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Compile Data Set for Download or QSAR

Found 56 hits from Amicus Therapeutics, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucosylceramidase


(Homo sapiens (human))
BDBM108418
PNG
(US8604206, 13 | US8604206, 14)
Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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0.900n/a 17.1n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108417
PNG
(US8604206, 6)
Show SMILES O[C@@H]1CNC[C@H](C(F)F)[C@H]1O
Show InChI InChI=1S/C6H11F2NO2/c7-6(8)3-1-9-2-4(10)5(3)11/h3-6,9-11H,1-2H2/t3-,4+,5+/m0/s1
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3.06n/a 5.80n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108418
PNG
(US8604206, 13 | US8604206, 14)
Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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4n/a 7n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108423
PNG
(US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...)
Show SMILES O[C@@H]([C@H]1CNC[C@@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C12H17NO3/c14-10-7-13-6-9(12(10)16)11(15)8-4-2-1-3-5-8/h1-5,9-16H,6-7H2/t9-,10-,11-,12-/m1/s1
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8.90n/a 17n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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10n/a 20n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108417
PNG
(US8604206, 6)
Show SMILES O[C@@H]1CNC[C@H](C(F)F)[C@H]1O
Show InChI InChI=1S/C6H11F2NO2/c7-6(8)3-1-9-2-4(10)5(3)11/h3-6,9-11H,1-2H2/t3-,4+,5+/m0/s1
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13.6n/a 25.9n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108424
PNG
(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Show SMILES CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H17NO3/c1-8(2,12)5-3-9-4-6(10)7(5)11/h5-7,9-12H,3-4H2,1-2H3/t5-,6+,7+/m0/s1
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15n/a 29n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108418
PNG
(US8604206, 13 | US8604206, 14)
Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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16n/a 38n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM47182
PNG
(US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...)
Show SMILES CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H16FNO2/c1-2-6(9)5-3-10-4-7(11)8(5)12/h5-8,10-12H,2-4H2,1H3/t5?,6-,7-,8-/m1/s1
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31n/a 60n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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35n/a 66n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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44n/a 107n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108418
PNG
(US8604206, 13 | US8604206, 14)
Show SMILES CC(F)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H14FNO2/c1-4(8)5-2-9-3-6(10)7(5)11/h4-7,9-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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49.8n/a 94.6n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108422
PNG
(US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol)
Show SMILES O[C@@H]1CNC[C@H](Cc2ccccc2)[C@H]1O
Show InChI InChI=1S/C12H17NO2/c14-11-8-13-7-10(12(11)15)6-9-4-2-1-3-5-9/h1-5,10-15H,6-8H2/t10-,11+,12+/m0/s1
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67n/a 127n/an/an/an/a7.0n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108424
PNG
(US8604206, (3R,4R,5S)-5(2-hydroxypropan-2-yl)piper...)
Show SMILES CC(C)(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H17NO3/c1-8(2,12)5-3-9-4-6(10)7(5)11/h5-7,9-12H,3-4H2,1-2H3/t5-,6+,7+/m0/s1
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97n/a 234n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM47182
PNG
(US8604206, (3R,4R,5S)-5-((R)-1-fluoropropyl)-piper...)
Show SMILES CC[C@@H](F)C1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H16FNO2/c1-2-6(9)5-3-10-4-7(11)8(5)12/h5-8,10-12H,2-4H2,1H3/t5?,6-,7-,8-/m1/s1
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121n/a 291n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108419
PNG
(US8604206, 10 | US8604206, 9)
Show SMILES CC(O)[C@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-4(9)5-2-8-3-6(10)7(5)11/h4-11H,2-3H2,1H3/t4?,5-,6-,7-/m1/s1
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142n/a 343n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108422
PNG
(US8604206, (3R,4R,5S)-5-benzyl-piperidine-3,4-diol)
Show SMILES O[C@@H]1CNC[C@H](Cc2ccccc2)[C@H]1O
Show InChI InChI=1S/C12H17NO2/c14-11-8-13-7-10(12(11)15)6-9-4-2-1-3-5-9/h1-5,10-15H,6-8H2/t10-,11+,12+/m0/s1
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273n/a 659n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238210
PNG
(US9402837, 16)
Show SMILES OC[C@H]1CN(CC2CCNCC2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H24N2O3/c15-8-10-6-14(7-11(16)12(10)17)5-9-1-3-13-4-2-9/h9-13,15-17H,1-8H2/t10-,11-,12-/m1/s1
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440n/a 1.07E+3n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238214
PNG
(US9402837, 24)
Show SMILES CC(C)CCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C12H25NO3/c1-9(2)4-3-5-13-6-10(8-14)12(16)11(15)7-13/h9-12,14-16H,3-8H2,1-2H3/t10-,11-,12-/m1/s1
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880n/a 2.13E+3n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM108423
PNG
(US8604206, (3R,4R,5R)-5((S)-hydroxy(phenyl)methyl)...)
Show SMILES O[C@@H]([C@H]1CNC[C@@H](O)[C@@H]1O)c1ccccc1
Show InChI InChI=1S/C12H17NO3/c14-10-7-13-6-9(12(10)16)11(15)8-4-2-1-3-5-8/h1-5,9-16H,6-7H2/t9-,10-,11-,12-/m1/s1
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1.36E+3n/a 3.29E+3n/an/an/an/a5.2n/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...


US Patent US8604206 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RDR
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238200
PNG
(US9402837, 4)
Show SMILES CC(C)=CCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C11H21NO3/c1-8(2)3-4-12-5-9(7-13)11(15)10(14)6-12/h3,9-11,13-15H,4-7H2,1-2H3/t9-,10-,11-/m1/s1
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1.66E+3n/a 4.00E+3n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238201
PNG
(US9402837, 5)
Show SMILES COCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C9H19NO4/c1-14-3-2-10-4-7(6-11)9(13)8(12)5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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2.48E+3n/a 5.99E+3n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238208
PNG
(US9402837, 13)
Show SMILES OC[C@H]1CN(CCc2ccccc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C14H21NO3/c16-10-12-8-15(9-13(17)14(12)18)7-6-11-4-2-1-3-5-11/h1-5,12-14,16-18H,6-10H2/t12-,13-,14-/m1/s1
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3.11E+3n/a 7.50E+3n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238207
PNG
(US9402837, 12)
Show SMILES Nc1ccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)cc1
Show InChI InChI=1S/C13H20N2O3/c14-11-3-1-9(2-4-11)5-15-6-10(8-16)13(18)12(17)7-15/h1-4,10,12-13,16-18H,5-8,14H2/t10-,12-,13-/m1/s1
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3.88E+3n/a 9.36E+3n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238204
PNG
(US9402837, 8)
Show SMILES Cc1cccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)c1
Show InChI InChI=1S/C14H21NO3/c1-10-3-2-4-11(5-10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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5.26E+3n/a 1.27E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238213
PNG
(US9402837, 23)
Show SMILES OC[C@H]1CN(CC2CCCC2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H23NO3/c14-8-10-6-13(7-11(15)12(10)16)5-9-3-1-2-4-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1
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6.48E+3n/a 1.56E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238212
PNG
(US9402837, 19)
Show SMILES OC[C@H]1CN(Cc2ccncc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H18N2O3/c15-8-10-6-14(7-11(16)12(10)17)5-9-1-3-13-4-2-9/h1-4,10-12,15-17H,5-8H2/t10-,11-,12-/m1/s1
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8.02E+3n/a 1.94E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238216
PNG
(US9402837, 18)
Show SMILES OC[C@H]1CN(Cc2cccs2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C11H17NO3S/c13-7-8-4-12(6-10(14)11(8)15)5-9-2-1-3-16-9/h1-3,8,10-11,13-15H,4-7H2/t8-,10-,11-/m1/s1
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1.14E+4n/a 2.76E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238197
PNG
(US9402837, 1)
Show SMILES CCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C9H19NO3/c1-2-3-10-4-7(6-11)9(13)8(12)5-10/h7-9,11-13H,2-6H2,1H3/t7-,8-,9-/m1/s1
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1.48E+4n/a 3.58E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238199
PNG
(US9402837, 3)
Show SMILES CCCCCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C13H27NO3/c1-2-3-4-5-6-7-14-8-11(10-15)13(17)12(16)9-14/h11-13,15-17H,2-10H2,1H3/t11-,12-,13-/m1/s1
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1.73E+4n/a 4.17E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238215
PNG
(US9402837, 25)
Show SMILES OC[C@H]1CN(Cc2ccc(cc2)[N+]([O-])=O)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H18N2O5/c16-8-10-6-14(7-12(17)13(10)18)5-9-1-3-11(4-2-9)15(19)20/h1-4,10,12-13,16-18H,5-8H2/t10-,12-,13-/m1/s1
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1.86E+4n/a 4.50E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238209
PNG
(US9402837, 15)
Show SMILES OC[C@H]1CN(CC2CCOCC2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H23NO4/c14-8-10-6-13(7-11(15)12(10)16)5-9-1-3-17-4-2-9/h9-12,14-16H,1-8H2/t10-,11-,12-/m1/s1
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2.04E+4n/a 4.92E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238203
PNG
(US9402837, 7)
Show SMILES Cc1ccccc1CN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C14H21NO3/c1-10-4-2-3-5-11(10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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2.88E+4n/a 6.95E+4n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238205
PNG
(US9402837, 9)
Show SMILES Cc1ccc(CN2C[C@@H](O)[C@H](O)[C@@H](CO)C2)cc1
Show InChI InChI=1S/C14H21NO3/c1-10-2-4-11(5-3-10)6-15-7-12(9-16)14(18)13(17)8-15/h2-5,12-14,16-18H,6-9H2,1H3/t12-,13-,14-/m1/s1
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5.37E+4n/a 1.30E+5n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238202
PNG
(US9402837, 6)
Show SMILES OC[C@H]1CN(Cc2ccccc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H19NO3/c15-9-11-7-14(8-12(16)13(11)17)6-10-4-2-1-3-5-10/h1-5,11-13,15-17H,6-9H2/t11-,12-,13-/m1/s1
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8.30E+4n/a 2.00E+5n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238206
PNG
(US9402837, 10)
Show SMILES OC[C@H]1CN(Cc2ccc(F)cc2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H18FNO3/c14-11-3-1-9(2-4-11)5-15-6-10(8-16)13(18)12(17)7-15/h1-4,10,12-13,16-18H,5-8H2/t10-,12-,13-/m1/s1
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1.12E+5n/a 2.70E+5n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238211
PNG
(US9402837, 17)
Show SMILES OC[C@H]1CN(Cc2ccco2)C[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C11H17NO4/c13-7-8-4-12(6-10(14)11(8)15)5-9-2-1-3-16-9/h1-3,8,10-11,13-15H,4-7H2/t8-,10-,11-/m1/s1
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1.16E+5n/a 2.80E+5n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
Glucosylceramidase


(Homo sapiens (human))
BDBM238198
PNG
(US9402837, 2)
Show SMILES CCCCCN1C[C@@H](O)[C@H](O)[C@@H](CO)C1
Show InChI InChI=1S/C11H23NO3/c1-2-3-4-5-12-6-9(8-13)11(15)10(14)7-12/h9-11,13-15H,2-8H2,1H3/t9-,10-,11-/m1/s1
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4.06E+5n/a 9.80E+5n/an/an/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
To 2.5 μl of supernatant (in 96-well plates) was added 17.5 μl reaction buffer (citrate phosphate buffer, pH 4.5, no Triton X-100), and 50 μ...


US Patent US9402837 (2016)


BindingDB Entry DOI: 10.7270/Q2MS3RPB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM50259956
PNG
(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | CHE...)
Show SMILES OC[C@H]1N[C@H](CO)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6+,7+/m1/s1
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n/an/an/an/a 2.81E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/an/an/a 9.88E+4n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190540
PNG
(US9181184, 27)
Show SMILES CCCCOc1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C17H27NO5/c1-2-3-8-23-13-6-4-12(5-7-13)9-18-10-15(20)17(22)16(21)14(18)11-19/h4-7,14-17,19-22H,2-3,8-11H2,1H3/t14-,15+,16-,17-/m1/s1
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n/an/an/an/a 1.73E+4n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190539
PNG
(US9181184, 26)
Show SMILES CCCCCOc1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C18H29NO5/c1-2-3-4-9-24-14-7-5-13(6-8-14)10-19-11-16(21)18(23)17(22)15(19)12-20/h5-8,15-18,20-23H,2-4,9-12H2,1H3/t15-,16+,17-,18-/m1/s1
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n/an/an/an/a 6.60E+3n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190538
PNG
(US9181184, 25)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C14H18F3NO5/c15-14(16,17)23-9-3-1-8(2-4-9)5-18-6-11(20)13(22)12(21)10(18)7-19/h1-4,10-13,19-22H,5-7H2/t10-,11+,12-,13-/m1/s1
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n/an/an/an/a 6.65E+4n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190537
PNG
(US9181184, 24)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1C([N+]#[C-])c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H17F3N2O4/c1-19-14(8-2-4-9(5-3-8)15(16,17)18)20-6-11(22)13(24)12(23)10(20)7-21/h2-5,10-14,21-24H,6-7H2/t10-,11+,12-,13-,14?/m1/s1
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n/an/an/an/a 7.71E+4n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190536
PNG
(US9181184, 23)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H18F3NO4/c15-14(16,17)9-3-1-8(2-4-9)5-18-6-11(20)13(22)12(21)10(18)7-19/h1-4,10-13,19-22H,5-7H2/t10-,11+,12-,13-/m1/s1
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n/an/an/an/a 1.21E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190535
PNG
(US9181184, 21)
Show SMILES CCOCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H21NO5/c1-2-16-4-3-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
UniProtKB/SwissProt

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n/an/an/an/a 2.10E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190534
PNG
(US9181184, 20)
Show SMILES COCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H19NO5/c1-15-3-2-10-4-7(12)9(14)8(13)6(10)5-11/h6-9,11-14H,2-5H2,1H3/t6-,7+,8-,9-/m1/s1
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n/an/an/an/a 4.68E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190533
PNG
(US9181184, 19)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCOCC(F)(F)F
Show InChI InChI=1S/C10H18F3NO5/c11-10(12,13)5-19-2-1-14-3-7(16)9(18)8(17)6(14)4-15/h6-9,15-18H,1-5H2/t6-,7+,8-,9-/m1/s1
UniProtKB/SwissProt

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n/an/an/an/a 3.72E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190531
PNG
(US9181184, 17 | US9181184, 18)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CC1CCCO1
Show InChI InChI=1S/C11H21NO5/c13-6-8-10(15)11(16)9(14)5-12(8)4-7-2-1-3-17-7/h7-11,13-16H,1-6H2/t7?,8-,9+,10-,11-/m1/s1
UniProtKB/SwissProt

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n/an/an/an/a 1.04E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM190531
PNG
(US9181184, 17 | US9181184, 18)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CC1CCCO1
Show InChI InChI=1S/C11H21NO5/c13-6-8-10(15)11(16)9(14)5-12(8)4-7-2-1-3-17-7/h7-11,13-16H,1-6H2/t7?,8-,9+,10-,11-/m1/s1
UniProtKB/SwissProt

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n/an/an/an/a 6.53E+5n/an/an/an/a



Amicus Therapeutics, Inc.

US Patent


Assay Description
Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho...


US Patent US9181184 (2015)


BindingDB Entry DOI: 10.7270/Q2T43RWB
More data for this
Ligand-Target Pair
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