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Compile Data Set for Download or QSAR

Found 78 hits from Array BioPharma Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493611
PNG
(CHEMBL2436807)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(Br)c2)c1F
PDB
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n/an/a 0.760n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493601
PNG
(CHEMBL2436919)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccccc2)c1F
PDB
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n/an/a 1n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493632
PNG
(CHEMBL2436796)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(c2)C(F)(F)F)c1F
PDB
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n/an/a 1n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493623
PNG
(CHEMBL2436806)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(Cl)c2)c1F
PDB
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n/an/a 1.10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493608
PNG
(CHEMBL2436789)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(OC)cc2)c1F
PDB
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n/an/a 1.10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493630
PNG
(CHEMBL2436921)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)cc2)c1F
PDB
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n/an/a 1.10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493606
PNG
(CHEMBL2436795)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(OC)c2)c1F
PDB
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n/an/a 1.20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493616
PNG
(CHEMBL2436790)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(C)cc2)c1F
PDB
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n/an/a 1.30n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493628
PNG
(CHEMBL2436791)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(cc2)C(F)(F)F)c1F
PDB
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n/an/a 1.40n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493615
PNG
(CHEMBL2436794)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(cc2)S(C)(=O)=O)c1F
PDB
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n/an/a 1.40n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493609
PNG
(CHEMBL2436803)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Cl)c(Cl)c2)c1F
PDB
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n/an/a 1.5n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493602
PNG
(CHEMBL2436813)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccccc2)c1F
PDB
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n/an/a 1.60n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493626
PNG
(CHEMBL2436804)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Br)cc2)c1F
PDB
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n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493627
PNG
(CHEMBL2436808)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Cl)cc2)c1F
PDB
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n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493612
PNG
(CHEMBL2436809)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2)c1F
PDB
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n/an/a 2.40n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493620
PNG
(CHEMBL2436792)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(OC(F)(F)F)cc2)c1F
PDB
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n/an/a 2.5n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493607
PNG
(CHEMBL2436793)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(cc2)C#N)c1F
PDB
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n/an/a 2.70n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493605
PNG
(CHEMBL2436798)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccnc2)c1F
PDB
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493631
PNG
(CHEMBL2436805)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(F)c2)c1F
PDB
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n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493618
PNG
(CHEMBL2436797)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccncc2)c1F
PDB
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n/an/a 3.20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493619
PNG
(CHEMBL2436802)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(F)c(F)c2)c1F
PDB
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n/an/a 3.40n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493621
PNG
(CHEMBL2436920)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(F)cc2)c1F
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n/an/a 4.40n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50485103
PNG
(CHEMBL2030242)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(nn3c2)-c2ccccc2)c1F
Show InChI InChI=1S/C22H19F2N5O3S/c1-2-10-33(31,32)28-17-9-8-16(23)20(21(17)24)22(30)26-15-12-25-19-11-18(27-29(19)13-15)14-6-4-3-5-7-14/h3-9,11-13,28H,2,10H2,1H3,(H,26,30)
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n/an/a 4.60n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493624
PNG
(CHEMBL2436799)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccccc2F)c1F
PDB
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n/an/a 8n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493617
PNG
(CHEMBL2436810)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(nn3c2)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C22H18ClF2N5O3S/c1-2-9-34(32,33)29-17-8-7-16(24)20(21(17)25)22(31)27-15-11-26-19-10-18(28-30(19)12-15)13-3-5-14(23)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,31)
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n/an/a 8.20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50485096
PNG
(CHEMBL2030244)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(nn3c2)-c2ccc(F)cc2)c1F
Show InChI InChI=1S/C22H18F3N5O3S/c1-2-9-34(32,33)29-17-8-7-16(24)20(21(17)25)22(31)27-15-11-26-19-10-18(28-30(19)12-15)13-3-5-14(23)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,31)
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n/an/a 11n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50485103
PNG
(CHEMBL2030242)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(nn3c2)-c2ccccc2)c1F
Show InChI InChI=1S/C22H19F2N5O3S/c1-2-10-33(31,32)28-17-9-8-16(23)20(21(17)24)22(30)26-15-12-25-19-11-18(27-29(19)13-15)14-6-4-3-5-7-14/h3-9,11-13,28H,2,10H2,1H3,(H,26,30)
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n/an/a 12n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50484247
PNG
(CHEMBL1822110)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]ncc3c2)c1F
PDB
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n/an/a 18n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493612
PNG
(CHEMBL2436809)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(Cl)cc2)c1F
PDB
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n/an/a 20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493630
PNG
(CHEMBL2436921)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccc(F)cc2)c1F
PDB
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n/an/a 20n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493610
PNG
(CHEMBL2436800)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccccc2Cl)c1F
PDB
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n/an/a 27n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493600
PNG
(CHEMBL2436801)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccccc2Br)c1F
PDB
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n/an/a 27n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493603
PNG
(CHEMBL2436926)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)C2CCC2)c1F
PDB
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n/an/a 31n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493601
PNG
(CHEMBL2436919)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccccc2)c1F
PDB
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n/an/a 32n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493629
PNG
(CHEMBL2436922)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(C)nc3c2)c1F
PDB
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n/an/a 40n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50484239
PNG
(CHEMBL1822078)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]ccc3c2)c1F
PDB
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n/an/a 42n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493616
PNG
(CHEMBL2436790)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(C)cc2)c1F
PDB
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n/an/a 49n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50485096
PNG
(CHEMBL2030244)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(nn3c2)-c2ccc(F)cc2)c1F
Show InChI InChI=1S/C22H18F3N5O3S/c1-2-9-34(32,33)29-17-8-7-16(24)20(21(17)25)22(31)27-15-11-26-19-10-18(28-30(19)12-15)13-3-5-14(23)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,31)
PDB
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n/an/a 54n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493622
PNG
(CHEMBL2436923)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(CC)nc3c2)c1F
PDB
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n/an/a 59n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493604
PNG
(CHEMBL2436924)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)C(C)C)c1F
PDB
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n/an/a 60n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493626
PNG
(CHEMBL2436804)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Br)cc2)c1F
PDB
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n/an/a 61n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50484699
PNG
(CHEMBL1945163)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cnc3c2)c1F
PDB
MMDB

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n/an/a 61n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50484247
PNG
(CHEMBL1822110)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]ncc3c2)c1F
PDB
MMDB

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n/an/a 62n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493623
PNG
(CHEMBL2436806)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2cccc(Cl)c2)c1F
PDB
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n/an/a 68n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493625
PNG
(CHEMBL2436925)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)C(C)(C)C)c1F
PDB
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n/an/a 69n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length B-Raf V600E mutant (unknown origin)


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493609
PNG
(CHEMBL2436803)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(Cl)c(Cl)c2)c1F
PDB
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n/an/a 81n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493620
PNG
(CHEMBL2436792)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(OC(F)(F)F)cc2)c1F
PDB
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n/an/a 86n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493628
PNG
(CHEMBL2436791)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(nc3c2)-c2ccc(cc2)C(F)(F)F)c1F
PDB
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n/an/a 89n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50493617
PNG
(CHEMBL2436810)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(nn3c2)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C22H18ClF2N5O3S/c1-2-9-34(32,33)29-17-8-7-16(24)20(21(17)25)22(31)27-15-11-26-19-10-18(28-30(19)12-15)13-3-5-14(23)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,31)
PDB
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n/an/a 90n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
BRAF/CRAF


(Homo sapiens (Human))
BDBM50484239
PNG
(CHEMBL1822078)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]ccc3c2)c1F
PDB
MMDB

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n/an/a 94n/an/an/an/an/an/a



Array BioPharma Inc.

Curated by ChEMBL


Assay Description
Inhibition of B-Raf V600E mutant in human Malme-3M cells assessed as basal ERK phosphorylation


Bioorg Med Chem Lett 23: 5896-9 (2013)

More data for this
Ligand-Target Pair
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