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Compile Data Set for Download or QSAR

Found 212 hits from Array BioPharma Inc.; Genentech, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase ERK2


(Homo sapiens (human))
BDBM193676
PNG
(US9670208, Example 295 4-(3-(cyclopropylmethyl)-[1...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC3CC3)nnc2c1
Show InChI InChI=1S/C19H19N7/c1-25-17(5-8-21-25)22-16-11-14(4-7-20-16)15-6-9-26-18(10-13-2-3-13)23-24-19(26)12-15/h4-9,11-13H,2-3,10H2,1H3,(H,20,22)
PDB

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n/an/a 0.400n/an/an/an/an/an/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193385
PNG
(US9670208, Example 57)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(Cl)c3Cl)nnc2c1
Show InChI InChI=1S/C21H16Cl2N8/c1-30-17(6-9-25-30)27-21-24-8-5-16(26-21)13-7-10-31-18(11-13)28-29-19(31)12-14-3-2-4-15(22)20(14)23/h2-11H,12H2,1H3,(H,24,26,27)
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n/an/a 0.5n/an/an/an/an/an/a



Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192361
PNG
(US9187462, I-41)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C26H26F2N6O3/c1-34-15-19(14-30-34)23(16-4-6-21(7-5-16)37-25(27)28)33-24(35)17-2-3-18-13-29-26(32-22(18)12-17)31-20-8-10-36-11-9-20/h2-7,12-15,20,23,25H,8-11H2,1H3,(H,33,35)(H,29,31,32)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192386
PNG
(US9187462, I-66)
Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C26H26ClFN6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)20(27)9-15)33-25(35)16-10-21(28)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192385
PNG
(US9187462, I-65)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C26H23ClFN7O2/c1-35-14-18(12-31-35)24(15-2-3-16(11-29)21(27)8-15)34-25(36)17-9-22(28)20-13-30-26(33-23(20)10-17)32-19-4-6-37-7-5-19/h2-3,8-10,12-14,19,24H,4-7H2,1H3,(H,34,36)(H,30,32,33)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193773
PNG
(US9670208, Example 402 4-(3-(4-fluorobenzyl)-[1,2,...)
Show SMILES Fc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1
Show InChI InChI=1S/C22H21FN6O/c23-17-3-1-15(2-4-17)13-20-27-28-21-14-16(6-10-29(20)21)19-5-9-24-22(26-19)25-18-7-11-30-12-8-18/h1-6,9-10,14,18H,7-8,11-13H2,(H,24,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193675
PNG
(US9670208, Example 279 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(CC(C)(C)C)nnc2c1
Show InChI InChI=1S/C20H23N7/c1-20(2,3)13-19-25-24-18-12-15(7-10-27(18)19)14-5-8-21-16(11-14)23-17-6-9-22-26(17)4/h5-12H,13H2,1-4H3,(H,21,23)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193672
PNG
(US9670208, Example 278 4-(3-(pyridin-2-ylmethyl)-[...)
Show SMILES C(c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1)c1ccccn1
Show InChI InChI=1S/C21H21N7O/c1-2-8-22-17(3-1)14-20-27-26-19-13-15(5-10-28(19)20)18-4-9-23-21(25-18)24-16-6-11-29-12-7-16/h1-5,8-10,13,16H,6-7,11-12,14H2,(H,23,24,25)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192322
PNG
(US9187462, I-2)
Show SMILES Cn1cc(cn1)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193781
PNG
(US9670208, Example 493 4-(3-((6-ethoxypyridin-3-yl...)
Show SMILES CCOc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cn1
Show InChI InChI=1S/C22H21N9O/c1-3-32-21-5-4-15(14-24-21)12-19-28-29-20-13-16(8-11-31(19)20)17-6-9-23-22(26-17)27-18-7-10-25-30(18)2/h4-11,13-14H,3,12H2,1-2H3,(H,23,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM191370
PNG
(US9670208, Example 35)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cc(ccn3)C3CC3)nnc2c1
Show InChI InChI=1S/C23H21N9/c1-31-20(6-10-26-31)28-23-25-9-5-19(27-23)17-7-11-32-21(13-17)29-30-22(32)14-18-12-16(4-8-24-18)15-2-3-15/h4-13,15H,2-3,14H2,1H3,(H,25,27,28)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM120116
PNG
(US8697715, 209 | US9259470, 209)
Show SMILES Cn1cc(cn1)C(c1ccc(Cl)c(Cl)c1)n1ccc(cc1=O)-c1nc(NC2CCOCC2)ncc1F
Show InChI InChI=1S/C25H23Cl2FN6O2/c1-33-14-17(12-30-33)24(16-2-3-19(26)20(27)10-16)34-7-4-15(11-22(34)35)23-21(28)13-29-25(32-23)31-18-5-8-36-9-6-18/h2-4,7,10-14,18,24H,5-6,8-9H2,1H3,(H,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9259470 (2016)


BindingDB Entry DOI: 10.7270/Q28S4NSQ
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193381
PNG
(US9670208, Example 49)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)cc1
Show InChI InChI=1S/C22H20N8O/c1-29-19(8-11-24-29)26-22-23-10-7-18(25-22)16-9-12-30-20(27-28-21(30)14-16)13-15-3-5-17(31-2)6-4-15/h3-12,14H,13H2,1-2H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193776
PNG
(US9670208, Example 403 4-(3-(3-fluoro-4-methoxyben...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cc1F
Show InChI InChI=1S/C23H23FN6O2/c1-31-20-3-2-15(12-18(20)24)13-21-28-29-22-14-16(5-9-30(21)22)19-4-8-25-23(27-19)26-17-6-10-32-11-7-17/h2-5,8-9,12,14,17H,6-7,10-11,13H2,1H3,(H,25,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193756
PNG
(US9670208, Example 317 4-(3-((4,4-difluorocyclohex...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CC3CCC(F)(F)CC3)nnc2c1
Show InChI InChI=1S/C21H22F2N8/c1-30-17(5-10-25-30)27-20-24-9-4-16(26-20)15-6-11-31-18(28-29-19(31)13-15)12-14-2-7-21(22,23)8-3-14/h4-6,9-11,13-14H,2-3,7-8,12H2,1H3,(H,24,26,27)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193412
PNG
(US9670208, Example 276 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cc1ccnc(Cc2nnc3cc(ccn23)-c2ccnc(Nc3ccnn3C)n2)c1
Show InChI InChI=1S/C21H19N9/c1-14-3-7-22-16(11-14)13-20-28-27-19-12-15(6-10-30(19)20)17-4-8-23-21(25-17)26-18-5-9-24-29(18)2/h3-12H,13H2,1-2H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193410
PNG
(US9670208, Example 272 4-(3-((6-methoxypyridin-3-y...)
Show SMILES COc1ccc(Cc2nnc3cc(ccn23)-c2ccnc(NC3CCOCC3)n2)cn1
Show InChI InChI=1S/C22H23N7O2/c1-30-21-3-2-15(14-24-21)12-19-27-28-20-13-16(5-9-29(19)20)18-4-8-23-22(26-18)25-17-6-10-31-11-7-17/h2-5,8-9,13-14,17H,6-7,10-12H2,1H3,(H,23,25,26)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193396
PNG
(US9670208, Example 121)
Show SMILES Cn1nccc1Nc1cc(ccn1)-c1ccn2c(nnc2c1)[C@H](O)Cc1ccccc1
Show InChI InChI=1S/C23H21N7O/c1-29-21(8-11-25-29)26-20-14-17(7-10-24-20)18-9-12-30-22(15-18)27-28-23(30)19(31)13-16-5-3-2-4-6-16/h2-12,14-15,19,31H,13H2,1H3,(H,24,26)/t19-/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192364
PNG
(US9187462, I-44)
Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C26H27ClN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192352
PNG
(US9187462, I-32)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C26H27FN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192436
PNG
(US9187462, II-46)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cncn1C
Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-29-13-22(34)24(15-3-4-23(36-2)20(28)9-15)33-25(35)16-10-19(27)18-12-30-26(32-21(18)11-16)31-17-5-7-37-8-6-17/h3-4,9-14,17,24H,5-8H2,1-2H3,(H,33,35)(H,30,31,32)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192368
PNG
(US9187462, I-48)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C26H24ClN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192388
PNG
(BDBM192402 | US9187462, I-68)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1
Show InChI InChI=1S/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192389
PNG
(US9187462, I-69)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192335
PNG
(US9187462, I-15)
Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)/t13?,21-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192403
PNG
(US9187462, II-13)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C27H28F2N6O3/c1-35-14-17(12-31-35)25(15-3-8-24(38-2)22(29)9-15)34-26(37)16-10-21(28)20-13-30-27(33-23(20)11-16)32-18-4-6-19(36)7-5-18/h3,8-14,18-19,25,36H,4-7H2,1-2H3,(H,34,37)(H,30,32,33)/t18-,19-,25-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192359
PNG
(US9187462, I-39)
Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@]1(F)CCNC1
Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25+/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192388
PNG
(BDBM192402 | US9187462, I-68)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cccc(F)c1
Show InChI InChI=1S/C25H24F2N6O2/c1-33-14-17(12-29-33)23(15-3-2-4-18(26)9-15)32-24(34)16-10-21(27)20-13-28-25(31-22(20)11-16)30-19-5-7-35-8-6-19/h2-4,9-14,19,23H,5-8H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192437
PNG
(US9187462, II-47)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnco1
Show InChI InChI=1S/C25H23F2N5O4/c1-34-21-3-2-14(8-19(21)27)23(22-12-28-13-36-22)32-24(33)15-9-18(26)17-11-29-25(31-20(17)10-15)30-16-4-6-35-7-5-16/h2-3,8-13,16,23H,4-7H2,1H3,(H,32,33)(H,29,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192438
PNG
(US9187462, II-48)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnnn1C
Show InChI InChI=1S/C25H25F2N7O3/c1-34-21(13-29-33-34)23(14-3-4-22(36-2)19(27)9-14)32-24(35)15-10-18(26)17-12-28-25(31-20(17)11-15)30-16-5-7-37-8-6-16/h3-4,9-13,16,23H,5-8H2,1-2H3,(H,32,35)(H,28,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192332
PNG
(US9187462, I-12)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192342
PNG
(US9187462, I-22)
Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-7-4-21(33-34)23(14-2-3-18(26)20(28)10-14)32-24(35)15-11-19(27)17-13-29-25(31-22(17)12-15)30-16-5-8-36-9-6-16/h2-4,7,10-13,16,23H,5-6,8-9H2,1H3,(H,32,35)(H,29,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192367
PNG
(US9187462, I-47)
Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCO[C@H](CO)C3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C26H26ClFN6O3/c1-34-13-18(12-30-34)24(15-4-5-21(27)22(28)8-15)33-25(36)16-2-3-17-11-29-26(32-23(17)9-16)31-19-6-7-37-20(10-19)14-35/h2-5,8-9,11-13,19-20,24,35H,6-7,10,14H2,1H3,(H,33,36)(H,29,31,32)/t19-,20+,24+/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192443
PNG
(US9187462, II-53)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(Nc3ccnn3C)nc2c1)c1cncn1C
Show InChI InChI=1S/C25H22F2N8O2/c1-34-13-28-12-20(34)23(14-4-5-21(37-3)18(27)8-14)33-24(36)15-9-17(26)16-11-29-25(31-19(16)10-15)32-22-6-7-30-35(22)2/h4-13,23H,1-3H3,(H,33,36)(H,29,31,32)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193411
PNG
(US9670208, Example 275 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(Cc3cccc(n3)-c3ccccc3)nnc2c1
Show InChI InChI=1S/C26H21N9/c1-34-23(11-14-28-34)31-26-27-13-10-22(30-26)19-12-15-35-24(16-19)32-33-25(35)17-20-8-5-9-21(29-20)18-6-3-2-4-7-18/h2-16H,17H2,1H3,(H,27,30,31)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192353
PNG
(US9187462, I-33)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)21(28)9-15)33-25(35)16-10-20(27)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (human))
BDBM120117
PNG
(US8697715, 250 | US9259470, 250)
Show SMILES Clc1ccc2cc(Cn3ccc(cc3=O)-c3ccnc(NC4CCOCC4)n3)[nH]c2c1
Show InChI InChI=1S/C23H22ClN5O2/c24-17-2-1-15-11-19(26-21(15)13-17)14-29-8-4-16(12-22(29)30)20-3-7-25-23(28-20)27-18-5-9-31-10-6-18/h1-4,7-8,11-13,18,26H,5-6,9-10,14H2,(H,25,27,28)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9259470 (2016)


BindingDB Entry DOI: 10.7270/Q28S4NSQ
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192356
PNG
(US9187462, I-36)
Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@]1(F)CCNC1
Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192351
PNG
(US9187462, I-31)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1C[C@H](F)CN1
Show InChI InChI=1S/C26H29F2N5O3/c1-35-23-5-4-15(10-20(23)28)24(22-12-18(27)14-29-22)33-25(34)16-2-3-17-13-30-26(32-21(17)11-16)31-19-6-8-36-9-7-19/h2-5,10-11,13,18-19,22,24,29H,6-9,12,14H2,1H3,(H,33,34)(H,30,31,32)/t18-,22+,24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193754
PNG
(US9670208, Example 306 N-(1-methyl-1H-pyrazol-5-yl...)
Show SMILES Cn1nccc1Nc1nccc(n1)-c1ccn2c(CS(=O)(=O)c3ccccc3)nnc2c1
Show InChI InChI=1S/C21H18N8O2S/c1-28-18(8-11-23-28)25-21-22-10-7-17(24-21)15-9-12-29-19(13-15)26-27-20(29)14-32(30,31)16-5-3-2-4-6-16/h2-13H,14H2,1H3,(H,22,24,25)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM193780
PNG
(US9670208, Example 467 N-(1-(3-chloro-4-fluorophen...)
Show SMILES CC(=O)NC(Cc1nnc2cc(ccn12)-c1ccnc(Nc2ccnn2C)n1)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C24H21ClFN9O/c1-14(36)29-20(15-3-4-18(26)17(25)11-15)13-23-33-32-22-12-16(7-10-35(22)23)19-5-8-27-24(30-19)31-21-6-9-28-34(21)2/h3-12,20H,13H2,1-2H3,(H,29,36)(H,27,30,31)
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...


US Patent US9670208 (2017)


BindingDB Entry DOI: 10.7270/Q2RJ4GMB
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192327
PNG
(US9187462, I-7)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1
Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23+/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192442
PNG
(US9187462, II-52)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1nccn1C
Show InChI InChI=1S/C26H26F2N6O3/c1-34-8-7-29-24(34)23(15-3-4-22(36-2)20(28)11-15)33-25(35)16-12-19(27)18-14-30-26(32-21(18)13-16)31-17-5-9-37-10-6-17/h3-4,7-8,11-14,17,23H,5-6,9-10H2,1-2H3,(H,33,35)(H,30,31,32)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192355
PNG
(US9187462, I-35)
Show SMILES C[C@@H]1CC[C@@H](N1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C26H29ClFN5O2/c1-15-2-7-22(30-15)24(16-5-6-20(27)21(28)12-16)33-25(34)17-3-4-18-14-29-26(32-23(18)13-17)31-19-8-10-35-11-9-19/h3-6,12-15,19,22,24,30H,2,7-11H2,1H3,(H,33,34)(H,29,31,32)/t15-,22-,24+/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192346
PNG
(US9187462, I-26)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(N[C@H](C)C3CC3)nc2c1)[C@H]1CCCN1
Show InChI InChI=1S/C26H30FN5O2/c1-15(16-5-6-16)30-26-29-14-19-8-7-18(13-22(19)31-26)25(33)32-24(21-4-3-11-28-21)17-9-10-23(34-2)20(27)12-17/h7-10,12-16,21,24,28H,3-6,11H2,1-2H3,(H,32,33)(H,29,30,31)/t15-,21-,24+/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192381
PNG
(US9187462, I-61)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@@H]3CCOC3)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C25H24F2N6O3/c1-33-12-16(10-29-33)23(14-3-4-22(35-2)20(27)7-14)32-24(34)15-8-19(26)18-11-28-25(31-21(18)9-15)30-17-5-6-36-13-17/h3-4,7-12,17,23H,5-6,13H2,1-2H3,(H,32,34)(H,28,30,31)/t17-,23+/m1/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192340
PNG
(US9187462, I-20)
Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C25H24ClFN6O2/c1-33-9-6-21(32-33)23(15-4-5-19(26)20(27)12-15)31-24(34)16-2-3-17-14-28-25(30-22(17)13-16)29-18-7-10-35-11-8-18/h2-6,9,12-14,18,23H,7-8,10-11H2,1H3,(H,31,34)(H,28,29,30)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192323
PNG
(US9187462, I-3)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@H]1CCCN1
Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192408
PNG
(US9187462, II-18)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3cc(C)nn3C)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C26H25FN8O2/c1-15-9-23(35(3)33-15)31-26-28-12-18-6-5-17(11-21(18)30-26)25(36)32-24(19-13-29-34(2)14-19)16-7-8-22(37-4)20(27)10-16/h5-14,24H,1-4H3,(H,32,36)(H,28,30,31)/t24-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
MAP kinase ERK2


(Homo sapiens (human))
BDBM192406
PNG
(US9187462, II-16)
Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(Nc3ccnn3C)nc2c1)c1cnn(C)c1
Show InChI InChI=1S/C25H23FN8O2/c1-33-14-18(13-29-33)23(15-6-7-21(36-3)19(26)10-15)32-24(35)16-4-5-17-12-27-25(30-20(17)11-16)31-22-8-9-28-34(22)2/h4-14,23H,1-3H3,(H,32,35)(H,27,30,31)/t23-/m0/s1
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Array BioPharma Inc.; Genentech, Inc.

US Patent


Assay Description
Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...


US Patent US9187462 (2015)


BindingDB Entry DOI: 10.7270/Q21G0K2P
More data for this
Ligand-Target Pair
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