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Compile Data Set for Download or QSAR

Found 32 hits from Anhui Agricultural University   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50137968
PNG
(CHEMBL3754002)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C23H17F2N3O/c24-20-12-10-17(11-13-20)23-19(15-28(27-23)21-7-2-1-3-8-21)14-26-29-16-18-6-4-5-9-22(18)25/h1-15H,16H2/b26-14+
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n/an/a 280n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50022815
PNG
((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Show SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Show InChI InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
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n/an/a 570n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137968
PNG
(CHEMBL3754002)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C23H17F2N3O/c24-20-12-10-17(11-13-20)23-19(15-28(27-23)21-7-2-1-3-8-21)14-26-29-16-18-6-4-5-9-22(18)25/h1-15H,16H2/b26-14+
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n/an/a 1.18E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50137851
PNG
(CHEMBL3752866)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H16Cl2FN3O/c24-19-9-6-17(22(25)12-19)15-30-27-13-18-14-29(21-4-2-1-3-5-21)28-23(18)16-7-10-20(26)11-8-16/h1-14H,15H2/b27-13+
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n/an/a 1.26E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137701
PNG
(CHEMBL3752369)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H17ClFN3O/c24-22-9-5-4-6-18(22)16-29-26-14-19-15-28(21-7-2-1-3-8-21)27-23(19)17-10-12-20(25)13-11-17/h1-15H,16H2/b26-14+
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n/an/a 1.74E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50137701
PNG
(CHEMBL3752369)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H17ClFN3O/c24-22-9-5-4-6-18(22)16-29-26-14-19-15-28(21-7-2-1-3-8-21)27-23(19)17-10-12-20(25)13-11-17/h1-15H,16H2/b26-14+
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n/an/a 3.12E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50138037
PNG
(CHEMBL3752051)
Show SMILES Fc1ccccc1CO\N=C\c1cn(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H18FN3O/c24-22-14-8-7-11-19(22)17-28-25-15-20-16-27(21-12-5-2-6-13-21)26-23(20)18-9-3-1-4-10-18/h1-16H,17H2/b25-15+
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n/an/a 6.57E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 7.20E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137851
PNG
(CHEMBL3752866)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H16Cl2FN3O/c24-19-9-6-17(22(25)12-19)15-30-27-13-18-14-29(21-4-2-1-3-5-21)28-23(18)16-7-10-20(26)11-8-16/h1-14H,15H2/b27-13+
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n/an/a 7.22E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137967
PNG
(CHEMBL3752088)
Show SMILES Fc1ccccc1CO\N=C\c1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C23H17ClFN3O/c24-20-12-10-17(11-13-20)23-19(15-28(27-23)21-7-2-1-3-8-21)14-26-29-16-18-6-4-5-9-22(18)25/h1-15H,16H2/b26-14+
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n/an/a 8.03E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137656
PNG
(CHEMBL3753671)
Show SMILES Clc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H17Cl2N3O/c24-20-12-10-17(11-13-20)23-19(15-28(27-23)21-7-2-1-3-8-21)14-26-29-16-18-6-4-5-9-22(18)25/h1-15H,16H2/b26-14+
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n/an/a 9.08E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50137685
PNG
(CHEMBL3753973)
Show SMILES Clc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H16Cl3N3O/c24-19-9-6-16(7-10-19)23-18(14-29(28-23)21-4-2-1-3-5-21)13-27-30-15-17-8-11-20(25)12-22(17)26/h1-14H,15H2/b27-13+
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n/an/a 9.36E+3n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138037
PNG
(CHEMBL3752051)
Show SMILES Fc1ccccc1CO\N=C\c1cn(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H18FN3O/c24-22-14-8-7-11-19(22)17-28-25-15-20-16-27(21-12-5-2-6-13-21)26-23(20)18-9-3-1-4-10-18/h1-16H,17H2/b25-15+
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n/an/a 1.04E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137685
PNG
(CHEMBL3753973)
Show SMILES Clc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H16Cl3N3O/c24-19-9-6-16(7-10-19)23-18(14-29(28-23)21-4-2-1-3-5-21)13-27-30-15-17-8-11-20(25)12-22(17)26/h1-14H,15H2/b27-13+
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n/an/a 1.08E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50137967
PNG
(CHEMBL3752088)
Show SMILES Fc1ccccc1CO\N=C\c1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C23H17ClFN3O/c24-20-12-10-17(11-13-20)23-19(15-28(27-23)21-7-2-1-3-8-21)14-26-29-16-18-6-4-5-9-22(18)25/h1-15H,16H2/b26-14+
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n/an/a 1.24E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50137656
PNG
(CHEMBL3753671)
Show SMILES Clc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C23H17Cl2N3O/c24-20-12-10-17(11-13-20)23-19(15-28(27-23)21-7-2-1-3-8-21)14-26-29-16-18-6-4-5-9-22(18)25/h1-15H,16H2/b26-14+
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n/an/a 1.38E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138034
PNG
(CHEMBL3752413)
Show SMILES Clc1ccc(CO\N=C\c2cn(nc2-c2ccccc2)-c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C23H17Cl2N3O/c24-20-12-11-18(22(25)13-20)16-29-26-14-19-15-28(21-9-5-2-6-10-21)27-23(19)17-7-3-1-4-8-17/h1-15H,16H2/b26-14+
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n/an/a 1.68E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138021
PNG
(CHEMBL3752400)
Show SMILES Fc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H18FN3O/c24-21-13-11-19(12-14-21)23-20(15-25-28-17-18-7-3-1-4-8-18)16-27(26-23)22-9-5-2-6-10-22/h1-16H,17H2/b25-15+
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n/an/a 1.76E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138042
PNG
(CHEMBL3752044)
Show SMILES C(O\N=C\c1cn(nc1-c1ccccc1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H19N3O/c1-4-10-19(11-5-1)18-27-24-16-21-17-26(22-14-8-3-9-15-22)25-23(21)20-12-6-2-7-13-20/h1-17H,18H2/b24-16+
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n/an/a 1.83E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137952
PNG
(CHEMBL3753798)
Show SMILES Clc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H18ClN3O/c24-21-13-11-19(12-14-21)23-20(15-25-28-17-18-7-3-1-4-8-18)16-27(26-23)22-9-5-2-6-10-22/h1-16H,17H2/b25-15+
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n/an/a 1.85E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138036
PNG
(CHEMBL3752641)
Show SMILES Clc1ccccc1CO\N=C\c1cn(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C23H18ClN3O/c24-22-14-8-7-11-19(22)17-28-25-15-20-16-27(21-12-5-2-6-13-21)26-23(20)18-9-3-1-4-10-18/h1-16H,17H2/b25-15+
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n/an/a 1.91E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137970
PNG
(CHEMBL3754379)
Show SMILES COc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C24H20ClN3O2/c1-29-22-13-11-18(12-14-22)24-20(16-28(27-24)21-8-3-2-4-9-21)15-26-30-17-19-7-5-6-10-23(19)25/h2-16H,17H2,1H3/b26-15+
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n/an/a 2.02E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137969
PNG
(CHEMBL3753152)
Show SMILES COc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C24H20FN3O2/c1-29-22-13-11-18(12-14-22)24-20(16-28(27-24)21-8-3-2-4-9-21)15-26-30-17-19-7-5-6-10-23(19)25/h2-16H,17H2,1H3/b26-15+
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n/an/a 2.02E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50138031
PNG
(CHEMBL3753037)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C24H20ClN3O/c1-18-11-13-19(14-12-18)24-21(16-28(27-24)22-8-3-2-4-9-22)15-26-29-17-20-7-5-6-10-23(20)25/h2-16H,17H2,1H3/b26-15+
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n/an/a 2.15E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50138024
PNG
(CHEMBL3754755)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H21N3O/c1-19-12-14-21(15-13-19)24-22(16-25-28-18-20-8-4-2-5-9-20)17-27(26-24)23-10-6-3-7-11-23/h2-17H,18H2,1H3/b25-16+
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n/an/a>2.50E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM50138032
PNG
(CHEMBL3754182)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C24H19Cl2N3O/c1-17-7-9-18(10-8-17)24-20(15-29(28-24)22-5-3-2-4-6-22)14-27-30-16-19-11-12-21(25)13-23(19)26/h2-15H,16H2,1H3/b27-14+
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Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma (unknown origin) after 4 hrs


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138022
PNG
(CHEMBL3752335)
Show SMILES COc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H21N3O2/c1-28-23-14-12-20(13-15-23)24-21(16-25-29-18-19-8-4-2-5-9-19)17-27(26-24)22-10-6-3-7-11-22/h2-17H,18H2,1H3/b25-16+
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n/an/a 2.63E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50137971
PNG
(CHEMBL3753949)
Show SMILES COc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C24H19Cl2N3O2/c1-30-22-11-8-17(9-12-22)24-19(15-29(28-24)21-5-3-2-4-6-21)14-27-31-16-18-7-10-20(25)13-23(18)26/h2-15H,16H2,1H3/b27-14+
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n/an/a 2.72E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138030
PNG
(CHEMBL3754381)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1F)-c1ccccc1
Show InChI InChI=1S/C24H20FN3O/c1-18-11-13-19(14-12-18)24-21(16-28(27-24)22-8-3-2-4-9-22)15-26-29-17-20-7-5-6-10-23(20)25/h2-16H,17H2,1H3/b26-15+
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n/an/a 2.80E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138031
PNG
(CHEMBL3753037)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1Cl)-c1ccccc1
Show InChI InChI=1S/C24H20ClN3O/c1-18-11-13-19(14-12-18)24-21(16-28(27-24)22-8-3-2-4-9-22)15-26-29-17-20-7-5-6-10-23(20)25/h2-16H,17H2,1H3/b26-15+
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n/an/a 3.46E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138032
PNG
(CHEMBL3754182)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccc(Cl)cc1Cl)-c1ccccc1
Show InChI InChI=1S/C24H19Cl2N3O/c1-17-7-9-18(10-8-17)24-20(15-29(28-24)22-5-3-2-4-6-22)14-27-30-16-19-11-12-21(25)13-23(19)26/h2-15H,16H2,1H3/b27-14+
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n/an/a 3.83E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50138024
PNG
(CHEMBL3754755)
Show SMILES Cc1ccc(cc1)-c1nn(cc1\C=N\OCc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C24H21N3O/c1-19-12-14-21(15-13-19)24-22(16-25-28-18-20-8-4-2-5-9-20)17-27(26-24)23-10-6-3-7-11-23/h2-17H,18H2,1H3/b25-16+
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n/an/a 4.06E+4n/an/an/an/an/an/a



Anhui Agricultural University

Curated by ChEMBL


Assay Description
Inhibition of PI3K-gamma in mouse lymph node cells assessed as inhibition of ConA-stimulated T cell proliferation


Eur J Med Chem 108: 586-93 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.020
BindingDB Entry DOI: 10.7270/Q2T72K8V
More data for this
Ligand-Target Pair