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Compile Data Set for Download or QSAR

Found 122 hits from Amgen   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500213
PNG
(CHEMBL3746243)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1c(Cl)cnc(N)c1F
Show InChI InChI=1S/C25H24ClFN4O3S2/c1-25(2,32)14-8-9-29-18(11-14)16-5-3-4-13-10-19(35-23(13)16)22(31-36(33,34)15-6-7-15)20-17(26)12-30-24(28)21(20)27/h3-5,8-12,15,22,31-32H,6-7H2,1-2H3,(H2,28,30)/t22-/m0/s1
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n/an/a 3.80n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500210
PNG
(CHEMBL3745887)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1nc(N)ccc1Cl
Show InChI InChI=1S/C25H25ClN4O3S2/c1-25(2,31)15-10-11-28-19(13-15)17-5-3-4-14-12-20(34-24(14)17)23(30-35(32,33)16-6-7-16)22-18(26)8-9-21(27)29-22/h3-5,8-13,16,23,30-31H,6-7H2,1-2H3,(H2,27,29)/t23-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500200
PNG
(CHEMBL3746444)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1nc(N)c(F)cc1Cl
Show InChI InChI=1S/C25H24ClFN4O3S2/c1-25(2,32)14-8-9-29-19(11-14)16-5-3-4-13-10-20(35-23(13)16)22(31-36(33,34)15-6-7-15)21-17(26)12-18(27)24(28)30-21/h3-5,8-12,15,22,31-32H,6-7H2,1-2H3,(H2,28,30)/t22-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500205
PNG
(CHEMBL3746456)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)c1ccc2OCCCOc2c1)c1cc2ccccc2s1
Show InChI InChI=1S/C24H20ClNO4S2/c25-19-8-3-2-7-18(19)24(23-14-16-6-1-4-9-22(16)31-23)26-32(27,28)17-10-11-20-21(15-17)30-13-5-12-29-20/h1-4,6-11,14-15,24,26H,5,12-13H2/t24-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500201
PNG
(CHEMBL3746034)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1nc(N)ncc1Cl
Show InChI InChI=1S/C24H24ClN5O3S2/c1-24(2,31)14-8-9-27-18(11-14)16-5-3-4-13-10-19(34-22(13)16)21(30-35(32,33)15-6-7-15)20-17(25)12-28-23(26)29-20/h3-5,8-12,15,21,30-31H,6-7H2,1-2H3,(H2,26,28,29)/t21-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500203
PNG
(CHEMBL3746655)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1cc(N)ncc1Cl
Show InChI InChI=1S/C25H25ClN4O3S2/c1-25(2,31)15-8-9-28-20(11-15)17-5-3-4-14-10-21(34-24(14)17)23(30-35(32,33)16-6-7-16)18-12-22(27)29-13-19(18)26/h3-5,8-13,16,23,30-31H,6-7H2,1-2H3,(H2,27,29)/t23-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500204
PNG
(CHEMBL3747784)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)c1ccc2OCCCOc2c1)c1cc2ccccc2o1
Show InChI InChI=1S/C24H20ClNO5S/c25-19-8-3-2-7-18(19)24(23-14-16-6-1-4-9-20(16)31-23)26-32(27,28)17-10-11-21-22(15-17)30-13-5-12-29-21/h1-4,6-11,14-15,24,26H,5,12-13H2/t24-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500193
PNG
(CHEMBL3747365)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1c(F)cccc1Cl
Show InChI InChI=1S/C26H24ClFN2O3S2/c1-26(2,31)16-11-12-29-21(14-16)18-6-3-5-15-13-22(34-25(15)18)24(30-35(32,33)17-9-10-17)23-19(27)7-4-8-20(23)28/h3-8,11-14,17,24,30-31H,9-10H2,1-2H3/t24-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500206
PNG
(CHEMBL3746828)
Show SMILES FC1COc2ccc(cc2OC1)S(=O)(=O)N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl
Show InChI InChI=1S/C24H19ClFNO4S2/c25-19-7-3-2-6-18(19)24(23-11-15-5-1-4-8-22(15)32-23)27-33(28,29)17-9-10-20-21(12-17)31-14-16(26)13-30-20/h1-12,16,24,27H,13-14H2/t16?,24-/m1/s1
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n/an/a 74n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500216
PNG
(CHEMBL3745736)
Show SMILES OC1COc2ccc(cc2OC1)S(=O)(=O)N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl
Show InChI InChI=1S/C24H20ClNO5S2/c25-19-7-3-2-6-18(19)24(23-11-15-5-1-4-8-22(15)32-23)26-33(28,29)17-9-10-20-21(12-17)31-14-16(27)13-30-20/h1-12,16,24,26-27H,13-14H2/t16?,24-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500202
PNG
(CHEMBL3746320)
Show SMILES CC(C)(O)c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl
Show InChI InChI=1S/C26H25ClN2O3S2/c1-26(2,30)17-12-13-28-22(15-17)20-8-5-6-16-14-23(33-25(16)20)24(19-7-3-4-9-21(19)27)29-34(31,32)18-10-11-18/h3-9,12-15,18,24,29-30H,10-11H2,1-2H3/t24-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500195
PNG
(CHEMBL3746391)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)c1ccc2OCCCOc2c1)c1nc2cccnc2s1
Show InChI InChI=1S/C22H18ClN3O4S2/c23-16-6-2-1-5-15(16)20(22-25-17-7-3-10-24-21(17)31-22)26-32(27,28)14-8-9-18-19(13-14)30-12-4-11-29-18/h1-3,5-10,13,20,26H,4,11-12H2/t20-/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500199
PNG
(CHEMBL3747490)
Show SMILES C[C@](O)(c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H22ClF3N2O3S2/c1-25(33,26(28,29)30)16-11-12-31-21(14-16)19-7-4-5-15-13-22(36-24(15)19)23(18-6-2-3-8-20(18)27)32-37(34,35)17-9-10-17/h2-8,11-14,17,23,32-33H,9-10H2,1H3/t23-,25+/m1/s1
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n/an/a 190n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500198
PNG
(CHEMBL3745752)
Show SMILES C[C@@](O)(c1ccnc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C26H22ClF3N2O3S2/c1-25(33,26(28,29)30)16-11-12-31-21(14-16)19-7-4-5-15-13-22(36-24(15)19)23(18-6-2-3-8-20(18)27)32-37(34,35)17-9-10-17/h2-8,11-14,17,23,32-33H,9-10H2,1H3/t23-,25-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500207
PNG
(CHEMBL3747590)
Show SMILES FC1(F)COc2ccc(cc2OC1)S(=O)(=O)N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl
Show InChI InChI=1S/C24H18ClF2NO4S2/c25-18-7-3-2-6-17(18)23(22-11-15-5-1-4-8-21(15)33-22)28-34(29,30)16-9-10-19-20(12-16)32-14-24(26,27)13-31-19/h1-12,23,28H,13-14H2/t23-/m1/s1
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n/an/a 810n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500194
PNG
(CHEMBL3746716)
Show SMILES O=S(=O)(N[C@@H](c1cc2ccccc2o1)c1ccccc1)c1ccc2OCCCOc2c1
Show InChI InChI=1S/C24H21NO5S/c26-31(27,19-11-12-21-22(16-19)29-14-6-13-28-21)25-24(17-7-2-1-3-8-17)23-15-18-9-4-5-10-20(18)30-23/h1-5,7-12,15-16,24-25H,6,13-14H2/t24-/m1/s1
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n/an/a 870n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500197
PNG
(CHEMBL3746823)
Show SMILES O=S(=O)(NC(c1cc2ccccc2o1)c1ccccc1)c1ccc2OCCCOc2c1
Show InChI InChI=1S/C24H21NO5S/c26-31(27,19-11-12-21-22(16-19)29-14-6-13-28-21)25-24(17-7-2-1-3-8-17)23-15-18-9-4-5-10-20(18)30-23/h1-5,7-12,15-16,24-25H,6,13-14H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500215
PNG
(CHEMBL3746762)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)c1ccc2OCCOc2c1)c1cc2ccccc2s1
Show InChI InChI=1S/C23H18ClNO4S2/c24-18-7-3-2-6-17(18)23(22-13-15-5-1-4-8-21(15)30-22)25-31(26,27)16-9-10-19-20(14-16)29-12-11-28-19/h1-10,13-14,23,25H,11-12H2/t23-/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500214
PNG
(CHEMBL3746954)
Show SMILES C[C@](O)(c1cccc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H23ClF3NO3S2/c1-26(33,27(29,30)31)18-8-4-6-16(14-18)20-10-5-7-17-15-23(36-25(17)20)24(21-9-2-3-11-22(21)28)32-37(34,35)19-12-13-19/h2-11,14-15,19,24,32-33H,12-13H2,1H3/t24-,26+/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500196
PNG
(CHEMBL3746846)
Show SMILES C[C@@](O)(c1cccc(c1)-c1cccc2cc(sc12)[C@H](NS(=O)(=O)C1CC1)c1ccccc1Cl)C(F)(F)F
Show InChI InChI=1S/C27H23ClF3NO3S2/c1-26(33,27(29,30)31)18-8-4-6-16(14-18)20-10-5-7-17-15-23(36-25(17)20)24(21-9-2-3-11-22(21)28)32-37(34,35)19-12-13-19/h2-11,14-15,19,24,32-33H,12-13H2,1H3/t24-,26-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500211
PNG
(CHEMBL3746703)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)c1ccc2OCOc2c1)c1cc2ccccc2s1
Show InChI InChI=1S/C22H16ClNO4S2/c23-17-7-3-2-6-16(17)22(21-11-14-5-1-4-8-20(14)29-21)24-30(25,26)15-9-10-18-19(12-15)28-13-27-18/h1-12,22,24H,13H2/t22-/m1/s1
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n/an/a 6.50E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500208
PNG
(CHEMBL3745912)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl
Show InChI InChI=1S/C22H18ClNO3S2/c1-27-16-10-12-17(13-11-16)29(25,26)24-22(18-7-3-4-8-19(18)23)21-14-15-6-2-5-9-20(15)28-21/h2-14,22,24H,1H3/t22-/m1/s1
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n/an/a 7.30E+3n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500212
PNG
(CHEMBL3747326)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)C1CC1)c1cc2ccccc2s1
Show InChI InChI=1S/C18H16ClNO2S2/c19-15-7-3-2-6-14(15)18(20-24(21,22)13-9-10-13)17-11-12-5-1-4-8-16(12)23-17/h1-8,11,13,18,20H,9-10H2/t18-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Glucokinase regulatory protein


(Homo sapiens (Human))
BDBM50500209
PNG
(CHEMBL3747144)
Show SMILES Clc1ccccc1[C@@H](NS(=O)(=O)c1ccccc1)c1cc2ccccc2s1
Show InChI InChI=1S/C21H16ClNO2S2/c22-18-12-6-5-11-17(18)21(20-14-15-8-4-7-13-19(15)26-20)23-27(24,25)16-9-2-1-3-10-16/h1-14,21,23H/t21-/m1/s1
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n/an/a>3.30E+4n/an/an/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Binding affinity to human biotinylated AviTag GKRP assessed as inhibition of protein interaction with fluorescein tagged human glucokinase by AlphaSc...


J Med Chem 58: 9663-79 (2015)

More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM50158345
PNG
(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Show SMILES FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
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n/an/an/an/a>2.50E+4n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM23165
PNG
(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Show SMILES CCCCCCCCc1ccc(CC[C@](N)(CO)COP(O)(O)=O)cc1
Show InChI InChI=1/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)/t19-/s2
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n/an/an/an/a 27n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM50361891
PNG
(CHEMBL1938952)
Show SMILES COc1ccncc1C(=O)NC(=O)Nc1ccc(-c2ccccc2)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H16F3N3O3/c1-30-18-9-10-25-12-16(18)19(28)27-20(29)26-14-7-8-15(13-5-3-2-4-6-13)17(11-14)21(22,23)24/h2-12H,1H3,(H2,26,27,28,29)
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n/an/an/an/a>2.50E+4n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50158345
PNG
(5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3...)
Show SMILES FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
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n/an/an/an/a 270n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361891
PNG
(CHEMBL1938952)
Show SMILES COc1ccncc1C(=O)NC(=O)Nc1ccc(-c2ccccc2)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H16F3N3O3/c1-30-18-9-10-25-12-16(18)19(28)27-20(29)26-14-7-8-15(13-5-3-2-4-6-13)17(11-14)21(22,23)24/h2-12H,1H3,(H2,26,27,28,29)
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n/an/an/an/a 35n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50158348
PNG
((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/s2
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n/an/an/an/a 18n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50158336
PNG
(2-(4-octylphenethyl)-2-aminopropane-1,3-diol | 2-A...)
Show SMILES CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
Show InChI InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
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n/an/an/an/a 2n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361892
PNG
(CHEMBL1938937)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C24H17F3N2O2/c1-29-14-19(22(30)18-9-5-6-10-21(18)29)23(31)28-16-11-12-17(15-7-3-2-4-8-15)20(13-16)24(25,26)27/h2-14H,1H3,(H,28,31)
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n/an/an/an/a 70n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361893
PNG
(CHEMBL1938939)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ncccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-17(21(30)20-19(29)8-5-11-27-20)22(31)28-15-9-10-16(14-6-3-2-4-7-14)18(12-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 4.10E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361894
PNG
(CHEMBL1938938)
Show SMILES Cn1nc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-19-10-6-5-9-17(19)21(30)20(28-29)22(31)27-15-11-12-16(14-7-3-2-4-8-14)18(13-15)23(24,25)26/h2-13H,1H3,(H,27,31)
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n/an/an/an/a 41n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361895
PNG
(CHEMBL1938940)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-18(21(30)17-12-27-10-9-20(17)29)22(31)28-15-7-8-16(14-5-3-2-4-6-14)19(11-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361896
PNG
(CHEMBL1938942)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2cccnc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-18(20(30)17-8-5-11-27-21(17)29)22(31)28-15-9-10-16(14-6-3-2-4-7-14)19(12-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 190n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361897
PNG
(CHEMBL1938941)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ccncc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-18(21(30)17-9-10-27-12-20(17)29)22(31)28-15-7-8-16(14-5-3-2-4-6-14)19(11-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361898
PNG
(CHEMBL1938943)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(n2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-17(20(30)16-9-5-6-10-18(16)29)22(31)28-19-12-11-15(14-7-3-2-4-8-14)21(27-19)23(24,25)26/h2-13H,1H3,(H,27,28,31)
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n/an/an/an/a 42n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361899
PNG
(CHEMBL1938945)
Show SMILES Cn1cc(C(=O)Nc2cnc(-c3ccccc3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-17(21(30)16-9-5-6-10-19(16)29)22(31)28-15-11-18(23(24,25)26)20(27-12-15)14-7-3-2-4-8-14/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 2.90E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361900
PNG
(CHEMBL1938944)
Show SMILES Cn1cc(C(=O)Nc2cc(c(cn2)-c2ccccc2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-17(21(30)15-9-5-6-10-19(15)29)22(31)28-20-11-18(23(24,25)26)16(12-27-20)14-7-3-2-4-8-14/h2-13H,1H3,(H,27,28,31)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361901
PNG
(CHEMBL1938946)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccn3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-17(21(30)16-6-2-3-8-20(16)29)22(31)28-14-9-10-15(18(12-14)23(24,25)26)19-7-4-5-11-27-19/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 60n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361902
PNG
(CHEMBL1938947)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3cccnc3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-18(21(30)17-6-2-3-7-20(17)29)22(31)28-15-8-9-16(14-5-4-10-27-12-14)19(11-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 310n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361903
PNG
(CHEMBL1938949)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(n2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C22H15F3N4O2/c1-29-12-16(19(30)15-11-26-10-9-17(15)29)21(31)28-18-8-7-14(13-5-3-2-4-6-13)20(27-18)22(23,24)25/h2-12H,1H3,(H,27,28,31)
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n/an/an/an/a 20n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361904
PNG
(CHEMBL1938948)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccncc3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-18(21(30)17-4-2-3-5-20(17)29)22(31)28-15-6-7-16(14-8-10-27-11-9-14)19(12-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 450n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361905
PNG
(CHEMBL1938950)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccn3)c(c2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C22H15F3N4O2/c1-29-12-16(20(30)15-11-26-9-7-19(15)29)21(31)28-13-5-6-14(17(10-13)22(23,24)25)18-4-2-3-8-27-18/h2-12H,1H3,(H,28,31)
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n/an/an/an/a 200n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 1


(Homo sapiens (Human))
BDBM50361906
PNG
(CHEMBL1938951)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccn3)c(n2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C21H14F3N5O2/c1-29-11-14(18(30)13-10-25-9-7-16(13)29)20(31)28-17-6-5-12(15-4-2-3-8-26-15)19(27-17)21(22,23)24/h2-11H,1H3,(H,27,28,31)
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n/an/an/an/a 210n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P1 receptor expressed in human U2OS cells co-expressing eGFP assessed as receptor internalization into cytoplasm using Ho...


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM50361906
PNG
(CHEMBL1938951)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccn3)c(n2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C21H14F3N5O2/c1-29-11-14(18(30)13-10-25-9-7-16(13)29)20(31)28-17-6-5-12(15-4-2-3-8-26-15)19(27-17)21(22,23)24/h2-11H,1H3,(H,27,28,31)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM50361905
PNG
(CHEMBL1938950)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccn3)c(c2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C22H15F3N4O2/c1-29-12-16(20(30)15-11-26-9-7-19(15)29)21(31)28-13-5-6-14(17(10-13)22(23,24)25)18-4-2-3-8-27-18/h2-12H,1H3,(H,28,31)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM50361903
PNG
(CHEMBL1938949)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccccc3)c(n2)C(F)(F)F)c(=O)c2cnccc12
Show InChI InChI=1S/C22H15F3N4O2/c1-29-12-16(19(30)15-11-26-10-9-17(15)29)21(31)28-18-8-7-14(13-5-3-2-4-6-13)20(27-18)22(23,24)25/h2-12H,1H3,(H,27,28,31)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM50361904
PNG
(CHEMBL1938948)
Show SMILES Cn1cc(C(=O)Nc2ccc(-c3ccncc3)c(c2)C(F)(F)F)c(=O)c2ccccc12
Show InChI InChI=1S/C23H16F3N3O2/c1-29-13-18(21(30)17-4-2-3-5-20(17)29)22(31)28-15-6-7-16(14-8-10-27-11-9-14)19(12-15)23(24,25)26/h2-13H,1H3,(H,28,31)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Amgen

Curated by ChEMBL


Assay Description
Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 22: 527-31 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.085
BindingDB Entry DOI: 10.7270/Q2PG1S67
More data for this
Ligand-Target Pair
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