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Compile Data Set for Download or QSAR

Found 57 hits from Amarit Bioscience, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50249090
PNG
(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
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96n/an/an/an/an/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50249090
PNG
(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
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n/an/a 290n/an/an/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068649
PNG
(CHEMBL3402361)
Show SMILES Nc1cccc(Nc2ncc(F)c(Nc3cccc(N)c3)n2)c1
Show InChI InChI=1S/C16H15FN6/c17-14-9-20-16(22-13-6-2-4-11(19)8-13)23-15(14)21-12-5-1-3-10(18)7-12/h1-9H,18-19H2,(H2,20,21,22,23)
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n/an/a 320n/an/an/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068662
PNG
(CHEMBL3402400)
Show SMILES CCOc1ccc(Nc2nc(Nc3cccc(OCC(=O)NC)c3)ncc2F)cc1
Show InChI InChI=1S/C21H22FN5O3/c1-3-29-16-9-7-14(8-10-16)25-20-18(22)12-24-21(27-20)26-15-5-4-6-17(11-15)30-13-19(28)23-2/h4-12H,3,13H2,1-2H3,(H,23,28)(H2,24,25,26,27)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068777
PNG
(CHEMBL3402399)
Show SMILES CC(C)(CO)c1ccc(Nc2nc(Nc3cccc(OCCO)c3)ncc2F)cc1
Show InChI InChI=1S/C22H25FN4O3/c1-22(2,14-29)15-6-8-16(9-7-15)25-20-19(23)13-24-21(27-20)26-17-4-3-5-18(12-17)30-11-10-28/h3-9,12-13,28-29H,10-11,14H2,1-2H3,(H2,24,25,26,27)
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n/an/an/an/a 280n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068778
PNG
(CHEMBL3402398)
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc(cc3)C(C)(C)C)n2)c1
Show InChI InChI=1S/C23H26FN5O2/c1-23(2,3)15-8-10-16(11-9-15)27-21-19(24)13-26-22(29-21)28-17-6-5-7-18(12-17)31-14-20(30)25-4/h5-13H,14H2,1-4H3,(H,25,30)(H2,26,27,28,29)
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n/an/an/an/a 430n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068779
PNG
(CHEMBL3402397 | US9499493, R945071)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3ccc(OCC#N)cc3)n2)c1
Show InChI InChI=1S/C18H14FN5O2/c19-16-11-21-18(23-13-2-1-3-14(25)10-13)24-17(16)22-12-4-6-15(7-5-12)26-9-8-20/h1-7,10-11,25H,9H2,(H2,21,22,23,24)
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n/an/an/an/a 210n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068795
PNG
(CHEMBL3402396)
Show SMILES NC(=O)COc1ccc(Nc2nc(Nc3cccc(O)c3)ncc2F)cc1
Show InChI InChI=1S/C18H16FN5O3/c19-15-9-21-18(23-12-2-1-3-13(25)8-12)24-17(15)22-11-4-6-14(7-5-11)27-10-16(20)26/h1-9,25H,10H2,(H2,20,26)(H2,21,22,23,24)
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n/an/an/an/a 1.55E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068797
PNG
(CHEMBL3402395)
Show SMILES Oc1cccc(Nc2nc(Nc3ccc(OCC#N)cc3)ncc2F)c1
Show InChI InChI=1S/C18H14FN5O2/c19-16-11-21-18(23-12-4-6-15(7-5-12)26-9-8-20)24-17(16)22-13-2-1-3-14(25)10-13/h1-7,10-11,25H,9H2,(H2,21,22,23,24)
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n/an/an/an/a 450n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068798
PNG
(CHEMBL3402394)
Show SMILES NC(=O)COc1ccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)cc1
Show InChI InChI=1S/C18H16FN5O3/c19-15-9-21-18(24-17(15)22-12-2-1-3-13(25)8-12)23-11-4-6-14(7-5-11)27-10-16(20)26/h1-9,25H,10H2,(H2,20,26)(H2,21,22,23,24)
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n/an/an/an/a 530n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068799
PNG
(CHEMBL3402393)
Show SMILES Cn1nnnc1COc1ccc(Nc2ncc(F)c(Nc3ccc(OCc4nnnn4C)cc3)n2)cc1
Show InChI InChI=1S/C22H21FN12O2/c1-34-19(28-30-32-34)12-36-16-7-3-14(4-8-16)25-21-18(23)11-24-22(27-21)26-15-5-9-17(10-6-15)37-13-20-29-31-33-35(20)2/h3-11H,12-13H2,1-2H3,(H2,24,25,26,27)
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n/an/an/an/a 760n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068800
PNG
(CHEMBL3402391)
Show SMILES CN(C)C(=O)CNc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C20H21FN6O2/c1-27(2)18(29)12-22-13-5-3-6-14(9-13)25-20-23-11-17(21)19(26-20)24-15-7-4-8-16(28)10-15/h3-11,22,28H,12H2,1-2H3,(H2,23,24,25,26)
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n/an/an/an/a 490n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068801
PNG
(CHEMBL3402390)
Show SMILES NC(=O)CNc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C18H17FN6O2/c19-15-9-22-18(25-17(15)23-13-5-2-6-14(26)8-13)24-12-4-1-3-11(7-12)21-10-16(20)27/h1-9,21,26H,10H2,(H2,20,27)(H2,22,23,24,25)
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n/an/an/an/a 440n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068802
PNG
(CHEMBL3400172)
Show SMILES COCCOc1cccc(Nc2ncc(F)c(Nc3cccc(OCCOC)c3)n2)c1
Show InChI InChI=1S/C22H25FN4O4/c1-28-9-11-30-18-7-3-5-16(13-18)25-21-20(23)15-24-22(27-21)26-17-6-4-8-19(14-17)31-12-10-29-2/h3-8,13-15H,9-12H2,1-2H3,(H2,24,25,26,27)
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n/an/an/an/a 4.15E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068803
PNG
(CHEMBL3402389)
Show SMILES OCCOc1cccc(Nc2ncc(F)c(Nc3cccc(OCCO)c3)n2)c1
Show InChI InChI=1S/C20H21FN4O4/c21-18-13-22-20(24-15-4-2-6-17(12-15)29-10-8-27)25-19(18)23-14-3-1-5-16(11-14)28-9-7-26/h1-6,11-13,26-27H,7-10H2,(H2,22,23,24,25)
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n/an/an/an/a 930n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068804
PNG
(CHEMBL3402388)
Show SMILES CNC(=O)CNc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C19H19FN6O2/c1-21-17(28)11-22-12-4-2-5-13(8-12)25-19-23-10-16(20)18(26-19)24-14-6-3-7-15(27)9-14/h2-10,22,27H,11H2,1H3,(H,21,28)(H2,23,24,25,26)
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n/an/an/an/a 290n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068805
PNG
(CHEMBL3402387)
Show SMILES CCOC(=O)CNc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C20H20FN5O3/c1-2-29-18(28)12-22-13-5-3-6-14(9-13)25-20-23-11-17(21)19(26-20)24-15-7-4-8-16(27)10-15/h3-11,22,27H,2,12H2,1H3,(H2,23,24,25,26)
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n/an/an/an/a 330n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068806
PNG
(CHEMBL3402386)
Show SMILES OCCOc1cccc(Nc2nc(Nc3cccc(O)c3)ncc2F)c1
Show InChI InChI=1S/C18H17FN4O3/c19-16-11-20-18(22-12-3-1-5-14(25)9-12)23-17(16)21-13-4-2-6-15(10-13)26-8-7-24/h1-6,9-11,24-25H,7-8H2,(H2,20,21,22,23)
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n/an/an/an/a 670n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068807
PNG
(CHEMBL3402385)
Show SMILES COC(=O)COc1ccc(Nc2nc(Nc3ccc(OCC(N)=O)cc3)ncc2F)cc1
Show InChI InChI=1S/C21H20FN5O5/c1-30-19(29)12-32-16-6-2-13(3-7-16)25-20-17(22)10-24-21(27-20)26-14-4-8-15(9-5-14)31-11-18(23)28/h2-10H,11-12H2,1H3,(H2,23,28)(H2,24,25,26,27)
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n/an/an/an/a 940n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068855
PNG
(CHEMBL3402384)
Show SMILES COC(=O)COc1ccc(Nc2ncc(F)c(Nc3ccc(OCC(N)=O)cc3)n2)cc1
Show InChI InChI=1S/C21H20FN5O5/c1-30-19(29)12-32-16-8-4-14(5-9-16)26-21-24-10-17(22)20(27-21)25-13-2-6-15(7-3-13)31-11-18(23)28/h2-10H,11-12H2,1H3,(H2,23,28)(H2,24,25,26,27)
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n/an/an/an/a 430n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068856
PNG
(CHEMBL3402383)
Show SMILES Fc1cnc(Nc2ccc(OCC#N)cc2)nc1Nc1ccc(OCC#N)cc1
Show InChI InChI=1S/C20H15FN6O2/c21-18-13-24-20(26-15-3-7-17(8-4-15)29-12-10-23)27-19(18)25-14-1-5-16(6-2-14)28-11-9-22/h1-8,13H,11-12H2,(H2,24,25,26,27)
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n/an/an/an/a 370n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068857
PNG
(CHEMBL3402380)
Show SMILES COC(=O)COc1ccc(Nc2ncc(F)c(Nc3ccc(OCC(=O)OC)cc3)n2)cc1
Show InChI InChI=1S/C22H21FN4O6/c1-30-19(28)12-32-16-7-3-14(4-8-16)25-21-18(23)11-24-22(27-21)26-15-5-9-17(10-6-15)33-13-20(29)31-2/h3-11H,12-13H2,1-2H3,(H2,24,25,26,27)
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n/an/an/an/a 380n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50249090
PNG
(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Show SMILES Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
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n/an/an/an/a 350n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM31853
PNG
(2,4-Bisanilinopyrimidine, 18)
Show SMILES Oc1ccc(Nc2ncc(F)c(Nc3ccc(O)cc3)n2)cc1
Show InChI InChI=1S/C16H13FN4O2/c17-14-9-18-16(20-11-3-7-13(23)8-4-11)21-15(14)19-10-1-5-12(22)6-2-10/h1-9,22-23H,(H2,18,19,20,21)
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n/an/an/an/a 3.40E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068858
PNG
(CHEMBL3402379)
Show SMILES Oc1cccc(Nc2ncc(c(Nc3cccc(O)c3)n2)C(F)(F)F)c1
Show InChI InChI=1S/C17H13F3N4O2/c18-17(19,20)14-9-21-16(23-11-4-2-6-13(26)8-11)24-15(14)22-10-3-1-5-12(25)7-10/h1-9,25-26H,(H2,21,22,23,24)
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n/an/an/an/a 270n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068859
PNG
(CHEMBL3402378)
Show SMILES Oc1cccc(Nc2ncc(C#N)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C17H13N5O2/c18-9-11-10-19-17(21-13-4-2-6-15(24)8-13)22-16(11)20-12-3-1-5-14(23)7-12/h1-8,10,23-24H,(H2,19,20,21,22)
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n/an/an/an/a 440n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068860
PNG
(CHEMBL3402377)
Show SMILES Oc1cccc(Nc2ncc(Br)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C16H13BrN4O2/c17-14-9-18-16(20-11-4-2-6-13(23)8-11)21-15(14)19-10-3-1-5-12(22)7-10/h1-9,22-23H,(H2,18,19,20,21)
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n/an/an/an/a 230n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068861
PNG
(CHEMBL3402376)
Show SMILES Oc1cccc(Nc2ncc(-c3ccccc3)c(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C22H18N4O2/c27-18-10-4-8-16(12-18)24-21-20(15-6-2-1-3-7-15)14-23-22(26-21)25-17-9-5-11-19(28)13-17/h1-14,27-28H,(H2,23,24,25,26)
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n/an/an/an/a 2.90E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068862
PNG
(CHEMBL3402375)
Show SMILES Oc1cccc(Nc2cc(nc(Nc3cccc(O)c3)n2)-c2ccccc2)c1
Show InChI InChI=1S/C22H18N4O2/c27-18-10-4-8-16(12-18)23-21-14-20(15-6-2-1-3-7-15)25-22(26-21)24-17-9-5-11-19(28)13-17/h1-14,27-28H,(H2,23,24,25,26)
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n/an/an/an/a 5.80E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068863
PNG
(CHEMBL3402374)
Show SMILES Cc1cnc(Nc2cccc(O)c2)nc1Nc1cccc(O)c1
Show InChI InChI=1S/C17H16N4O2/c1-11-10-18-17(20-13-5-3-7-15(23)9-13)21-16(11)19-12-4-2-6-14(22)8-12/h2-10,22-23H,1H3,(H2,18,19,20,21)
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n/an/an/an/a 900n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068864
PNG
(CHEMBL3402373)
Show SMILES Oc1cccc(Nc2ccnc(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C16H14N4O2/c21-13-5-1-3-11(9-13)18-15-7-8-17-16(20-15)19-12-4-2-6-14(22)10-12/h1-10,21-22H,(H2,17,18,19,20)
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n/an/an/an/a 500n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068865
PNG
(CHEMBL3402372)
Show SMILES OCc1cccc(Nc2ncc(F)c(Nc3cccc(CO)c3)n2)c1
Show InChI InChI=1S/C18H17FN4O2/c19-16-9-20-18(22-15-6-2-4-13(8-15)11-25)23-17(16)21-14-5-1-3-12(7-14)10-24/h1-9,24-25H,10-11H2,(H2,20,21,22,23)
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n/an/an/an/a 2.80E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068866
PNG
(CHEMBL3402371)
Show SMILES CC(C)Oc1ccc(Nc2ncc(F)c(Nc3ccc(OC(C)C)cc3)n2)cc1
Show InChI InChI=1S/C22H25FN4O2/c1-14(2)28-18-9-5-16(6-10-18)25-21-20(23)13-24-22(27-21)26-17-7-11-19(12-8-17)29-15(3)4/h5-15H,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068867
PNG
(CHEMBL3402370)
Show SMILES Fc1cnc(Nc2cccc(Cl)c2)nc1Nc1cccc(Cl)c1
Show InChI InChI=1S/C16H11Cl2FN4/c17-10-3-1-5-12(7-10)21-15-14(19)9-20-16(23-15)22-13-6-2-4-11(18)8-13/h1-9H,(H2,20,21,22,23)
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n/an/an/an/a 5.81E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068868
PNG
(CHEMBL3402369)
Show SMILES Fc1cnc(Nc2cccc(OC(F)(F)F)c2)nc1Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H11F7N4O2/c19-14-9-26-16(28-11-4-2-6-13(8-11)31-18(23,24)25)29-15(14)27-10-3-1-5-12(7-10)30-17(20,21)22/h1-9H,(H2,26,27,28,29)
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n/an/an/an/a 5.08E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068869
PNG
(CHEMBL3402368)
Show SMILES Fc1cnc(Nc2cccc(c2)C#N)nc1Nc1cccc(c1)C#N
Show InChI InChI=1S/C18H11FN6/c19-16-11-22-18(24-15-6-2-4-13(8-15)10-21)25-17(16)23-14-5-1-3-12(7-14)9-20/h1-8,11H,(H2,22,23,24,25)
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n/an/an/an/a 950n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068870
PNG
(CHEMBL3402367)
Show SMILES Fc1cnc(Nc2ccc(cc2)C#N)nc1Nc1ccc(cc1)C#N
Show InChI InChI=1S/C18H11FN6/c19-16-11-22-18(24-15-7-3-13(10-21)4-8-15)25-17(16)23-14-5-1-12(9-20)2-6-14/h1-8,11H,(H2,22,23,24,25)
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n/an/an/an/a 9.83E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068871
PNG
(CHEMBL3402366)
Show SMILES Fc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1Nc1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C24H27FN6O2/c25-22-17-26-24(28-19-3-7-21(8-4-19)31-11-15-33-16-12-31)29-23(22)27-18-1-5-20(6-2-18)30-9-13-32-14-10-30/h1-8,17H,9-16H2,(H2,26,27,28,29)
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n/an/an/an/a 4.14E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068872
PNG
(CHEMBL3402363)
Show SMILES CCOc1ccc(Nc2ccnc(Nc3ccc(OCC)cc3)n2)cc1
Show InChI InChI=1S/C20H22N4O2/c1-3-25-17-9-5-15(6-10-17)22-19-13-14-21-20(24-19)23-16-7-11-18(12-8-16)26-4-2/h5-14H,3-4H2,1-2H3,(H2,21,22,23,24)
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n/an/an/an/a 3.38E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068649
PNG
(CHEMBL3402361)
Show SMILES Nc1cccc(Nc2ncc(F)c(Nc3cccc(N)c3)n2)c1
Show InChI InChI=1S/C16H15FN6/c17-14-9-20-16(22-13-6-2-4-11(19)8-13)23-15(14)21-12-5-1-3-10(18)7-12/h1-9H,18-19H2,(H2,20,21,22,23)
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n/an/an/an/a 460n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068873
PNG
(CHEMBL3402360)
Show SMILES Nc1ccc(Nc2ncc(F)c(Nc3ccc(N)cc3)n2)cc1
Show InChI InChI=1S/C16H15FN6/c17-14-9-20-16(22-13-7-3-11(19)4-8-13)23-15(14)21-12-5-1-10(18)2-6-12/h1-9H,18-19H2,(H2,20,21,22,23)
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n/an/an/an/a 4.25E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068874
PNG
(CHEMBL3402359)
Show SMILES COc1cccc(Nc2ncc(F)c(Nc3cccc(OC)c3)n2)c1
Show InChI InChI=1S/C18H17FN4O2/c1-24-14-7-3-5-12(9-14)21-17-16(19)11-20-18(23-17)22-13-6-4-8-15(10-13)25-2/h3-11H,1-2H3,(H2,20,21,22,23)
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n/an/an/an/a 1.73E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM31850
PNG
(2,4-Bisanilinopyrimidine, 12)
Show SMILES COc1ccc(Nc2ncc(F)c(Nc3ccc(OC)cc3)n2)cc1
Show InChI InChI=1S/C18H17FN4O2/c1-24-14-7-3-12(4-8-14)21-17-16(19)11-20-18(23-17)22-13-5-9-15(25-2)10-6-13/h3-11H,1-2H3,(H2,20,21,22,23)
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n/an/an/an/a 1.43E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068875
PNG
(CHEMBL3402358)
Show SMILES CCOc1cccc(Nc2ncc(F)c(Nc3cccc(OCC)c3)n2)c1
Show InChI InChI=1S/C20H21FN4O2/c1-3-26-16-9-5-7-14(11-16)23-19-18(21)13-22-20(25-19)24-15-8-6-10-17(12-15)27-4-2/h5-13H,3-4H2,1-2H3,(H2,22,23,24,25)
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n/an/an/an/a 3.10E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50396072
PNG
(CHEMBL2170583)
Show SMILES CCOc1ccc(Nc2ncc(F)c(Nc3ccc(OCC)cc3)n2)cc1
Show InChI InChI=1S/C20H21FN4O2/c1-3-26-16-9-5-14(6-10-16)23-19-18(21)13-22-20(25-19)24-15-7-11-17(12-8-15)27-4-2/h5-13H,3-4H2,1-2H3,(H2,22,23,24,25)
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n/an/an/an/a 1.67E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assay


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068857
PNG
(CHEMBL3402380)
Show SMILES COC(=O)COc1ccc(Nc2ncc(F)c(Nc3ccc(OCC(=O)OC)cc3)n2)cc1
Show InChI InChI=1S/C22H21FN4O6/c1-30-19(28)12-32-16-7-3-14(4-8-16)25-21-18(23)11-24-22(27-21)26-15-5-9-17(10-6-15)33-13-20(29)31-2/h3-11H,12-13H2,1-2H3,(H2,24,25,26,27)
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n/an/an/an/a 1.70E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068855
PNG
(CHEMBL3402384)
Show SMILES COC(=O)COc1ccc(Nc2ncc(F)c(Nc3ccc(OCC(N)=O)cc3)n2)cc1
Show InChI InChI=1S/C21H20FN5O5/c1-30-19(29)12-32-16-8-4-14(5-9-16)26-21-24-10-17(22)20(27-21)25-13-2-6-15(7-3-13)31-11-18(23)28/h2-10H,11-12H2,1H3,(H2,23,28)(H2,24,25,26,27)
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n/an/an/an/a 2.48E+3n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068807
PNG
(CHEMBL3402385)
Show SMILES COC(=O)COc1ccc(Nc2nc(Nc3ccc(OCC(N)=O)cc3)ncc2F)cc1
Show InChI InChI=1S/C21H20FN5O5/c1-30-19(29)12-32-16-6-2-13(3-7-16)25-20-17(22)10-24-21(27-20)26-14-4-8-15(9-5-14)31-11-18(23)28/h2-10H,11-12H2,1H3,(H2,23,28)(H2,24,25,26,27)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068798
PNG
(CHEMBL3402394)
Show SMILES NC(=O)COc1ccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)cc1
Show InChI InChI=1S/C18H16FN5O3/c19-15-9-21-18(24-17(15)22-12-2-1-3-13(25)8-12)23-11-4-6-14(7-5-11)27-10-16(20)26/h1-9,25H,10H2,(H2,20,26)(H2,21,22,23,24)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM50068797
PNG
(CHEMBL3402395)
Show SMILES Oc1cccc(Nc2nc(Nc3ccc(OCC#N)cc3)ncc2F)c1
Show InChI InChI=1S/C18H14FN5O2/c19-16-11-21-18(23-12-4-6-15(7-5-12)26-9-8-20)24-17(16)22-13-2-1-3-14(25)10-13/h1-7,10-11,25H,9H2,(H2,21,22,23,24)
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n/an/an/an/a 1.00E+4n/an/an/an/a



Amarit Bioscience, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...


Bioorg Med Chem Lett 25: 2117-21 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.075
BindingDB Entry DOI: 10.7270/Q2R49SFK
More data for this
Ligand-Target Pair
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