BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 34 hits from Ambit Biosciences Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a>200n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR2


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 2.20n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRbeta


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310629
PNG
(CHEMBL1081166 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)Cc3ccccc3)cc2)no1
Show InChI InChI=1S/C22H24N4O3/c1-22(2,3)18-14-19(26-29-18)25-21(28)24-17-11-9-16(10-12-17)23-20(27)13-15-7-5-4-6-8-15/h4-12,14H,13H2,1-3H3,(H,23,27)(H2,24,25,26,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 510n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310630
PNG
(CHEMBL1081167 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)C3CCNCC3)cc2)no1
Show InChI InChI=1S/C20H27N5O3/c1-20(2,3)16-12-17(25-28-16)24-19(27)23-15-6-4-14(5-7-15)22-18(26)13-8-10-21-11-9-13/h4-7,12-13,21H,8-11H2,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 240n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310631
PNG
(CHEMBL1081169 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccccc3)cc2)no1
Show InChI InChI=1S/C21H22N4O3/c1-21(2,3)17-13-18(25-28-17)24-20(27)23-16-11-9-15(10-12-16)22-19(26)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.980n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310632
PNG
(CHEMBL1081345 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc4ccccc4c3)cc2)no1
Show InChI InChI=1S/C25H24N4O3/c1-25(2,3)21-15-22(29-32-21)28-24(31)27-20-12-10-19(11-13-20)26-23(30)18-9-8-16-6-4-5-7-17(16)14-18/h4-15H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.75n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310633
PNG
(CHEMBL1081346 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccccn3)cc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-12-17(25-28-16)24-19(27)23-14-9-7-13(8-10-14)22-18(26)15-6-4-5-11-21-15/h4-12H,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.760n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310634
PNG
(CHEMBL1078027 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cccnc3)cc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-11-17(25-28-16)24-19(27)23-15-8-6-14(7-9-15)22-18(26)13-5-4-10-21-12-13/h4-12H,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 15n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310635
PNG
(CHEMBL1082075 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccncc3)cc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-12-17(25-28-16)24-19(27)23-15-6-4-14(5-7-15)22-18(26)13-8-10-21-11-9-13/h4-12H,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 10.1n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310636
PNG
(CHEMBL1079544 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cccc(=O)[nH]3)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)22-13-9-7-12(8-10-13)21-18(27)14-5-4-6-17(26)23-14/h4-11H,1-3H3,(H,21,27)(H,23,26)(H2,22,24,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 2.5n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.740n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310638
PNG
(CHEMBL1080063 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES Cc1ccc2sc(cc2c1)C(=O)Nc1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1
Show InChI InChI=1S/C24H24N4O3S/c1-14-5-10-18-15(11-14)12-19(32-18)22(29)25-16-6-8-17(9-7-16)26-23(30)27-21-13-20(31-28-21)24(2,3)4/h5-13H,1-4H3,(H,25,29)(H2,26,27,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 0.770n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310639
PNG
(CHEMBL1080064 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3nccc4ccccc34)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)19-14-20(29-32-19)28-23(31)27-17-10-8-16(9-11-17)26-22(30)21-18-7-5-4-6-15(18)12-13-25-21/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.740n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 1.10n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 1.60n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310640
PNG
(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-N-phenylbe...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2)no1
Show InChI InChI=1S/C21H22N4O3/c1-21(2,3)17-13-18(25-28-17)24-20(27)23-16-11-9-14(10-12-16)19(26)22-15-7-5-4-6-8-15/h4-13H,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 7.40n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310641
PNG
(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-N-(pyridin...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)C(=O)Nc2ccccn2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)15-12-17(25-28-15)24-19(27)22-14-9-7-13(8-10-14)18(26)23-16-6-4-5-11-21-16/h4-12H,1-3H3,(H,21,23,26)(H2,22,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 8.15n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310642
PNG
(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-N-(pyridin...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)C(=O)Nc2cccnc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-11-17(25-28-16)24-19(27)23-14-8-6-13(7-9-14)18(26)22-15-5-4-10-21-12-15/h4-12H,1-3H3,(H,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 25n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50310643
PNG
(4-(3-(5-tert-butylisoxazol-3-yl)ureido)-N-(pyridin...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)C(=O)Nc2ccncc2)no1
Show InChI InChI=1S/C20H21N5O3/c1-20(2,3)16-12-17(25-28-16)24-19(27)23-14-6-4-13(5-7-14)18(26)22-15-8-10-21-11-9-15/h4-12H,1-3H3,(H,21,22,26)(H2,23,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 38.4n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to FLT3


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 0.960n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to KIT


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 1.80n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to KIT


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 7.5n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to KIT


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 4.40n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 8.5n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Macrophage colony stimulating factor receptor


(Homo sapiens (human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 10n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to CSF1R


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Re


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 4.70n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to RET


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Re


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 7.30n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to RET


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Re


(Homo sapiens (Human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 3n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to RET


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 1n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRalpha


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 9.90n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRalpha


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a 4.30n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRalpha


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50310637
PNG
(CHEMBL1079545 | N-(4-(3-(5-tert-butylisoxazol-3-yl...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1
Show InChI InChI=1S/C20H21N5O4/c1-20(2,3)15-11-16(25-29-15)24-19(28)23-13-8-6-12(7-9-13)22-18(27)17-14(26)5-4-10-21-17/h4-11,26H,1-3H3,(H,22,27)(H2,23,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 2.60n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRbeta


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50310628
PNG
(AB-460 | CHEMBL1081509 | N-(4-(3-(5-tert-butylisox...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1
Show InChI InChI=1S/C24H23N5O3/c1-24(2,3)20-13-21(29-32-20)28-23(31)27-18-10-8-17(9-11-18)26-22(30)19-12-15-6-4-5-7-16(15)14-25-19/h4-14H,1-3H3,(H,26,30)(H2,27,28,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 7n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to PDGFRbeta


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50300691
PNG
(Benzo[d]imidazo[2,1-b]thiazole-2-carboxylic acid {...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cn4c(n3)sc3ccccc43)cc2)no1
Show InChI InChI=1S/C24H22N6O3S/c1-24(2,3)19-12-20(29-33-19)28-22(32)26-15-10-8-14(9-11-15)25-21(31)16-13-30-17-6-4-5-7-18(17)34-23(30)27-16/h4-13H,1-3H3,(H,25,31)(H2,26,28,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/a>200n/an/an/an/an/a



Ambit Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity to VEGFR2


Bioorg Med Chem Lett 19: 5182-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.024
BindingDB Entry DOI: 10.7270/Q2PG1RVB
More data for this
Ligand-Target Pair