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Compile Data Set for Download or QSAR

Found 283 hits from Array BioPharma, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136642
PNG
(US10047097, 59 | US8865698, 59 | US9676783, 59)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1
Show InChI InChI=1S/C22H18F2N6O/c23-14-6-7-16(24)15(12-14)19-5-3-10-29(19)20-8-11-30-21(28-20)18(13-26-30)27-22(31)17-4-1-2-9-25-17/h1-2,4,6-9,11-13,19H,3,5,10H2,(H,27,31)/t19-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136646
PNG
(US10047097, 63 | US8865698, 63 | US9676783, 63)
Show SMILES Cc1cccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-9-26-21(14)23(32)28-18-13-27-31-11-8-20(29-22(18)31)30-10-3-5-19(30)16-12-15(24)6-7-17(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,28,32)/t19-/m1/s1
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n/an/a 1.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200576
PNG
(US9227975, 4)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C24H22F2N6O3S/c1-36(34,35)30-17-7-4-15(5-8-17)24(33)28-23-14-27-21-10-11-22(29-32(21)23)31-12-2-3-20(31)18-13-16(25)6-9-19(18)26/h4-11,13-14,20,30H,2-3,12H2,1H3,(H,28,33)/t20-/m1/s1
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n/an/a 2.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200614
PNG
(US9227975, 40)
Show SMILES O[C@@H]1CN(C[C@H]1O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O3/c22-12-3-4-14(23)13(8-12)15-2-1-7-28(15)19-6-5-18-24-9-20(29(18)26-19)25-21(32)27-10-16(30)17(31)11-27/h3-6,8-9,15-17,30-31H,1-2,7,10-11H2,(H,25,32)/t15-,16-,17-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136640
PNG
(US10047097, 57 | US8865698, 57 | US9676783, 57)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cnccn3)c2n1
Show InChI InChI=1S/C21H17F2N7O/c22-13-3-4-15(23)14(10-13)18-2-1-8-29(18)19-5-9-30-20(28-19)16(12-26-30)27-21(31)17-11-24-6-7-25-17/h3-7,9-12,18H,1-2,8H2,(H,27,31)/t18-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200633
PNG
(US9227975, 57)
Show SMILES Cn1nc(ccc1=O)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H19F2N7O2/c1-29-21(32)9-6-16(27-29)22(33)26-20-12-25-18-7-8-19(28-31(18)20)30-10-2-3-17(30)14-11-13(23)4-5-15(14)24/h4-9,11-12,17H,2-3,10H2,1H3,(H,26,33)/t17-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136650
PNG
(US10047097, 67 | US8865698, 67 | US9676783, 67)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ncccn3)c2n1
Show InChI InChI=1S/C21H17F2N7O/c22-13-4-5-15(23)14(11-13)17-3-1-9-29(17)18-6-10-30-20(28-18)16(12-26-30)27-21(31)19-24-7-2-8-25-19/h2,4-8,10-12,17H,1,3,9H2,(H,27,31)/t17-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136638
PNG
(US10047097, 55 | US8865698, 55 | US9676783, 55)
Show SMILES CC(C)Nc1nc(cs1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H23F2N7OS/c1-13(2)27-23-29-18(12-34-23)22(33)28-17-11-26-32-9-7-20(30-21(17)32)31-8-3-4-19(31)15-10-14(24)5-6-16(15)25/h5-7,9-13,19H,3-4,8H2,1-2H3,(H,27,29)(H,28,33)/t19-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136641
PNG
(US10047097, 58 | US8865698, 58 | US9676783, 58)
Show SMILES Cc1cnc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H19F2N7O/c1-13-10-26-18(11-25-13)22(32)28-17-12-27-31-8-6-20(29-21(17)31)30-7-2-3-19(30)15-9-14(23)4-5-16(15)24/h4-6,8-12,19H,2-3,7H2,1H3,(H,28,32)/t19-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136667
PNG
(US10047097, 84 | US8865698, 84 | US9676783, 84)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1S/C22H22F4N6O2/c23-13-3-4-16(22(24,25)26)15(10-13)18-2-1-7-31(18)19-6-9-32-20(29-19)17(11-27-32)28-21(34)30-8-5-14(33)12-30/h3-4,6,9-11,14,18,33H,1-2,5,7-8,12H2,(H,28,34)/t14-,18+/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136654
PNG
(US10047097, 71 | US8865698, 71 | US9676783, 71)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cccc(Cl)n3)c2n1
Show InChI InChI=1S/C22H17ClF2N6O/c23-19-5-1-3-16(27-19)22(32)28-17-12-26-31-10-8-20(29-21(17)31)30-9-2-4-18(30)14-11-13(24)6-7-15(14)25/h1,3,5-8,10-12,18H,2,4,9H2,(H,28,32)/t18-/m1/s1
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n/an/a 3.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200582
PNG
(US9227975, 10)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)17-2-1-8-28(17)19-6-5-18-24-11-20(29(18)26-19)25-21(31)27-9-7-14(30)12-27/h3-6,10-11,14,17,30H,1-2,7-9,12H2,(H,25,31)/t14-,17+/m0/s1
PDB
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n/an/a 3.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136644
PNG
(US10047097, 61 | US8865698, 61 | US9676783, 61)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccc(Cl)cn3)c2n1
Show InChI InChI=1S/C22H17ClF2N6O/c23-13-3-6-17(26-11-13)22(32)28-18-12-27-31-9-7-20(29-21(18)31)30-8-1-2-19(30)15-10-14(24)4-5-16(15)25/h3-7,9-12,19H,1-2,8H2,(H,28,32)/t19-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136651
PNG
(US10047097, 68 | US8865698, 68 | US9676783, 68)
Show SMILES Fc1cccc(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3ccccn3)c2n1
Show InChI InChI=1S/C22H19FN6O/c23-16-6-3-5-15(13-16)19-8-4-11-28(19)20-9-12-29-21(27-20)18(14-25-29)26-22(30)17-7-1-2-10-24-17/h1-3,5-7,9-10,12-14,19H,4,8,11H2,(H,26,30)/t19-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136645
PNG
(US10047097, 62 | US8865698, 62 | US9676783, 62)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)c3cc(Cl)ccn3)c2n1
Show InChI InChI=1S/C22H17ClF2N6O/c23-13-5-7-26-17(10-13)22(32)28-18-12-27-31-9-6-20(29-21(18)31)30-8-1-2-19(30)15-11-14(24)3-4-16(15)25/h3-7,9-12,19H,1-2,8H2,(H,28,32)/t19-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136624
PNG
(US10047097, 41 | US8865698, 41 | US9676783, 41)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1S/C21H22ClFN6O2/c22-16-4-3-13(23)10-15(16)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18-/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136643
PNG
(US10047097, 60 | US8865698, 60 | US9676783, 60)
Show SMILES Cc1cccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C23H20F2N6O/c1-14-4-2-5-18(27-14)23(32)28-19-13-26-31-11-9-21(29-22(19)31)30-10-3-6-20(30)16-12-15(24)7-8-17(16)25/h2,4-5,7-9,11-13,20H,3,6,10H2,1H3,(H,28,32)/t20-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136635
PNG
(US10047097, 52 | US8865698, 52 | US9676783, 52)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3(CC3)C#N)c2n1
Show InChI InChI=1S/C21H18F2N6O/c22-13-3-4-15(23)14(10-13)17-2-1-8-28(17)18-5-9-29-19(27-18)16(11-25-29)26-20(30)21(12-24)6-7-21/h3-5,9-11,17H,1-2,6-8H2,(H,26,30)/t17-/m1/s1
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n/an/a 4.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136601
PNG
(US10047097, 18 | US8865698, 18 | US9676783, 18)
Show SMILES Fc1ccc(NC(=O)Nc2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-19-13-27-32-11-9-21(30-22(19)32)31-10-1-2-20(31)17-12-15(25)5-8-18(17)26/h3-9,11-13,20H,1-2,10H2,(H2,28,29,33)/t20-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136682
PNG
(US10047097, 99 | US8865698, 99 | US9676783, 99)
Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1
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n/an/a 4.65n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136688
PNG
(US10047097, 105 | US8865698, 105 | US9676783, 105)
Show SMILES OC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H15F2N5O3/c19-10-3-4-12(20)11(8-10)14-2-1-6-24(14)15-5-7-25-16(23-15)13(9-21-25)22-17(26)18(27)28/h3-5,7-9,14H,1-2,6H2,(H,22,26)(H,27,28)/t14-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136616
PNG
(US10047097, 33 | US8865698, 33 | US9676783, 33)
Show SMILES COC(=O)C1(CC1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C22H21F2N5O3/c1-32-21(31)22(7-8-22)20(30)26-16-12-25-29-10-6-18(27-19(16)29)28-9-2-3-17(28)14-11-13(23)4-5-15(14)24/h4-6,10-12,17H,2-3,7-9H2,1H3,(H,26,30)/t17-/m1/s1
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n/an/a 4.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136603
PNG
(US10047097, 20 | US8865698, 20 | US9676783, 20)
Show SMILES COc1ccc(NC(=O)Nc2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-20-14-27-32-12-10-22(30-23(20)32)31-11-2-3-21(31)18-13-15(25)4-9-19(18)26/h4-10,12-14,21H,2-3,11H2,1H3,(H2,28,29,33)/t21-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136587
PNG
(US10047097, 4 | US8865698, 4 | US9676783, 4)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccccc3)c2n1
Show InChI InChI=1S/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)20-7-4-11-30(20)21-10-12-31-22(29-21)19(14-26-31)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-10,12-14,20H,4,7,11H2,(H2,27,28,32)/t20-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136634
PNG
(US10047097, 51 | US8865698, 51 | US9676783, 51)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)C3(CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C21H18F5N5O/c22-12-3-4-14(23)13(10-12)16-2-1-8-30(16)17-5-9-31-18(29-17)15(11-27-31)28-19(32)20(6-7-20)21(24,25)26/h3-5,9-11,16H,1-2,6-8H2,(H,28,32)/t16-/m1/s1
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n/an/a 5.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200575
PNG
(US9227975, 3)
Show SMILES CC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N5O/c1-11(26)22-18-10-21-16-6-7-17(23-25(16)18)24-8-2-3-15(24)13-9-12(19)4-5-14(13)20/h4-7,9-10,15H,2-3,8H2,1H3,(H,22,26)/t15-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200604
PNG
(US9227975, 30)
Show SMILES COc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C24H22F2N6O2/c1-34-17-7-5-16(6-8-17)28-24(33)29-23-14-27-21-10-11-22(30-32(21)23)31-12-2-3-20(31)18-13-15(25)4-9-19(18)26/h4-11,13-14,20H,2-3,12H2,1H3,(H2,28,29,33)/t20-/m1/s1
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n/an/a 5.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136662
PNG
(US10047097, 79 | US8865698, 79 | US9676783, 79)
Show SMILES COc1ncccc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C23H21FN6O2/c1-32-23-17(7-3-10-25-23)22(31)27-18-14-26-30-12-9-20(28-21(18)30)29-11-4-8-19(29)15-5-2-6-16(24)13-15/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/m1/s1
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n/an/a 5.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136668
PNG
(US10047097, 85 | US8865698, 85 | US9676783, 85)
Show SMILES O[C@@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1S/C22H22F4N6O2/c23-13-3-4-16(22(24,25)26)15(10-13)18-2-1-7-31(18)19-6-9-32-20(29-19)17(11-27-32)28-21(34)30-8-5-14(33)12-30/h3-4,6,9-11,14,18,33H,1-2,5,7-8,12H2,(H,28,34)/t14-,18-/m1/s1
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n/an/a 5.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136652
PNG
(US10047097, 69 | US8865698, 69 | US9676783, 69)
Show SMILES Cc1cccnc1C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C23H21FN6O/c1-15-5-3-10-25-21(15)23(31)27-18-14-26-30-12-9-20(28-22(18)30)29-11-4-8-19(29)16-6-2-7-17(24)13-16/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/m1/s1
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n/an/a 6.20n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136628
PNG
(US10047097, 45 | US8865698, 45 | US9676783, 45)
Show SMILES CC(C)(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H23F2N5O/c1-21(2,3)20(29)25-16-12-24-28-10-8-18(26-19(16)28)27-9-4-5-17(27)14-11-13(22)6-7-15(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H,25,29)/t17-/m1/s1
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n/an/a 6.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136665
PNG
(US10047097, 82 | US8865698, 82 | US9676783, 82)
Show SMILES Cc1cnc(cn1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C22H20FN7O/c1-14-11-25-18(12-24-14)22(31)27-17-13-26-30-9-7-20(28-21(17)30)29-8-3-6-19(29)15-4-2-5-16(23)10-15/h2,4-5,7,9-13,19H,3,6,8H2,1H3,(H,27,31)/t19-/m1/s1
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n/an/a 6.60n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200599
PNG
(US9227975, 26)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)N3CCCCC3)n2n1
Show InChI InChI=1S/C22H24F2N6O/c23-15-6-7-17(24)16(13-15)18-5-4-12-29(18)20-9-8-19-25-14-21(30(19)27-20)26-22(31)28-10-2-1-3-11-28/h6-9,13-14,18H,1-5,10-12H2,(H,26,31)/t18-/m1/s1
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n/an/a 7.10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136658
PNG
(US10047097, 75 | US8865698, 75 | US9676783, 75)
Show SMILES COc1cccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C23H21FN6O2/c1-32-21-9-3-7-17(26-21)23(31)27-18-14-25-30-12-10-20(28-22(18)30)29-11-4-8-19(29)15-5-2-6-16(24)13-15/h2-3,5-7,9-10,12-14,19H,4,8,11H2,1H3,(H,27,31)/t19-/m1/s1
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n/an/a 7.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136647
PNG
(US10047097, 64 | US8865698, 64 | US9676783, 64)
Show SMILES CC(C)(CO)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H23F2N5O2/c1-21(2,12-29)20(30)25-16-11-24-28-9-7-18(26-19(16)28)27-8-3-4-17(27)14-10-13(22)5-6-15(14)23/h5-7,9-11,17,29H,3-4,8,12H2,1-2H3,(H,25,30)/t17-/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136681
PNG
(US10047097, 98 | US8865698, 98 | US9676783, 98)
Show SMILES CNC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H18F2N6O2/c1-22-18(28)19(29)24-14-10-23-27-8-6-16(25-17(14)27)26-7-2-3-15(26)12-9-11(20)4-5-13(12)21/h4-6,8-10,15H,2-3,7H2,1H3,(H,22,28)(H,24,29)/t15-/m1/s1
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n/an/a 7.65n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136687
PNG
(US10047097, 104 | US8865698, 104 | US9676783, 104)
Show SMILES COC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H17F2N5O3/c1-29-19(28)18(27)23-14-10-22-26-8-6-16(24-17(14)26)25-7-2-3-15(25)12-9-11(20)4-5-13(12)21/h4-6,8-10,15H,2-3,7H2,1H3,(H,23,27)/t15-/m1/s1
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n/an/a 7.65n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136664
PNG
(US10047097, 81 | US8865698, 81 | US9676783, 81)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1Cl
Show InChI InChI=1S/C21H22ClFN6O2/c22-16-4-3-13(23)10-15(16)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200573
PNG
(US9227975, 1)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccc2ncc(NC(=O)Nc3ccccc3)n2n1
Show InChI InChI=1S/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)19-7-4-12-30(19)21-11-10-20-26-14-22(31(20)29-21)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-11,13-14,19H,4,7,12H2,(H2,27,28,32)/t19-/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200622
PNG
(US9227975, 48)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1(C)C)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C28H35F2N7O3/c1-27(2,3)40-26(39)36-14-13-34(17-28(36,4)5)25(38)32-24-16-31-22-10-11-23(33-37(22)24)35-12-6-7-21(35)19-15-18(29)8-9-20(19)30/h8-11,15-16,21H,6-7,12-14,17H2,1-5H3,(H,32,38)/t21-/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136656
PNG
(US10047097, 73 | US8865698, 73 | US9676783, 73)
Show SMILES Cn1ccc(n1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C21H20FN7O/c1-27-10-7-16(26-27)21(30)24-17-13-23-29-11-8-19(25-20(17)29)28-9-3-6-18(28)14-4-2-5-15(22)12-14/h2,4-5,7-8,10-13,18H,3,6,9H2,1H3,(H,24,30)/t18-/m1/s1
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n/an/a 8.5n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136620
PNG
(US10047097, 37 | US8865698, 37 | US9676783, 37)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F
Show InChI InChI=1S/C22H23F3N6O2/c23-13-3-4-15(20(24)25)16(10-13)18-2-1-7-30(18)19-6-9-31-21(28-19)17(11-26-31)27-22(33)29-8-5-14(32)12-29/h3-4,6,9-11,14,18,20,32H,1-2,5,7-8,12H2,(H,27,33)/t14-,18+/m0/s1
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n/an/a 8.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200629
PNG
(US9227975, 54)
Show SMILES CC1(O)CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c1-21(31)11-27(12-21)20(30)25-19-10-24-17-6-7-18(26-29(17)19)28-8-2-3-16(28)14-9-13(22)4-5-15(14)23/h4-7,9-10,16,31H,2-3,8,11-12H2,1H3,(H,25,30)/t16-/m1/s1
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n/an/a 8.90n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50339823
PNG
(CHEMBL1761090 | N-((2S)-3-(8',9'-dihydro-3'H-spiro...)
Show SMILES CCOCCN(C[C@@H](O)CN1CCCC2(CCc3c(O2)ccc2[nH]ncc32)C1)S(=O)(=O)c1c(C)cccc1C
Show InChI InChI=1S/C29H40N4O5S/c1-4-37-16-15-33(39(35,36)28-21(2)7-5-8-22(28)3)19-23(34)18-32-14-6-12-29(20-32)13-11-24-25-17-30-31-26(25)9-10-27(24)38-29/h5,7-10,17,23,34H,4,6,11-16,18-20H2,1-3H3,(H,30,31)/t23-,29?/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Array BioPharma, Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 by IMAP assay


Bioorg Med Chem Lett 21: 2410-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.073
BindingDB Entry DOI: 10.7270/Q2KW5G9K
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200586
PNG
(US9227975, 13)
Show SMILES OC1CN(C1)C(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H20F2N6O2/c21-12-3-4-15(22)14(8-12)16-2-1-7-27(16)18-6-5-17-23-9-19(28(17)25-18)24-20(30)26-10-13(29)11-26/h3-6,8-9,13,16,29H,1-2,7,10-11H2,(H,24,30)/t16-/m1/s1
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n/an/a 9.40n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136597
PNG
(US10047097, 14 | US8865698, 14 | US9676783, 14)
Show SMILES O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
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n/an/a 9.70n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200603
PNG
(US9227975, 29)
Show SMILES CC(C)(C)NC(=O)Nc1cnc2ccc(nn12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N6O/c1-21(2,3)26-20(30)25-19-12-24-17-8-9-18(27-29(17)19)28-10-4-5-16(28)14-11-13(22)6-7-15(14)23/h6-9,11-12,16H,4-5,10H2,1-3H3,(H2,25,26,30)/t16-/m1/s1
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n/an/a 9.80n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM200595
PNG
(US9227975, 22)
Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccc(nn23)N2CCC[C@@H]2c2cc(F)ccc2F)cc1
Show InChI InChI=1S/C23H19F3N6O/c24-14-3-6-16(7-4-14)28-23(33)29-22-13-27-20-9-10-21(30-32(20)22)31-11-1-2-19(31)17-12-15(25)5-8-18(17)26/h3-10,12-13,19H,1-2,11H2,(H2,28,29,33)/t19-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US9227975 (2016)


BindingDB Entry DOI: 10.7270/Q2GQ6WKV
More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50339824
PNG
(CHEMBL1761089 | N-(2-ethoxyethyl)-N-((2S)-2-hydrox...)
Show SMILES CCOCCN(C[C@@H](O)CN1CCCC2(CCc3cc4C(=O)NCc4cc3O2)C1)S(=O)(=O)c1c(C)cccc1C
Show InChI InChI=1S/C30H41N3O6S/c1-4-38-14-13-33(40(36,37)28-21(2)7-5-8-22(28)3)19-25(34)18-32-12-6-10-30(20-32)11-9-23-15-26-24(16-27(23)39-30)17-31-29(26)35/h5,7-8,15-16,25,34H,4,6,9-14,17-20H2,1-3H3,(H,31,35)/t25-,30?/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Array BioPharma, Inc.

Curated by ChEMBL


Assay Description
Inhibition of AKT1 by IMAP assay


Bioorg Med Chem Lett 21: 2410-4 (2011)


Article DOI: 10.1016/j.bmcl.2011.02.073
BindingDB Entry DOI: 10.7270/Q2KW5G9K
More data for this
Ligand-Target Pair
Tyrosine kinase receptor A (TrkA)


(Homo sapiens (Human))
BDBM136602
PNG
(US10047097, 19 | US8865698, 19 | US9676783, 19)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccc(Cl)cc3)c2n1
Show InChI InChI=1S/C23H19ClF2N6O/c24-14-3-6-16(7-4-14)28-23(33)29-19-13-27-32-11-9-21(30-22(19)32)31-10-1-2-20(31)17-12-15(25)5-8-18(17)26/h3-9,11-13,20H,1-2,10H2,(H2,28,29,33)/t20-/m1/s1
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n/an/a 10.1n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Immulon 4HBX 384-well microtiter plates (Thermo part #8755) were coated with a 0.025 mg/mL solution of poly (Glu, Ala, Tyr; 6:3:1; Sigma P3899). Vari...


US Patent US9676783 (2017)


Article DOI: 10.1021/jm9800595
BindingDB Entry DOI: 10.7270/Q26H4FK5
More data for this
Ligand-Target Pair
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