@@H](O)[C@@H]2O)O1
Show InChI InChI=1S/C9H15FN2O3/c1-11-9-12-6-5(15-9)2-4(3-10)7(13)8(6)14/h4-8,13-14H,2-3H2,1H3,(H,11,12)/t4-,5+,6+,7-,8-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9199949 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NR8
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM70719
PNG
(US9695197, 1)
Show SMILES CCNC1=N[C@H]2[C@@H](O1)S[C@H](CO)[C@@H](O)[C@@H]2O
Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)16-8(5)15-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8+/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9695197 (2017)


BindingDB Entry DOI: 10.7270/Q247481J
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267964
PNG
((3aR,5R,6S,7R,7aR)-5-(((2- hydroxyethyl)amino)meth...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNCCO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C10H19N3O4S/c1-11-10-13-6-8(16)7(15)5(4-12-2-3-14)17-9(6)18-10/h5-9,12,14-16H,2-4H2,1H3,(H,11,13)/t5-,6-,7-,8-,9-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM70885
PNG
(US9695197, 2)
Show SMILES CCNC1=N[C@H]2[C@@H](S1)S[C@H](CO)[C@@H](O)[C@@H]2O
Show InChI InChI=1S/C9H16N2O3S2/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
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3n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9695197 (2017)


BindingDB Entry DOI: 10.7270/Q247481J
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267943
PNG
((3aR,5R,6S,7R,7aR)-5-(((2- methoxyethyl)amino)meth...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNCCOC)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C11H21N3O4S/c1-12-11-14-7-9(16)8(15)6(18-10(7)19-11)5-13-3-4-17-2/h6-10,13,15-16H,3-5H2,1-2H3,(H,12,14)/t6-,7-,8-,9-,10-/m1/s1
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3.30n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240654
PNG
(US9409924, 20)
Show SMILES CNC1=N[C@@H]2C[C@H](O)[C@H](O[C@@H]2S1)[C@@H](O)C(F)(F)F
Show InChI InChI=1S/C9H13F3N2O3S/c1-13-8-14-3-2-4(15)5(17-7(3)18-8)6(16)9(10,11)12/h3-7,15-16H,2H2,1H3,(H,13,14)/t3-,4+,5+,6-,7-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240650
PNG
(US9409924, 9)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2F)S1
Show InChI InChI=1S/C9H12F4N2O3S/c1-14-8-15-3-2(10)4(16)5(18-7(3)19-8)6(17)9(11,12)13/h2-7,16-17H,1H3,(H,14,15)/t2-,3-,4+,5+,6-,7-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267941
PNG
((3aR,5R,6S,7R,7aR)-5- ((ethylamino)methyl)-2- (met...)
Show SMILES CCNC[C@H]1O[C@@H]2SC(NC)=N[C@@H]2[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C10H19N3O3S/c1-3-12-4-5-7(14)8(15)6-9(16-5)17-10(11-2)13-6/h5-9,12,14-15H,3-4H2,1-2H3,(H,11,13)/t5-,6-,7-,8-,9-/m1/s1
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3.70n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267942
PNG
((3aR,5R,6S,7R,7aR)-5- ((allylamino)methyl)-2- (met...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNCC=C)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C11H19N3O3S/c1-3-4-13-5-6-8(15)9(16)7-10(17-6)18-11(12-2)14-7/h3,6-10,13,15-16H,1,4-5H2,2H3,(H,12,14)/t6-,7-,8-,9-,10-/m1/s1
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3.80n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267965
PNG
(2-((((3aR,5R,6S,7R,7aR)-6,7- dihydroxy-2-(methylam...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNC[N+]#[C-])[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C10H16N4O3S/c1-11-4-13-3-5-7(15)8(16)6-9(17-5)18-10(12-2)14-6/h5-9,13,15-16H,3-4H2,2H3,(H,12,14)/t5-,6-,7-,8-,9-/m1/s1
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5.40n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267937
PNG
((3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((isopropylam...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CNC(C)C)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C12H23N3O3S/c1-4-13-12-15-8-10(17)9(16)7(5-14-6(2)3)18-11(8)19-12/h6-11,14,16-17H,4-5H2,1-3H3,(H,13,15)/t7-,8-,9-,10-,11-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267939
PNG
((3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((methylamino...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CNC)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C10H19N3O3S/c1-3-12-10-13-6-8(15)7(14)5(4-11-2)16-9(6)17-10/h5-9,11,14-15H,3-4H2,1-2H3,(H,12,13)/t5-,6-,7-,8-,9-/m1/s1
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5.60n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205424
PNG
(US9243020, 19)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H14F2N2O3S/c1-2-12-9-13-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5+,6+,8-/m1/s1
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5.70n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267945
PNG
((3aR,5R,6S,7R,7aR)-5- ((cyclopropylamino)methyl)-2...)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H](CNC3CC3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C12H21N3O3S/c1-15(2)12-14-8-10(17)9(16)7(18-11(8)19-12)5-13-6-3-4-6/h6-11,13,16-17H,3-5H2,1-2H3/t7-,8-,9-,10-,11-/m1/s1
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6n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267963
PNG
((3aR,5R,6S,7R,7aR)-5-(((3- hydroxypropyl)amino)met...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNCCCO)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C11H21N3O4S/c1-12-11-14-7-9(17)8(16)6(18-10(7)19-11)5-13-3-2-4-15/h6-10,13,15-17H,2-5H2,1H3,(H,12,14)/t6-,7-,8-,9-,10-/m1/s1
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6n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267962
PNG
((3aR,5R,6S,7R,7aR)-2- (methylamino)-5-(((tetrahydr...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNC3CCOCC3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C13H23N3O4S/c1-14-13-16-9-11(18)10(17)8(20-12(9)21-13)6-15-7-2-4-19-5-3-7/h7-12,15,17-18H,2-6H2,1H3,(H,14,16)/t8-,9-,10-,11-,12-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267966
PNG
((3aR,5R,6S,7R,7aR)-5-(((1H-pyrazol- 3-yl)amino)met...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNc3cc[nH]n3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C11H17N5O3S/c1-12-11-15-7-9(18)8(17)5(19-10(7)20-11)4-13-6-2-3-14-16-6/h2-3,5,7-10,17-18H,4H2,1H3,(H,12,15)(H2,13,14,16)/t5-,7-,8-,9-,10-/m1/s1
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6.80n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193651
PNG
(US9199949, 10)
Show SMILES OC[C@H]1C[C@@H]2OC(=N[C@@H]2[C@H](F)[C@@H]1O)N1CCC1
Show InChI InChI=1S/C11H17FN2O3/c12-8-9-7(4-6(5-15)10(8)16)17-11(13-9)14-2-1-3-14/h6-10,15-16H,1-5H2/t6-,7+,8+,9+,10-/m1/s1
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Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9199949 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NR8
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM255773
PNG
((3aR,5R,6S,7S,7aR)-2-(ethylamino)- 5-(hydroxymethy...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@H]2O)S1
Show InChI InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7+,8-/m1/s1
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7.30n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
A variety of tissue culture cell lines, expressing endogenous levels of O-GlcNAcase, can be utilized; examples include rat PC-12, and human U-87, or ...


US Patent US9701693 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM193652
PNG
(US9199949, 12)
Show SMILES CNC1=N[C@H]2[C@H](C[C@H](CO)[C@@H](O)[C@H]2F)O1
Show InChI InChI=1S/C9H15FN2O3/c1-11-9-12-7-5(15-9)2-4(3-13)8(14)6(7)10/h4-8,13-14H,2-3H2,1H3,(H,11,12)/t4-,5+,6+,7+,8-/m1/s1
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8.60n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9199949 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NR8
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267948
PNG
((3aR,5R,6S,7R,7aR)-5- ((cyclohexylamino)methyl)-2-...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](CNC3CCCCC3)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C14H25N3O3S/c1-15-14-17-10-12(19)11(18)9(20-13(10)21-14)7-16-8-5-3-2-4-6-8/h8-13,16,18-19H,2-7H2,1H3,(H,15,17)/t9-,10-,11-,12-,13-/m1/s1
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9.30n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240651
PNG
(US9409924, 11)
Show SMILES CN(C)C1=N[C@H]2[C@H](O[C@H]([C@@H](O)C(F)(F)F)[C@@H](O)[C@@H]2F)S1
Show InChI InChI=1S/C10H14F4N2O3S/c1-16(2)9-15-4-3(11)5(17)6(19-8(4)20-9)7(18)10(12,13)14/h3-8,17-18H,1-2H3/t3-,4-,5+,6+,7-,8-/m1/s1
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9.5n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267784
PNG
(((3aR,5R,6S,7R,7aR)-6,7-dihydroxy- 2-(methylamino)...)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](COC(=O)N(C)C)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C11H19N3O5S/c1-12-10-13-6-8(16)7(15)5(19-9(6)20-10)4-18-11(17)14(2)3/h5-9,15-16H,4H2,1-3H3,(H,12,13)/t5-,6-,7-,8-,9-/m1/s1
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9.90n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
Dihydrodipicolinate synthase-like, mitochondrial


(Homo sapiens)
BDBM267968
PNG
((3aR,5R,6S,7R,7aR)-5 (aminomethyl)-2-(ethylamino)-...)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H](CN)[C@@H](O)[C@@H]2O)S1
Show InChI InChI=1S/C9H17N3O3S/c1-2-11-9-12-5-7(14)6(13)4(3-10)15-8(5)16-9/h4-8,13-14H,2-3,10H2,1H3,(H,11,12)/t4-,5-,6-,7-,8-/m1/s1
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11n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9718854 (2017)

More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240647
PNG
(US9409924, 3)
Show SMILES CCNC1=N[C@H]2[C@H](O[C@H]([C@H](C)O)[C@@H](O)[C@@H]2F)S1
Show InChI InChI=1S/C10H17FN2O3S/c1-3-12-10-13-6-5(11)7(15)8(4(2)14)16-9(6)17-10/h4-9,14-15H,3H2,1-2H3,(H,12,13)/t4-,5+,6+,7-,8+,9+/m0/s1
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12n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM240656
PNG
(US9409924, 32)
Show SMILES O[C@H]([C@H]1O[C@@H]2SC(=N[C@@H]2[C@@H](F)[C@@H]1O)N1CCC1)C(F)(F)F
Show InChI InChI=1S/C11H14F4N2O3S/c12-4-5-9(21-10(16-5)17-2-1-3-17)20-7(6(4)18)8(19)11(13,14)15/h4-9,18-19H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1
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13n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9409924 (2016)


BindingDB Entry DOI: 10.7270/Q26H4G90
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205421
PNG
(US9243020, 4)
Show SMILES CN(C)C1=N[C@@H]2C[C@H](O)[C@@H](CO)O[C@@H]2S1
Show InChI InChI=1S/C9H16N2O3S/c1-11(2)9-10-5-3-6(13)7(4-12)14-8(5)15-9/h5-8,12-13H,3-4H2,1-2H3/t5-,6+,7-,8-/m1/s1
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13n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase)


(Homo sapiens (Human))
BDBM205428
PNG
(US9243020, 33)
Show SMILES CNC1=N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@H]2F)S1
Show InChI InChI=1S/C8H11F3N2O2S/c1-12-8-13-3-2(9)4(14)5(6(10)11)15-7(3)16-8/h2-7,14H,1H3,(H,12,13)/t2-,3+,4-,5-,7+/m0/s1
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13n/an/an/an/an/an/an/an/a



Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp.

US Patent


Assay Description
Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...


US Patent US9243020 (2016)


BindingDB Entry DOI: 10.7270/Q2542MD4
More data for this
Ligand-Target Pair
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